PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32791891-16 2021 Pendrin may be more important than NIS in the mediation of placental iodide transport. Iodides 69-75 solute carrier family 26 member 4 Rattus norvegicus 0-7 26791486-0 2016 Iodide excess regulates its own efflux: a possible involvement of pendrin. Iodides 0-6 solute carrier family 26 member 4 Rattus norvegicus 66-73 26791486-3 2016 Previous studies demonstrated that pendrin is able to mediate apical efflux of iodide in thyrocytes. Iodides 79-85 solute carrier family 26 member 4 Rattus norvegicus 35-42 26791486-8 2016 Our results indicate that iodide excess increases pendrin abundance and plasma membrane insertion after 24 h of treatment. Iodides 26-32 solute carrier family 26 member 4 Rattus norvegicus 50-57 26791486-9 2016 Moreover, iodide excess increases pendrin half-life. Iodides 10-16 solute carrier family 26 member 4 Rattus norvegicus 34-41 26791486-11 2016 In conclusion, these data suggest that pendrin may have an important role in mediating iodide efflux in thyrocytes, especially under conditions of iodide excess. Iodides 87-93 solute carrier family 26 member 4 Rattus norvegicus 39-46 26791486-11 2016 In conclusion, these data suggest that pendrin may have an important role in mediating iodide efflux in thyrocytes, especially under conditions of iodide excess. Iodides 147-153 solute carrier family 26 member 4 Rattus norvegicus 39-46 22178794-0 2012 Iodide treatment acutely increases pendrin (SLC26A4) mRNA expression in the rat thyroid and the PCCl3 thyroid cell line by transcriptional mechanisms. Iodides 0-6 solute carrier family 26 member 4 Rattus norvegicus 35-42 25298423-2 2014 Several reports point to pendrin as a candidate protein for iodide export from thyroid cells into the follicular lumen. Iodides 60-66 solute carrier family 26 member 4 Rattus norvegicus 25-32 25298423-5 2014 Moreover, ANO1 properties, i.e., activation by intracellular calcium (i.e., by ionomycin or by ATP), low but positive affinity for pertechnetate, and nonrequirement for chloride, better fit with the iodide release characteristics of PCCl3 and FRTL-5 rat thyroid cell lines than the dissimilar properties of pendrin. Iodides 199-205 solute carrier family 26 member 4 Rattus norvegicus 307-314 22178794-0 2012 Iodide treatment acutely increases pendrin (SLC26A4) mRNA expression in the rat thyroid and the PCCl3 thyroid cell line by transcriptional mechanisms. Iodides 0-6 solute carrier family 26 member 4 Rattus norvegicus 44-51 22178794-3 2012 This study attempted to investigate whether iodide administration affects SLC26A4 mRNA expression in rat thyroid and in PCCl3 cells. Iodides 44-50 solute carrier family 26 member 4 Rattus norvegicus 74-81 22178794-6 2012 Iodide administration significantly increased SLC26A4 mRNA content in both models. Iodides 0-6 solute carrier family 26 member 4 Rattus norvegicus 46-53 22178794-8 2012 These data show that intracellular iodide rapidly upregulates SLC26A4 mRNA expression. Iodides 35-41 solute carrier family 26 member 4 Rattus norvegicus 62-69 10650967-0 2000 Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells. Iodides 88-94 solute carrier family 26 member 4 Rattus norvegicus 0-7 22109890-7 2012 The increase in pendrin membrane abundance correlates with a decrease in intracellular iodide as determined by measuring intracellular (125)iodide and can be inhibited by specific blocking of pendrin. Iodides 87-93 solute carrier family 26 member 4 Rattus norvegicus 16-23 22109890-7 2012 The increase in pendrin membrane abundance correlates with a decrease in intracellular iodide as determined by measuring intracellular (125)iodide and can be inhibited by specific blocking of pendrin. Iodides 87-93 solute carrier family 26 member 4 Rattus norvegicus 192-199 22109890-7 2012 The increase in pendrin membrane abundance correlates with a decrease in intracellular iodide as determined by measuring intracellular (125)iodide and can be inhibited by specific blocking of pendrin. Iodides 140-146 solute carrier family 26 member 4 Rattus norvegicus 16-23 22109890-7 2012 The increase in pendrin membrane abundance correlates with a decrease in intracellular iodide as determined by measuring intracellular (125)iodide and can be inhibited by specific blocking of pendrin. Iodides 140-146 solute carrier family 26 member 4 Rattus norvegicus 192-199 22109890-9 2012 These results demonstrate that pendrin translocates to the membrane in response to TSH and suggest that it may have a physiological role in apical iodide transport and thyroid hormone synthesis. Iodides 147-153 solute carrier family 26 member 4 Rattus norvegicus 31-38 23662038-11 2006 The most promising of these was Pendrin, or Slc26a4, a solute carrier of chloride and iodide active in the kidney, thyroid, and inner ear. Iodides 86-92 solute carrier family 26 member 4 Rattus norvegicus 32-39 23662038-11 2006 The most promising of these was Pendrin, or Slc26a4, a solute carrier of chloride and iodide active in the kidney, thyroid, and inner ear. Iodides 86-92 solute carrier family 26 member 4 Rattus norvegicus 44-51 12107249-3 2002 We show here, using COS-7 cells and Chinese hamster ovary cells transfected with expression vectors encoding sodium iodide symporter or human Pendred syndrome gene cDNA and by comparison with studies using rat thyroid FRTL-5 cells, that pendrin is an iodide-specific transporter in mammalian cells and is responsible for iodide efflux in the thyroid. Iodides 251-257 solute carrier family 26 member 4 Rattus norvegicus 237-244 10650967-9 2000 Together, these results suggest that pendrin is an apical porter of iodide in the thyroid and that the expression and function of both the apical and basal iodide porters are coordinately regulated by follicular TG. Iodides 68-74 solute carrier family 26 member 4 Rattus norvegicus 37-44 18459119-1 2008 We studied the expression and the hormonal regulation of the PDS gene product, pendrin, which is, in thyrocytes, responsible for the iodide transport out of the cell. Iodides 133-139 solute carrier family 26 member 4 Rattus norvegicus 79-86 10650967-0 2000 Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells. Iodides 88-94 solute carrier family 26 member 4 Rattus norvegicus 36-57 10650967-0 2000 Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells. Iodides 88-94 solute carrier family 26 member 4 Rattus norvegicus 59-62