PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31978676-11	2020	Administration of TUDCA lead to a partial decrease in GRP78 expression, NFkappaB1 mRNA, NF-kappaB p65 protein, C22-C24 CERs and C1P levels along with a decrease in caspase-3 and -12 activity.	ursodoxicoltaurine	18-23	caspase 3	Homo sapiens	164-173	
31869409-9	2020	Treatment with H2O2 increased apoptosis and the activity of the pro-apoptotic factors caspase-8 and caspase-3, both of which were attenuated by TUDCA.	ursodoxicoltaurine	144-149	caspase 3	Homo sapiens	100-109	
30324160-8	2018	In the EC group, both apoptotic genes were reduced by ER stress inhibitor treatments compared to control (p<0.05) except Caspase-3 gene by TUDCA treatment.	ursodoxicoltaurine	142-147	caspase 3	Homo sapiens	124-133	
29751043-8	2018	In addition, TUDCA suppressed gentamicin-induced endoplasmic reticulum stress as reflected by inversing the expression levels of Binding immunoglobulin protein (Bip), CCAAT/-enhancer-binding protein homologous protein (CHOP) and Caspase 3.	ursodoxicoltaurine	13-18	caspase 3	Homo sapiens	229-238	
26950211-7	2016	RESULTS: Preconditioning with the pro-apoptotic bile acids GCDCA, taurocholic acid, or the protective bile acids (tauro)ursodeoxycholic acid reduced GCDCA-induced caspase-3/7 activity in HepG2.rNtcp cells.	ursodoxicoltaurine	113-140	caspase 3	Homo sapiens	163-172	
26355342-10	2015	In contrast, the LPS challenge is blocked by the ER stress inhibitor TUDCA, resulting in: CHOP downregulation, reduced caspase-1, caspase-11, caspase-3 activities, lowered interleukin-1beta secretion and rescue from cell death.	ursodoxicoltaurine	69-74	caspase 3	Homo sapiens	142-151	
17559149-7	2007	However, inhibition studies performed using tauroursodeoxycholic acid (TUDCA) demonstrate its ability to inhibit caspase-4 and caspase-3/7 activation, mitochondrial cytochrome c release, and caspase-3 cleavage induced by ZAAT and to promote cell survival.	ursodoxicoltaurine	44-69	caspase 3	Homo sapiens	127-136	
17559149-7	2007	However, inhibition studies performed using tauroursodeoxycholic acid (TUDCA) demonstrate its ability to inhibit caspase-4 and caspase-3/7 activation, mitochondrial cytochrome c release, and caspase-3 cleavage induced by ZAAT and to promote cell survival.	ursodoxicoltaurine	44-69	caspase 3	Homo sapiens	191-200	
17559149-7	2007	However, inhibition studies performed using tauroursodeoxycholic acid (TUDCA) demonstrate its ability to inhibit caspase-4 and caspase-3/7 activation, mitochondrial cytochrome c release, and caspase-3 cleavage induced by ZAAT and to promote cell survival.	ursodoxicoltaurine	71-76	caspase 3	Homo sapiens	127-136	
17559149-7	2007	However, inhibition studies performed using tauroursodeoxycholic acid (TUDCA) demonstrate its ability to inhibit caspase-4 and caspase-3/7 activation, mitochondrial cytochrome c release, and caspase-3 cleavage induced by ZAAT and to promote cell survival.	ursodoxicoltaurine	71-76	caspase 3	Homo sapiens	191-200	
12773247-5	2003	Following incubation of HepG2 cells either with TDCA alone, or coincubation with TUDCA and TDCA, the releasing level of cytochrome c from mitochondria into cytosol was determined by western blot, also the activity of caspase-3, 8, 9.	ursodoxicoltaurine	81-86	caspase 3	Homo sapiens	217-226	
12773247-8	2003	TUDCA significantly inhibited the release of cytochrome C from mitochondria into cytosol, and the activity of caspase-9, 3 (t > or = 13.00, P < 0.01), especially at 12 h, caspase-3 activity decreased by 54.9% (t = 16.88, P < 0.01) and 52.5%, however it had no obvious effect on the activity of caspase-8 (t = 1.94, P > 0.05).	ursodoxicoltaurine	0-5	caspase 3	Homo sapiens	177-186	
35562919-5	2022	Experiments in vitro demonstrated that TUDCA prevented hyperosmotically induced cell death by reducing nuclear DNA fragmentation and caspase-3 activation.	ursodoxicoltaurine	39-44	caspase 3	Homo sapiens	133-142