PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27106542-4 2016 The ER stress inhibitor tauroursodeoxycholic acid (TUDCA) given at reperfusion resulted in a significant reduction of GRP78 expression 30 and 60 min after the onset of reperfusion, an effect that was reversed by the zinc chelator N,N,N",N"-tetrakis-(2-pyridylmethyl) ethylenediamine (TPEN). ursodoxicoltaurine 24-49 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 118-123 28797762-4 2017 Ceramide promoted the transcriptional and translational expression of COX-2 and BiP in VSMCs, which were blocked by the ER stress inhibitors, 4-PBA and TUDCA. ursodoxicoltaurine 152-157 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 80-83 27904664-6 2016 The level of GRP78 (ER chaperone) expression was significantly upregulated by 30 microM TUDCA. ursodoxicoltaurine 88-93 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 13-18 31452457-11 2019 The intrathecal injection of tauroursodeoxycholic acid (TUD) as a specific inhibitor of ER stress attenuated BCP and reduced the expression of GRP78, ATF6, p-52 PERK, p-IRE1, and cleaved caspase-3 in the spinal cord. ursodoxicoltaurine 29-54 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 143-148 31452457-11 2019 The intrathecal injection of tauroursodeoxycholic acid (TUD) as a specific inhibitor of ER stress attenuated BCP and reduced the expression of GRP78, ATF6, p-52 PERK, p-IRE1, and cleaved caspase-3 in the spinal cord. ursodoxicoltaurine 56-59 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 143-148 27106542-4 2016 The ER stress inhibitor tauroursodeoxycholic acid (TUDCA) given at reperfusion resulted in a significant reduction of GRP78 expression 30 and 60 min after the onset of reperfusion, an effect that was reversed by the zinc chelator N,N,N",N"-tetrakis-(2-pyridylmethyl) ethylenediamine (TPEN). ursodoxicoltaurine 51-56 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 118-123 27106542-5 2016 The immunofluorescence study also showed that the effect of TUDCA on GRP78 expression was reversed by TPEN. ursodoxicoltaurine 60-65 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 69-74 19755525-8 2009 TUDCA normalized levels of GRP78 and GRP94 and mitochondrial GSK-3beta in OLETF rats. ursodoxicoltaurine 0-5 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 27-32 25010593-6 2014 Treatment with molecular chaperone glucose-regulated protein 78 kDa (GRP78, also known as BiP) or protein disulfite isomerase (PDI), and chemical chaperones taurine-conjugated ursodeoxycholic acid (TUDCA) or 4-phenylbutyrate (PBA), alleviated ER stress and increased insulin secretion in hIAPP-expressing cells. ursodoxicoltaurine 198-203 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 69-74 25010593-6 2014 Treatment with molecular chaperone glucose-regulated protein 78 kDa (GRP78, also known as BiP) or protein disulfite isomerase (PDI), and chemical chaperones taurine-conjugated ursodeoxycholic acid (TUDCA) or 4-phenylbutyrate (PBA), alleviated ER stress and increased insulin secretion in hIAPP-expressing cells. ursodoxicoltaurine 198-203 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 90-93 22972029-9 2013 TUDCA also attenuated palmitate-induced expressions of GRP78, CHOP and ATF4 in INS-1 cells. ursodoxicoltaurine 0-5 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 55-60 21778463-8 2011 Furthermore, TUDCA prevented caerulein-induced BiP upregulation, reduced XBP-1 splicing, and caspase 12 and 3 activation. ursodoxicoltaurine 13-18 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 47-50 20671193-9 2010 Furthermore, TUDCA prevented the CCK-8-induced BiP upregulation, diminished PERK and JNK phosphorylation, and prohibited the expression of CHOP, caspase 3 activation and apoptosis. ursodoxicoltaurine 13-18 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 47-50 27496879-4 2016 Lower mRNA levels of the ER stress biomarkers GRP78, ATF6, ATF4, and XBP-1s in the SFO and PVN of TUDCA-treated HF rats validated the efficacy of the TUDCA dose. ursodoxicoltaurine 98-103 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 46-51 27496879-4 2016 Lower mRNA levels of the ER stress biomarkers GRP78, ATF6, ATF4, and XBP-1s in the SFO and PVN of TUDCA-treated HF rats validated the efficacy of the TUDCA dose. ursodoxicoltaurine 150-155 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 46-51 35607370-12 2022 In conclusion, downregulation of GRP78 and CHOP expression is one of the mechanisms by which TUDCA inhibits TGF-beta1-induced renal mesangial cell fibrosis. ursodoxicoltaurine 93-98 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 33-38