PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10694037-6 1999 This was supported by the absence of changes in plants treated with Cd in the Mn-SOD activity, responsible for O2*- removal in the peroxisomal matrix. Oxygen 111-115 superoxide dismutase 2 Homo sapiens 78-84 10919671-1 2000 Manganese-containing superoxide dismutase (MnSOD) is an essential primary antioxidant enzyme that converts superoxide radical to hydrogen peroxide and molecular oxygen within the mitochondrial matrix. Oxygen 161-167 superoxide dismutase 2 Homo sapiens 0-41 10919671-1 2000 Manganese-containing superoxide dismutase (MnSOD) is an essential primary antioxidant enzyme that converts superoxide radical to hydrogen peroxide and molecular oxygen within the mitochondrial matrix. Oxygen 161-167 superoxide dismutase 2 Homo sapiens 43-48 10889449-3 2000 In the presence of the oxygen free radical spin trapping reagent, 5,5-dimethyl pyrroline-N-oxide (DMPO), the induction of MnSOD gene expression by TNF-alpha was significantly reduced. Oxygen 23-29 superoxide dismutase 2 Homo sapiens 122-127 8903482-1 1996 Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme involved in scavenging O2-. Oxygen 88-90 superoxide dismutase 2 Homo sapiens 0-30 10511315-4 1999 Incubating cells in 3% oxygen can prevent the inhibition of cellular proliferation mediated by MnSOD, suggesting that oxygen is a prerequisite component of the MnSOD-dependent proliferative inhibition. Oxygen 23-29 superoxide dismutase 2 Homo sapiens 95-100 10511315-4 1999 Incubating cells in 3% oxygen can prevent the inhibition of cellular proliferation mediated by MnSOD, suggesting that oxygen is a prerequisite component of the MnSOD-dependent proliferative inhibition. Oxygen 23-29 superoxide dismutase 2 Homo sapiens 160-165 10511315-4 1999 Incubating cells in 3% oxygen can prevent the inhibition of cellular proliferation mediated by MnSOD, suggesting that oxygen is a prerequisite component of the MnSOD-dependent proliferative inhibition. Oxygen 118-124 superoxide dismutase 2 Homo sapiens 95-100 10511315-4 1999 Incubating cells in 3% oxygen can prevent the inhibition of cellular proliferation mediated by MnSOD, suggesting that oxygen is a prerequisite component of the MnSOD-dependent proliferative inhibition. Oxygen 118-124 superoxide dismutase 2 Homo sapiens 160-165 9409558-1 1997 Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme that dismutates potentially toxic superoxide radical into hydrogen peroxide and dioxygen. Oxygen 145-153 superoxide dismutase 2 Homo sapiens 0-30 9409558-1 1997 Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme that dismutates potentially toxic superoxide radical into hydrogen peroxide and dioxygen. Oxygen 145-153 superoxide dismutase 2 Homo sapiens 32-37 9886257-2 1999 MnSOD dismutates the superoxide anion (O2*-) derived from the reduction of molecular oxygen to hydrogen peroxide (H2O2), which is detoxified by glutathione peroxidase to water and molecular oxygen. Oxygen 85-91 superoxide dismutase 2 Homo sapiens 0-5 9886257-2 1999 MnSOD dismutates the superoxide anion (O2*-) derived from the reduction of molecular oxygen to hydrogen peroxide (H2O2), which is detoxified by glutathione peroxidase to water and molecular oxygen. Oxygen 190-196 superoxide dismutase 2 Homo sapiens 0-5 8903482-1 1996 Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme involved in scavenging O2-. Oxygen 88-90 superoxide dismutase 2 Homo sapiens 32-37 8605177-1 1996 Human manganese superoxide dismutase (MnSOD) is a homotetrameric enzyme which protects mitochondria against oxygen-mediated free radical damage. Oxygen 108-114 superoxide dismutase 2 Homo sapiens 