PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9439587-14	1998	The sequence alignment of cytochrome P4501A1 with cytochrome P450102 predicts that this region might correspond to beta-sheet structure localized on the distal side of the heme ring near the I helix and the oxygen binding pocket.	Oxygen	207-213	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	26-44	
10597900-11	1999	The dependency on NADPH, temperature and time for inhibition of CYP1A1 suggests that metabolism of either isoflavone or molecular oxygen to reactive species is required.	Oxygen	130-136	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	64-70	
9211913-1	1997	Aryl hydrocarbon receptor nuclear translocator (ARNT) is a component of the transcription factors, aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor 1, which transactivate their target genes, such as CYP1A1 and erythropoietin, in response to xenobiotic aromatic hydrocarbons and to low O2 concentration, respectively.	Oxygen	297-299	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	211-217	
7607137-6	1995	We conclude that induction of a functional CYP1A1 monooxygenase by TCDD stimulates a pathway that generates thiol-sensitive reactive oxygen intermediates which, in turn, are responsible for the TCDD-dependent activation of genes linked to the LTR.	Oxygen	54-60	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	43-49	
8541016-3	1995	We have observed the induction of a specific cytochrome P-450 monooxygenase, P-450IA1 (CYP1A1), to be a sensitive method for assessing the response of microcarrier-attached Hep G2 cells to stress resulting from hydrodynamic shear and oxygen deprivation.	Oxygen	66-72	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	87-93	
21362406-0	2011	Augmented oxygen-mediated transcriptional activation of cytochrome P450 (CYP)1A expression and increased susceptibilities to hyperoxic lung injury in transgenic mice carrying the human CYP1A1 or mouse 1A2 promoter in vivo.	Oxygen	10-16	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	185-191	
24266295-6	2013	Enzyme CYP P450 1A1, which is encoded by the CYP1A1 gene, is vital in the monooxygenation of lipofilic substrates, while GSTM1 and GSTT1 are the most abundant isophorms that conjugate and neutralize oxygen products.	Oxygen	78-84	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	45-51	
23353840-13	2012	This ligand orientation is in CYP1A1/1A2 further stabilized by two hydrogen bonds; one between an oxygen atom of the AAI nitro-group and the hydroxyl group of Ser122/Thr124; and the second bond between an oxygen atom of dioxolane ring of AAI and the hydroxyl group of Thr497/Thr498.	Oxygen	98-104	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	30-36	
23353840-13	2012	This ligand orientation is in CYP1A1/1A2 further stabilized by two hydrogen bonds; one between an oxygen atom of the AAI nitro-group and the hydroxyl group of Ser122/Thr124; and the second bond between an oxygen atom of dioxolane ring of AAI and the hydroxyl group of Thr497/Thr498.	Oxygen	205-211	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	30-36	
24355420-6	2014	Exposure to 1% O2 prior to PCB 126 treatment significantly inhibited CYP1A1 mRNA and protein expression in human HepG2 and HaCaT cells.	Oxygen	15-17	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	69-75	
17481694-8	2007	Generation of 3-OH-B(a)P in group II implicates the possibility of reactive oxygen species (O2- and H2O2) production in haemolysates during cytochrome P4501A1 (CYP1A1) mediated Phase-I-metabolism.	Oxygen	92-94	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	160-166	
17481694-8	2007	Generation of 3-OH-B(a)P in group II implicates the possibility of reactive oxygen species (O2- and H2O2) production in haemolysates during cytochrome P4501A1 (CYP1A1) mediated Phase-I-metabolism.	Oxygen	92-94	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	140-158	
17968679-5	2007	Constitutive CYP1A1 mRNA was measured by real time PCR in human pulmonary microvascular endothelial cells exposed to hypoxia (1 or 2.5% O2), 25 nM AHR siRNA, 25 nM hypoxia-inducible factor (HIF)-2alpha siRNA, or their combinations.	Oxygen	136-138	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19