PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34782065-7 2022 In multivariate analyses: age, body mass index, female sex, neck circumference, AHI, and desaturation markers (nadir and mean oxygen saturation) were independently associated with higher CRP. Oxygen 126-132 C-reactive protein Homo sapiens 187-190 34899724-10 2021 Potential risk factors for progression were investigated in the supportive care group and SpO2 < 97% and CRP elevation >1.5 mg/dL were common risk factors for O2 support and progression to severe disease. Oxygen 159-161 C-reactive protein Homo sapiens 105-108 34792741-7 2021 However, individuals who experienced lower oxygen saturation were more likely to exhibit higher total leukocyte and neutrophil counts, a higher neutrophil-lymphocyte ratio (NLR), and an increased concentration of C-reactive protein. Oxygen 43-49 C-reactive protein Homo sapiens 213-231 34158545-1 2021 The objective of the study was to develop and validate a prediction model that identifies COVID-19 patients at risk of requiring oxygen support based on five parameters: C-reactive protein (CRP), hypertension, age, and neutrophil and lymphocyte counts (CHANeL). Oxygen 129-135 C-reactive protein Homo sapiens 170-188 34556343-10 2021 Among clinical symptoms, dyspnea and anosmia were frequent, and in laboratory parameters, neutrophil lymphocyte ratio, high-sensitivity C-reactive protein, and D-dimer were higher in patients requiring oxygen. Oxygen 202-208 C-reactive protein Homo sapiens 136-154 34158545-1 2021 The objective of the study was to develop and validate a prediction model that identifies COVID-19 patients at risk of requiring oxygen support based on five parameters: C-reactive protein (CRP), hypertension, age, and neutrophil and lymphocyte counts (CHANeL). Oxygen 129-135 C-reactive protein Homo sapiens 190-193 34158545-8 2021 "CHANeL" prediction models based on serial CRP, neutrophil, and lymphocyte counts during the first 3 days of hospitalization, along with age and hypertension status, provide a reliable estimate of the risk of supplement oxygen requirement among patients hospitalized with COVID-19. Oxygen 220-226 C-reactive protein Homo sapiens 43-46 35244034-5 2022 The physiological and biochemical indexes, including immune inflammation indicators, electrolytes, myocardial enzyme profile, and functions of liver and kidney, were examined and investigated before and after hydrogen-oxygen therapy.The results showed significant decreases in the neutrophil percentage and the concentration and abnormal proportion of C-reactive protein in COVID-19 patients received additional hydrogen-oxygen therapy.This novel therapeutic may alleviate clinical symptoms of COVID-19 patients by suppressing inflammation responses. Oxygen 218-224 C-reactive protein Homo sapiens 352-370 34543566-1 2021 OBJECTIVE: This study"s objective was to evaluate interleukin-6 (IL-6) and C-reactive protein (CRP) responses and performance changes in obese women after 8 weeks of aerobic training with an intensity of 50 to 60% of their individual maximum oxygen uptake (VO2). Oxygen 242-248 C-reactive protein Homo sapiens 75-93 34543566-1 2021 OBJECTIVE: This study"s objective was to evaluate interleukin-6 (IL-6) and C-reactive protein (CRP) responses and performance changes in obese women after 8 weeks of aerobic training with an intensity of 50 to 60% of their individual maximum oxygen uptake (VO2). Oxygen 242-248 C-reactive protein Homo sapiens 95-98 35099054-7 2022 Patients requiring oxygen supplementation and/or the use of HFNOT/CPAP/BPAP had lower lymphocyte counts and higher levels of urea, C-reactive protein, D-dimer, troponin, glucose, lactate dehydrogenase (LDH) as well as higher white blood cell and neutrophil counts, The parameter that obtained the highest area under curve value in the receiver operator curve analysis for the necessary use of HFNOT/CPAP/BPAP or CPAP/BPAP was LDH activity. Oxygen 19-25 C-reactive protein Homo sapiens 131-149 33790636-10 2021 Oxygen saturation at presentation had a negative correlation with D-Dimer, age, and C reactive protein. Oxygen 0-6 C-reactive protein Homo sapiens 84-102 34023221-9 2021 Age, hemodialysis, and C-reactive protein (CRP) levels were candidate predictors of the need for oxygen supply in patients with COVID-19. Oxygen 97-103 C-reactive protein Homo sapiens 23-41 34023221-9 2021 Age, hemodialysis, and C-reactive