PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31147316-17	2019	NC preferentially inhibited the nontoxic E2 2-hydroxylation pathway mediated by CYP1A1, which might increase the risk of 4-OHE2-induced genotoxicity and cause severe drug-drug interactions.	4-ohe2	121-127	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	80-86	
30680817-1	2019	Human cytochrome P450 1B1 (CYP1B1)-mediated formation of 4-hydroxyestradiol (4-OHE2) from 17beta-estradiol plays an important role in the progression of human breast cancer, while the biotransformation of 17beta-estradiol to 2-hydroxyestradiol mediated by cytochrome P450 1A1 (CYP1A1) is considered as a less harmful pathway.	4-ohe2	77-83	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	256-275	
30680817-1	2019	Human cytochrome P450 1B1 (CYP1B1)-mediated formation of 4-hydroxyestradiol (4-OHE2) from 17beta-estradiol plays an important role in the progression of human breast cancer, while the biotransformation of 17beta-estradiol to 2-hydroxyestradiol mediated by cytochrome P450 1A1 (CYP1A1) is considered as a less harmful pathway.	4-ohe2	77-83	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	277-283	
12376470-2	2002	The two major pathways of estrogen metabolism, to the carcinogenic 4-hydroxyestradiol (4-OHE2) and to the non-carcinogenic 2-hydroxyestradiol (2-OHE2), are mediated by cytochromes P450 CYP1B1 and CYP1A1, respectively.	4-ohe2	87-93	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	196-202	
15050414-5	2004	Estradiol (E2) is usually metabolized by CYP1A1/1A2 and CYP3A4 to the 2-hydroxy estradiol (2-OHE2) and 4-hydroxy estradiol (4-OHE2) in human liver.	4-ohe2	124-130	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	41-47