PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20847398-8	2010	Importantly, TUDCA abrogated Abeta-induced JNK/caspase-2 signaling.	ursodoxicoltaurine	13-18	mitogen-activated protein kinase 8	Rattus norvegicus	43-46	
24333191-8	2014	In the HG groups supplemented with NT-4 and TUDCA, the numbers of TUNEL-positive, p-c-Jun- and p-JNK-immunopositive cells were significantly lower and the numbers of neurites were significantly higher than in the HG group without NT-4 and TUDCA.	ursodoxicoltaurine	44-49	mitogen-activated protein kinase 8	Rattus norvegicus	97-100	
24333191-10	2014	Neuroprotective effect of TUDCA and NT-4 is correlated with the suppression of p-c-Jun and p-JNK expression.	ursodoxicoltaurine	26-31	mitogen-activated protein kinase 8	Rattus norvegicus	93-96	
20671193-9	2010	Furthermore, TUDCA prevented the CCK-8-induced BiP upregulation, diminished PERK and JNK phosphorylation, and prohibited the expression of CHOP, caspase 3 activation and apoptosis.	ursodoxicoltaurine	13-18	mitogen-activated protein kinase 8	Rattus norvegicus	85-88	
20847398-9	2010	In conclusion, we show that JNK is the proximal stress sensor for soluble Abeta-induced toxicity, which translocates to the nucleus, activates caspase-2, and is strongly modulated by TUDCA in PC12 neuronal cells.	ursodoxicoltaurine	183-188	mitogen-activated protein kinase 8	Rattus norvegicus	28-31	
26044599-5	2015	This was due to a rapid TUDC-induced beta1-integrin-dependent cyclic AMP (cAMP) signal with induction of the dual specificity mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1), which prevented GCDC-induced phosphorylation of mitogen-activated protein kinase kinase 4 (MKK4) and c-jun-NH2-terminal kinase (JNK) activation.	ursodoxicoltaurine	24-28	mitogen-activated protein kinase 8	Rattus norvegicus	289-314	
26044599-5	2015	This was due to a rapid TUDC-induced beta1-integrin-dependent cyclic AMP (cAMP) signal with induction of the dual specificity mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1), which prevented GCDC-induced phosphorylation of mitogen-activated protein kinase kinase 4 (MKK4) and c-jun-NH2-terminal kinase (JNK) activation.	ursodoxicoltaurine	24-28	mitogen-activated protein kinase 8	Rattus norvegicus	316-319	
26044599-9	2015	CONCLUSION: TUDC exerts its anti-apoptotic effect via a beta1-integrin-mediated formation of cAMP, which prevents CD95 activation by hydrophobic bile acids at the levels of JNK activation and CD95 serine/threonine phosphorylation.	ursodoxicoltaurine	12-16	mitogen-activated protein kinase 8	Rattus norvegicus	173-176