protein (CRP) levels were candidate predictors of the need for oxygen supply in patients with COVID-19. Oxygen 97-103 C-reactive protein Homo sapiens 43-46 3385211-0 1988 Modulation of stimulus-dependent human platelet activation by C-reactive protein modified with active oxygen species. Oxygen 102-108 C-reactive protein Homo sapiens 62-80 34056870-8 2021 RESULTS: Surgical debridement, antibiotic, and hyperbaric oxygen therapy were used and discontinued over a 6-month period with normalization of C-reactive protein. Oxygen 58-64 C-reactive protein Homo sapiens 144-162 33992676-9 2021 Finally, when divided into three groups according to serum CRP levels, dose-dependent increases in the intracellular O2 - levels in blood cells and central memory and effector memory CD8+ T cells were most prominently observed in the high-CRP group. Oxygen 117-121 C-reactive protein Homo sapiens 59-62 33992676-9 2021 Finally, when divided into three groups according to serum CRP levels, dose-dependent increases in the intracellular O2 - levels in blood cells and central memory and effector memory CD8+ T cells were most prominently observed in the high-CRP group. Oxygen 117-121 C-reactive protein Homo sapiens 239-242 33068293-7 2021 After 72 hours, L and CRP had improved in the HFNC oxygen therapy group compared with the COT group, but the differences in WBC and PCT were not statistically significant. Oxygen 51-57 C-reactive protein Homo sapiens 22-25 33205000-8 2020 When stratifying inpatients in a low- and high oxygen demand group serum iron levels differed significantly between these two groups and showed a high negative correlation with the inflammatory parameters IL-6, procalcitonin, and CRP. Oxygen 47-53 C-reactive protein Homo sapiens 230-233 33402303-8 2021 Comorbid cardiovascular disease, lymphocytopenia, elevated CRP, liver enzyme and D-dimer levels, and higher chest CT score were significantly associated with an increase in oxygen requirement CONCLUSIONS: The expanded CURB-65 score can be a better predictor of an increase in oxygen requirement in patients with SARS-CoV-2 pneumonia. Oxygen 173-179 C-reactive protein Homo sapiens 59-62 33525211-11 2020 CRP was correlated significantly with the duration of stay in the ICU and the duration for oxygen supplementation (r=0.56 and 0.61, respectively; p<0.01). Oxygen 91-97 C-reactive protein Homo sapiens 0-3 33153974-4 2020 From analysis of 203 samples, CRP, IL-6, IL-10 and LDH were most strongly correlated with the WHO ordinal scale of illness severity, the fraction of inspired oxygen delivery, radiological evidence of ARDS and level of respiratory support (p <= 0.001). Oxygen 158-164 C-reactive protein Homo sapiens 30-33 32632417-11 2020 Severe cases of pneumonia requiring supplemental oxygen were more likely to exhibit bilateral alveolar or interstitial infiltrates on chest X-ray (55 6% vs. 0 0%; P-value = 0 003) and serum C-reactive protein (CRP) levels >10 mg/dL (33 0% vs. 0 0%; P-value = 0 05) at admission than those with no oxygen requirements. Oxygen 49-55 C-reactive protein Homo sapiens 190-208 33089038-5 2020 Among the 72 patients receiving supplemental oxygen without mechanical ventilation, severity of condition on the NEWS2 scale scores fell from 5 to 2 (P<0.001), C reactive protein levels fell from 95 to 14 mg/L (P<0.001), and lymphocyte counts rose from 900 to 1000/uL (P=0.036). Oxygen 45-51 C-reactive protein Homo sapiens 160-178 32921708-11 2020 CRP was correlated significantly with the duration of stay in the ICU and the duration for oxygen supplementation (r = 0.37 and 0.42 respectively; p: <0.01). Oxygen 91-97 C-reactive protein Homo sapiens 0-3 32458487-10 2020 In addition, decreasing lowest oxygen saturation (beta = -.159, P = .004) was also independently correlated with increasing hs-CRP concentrations in multivariate linear analysis after adjusting for confounders. Oxygen 31-37 C-reactive protein Homo sapiens 127-130 32959547-11 2020 Sputum production, chest discomfort, a large number of symptoms, abnormal procalcitonin and C-reactive protein levels, and abnormal chest X-ray or chest computed tomography findings were more common in patients requiring supplemental oxygen than in those not requiring supplemental oxygen. Oxygen 234-240 C-reactive protein Homo sapiens 92-110 32632417-11 2020 Severe cases of pneumonia requiring supplemental oxygen were more likely to exhibit bilateral