PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27106542-4	2016	The ER stress inhibitor tauroursodeoxycholic acid (TUDCA) given at reperfusion resulted in a significant reduction of GRP78 expression 30 and 60 min after the onset of reperfusion, an effect that was reversed by the zinc chelator N,N,N",N"-tetrakis-(2-pyridylmethyl) ethylenediamine (TPEN).	ursodoxicoltaurine	24-49	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	118-123	
28797762-4	2017	Ceramide promoted the transcriptional and translational expression of COX-2 and BiP in VSMCs, which were blocked by the ER stress inhibitors, 4-PBA and TUDCA.	ursodoxicoltaurine	152-157	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	80-83	
27904664-6	2016	The level of GRP78 (ER chaperone) expression was significantly upregulated by 30 microM TUDCA.	ursodoxicoltaurine	88-93	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	13-18	
31452457-11	2019	The intrathecal injection of tauroursodeoxycholic acid (TUD) as a specific inhibitor of ER stress attenuated BCP and reduced the expression of GRP78, ATF6, p-52 PERK, p-IRE1, and cleaved caspase-3 in the spinal cord.	ursodoxicoltaurine	29-54	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	143-148	
31452457-11	2019	The intrathecal injection of tauroursodeoxycholic acid (TUD) as a specific inhibitor of ER stress attenuated BCP and reduced the expression of GRP78, ATF6, p-52 PERK, p-IRE1, and cleaved caspase-3 in the spinal cord.	ursodoxicoltaurine	56-59	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	143-148	
27106542-4	2016	The ER stress inhibitor tauroursodeoxycholic acid (TUDCA) given at reperfusion resulted in a significant reduction of GRP78 expression 30 and 60 min after the onset of reperfusion, an effect that was reversed by the zinc chelator N,N,N",N"-tetrakis-(2-pyridylmethyl) ethylenediamine (TPEN).	ursodoxicoltaurine	51-56	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	118-123	
27106542-5	2016	The immunofluorescence study also showed that the effect of TUDCA on GRP78 expression was reversed by TPEN.	ursodoxicoltaurine	60-65	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	69-74	
19755525-8	2009	TUDCA normalized levels of GRP78 and GRP94 and mitochondrial GSK-3beta in OLETF rats.	ursodoxicoltaurine	0-5	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	27-32	
25010593-6	2014	Treatment with molecular chaperone glucose-regulated protein 78 kDa (GRP78, also known as BiP) or protein disulfite isomerase (PDI), and chemical chaperones taurine-conjugated ursodeoxycholic acid (TUDCA) or 4-phenylbutyrate (PBA), alleviated ER stress and increased insulin secretion in hIAPP-expressing cells.	ursodoxicoltaurine	198-203	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	69-74	
25010593-6	2014	Treatment with molecular chaperone glucose-regulated protein 78 kDa (GRP78, also known as BiP) or protein disulfite isomerase (PDI), and chemical chaperones taurine-conjugated ursodeoxycholic acid (TUDCA) or 4-phenylbutyrate (PBA), alleviated ER stress and increased insulin secretion in hIAPP-expressing cells.	ursodoxicoltaurine	198-203	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	90-93	
22972029-9	2013	TUDCA also attenuated palmitate-induced expressions of GRP78, CHOP and ATF4 in INS-1 cells.	ursodoxicoltaurine	0-5	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	55-60	
21778463-8	2011	Furthermore, TUDCA prevented caerulein-induced BiP upregulation, reduced XBP-1 splicing, and caspase 12 and 3 activation.	ursodoxicoltaurine	13-18	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	47-50	
20671193-9	2010	Furthermore, TUDCA prevented the CCK-8-induced BiP upregulation, diminished PERK and JNK phosphorylation, and prohibited the expression of CHOP, caspase 3 activation and apoptosis.	ursodoxicoltaurine	13-18	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	47-50	
27496879-4	2016	Lower mRNA levels of the ER stress biomarkers GRP78, ATF6, ATF4, and XBP-1s in the SFO and PVN of TUDCA-treated HF rats validated the efficacy of the TUDCA dose.	ursodoxicoltaurine	98-103	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	46-51	
27496879-4	2016	Lower mRNA levels of the ER stress biomarkers GRP78, ATF6, ATF4, and XBP-1s in the SFO and PVN of TUDCA-treated HF rats validated the efficacy of the TUDCA dose.	ursodoxicoltaurine	150-155	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	46-51	
35607370-12	2022	In conclusion, downregulation of GRP78 and CHOP expression is one of the mechanisms by which TUDCA inhibits TGF-beta1-induced renal mesangial cell fibrosis.	ursodoxicoltaurine	93-98	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	33-38