38-43 8913477-1 1996 The oxygen free-radical scavenger recombinant human manganese superoxide dismutase (MnSOD) was studied for its effects on influenza virus infections in mice when used alone and in combination with ribavirin. Oxygen 4-10 superoxide dismutase 2 Homo sapiens 52-82 8913477-1 1996 The oxygen free-radical scavenger recombinant human manganese superoxide dismutase (MnSOD) was studied for its effects on influenza virus infections in mice when used alone and in combination with ribavirin. Oxygen 4-10 superoxide dismutase 2 Homo sapiens 84-89 8918266-1 1996 By utilizing the oxygen-sensitive Escherichia coli Mn-superoxide dismutase (Mn-SOD) promoter, we have developed a vector system that expresses high levels of cloned foreign genes. Oxygen 17-23 superoxide dismutase 2 Homo sapiens 76-82 8440412-5 1993 It is hypothesized that mitochondrial MnSOD, by scavenging oxygen radicals induced by cytokines, some cytotoxic drugs, and ionizing radiation, is protective and promotes the survival of cells from the lethal effects of these treatments. Oxygen 59-65 superoxide dismutase 2 Homo sapiens 38-43 7665413-11 1995 Arterial O2-to-inspired O2 fraction ratio was significantly improved at 6 and 12 h after smoke insufflation in SOD compared with CON at the same time points. Oxygen 9-11 superoxide dismutase 2 Homo sapiens 111-114 7665413-11 1995 Arterial O2-to-inspired O2 fraction ratio was significantly improved at 6 and 12 h after smoke insufflation in SOD compared with CON at the same time points. Oxygen 24-26 superoxide dismutase 2 Homo sapiens 111-114 7932852-3 1994 One of the antioxidant enzymes that is protective against reactive oxygen-induced damage is manganese superoxide dismutase (MnSOD), which is located in the mitochondria of mammalian cells. Oxygen 67-73 superoxide dismutase 2 Homo sapiens 92-122 7932852-3 1994 One of the antioxidant enzymes that is protective against reactive oxygen-induced damage is manganese superoxide dismutase (MnSOD), which is located in the mitochondria of mammalian cells. Oxygen 67-73 superoxide dismutase 2 Homo sapiens 124-129 8516341-2 1993 Evidence suggests that both CuZnSOD and MnSOD are important in pulmonary defense against oxygen toxicity. Oxygen 89-95 superoxide dismutase 2 Homo sapiens 40-45 8516341-4 1993 Likewise, transgenic overexpression of MnSOD, or induction of endogenous MnSOD by endotoxin, tumor necrosis factor, or interleukin 1, also protects animals against oxygen toxicity. Oxygen 164-170 superoxide dismutase 2 Homo sapiens 39-44 8516341-4 1993 Likewise, transgenic overexpression of MnSOD, or induction of endogenous MnSOD by endotoxin, tumor necrosis factor, or interleukin 1, also protects animals against oxygen toxicity. Oxygen 164-170 superoxide dismutase 2 Homo sapiens 73-78 4026967-6 1985 The increases in chemiluminescence and Mn-SOD activity suggests that the generation of a large amount of activated oxygen is associated with the pathogenesis and progression of alcoholic liver injury in humans. Oxygen 115-121 superoxide dismutase 2 Homo sapiens 39-45 1904900-11 1991 The induction of Mn-SOD by IFN-gamma and its synergistic induction by IFN-gamma in combination with TNF and IL-1 should protect healthy cells from the toxicity of O2- during an immune response, and may provide a mechanism for selective killing of infected cells. Oxygen 163-165 superoxide dismutase 2 Homo sapiens 17-23 35181309-2 2022 A few recent studies have reported that manganese superoxide dismutase (MnSOD) can effectively modulate EMT phenotype by influencing cellular redox environment via altering the intracellular ratio between O2- and H2O2. Oxygen 205-208 superoxide dismutase 