PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15050414-12 2004 Our results also indicated that the mTOR/FRAP inhibitor, rapamycin, inhibited 4-OHE2-induced HIF-1alpha and VEGF-A expression. 4-ohe2 78-84 mechanistic target of rapamycin kinase Homo sapiens 36-40 15050414-12 2004 Our results also indicated that the mTOR/FRAP inhibitor, rapamycin, inhibited 4-OHE2-induced HIF-1alpha and VEGF-A expression. 4-ohe2 78-84 mechanistic target of rapamycin kinase Homo sapiens 41-45 15050414-13 2004 These results suggest that the PI3K/Akt/FRAP signaling pathway is required for HIF-1alpha and VEGF-A expression induced by 4-OHE2, whereas the MAPK pathway is not required. 4-ohe2 123-129 mechanistic target of rapamycin kinase Homo sapiens 40-44 15050414-14 2004 The finding that induction of HIF-1alpha and VEGF-A expression occurs via the activation of the PI3K/Akt/FRAP signaling pathway could be an important mechanism of 4-OHE2-induced carcinogenesis. 4-ohe2 163-169 mechanistic target of rapamycin kinase Homo sapiens 105-109