PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12627974-7	2003	TUDCA markedly abrogated the Bax-induced membrane perturbation.	ursodoxicoltaurine	0-5	BCL2 associated X, apoptosis regulator	Homo sapiens	29-32	
16923170-3	2006	Tauroursodeoxycholic acid (TUDCA) modulates exogenous Abeta-induced apoptosis by interfering with E2F-1/p53/Bax.	ursodoxicoltaurine	27-32	BCL2 associated X, apoptosis regulator	Homo sapiens	108-111	
16923170-3	2006	Tauroursodeoxycholic acid (TUDCA) modulates exogenous Abeta-induced apoptosis by interfering with E2F-1/p53/Bax.	ursodoxicoltaurine	0-25	BCL2 associated X, apoptosis regulator	Homo sapiens	108-111	
16850250-6	2006	In contrast, the fluorescence change detected for Bax solution titrated against TUDCA in dimethylsulfoxide was greater than that observed with solvent alone.	ursodoxicoltaurine	80-85	BCL2 associated X, apoptosis regulator	Homo sapiens	50-53	
12627974-0	2003	Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytochrome C release in isolated mitochondria.	ursodoxicoltaurine	0-25	BCL2 associated X, apoptosis regulator	Homo sapiens	35-38	
12627974-2	2003	Tauroursodeoxycholic acid (TUDCA) modulates the apoptotic threshold, in part, by preventing Bax translocation both in vitro and in vivo.	ursodoxicoltaurine	0-25	BCL2 associated X, apoptosis regulator	Homo sapiens	92-95	
12627974-2	2003	Tauroursodeoxycholic acid (TUDCA) modulates the apoptotic threshold, in part, by preventing Bax translocation both in vitro and in vivo.	ursodoxicoltaurine	27-32	BCL2 associated X, apoptosis regulator	Homo sapiens	92-95	
12627974-10	2003	TUDCA is a potent inhibitor of Bax association with mitochondria.	ursodoxicoltaurine	0-5	BCL2 associated X, apoptosis regulator	Homo sapiens	31-34	
31963346-5	2020	The results showed that the activation of the IRE1alpha axis, but not of the PERK axis, of UPR contributed to FB1-induced ER stress-mediated hepatocyte toxicity; the activation of the Bax/Bak-mediated mitochondrial pathway lay downstream of IRE1alpha to trigger mitochondrial-dependent apoptosis in response to FB1; FB1-induced oxidative stress and ER stress augmented each other through a positive feedback mechanism; tauroursodeoxycholic acid (TUDCA)-mediated ER stress inactivation is an effective approach to counteract FB1-induced hepatotoxicity in vivo.	ursodoxicoltaurine	419-444	BCL2 associated X, apoptosis regulator	Homo sapiens	184-187	
31963346-5	2020	The results showed that the activation of the IRE1alpha axis, but not of the PERK axis, of UPR contributed to FB1-induced ER stress-mediated hepatocyte toxicity; the activation of the Bax/Bak-mediated mitochondrial pathway lay downstream of IRE1alpha to trigger mitochondrial-dependent apoptosis in response to FB1; FB1-induced oxidative stress and ER stress augmented each other through a positive feedback mechanism; tauroursodeoxycholic acid (TUDCA)-mediated ER stress inactivation is an effective approach to counteract FB1-induced hepatotoxicity in vivo.	ursodoxicoltaurine	446-451	BCL2 associated X, apoptosis regulator	Homo sapiens	184-187	
31814847-7	2019	The expression levels of the autophagy factor microtubule-associated protein light chain 3-II/I and the anti-apoptotic factor Bcl-2 increased following TUDCA treatment, while the expression of the pro-apoptotic factor Bax decreased.	ursodoxicoltaurine	152-157	BCL2 associated X, apoptosis regulator	Homo sapiens	218-221	
29751043-6	2018	TUDCA alleviated gentamicin-induced cell apoptosis, supported by the decreased Bax/Bcl2 ratio compared with that of gentamicin treated alone.	ursodoxicoltaurine	0-5	BCL2 associated X, apoptosis regulator	Homo sapiens	79-82	
27596970-1	2016	Tauroursodeoxycholic acid (TUDCA) is known to prevent apoptosis through the Bax pathway and to promote neovascularization by enhancing the mobilization of stem cells, their differentiation.	ursodoxicoltaurine	0-25	BCL2 associated X, apoptosis regulator	Homo sapiens	76-79	
27765486-7	2016	TUNEL assay showed that TUDCA treatment significantly reduced apoptosis in porcine SCNT blastocysts confirmed by decreased pro-apoptotic BAX and increased anti-apoptotic BCL2 mRNA levels.	ursodoxicoltaurine	24-29	BCL2 associated X, apoptosis regulator	Homo sapiens	137-140	
29718981-7	2018	In addition, the expression of Hdac1, Dnmt1 and Bax was significantly lower in blastocysts derived from TUDCA-treated donor cells than that from control group.	ursodoxicoltaurine	104-109	BCL2 associated X, apoptosis regulator	Homo sapiens	48-51	
27596970-1	2016	Tauroursodeoxycholic acid (TUDCA) is known to prevent apoptosis through the Bax pathway and to promote neovascularization by enhancing the mobilization of stem cells, their differentiation.	ursodoxicoltaurine	27-32	BCL2 associated X, apoptosis regulator	Homo sapiens	76-79	
25881988-12	2015	Tauroursodeoxycholic acid did not improve the developmental potential of buffalo embryos; however, it attenuated the TM-induced apoptosis by downregulating BAX and ER chaperones.	ursodoxicoltaurine	0-25	BCL2 associated X, apoptosis regulator	Homo sapiens	156-159