2 Homo sapiens 40-70 35181309-2 2022 A few recent studies have reported that manganese superoxide dismutase (MnSOD) can effectively modulate EMT phenotype by influencing cellular redox environment via altering the intracellular ratio between O2- and H2O2. Oxygen 205-208 superoxide dismutase 2 Homo sapiens 72-77 34981770-7 2022 The resulting neutron diffraction data permitted the visualization of a dioxygen species bound to the MnSOD active-site metal that was indicative of successful cryotrapping. Oxygen 72-80 superoxide dismutase 2 Homo sapiens 102-107 2607653-5 1989 On the other hand, an XOD-NH2OH method which detects SOD activities based on the O2-specific oxidation reaction showed the minimum detectable amount of 2.5 ng. Oxygen 81-83 superoxide dismutase 2 Homo sapiens 53-56 1394426-1 1992 The 2.2 A resolution crystal structure of recombinant human manganese superoxide dismutase, a homotetrameric enzyme that protects mitochondria against oxygen-mediated free radical damage, has been determined. Oxygen 151-157 superoxide dismutase 2 Homo sapiens 60-90 22723845-4 2012 Superoxide dismutase 2 (SOD2) is a mitochondrial enzyme that converts superoxide radicals to molecular oxygen and hydrogen peroxide, providing a first line of defense against ROS. Oxygen 103-109 superoxide dismutase 2 Homo sapiens 0-22 22723845-4 2012 Superoxide dismutase 2 (SOD2) is a mitochondrial enzyme that converts superoxide radicals to molecular oxygen and hydrogen peroxide, providing a first line of defense against ROS. Oxygen 103-109 superoxide dismutase 2 Homo sapiens 24-28 6316150-1 1983 Copper, zinc superoxide dismutase (SOD) catalyses the very rapid two-step dismutation of the toxic superoxide radical (O-2) to molecular oxygen and hydrogen peroxide through the alternate reduction and oxidation of the active-site copper. Oxygen 137-143 superoxide dismutase 2 Homo sapiens 35-38 34001853-3 2021 Further analysis indicated that mitochondrial superoxide dismutase (SOD)2, which converts O2- into H2O2 remained deacetylated in CLL cells due to SIRT3 overexpression resulting its constitutive activation. Oxygen 90-93 superoxide dismutase 2 Homo sapiens 46-73 32468046-0 2020 Excessive production of mitochondrion-derived reactive oxygen species induced by titanium ions leads to autophagic cell death of osteoblasts via the SIRT3/SOD2 pathway. Oxygen 55-61 superoxide dismutase 2 Homo sapiens 155-159 31901951-6 2020 We further verified that ACT001 elevated the levels of reactive oxygen species (ROS) by regulating NF-kappaB-targeted MnSOD. Oxygen 64-70 superoxide dismutase 2 Homo sapiens 118-123 32149414-10 2020 First, proper level of SOD2 helped CRC cells maintain mitochondrial function by disposal of superoxide (O2 .- ). Oxygen 104-106 superoxide dismutase 2 Homo sapiens 23-27 30932749-11 2019 Concomitantly, it enhances the scavenger of reactive oxygen species (SOD-2) to maintain moderate levels of oxidative stress. Oxygen 53-59 superoxide dismutase 2 Homo sapiens 69-74 31940867-6 2020 Overall, we found that SOD2 siRNA transfection in the spheroid form of MSCs increases the expression of apoptotic genes and decreases the clearance of mitochondrial reactive oxygen species (ROS). Oxygen 174-180 superoxide dismutase 2 Homo sapiens 23-27 31494578-5 2020 This gene encodes superoxide dismutase 2 (SOD2) or manganese-superoxide dismutase, a mitochondrial matrix protein that scavenges oxygen radicals produced by oxidation-reduction and electron transport reactions occurring in mitochondria via conversion of superoxide anion (O2 - ) into H2O2. Oxygen 129-135 superoxide dismutase 2 Homo sapiens 18-40 31494578-5 2020 This gene encodes superoxide