alveolar or interstitial infiltrates on chest X-ray (55 6% vs. 0 0%; P-value = 0 003) and serum C-reactive protein (CRP) levels >10 mg/dL (33 0% vs. 0 0%; P-value = 0 05) at admission than those with no oxygen requirements. Oxygen 49-55 C-reactive protein Homo sapiens 210-213 18475156-6 2008 In multiple linear regression analysis controlling for confounding factors related with sleep apnea syndrome, high-sensitivity C-reactive protein was significantly correlated with 3% oxygen desaturation index (P = 0.047). Oxygen 183-189 C-reactive protein Homo sapiens 127-145 31646893-8 2021 Partial correlation analysis showed that the mean least oxygen saturation was significantly correlated with CRP after adjustment for BMI Pearson"s correlation coefficients examining the relationship between BMI and total cholesterol; TG and CRP were found to be 0.531, 0.401, and 0.321. Oxygen 56-62 C-reactive protein Homo sapiens 108-111 31646893-8 2021 Partial correlation analysis showed that the mean least oxygen saturation was significantly correlated with CRP after adjustment for BMI Pearson"s correlation coefficients examining the relationship between BMI and total cholesterol; TG and CRP were found to be 0.531, 0.401, and 0.321. Oxygen 56-62 C-reactive protein Homo sapiens 241-244 31646893-9 2021 The correlation of CRP levels with disease severity as assessed by RDI, ESS, and least oxygen saturation was significant after adjustment for BMI. Oxygen 87-93 C-reactive protein Homo sapiens 19-22 30638307-3 2019 OBJECTIVES: We aimed to evaluate if COPD patients who meet the Medicare guidelines for nocturnal oxygen therapy (iNOT+) had higher serum hs-CRP and IL-6 than those who did not meet the guidelines for iNOT (iNOT-). Oxygen 97-103 C-reactive protein Homo sapiens 140-143 30638307-9 2019 CONCLUSION: COPD patients who have more than 5 minutes and 5% of their sleep time spent at oxygen saturation less than 88% have increased hs-CRP, which is associated with increased risk of future CVD. Oxygen 91-97 C-reactive protein Homo sapiens 141-144 30568518-0 2018 Relationship between oxygen cost and C-reactive protein response to marathon running in college recreational runners. Oxygen 21-27 C-reactive protein Homo sapiens 37-55 30568518-10 2018 Spearman correlation analysis showed that the change in CRP level was significantly positively correlated with oxygen cost (r=0.619, P=0.011) but not maximal oxygen uptake. Oxygen 111-117 C-reactive protein Homo sapiens 56-59 30568518-10 2018 Spearman correlation analysis showed that the change in CRP level was significantly positively correlated with oxygen cost (r=0.619, P=0.011) but not maximal oxygen uptake. Oxygen 158-164 C-reactive protein Homo sapiens 56-59 26546248-6 2016 CRP levels predicted shorter exercise times (R = -0.65, p = 0.006), lower oxygen consumption (VO2) at the anaerobic threshold (R = -0.66, p = 0.005), and lower peak VO2 (R = -0.70, p = 0.002), reflecting worse cardiovascular performance. Oxygen 74-80 C-reactive protein Homo sapiens 0-3 26546248-7 2016 CRP levels also significantly correlated with an elevated ventilation/carbon dioxide production slope (R = +0.64, p = 0.008), a reduced oxygen uptake efficiency slope (R = -0.55, p = 0.026), and reduced end-tidal CO2 level at rest and with exercise (R = -0.759, p = 0.001 and R = -0.739, p = 0.001, respectively), reflecting impaired gas exchange. Oxygen 136-142 C-reactive protein Homo sapiens 0-3 24262762-9 2014 The reduction in CRP levels correlated with the improvement in peak oxygen consumption (R = -0.60, p = 0.002). Oxygen 68-74 C-reactive protein Homo sapiens 17-20 22754038-8 2012 Oxygen desaturation index, hypoxia time, and minimum oxygen saturation (SaO2) significantly correlated with IL-6 and CRP levels, but apnea-hypopnea index did not. Oxygen 0-6 C-reactive protein Homo sapiens 117-120 18777130-7 2009 From the results of stepwise multiple linear regression analysis, the lowest oxygen saturation was a significant determinant of FMD (beta = 0.25, p < 0.01, adjusted R (2) = 6%), and BMI (beta = 0.22, p < 0.05) and waist-to-hip ratio (beta = 0.21, p < 0.05) were significant variables to explain CRP (adjusted R (2) = 11%, p < 0.01) in the middle aged patients. Oxygen 77-83 C-reactive protein Homo sapiens 304-307 19145387-8 2009 CRP value in this population had a statistically significant relation with admission to Intensive Care Unit (ICU) (p=0.008), length