dismutase 2 (SOD2) or manganese-superoxide dismutase, a mitochondrial matrix protein that scavenges oxygen radicals produced by oxidation-reduction and electron transport reactions occurring in mitochondria via conversion of superoxide anion (O2 - ) into H2O2. Oxygen 129-135 superoxide dismutase 2 Homo sapiens 42-46 31494578-5 2020 This gene encodes superoxide dismutase 2 (SOD2) or manganese-superoxide dismutase, a mitochondrial matrix protein that scavenges oxygen radicals produced by oxidation-reduction and electron transport reactions occurring in mitochondria via conversion of superoxide anion (O2 - ) into H2O2. Oxygen 129-135 superoxide dismutase 2 Homo sapiens 51-81 31494578-5 2020 This gene encodes superoxide dismutase 2 (SOD2) or manganese-superoxide dismutase, a mitochondrial matrix protein that scavenges oxygen radicals produced by oxidation-reduction and electron transport reactions occurring in mitochondria via conversion of superoxide anion (O2 - ) into H2O2. Oxygen 272-274 superoxide dismutase 2 Homo sapiens 18-40 31494578-5 2020 This gene encodes superoxide dismutase 2 (SOD2) or manganese-superoxide dismutase, a mitochondrial matrix protein that scavenges oxygen radicals produced by oxidation-reduction and electron transport reactions occurring in mitochondria via conversion of superoxide anion (O2 - ) into H2O2. Oxygen 272-274 superoxide dismutase 2 Homo sapiens 42-46 31494578-5 2020 This gene encodes superoxide dismutase 2 (SOD2) or manganese-superoxide dismutase, a mitochondrial matrix protein that scavenges oxygen radicals produced by oxidation-reduction and electron transport reactions occurring in mitochondria via conversion of superoxide anion (O2 - ) into H2O2. Oxygen 272-274 superoxide dismutase 2 Homo sapiens 51-81 31494578-6 2020 Measurement of hydroethidine oxidation showed a significant increase in O2 - levels in the patient"s skin fibroblasts, as compared with controls, and this was paralleled by reduced catalytic activity of SOD2 in patient fibroblasts and muscle. Oxygen 72-74 superoxide dismutase 2 Homo sapiens 204-208 31494578-8 2020 CONCLUSION: Our results provide evidence that defective SOD2 may lead to toxic increases in the levels of damaging oxygen radicals in the neonatal heart, which can result in rapidly developing heart failure and death. Oxygen 115-121 superoxide dismutase 2 Homo sapiens 56-60 31648572-7 2020 Abbreviations AKT protein kinase B ARMS alveolar rhabdomyosarcoma ATM ataxia telangiectasia mutated Bax Bcl-2-associated X protein Bcl-2 B-cell lymphoma 2 CDC2 cyclin-dependent kinase 2 Bcl-xL B-cell lymphoma-extra large c-FLIP cellular FLICE-like inhibitory protein CDDP cisplatin COX-2 cyclooxygenase-2 cyt c cytochrome c DNA-PKcs DNA-dependent protein kinase EGFR epidermal growth factor receptor EMT epithelial-mesenchymal transition ERK extracellular signal-regulated kinase ES Ewing`s sarcoma ETS2 erythroblastosis virus transcription factor 2 GBM glioblastoma multiforme HCC hepatocellular carcinoma HNSCC head and neck squamous cell carcinoma IAP inhibitor of apoptosis protein IkappaBalpha inhibitor of kappaB alpha IKK inhibitor of kappaB kinase IR ionizing radiation lncRNA long non-coding RNA luc luciferase Mcl-1 myeloid cell leukemia-1 MDR1 multidrug resistance protein 1 miR microRNA MMP-9 matrix metalloproteinase-9 mTOR mammalian target of rapamycin NB neuroblastoma NF-kappaB nuclear factor-kappaB NPC nasopharyngeal carcinoma NSCLC non-small cell lung cancer OSCC oral squamous cell carcinoma PARP poly-(ADP-ribose)-polymerase pH2AX phosphorylated histone 2AX-immunoreactive PI3K phosphatidylinositol 3-kinase Prp4K Pre-mRNA processing factor 4 kinase RCC renal cell carcinoma ROS reactive oxygen species SCC squamous cell carcinoma SLN solid lipid nanoparticle SOD2 superoxide dismutase 2 TERT telomerase reverse transcriptase TNF-alpha tumor necrosis factor-alpha TxnRd1 thioredoxin reductase-1 VEGF vascular endothelial growth factor XIAP X-linked inhibitor of apoptosis protein DeltaPsim mitochondrial membrane potential. Oxygen 293-299 superoxide dismutase 2 Homo sapiens 1381-1385 31591207-4 2019 Acetylated SOD2 promotes hypoxic signaling via increased mitochondrial reactive oxygen species (mtROS). Oxygen 80-86 superoxide dismutase 2 Homo sapiens 11-15 30819616-3 2019 Loss of MnSOD led to specific increases in mitochondrial O2- with no evident changes in hydrogen peroxide (H2O2), peroxynitrite (ONOO-), or copper/zinc superoxide dismutase (CuZnSOD) levels. Oxygen 57-60 superoxide dismutase 2 Homo sapiens 8-13 25578653-3 2015 Manganese superoxide dismutase (MnSOD), a primary mitochondrial antioxidant in mammals, has long been known to play a crucial role in radioadaptive protection by detoxifying O2( -) generated by mitochondrial oxidative phosphorylation. Oxygen 174-176 superoxide dismutase 2 Homo sapiens 0-30 30279321-2 2018 Mitochondria are the source of up to 90% of cellular ROS generation, and MnSOD performs its necessary bioprotective role by converting superoxide into oxygen and hydrogen peroxide. Oxygen 151-157 superoxide dismutase 2 Homo sapiens 73-78 28495429-2 2017 Into mitochondria, MnSOD catalyses superoxide radical producing HP and oxygen. Oxygen 71-77 superoxide dismutase 2 Homo sapiens 19-24 27829319-5 2017 OBJECTIVE: Evaluation of Sig1R, SOD1, and SOD2 expression in different concentrations of oxygen (1%, 10%, 21%) in colon adenocarcinoma cell lines. Oxygen 89-95 superoxide dismutase 2 Homo sapiens 42-46 27829319-10 2017 RESULTS: We observed significant changes in expression of Sig1R, SOD1, SOD2 due to different oxygen concentrations. Oxygen 93-99 superoxide dismutase 2 Homo sapiens 71-75 28100855-9 2016 Manganese, copper and zinc are a part of the group of superoxide dismutase enzymes (MnSOD, Cu/ZnSOD), which catalyse the superoxide anion dismutation into hydrogen peroxide and oxygen. Oxygen 177-183 superoxide dismutase 2 Homo sapiens 84-89 26359457-5 2015 Sod2 is an antioxidant enzyme that converts highly reactive superoxide (O2 ( -)) to hydrogen peroxide (H2O2) and oxygen (O2), and our data demonstrate that Sod2 is protumorigenic and prometastatic in OCCC. Oxygen 72-74 superoxide dismutase 2 Homo sapiens 0-4 26359457-5 2015 Sod2 is an antioxidant enzyme that converts highly reactive superoxide (O2 ( -)) to hydrogen peroxide (H2O2) and oxygen (O2), and our data demonstrate that Sod2 is protumorigenic and prometastatic in OCCC. Oxygen 72-74 superoxide dismutase 2 Homo sapiens 156-160 26359457-5 2015 Sod2 is an antioxidant enzyme that converts highly reactive superoxide (O2 ( -)) to hydrogen peroxide (H2O2) and oxygen (O2), and our data demonstrate that Sod2 is protumorigenic and prometastatic in OCCC. Oxygen 113-119 superoxide dismutase 2 Homo sapiens 0-4 26359457-5 2015 Sod2 is an antioxidant enzyme that converts highly reactive superoxide (O2 ( -)) to hydrogen peroxide (H2O2) and oxygen (O2), and our data demonstrate that Sod2 is protumorigenic and prometastatic in OCCC. Oxygen 113-119 superoxide dismutase 2 Homo sapiens 156-160 26359457-5 2015 Sod2 is an antioxidant enzyme that converts highly reactive superoxide (O2 ( -)) to hydrogen peroxide (H2O2) and oxygen (O2), and our data demonstrate that Sod2 is protumorigenic and prometastatic in OCCC. Oxygen 105-107 superoxide dismutase 2 Homo sapiens 0-4 26359457-5 2015 Sod2 is an antioxidant enzyme that converts highly reactive superoxide (O2 ( -)) to hydrogen peroxide (H2O2) and oxygen (O2), and our data demonstrate that Sod2 is protumorigenic and prometastatic in OCCC. Oxygen 105-107 superoxide dismutase 2 Homo sapiens 156-160 26359457-9 2015 First, Sod2 maintains highly functional mitochondria, by scavenging O2 ( -), to support the high metabolic activity of OCCC. Oxygen 68-70 superoxide dismutase 2 Homo sapiens 7-11 27721400-0 2017 Physical interaction of estrogen receptor with MnSOD: implication in mitochondrial O2.