of hospital stay (p=0.025) and need for supplementary oxygen during hospital stay (p=0.022). Oxygen 186-192 C-reactive protein Homo sapiens 0-3 19027603-0 2008 Associations of monocytes, neutrophil count, and C-reactive protein with maximal oxygen uptake in overweight women. Oxygen 81-87 C-reactive protein Homo sapiens 49-67 31992279-7 2020 Multiple logistic regression was performed for significant oxygen requirements using two different models using age, C-reactive protein (CRP), smoking duration, and BBE score (model 1) and age, CRP, BEP, and PEC (model 2). Oxygen 59-65 C-reactive protein Homo sapiens 117-135 31992279-7 2020 Multiple logistic regression was performed for significant oxygen requirements using two different models using age, C-reactive protein (CRP), smoking duration, and BBE score (model 1) and age, CRP, BEP, and PEC (model 2). Oxygen 59-65 C-reactive protein Homo sapiens 137-140 30114262-8 2018 High CRP levels were associated with younger age, higher body mass index (BMI), chronic obstructive pulmonary disease (COPD), lower peak oxygen consumption and higher endothelin-1 and aldosterone levels. Oxygen 137-143 C-reactive protein Homo sapiens 5-8 27858176-1 2017 We have shown that serum levels of reactive oxygen metabolites (ROM) were associated with C-reactive protein (CRP) and disease activity score based on the examination of 28 joints (DAS28) in patients with rheumatoid arthritis (RA); however, their clinical significance as biomarkers has not been elucidated. Oxygen 44-50 C-reactive protein Homo sapiens 90-108 27858176-1 2017 We have shown that serum levels of reactive oxygen metabolites (ROM) were associated with C-reactive protein (CRP) and disease activity score based on the examination of 28 joints (DAS28) in patients with rheumatoid arthritis (RA); however, their clinical significance as biomarkers has not been elucidated. Oxygen 44-50 C-reactive protein Homo sapiens 110-113 24521195-1 2014 OBJECTIVES: This study aimed to compare the levels of plasma B-type natriuretic peptide (BNP) and C-reactive protein (CRP) in relation to oxygen transport between patients with restrictive right ventricle (rRV) and those without (non-rRV) early after tetralogy of Fallot (TOF) repair. Oxygen 138-144 C-reactive protein Homo sapiens 118-121 24884656-6 2014 VO2 peak was correlated with body mass index, C-reactive protein, FEV1, FVC, RV, DLCO, VE/VCO2 peak, VD/VT, PaO2, PaCO2, P(A-a)O2, and breathing reserve. Oxygen 1-3 C-reactive protein Homo sapiens 46-64 22906280-1 2012 OBJECTIVE: This cross-sectional study investigated the correlation between diacron reactive oxygen metabolites (d-ROMs) and high-sensitivity C-reactive protein (hs-CRP) in subjects with or without metabolic syndrome. Oxygen 92-98 C-reactive protein Homo sapiens 141-159 19213794-6 2009 A significant correlation was found between CRP levels, time spent at night with arterial oxygen saturation <90% and ODI. Oxygen 90-96 C-reactive protein Homo sapiens 44-47 19281089-11 2008 CONCLUSIONS: These findings indicate that physiological determinants of tissue oxygen availability are independently associated with CRP blood levels. Oxygen 79-85 C-reactive protein Homo sapiens 133-136 19281089-0 2008 C-reactive protein correlates with tissue oxygen availability in patients with stable COPD. Oxygen 42-48 C-reactive protein Homo sapiens 0-18 17702269-6 2007 In addition, CRP was correlated with body mass index, waist-to-hip ratio, neck circumference, diastolic pressure, average O2 saturation and percentage of time below 90% O2 saturation but not with AHI. Oxygen 122-124 C-reactive protein Homo sapiens 13-16 17702269-6 2007 In addition, CRP was correlated with body mass index, waist-to-hip ratio, neck circumference, diastolic pressure, average O2 saturation and percentage of time below 90% O2 saturation but not with AHI. Oxygen 169-171 C-reactive protein Homo sapiens 13-16 16455829-8 2006 C-reactive protein levels in stable chronic obstructive pulmonary disease patients are best correlated with arterial oxygen tension and 6-min walk distance. Oxygen 117-123 C-reactive protein Homo sapiens 0-18 17215574-2 2007 This study intends to evaluate the relationship between C-reactive protein (CRP) and the newly established marker of lipid peroxidation, d-ROMs (reactive oxygen metabolites), in comparison with different indicators of oxidative stress. Oxygen 154-160 C-reactive