- upregulation and mTORC2 potentiation in estrogen-responsive breast cancer cells. Oxygen 83-85 superoxide dismutase 2 Homo sapiens 47-52 27721400-3 2017 Manganese superoxide dismutase (MnSOD) is the principal mitochondrial attribute governing mitochondrial O2.- homeostasis, raising the possibility that its functional alteration could be instrumental in augmenting mitochondrial O2.- levels in breast cancer cells. Oxygen 104-106 superoxide dismutase 2 Homo sapiens 0-30 27721400-3 2017 Manganese superoxide dismutase (MnSOD) is the principal mitochondrial attribute governing mitochondrial O2.- homeostasis, raising the possibility that its functional alteration could be instrumental in augmenting mitochondrial O2.- levels in breast cancer cells. Oxygen 104-106 superoxide dismutase 2 Homo sapiens 32-37 27721400-3 2017 Manganese superoxide dismutase (MnSOD) is the principal mitochondrial attribute governing mitochondrial O2.- homeostasis, raising the possibility that its functional alteration could be instrumental in augmenting mitochondrial O2.- levels in breast cancer cells. Oxygen 227-229 superoxide dismutase 2 Homo sapiens 0-30 27721400-3 2017 Manganese superoxide dismutase (MnSOD) is the principal mitochondrial attribute governing mitochondrial O2.- homeostasis, raising the possibility that its functional alteration could be instrumental in augmenting mitochondrial O2.- levels in breast cancer cells. Oxygen 227-229 superoxide dismutase 2 Homo sapiens 32-37 27721400-9 2017 In addition, we also observed diminished interaction of MnSOD with sirtuin-3, the key mitochondrial deacetylase that deacetylates MnSOD at critical K68 and thereby activates it for scavenging O2.-. Oxygen 192-194 superoxide dismutase 2 Homo sapiens 56-61 27721400-10 2017 Consequently, compromised deacetylation of MnSOD at K68 leading to its inhibition and a resultant buildup of O2.- within the mitochondria culminated in the activation of mTORC2. Oxygen 109-111 superoxide dismutase 2 Homo sapiens 43-48 27007876-11 2016 Compared with gene expression levels at 5 % O2, which were arbitrarily set as "1," 20 % O2 is associated with significantly higher expression of BAX (2.14 +- 0.47), G6PD (2.92 +- 1.06), MnSOD (2.87 +- 0.88), and HSP70.1 (8.68 +- 4.19). Oxygen 88-90 superoxide dismutase 2 Homo sapiens 186-191 27630759-1 2016 Mitochondrial superoxide dismutase 2 (SOD2) converts superoxide anions to hydrogen peroxide and oxygen. Oxygen 96-102 superoxide dismutase 2 Homo sapiens 38-42 26637092-15 2015 CONCLUSIONS: The profile of expression of SOD1 and SOD2 in cell lines SW480 and SW620 indicates differentiated response of tumor cells depending on access to oxygen. Oxygen 158-164 superoxide dismutase 2 Homo sapiens 51-55 25578653-3 2015 Manganese superoxide dismutase (MnSOD), a primary mitochondrial antioxidant in mammals, has long been known to play a crucial role in radioadaptive protection by detoxifying O2( -) generated by mitochondrial oxidative phosphorylation. Oxygen 174-176 superoxide dismutase 2 Homo sapiens 32-37 25071412-5 2014 Manganese Superoxide Dismutase (MnSOD) is a manganesedependant metallo-enzyme which plays a crucial role in protecting cells from anti-oxidative stress by eliminating reactive (superoxide) oxygen species. Oxygen 189-195 superoxide dismutase 2 Homo sapiens 0-30 25672499-6 2015 In PAH, acquired mitochondrial abnormalities, including epigenetic silencing of superoxide dismutase (SOD2), disrupt oxygen sensing creating a pseudo-hypoxic environment characterized by normoxic activation of hypoxia-inducible factor-1alpha (HIF-1alpha). Oxygen 117-123 superoxide dismutase 2 Homo sapiens 102-106 24825124-3 2014 Unlike the other known SODs (MnSOD, FeSOD, and (CuZn)SOD), which utilize "typical" biological nitrogen and oxygen donors, NiSOD utilizes a rather unexpected ligand set. Oxygen 107-113 superoxide dismutase 2 Homo sapiens 29-34 25071412-5 2014 Manganese Superoxide Dismutase (MnSOD) is a manganesedependant metallo-enzyme which plays a crucial role in protecting cells from anti-oxidative stress by eliminating reactive (superoxide) oxygen species. Oxygen 189-195 superoxide dismutase 2 Homo sapiens 32-37 23590434-7 2014 The periodic fluctuation in MnSOD activity during the cell cycle inversely correlates with cellular superoxide levels as well as glucose and oxygen consumption. Oxygen 141-147 superoxide dismutase 2 Homo sapiens 28-33 19699328-1 2010 Manganese superoxide dismutase is an important antioxidant defense metalloenzyme that protects cells from damage by the toxic oxygen metabolite, superoxide free radical, formed as an unavoidable by-product of aerobic metabolism. Oxygen 126-132 superoxide dismutase 2 Homo sapiens 0-30 20473639-7 2010 Manganese-containing superoxide dismutase (MnSOD) activity was unaffected by oxygen tension, but was elevated in young confluent cultures as compared with cultures in log-phase growth. Oxygen 77-83 superoxide dismutase 2 Homo sapiens 43-48 20473639-8 2010 MnSOD activity was significantly higher in senescent cultures than in early passage cultures and was also responsive to increased oxygen tension in senescent cultures. Oxygen 130-136 superoxide dismutase 2 Homo sapiens 0-5 22820117-4 2013 The mitochondria-localized antioxidant enzyme manganese superoxide dismutase (MnSOD) is vital to survival in our oxygen-rich atmosphere because it scavenges mitochondrial ROS. Oxygen 113-119 superoxide dismutase 2 Homo sapiens 46-76 22820117-4 2013 The mitochondria-localized antioxidant enzyme manganese superoxide dismutase (MnSOD) is vital to survival in our oxygen-rich atmosphere because it scavenges mitochondrial ROS. Oxygen 113-119 superoxide dismutase 2 Homo sapiens 78-83 20514411-5 2010 We observed that CuZnSOD and MnSOD overexpression prevents metabolic stress-induced necrosis and HMGB1 release by inhibiting mitochondrial ROS and intracellular O2- production in response to glucose depletion in two dimensional cell culture. Oxygen 161-163 superoxide dismutase 2 Homo sapiens 29-34 18413745-3 2008 The antioxidant enzyme manganese superoxide dismutase (MnSOD) modulates the cellular redox environment by converting superoxide (O(2)(*-)) to hydrogen peroxide and dioxygen. Oxygen 164-172 superoxide dismutase 2 Homo sapiens 23-53 18779124-1 2008 MnSOD, which is an important oxygen free radical scavenger in organisms, has an effect to resist oxidative stress and tumor. Oxygen 29-35 superoxide dismutase 2 Homo sapiens 0-5 18413745-3 2008 The antioxidant enzyme manganese superoxide dismutase (MnSOD) modulates the cellular redox environment by converting superoxide (O(2)(*-)) to hydrogen peroxide and dioxygen. Oxygen 164-172 superoxide dismutase 2 Homo sapiens 55-60 15642322-9 2004 Analysis with real-time PCR showed a maximum 3-6-fold increase in mRNA levels 9 hr after