protein Homo sapiens 56-74 17215574-2 2007 This study intends to evaluate the relationship between C-reactive protein (CRP) and the newly established marker of lipid peroxidation, d-ROMs (reactive oxygen metabolites), in comparison with different indicators of oxidative stress. Oxygen 154-160 C-reactive protein Homo sapiens 76-79 15987707-7 2005 The difference among the C-reactive protein groups was significant adjusting for all correlates of baseline C-reactive protein (P<0.001) and additionally for changes in body weight, glucose, insulin, LDL cholesterol, HDL cholesterol, triglycerides, systolic and diastolic blood pressure, and maximal oxygen uptake (P<0.001). Oxygen 303-309 C-reactive protein Homo sapiens 25-43 16708805-5 2005 RESULTS: Before the treatment, there was a significant positive correlation between CRP and AHI in all subjects (r = 0.615, P < 0.001), a significant negative correlation between CRP and the mean nocturnal oxygen saturation (r = -0.682, P < 0.001), and a significant negative correlation between CRP and the lowest nocturnal SaO2 (r = -0.61, P < 0.001). Oxygen 209-215 C-reactive protein Homo sapiens 182-185 16708805-5 2005 RESULTS: Before the treatment, there was a significant positive correlation between CRP and AHI in all subjects (r = 0.615, P < 0.001), a significant negative correlation between CRP and the mean nocturnal oxygen saturation (r = -0.682, P < 0.001), and a significant negative correlation between CRP and the lowest nocturnal SaO2 (r = -0.61, P < 0.001). Oxygen 209-215 C-reactive protein Homo sapiens 182-185 16774156-3 2006 We thus examined the relationship between serum C-reactive protein levels and nocturnal arterial oxygen desaturation, stratified by category of body mass index (BMI). Oxygen 97-103 C-reactive protein Homo sapiens 48-66 10368284-8 1999 CONCLUSIONS: The structure shows how large ligands containing PC may be bound by CRP via a phosphate oxygen that projects away from the surface of the protein. Oxygen 101-107 C-reactive protein Homo sapiens 81-84 15321699-6 2004 Co-infusion of the oxygen-derived free radical scavenger vitamin C significantly increased baseline FBF from 2.0 +/- 0.5 to 2.5 +/- 0.7 (mL/min/100 mL forearm tissue (P < 0.001)) and acetylcholine-stimulated FBF responses in patients with elevated CRP, but not in patients with low CRP serum levels. Oxygen 19-25 C-reactive protein Homo sapiens 251-254 15321699-6 2004 Co-infusion of the oxygen-derived free radical scavenger vitamin C significantly increased baseline FBF from 2.0 +/- 0.5 to 2.5 +/- 0.7 (mL/min/100 mL forearm tissue (P < 0.001)) and acetylcholine-stimulated FBF responses in patients with elevated CRP, but not in patients with low CRP serum levels. Oxygen 19-25 C-reactive protein Homo sapiens 285-288 15173538-7 2004 Significant positive correlations were found between log CRP levels and AHI (r =.53) and arousal index (r =.28), whereas an inverse correlation was found between the lowest nocturnal arterial oxygen saturation and log CRP levels (r = -.47). Oxygen 192-198 C-reactive protein Homo sapiens 218-221 9035817-1 1996 The effect of C-reactive protein on oxygen metabolism and lysosomal activity of the human blood neutrophils was found to depend on its ability to conform and to render both the pro- and anti-inflammatory results. Oxygen 36-42 C-reactive protein Homo sapiens 14-32 8054580-0 1993 [Stimulation of oxygen metabolism in human blood phagocytes as affected by tuftsin-like peptides derived from the C-reactive protein molecule]. Oxygen 16-22 C-reactive protein Homo sapiens 114-132 8054580-1 1993 Effects of synthetic peptides analogous to those cleaved by proteolysis from human C-reactive protein (CRP) molecule on the level of oxygen metabolism of blood neutrophils and monocytes were studied. Oxygen 133-139 C-reactive protein Homo sapiens 83-101 8054580-1 1993 Effects of synthetic peptides analogous to those cleaved by proteolysis from human C-reactive protein (CRP) molecule on the level of oxygen metabolism of blood neutrophils and monocytes were studied. Oxygen 133-139 C-reactive protein Homo sapiens 103-106 8054580-3 1993 CRP-derived peptides stimulated phagocyte oxygen metabolism as effectively as tuftsin. Oxygen 42-48 C-reactive protein Homo sapiens 0-3 7628659-0 1995 [Regulation of oxygen metabolism in human blood leukocytes by C-reactive protein]. Oxygen 15-21 C-reactive protein Homo sapiens 62-80