the 3 hr O2-exposure for the enzymes heme oxygenase-1 (HO-1), MnSOD and TrxR1 (the cytoplasmic form of TrxR). Oxygen 98-100 superoxide dismutase 2 Homo sapiens 151-156 17394531-5 2007 Additionally, we tested the hypothesis that mutant SOD1 increases mitochondrial-produced superoxide (O(2) (*)) levels and that SOD2 overexpression protects neurons from mutant SOD1-induced toxicity by reducing O(2) (*) levels in mitochondria. Oxygen 210-214 superoxide dismutase 2 Homo sapiens 127-131 17394531-8 2007 These elevated O(2) (*) levels in mitochondria were significantly diminished by the overexpression of SOD2. Oxygen 15-19 superoxide dismutase 2 Homo sapiens 102-106 18648594-11 2006 Recent findings suggest that employment of DR and multiple antioxidant agents (including, catalase, glutathione peroxidase, CuZn superoxide dismutase, and Mn superoxide dismutase = enzymes forming the primary defense against oxygen toxicity), and ozone therapy may mount an effective resistance to pathogenic factors relevant to the pathogenesis of cardiovascular episodes. Oxygen 225-231 superoxide dismutase 2 Homo sapiens 155-178 16485861-2 2005 Manganese superoxide dismutase (MnSOD) plays a major role in protecting the mitochondrion from oxidative damage due to superoxide radicals and other excited oxygen species. Oxygen 157-163 superoxide dismutase 2 Homo sapiens 0-30 16485861-2 2005 Manganese superoxide dismutase (MnSOD) plays a major role in protecting the mitochondrion from oxidative damage due to superoxide radicals and other excited oxygen species. Oxygen 157-163 superoxide dismutase 2 Homo sapiens 32-37 16298938-8 2005 In vitro exposure to FGF-20 increased expression of the Nrf2 transcription factor and oxygen radical scavenging enzymes such as MnSOD, activated signal transduction pathways (ERK and Akt) and resulted in increased survival of irradiated cells in vitro. Oxygen 86-92 superoxide dismutase 2 Homo sapiens 128-133 15642323-9 2004 Furthermore, Sod2-deficient cells showed dramatic mitochondrial damage, cytochrome C leakage, caspase 3 activation and increased apoptotic cell death when they were challenged with O2-. Oxygen 181-183 superoxide dismutase 2 Homo sapiens 13-17 12966547-2 2003 As a consequence, the production of the oxygen radical scavenger manganese superoxide dismutase (MnSOD) is increased. Oxygen 40-46 superoxide dismutase 2 Homo sapiens 97-102 11278550-1 2001 Manganese superoxide dismutase (Mn-SOD) is a primary antioxidant enzyme whose expression is essential for life in oxygen. Oxygen 114-120 superoxide dismutase 2 Homo sapiens 32-38 11536448-2 2001 We hypothesized that MnSOD increases in human lung in response to oxygen treatment, although this response could be restricted to certain cell types and depend on gestational age. Oxygen 66-72 superoxide dismutase 2 Homo sapiens 21-26 11536448-9 2001 However, the inability to induce MnSOD in response to oxygen treatment may result in a poor outcome. Oxygen 54-60 superoxide dismutase 2 Homo sapiens 33-38 14499631-8 2003 These results reveal differences in tumor and normal cell responses to changes in ambient oxygen tension and show that MnSOD activity is inducible when an appropriate stimulus is applied. Oxygen 90-96 superoxide dismutase 2 Homo sapiens 119-124 11179510-5 2001 The increase in MnSOD in the presence of Fe(3+)-NTA was greater under the condition of 20% O(2) than under the condition of 1% O(2). Oxygen 91-95 superoxide dismutase 2 Homo sapiens 16-21 11179510-5 2001 The increase in MnSOD in the presence of Fe(3+)-NTA was greater under the condition of 20% O(2) than under the condition of 1% O(2). Oxygen 127-131 superoxide dismutase 2 Homo sapiens 16-21