PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15611814-5 2004 Thus, thyroid iodide organification depends on TPO activity, which is modulated by the concentration of substrates (thyroglobulin and iodide) and cofactor (hydrogen peroxide). Iodides 14-20 thyroglobulin Homo sapiens 116-129 28153798-4 2017 The iodination of the tyrosyl residues of TG preceeds TH biosynthesis, which depends on the interaction of iodide, TG, hydrogen peroxide (H2O2) and thyroid peroxidase (TPO) at the apical plasma membrane of thyrocytes. Iodides 107-113 thyroglobulin Homo sapiens 42-44 22498723-1 2012 Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8. Iodides 179-185 thyroglobulin Homo sapiens 218-220 22498723-1 2012 Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8. Iodides 179-185 thyroglobulin Homo sapiens 218-220 19265500-2 2009 The aim of this study was to clarify these conflicting results by examining if prolonged high iodide exposition with or without interferon (IFN)-gamma has an effect on human primary thyroid cell proliferation, thyroglobulin (Tg) production, and intercellular adhesion molecule-1 (ICAM-1) and human leukocyte antigen (HLA)-DR expression. Iodides 94-100 thyroglobulin Homo sapiens 210-223 17900225-2 2007 Evolutionary pressure has sculpted Tg into a large molecular scaffolding to allow organification of iodide and its incorporation into thyroid hormones. Iodides 100-106 thyroglobulin Homo sapiens 35-37 17532758-1 2007 CONTEXT: Thyroid dyshormonogenesis is associated with mutations in the thyroglobulin (TG) gene and characterized by normal organification of iodide and low serum TG. Iodides 141-147 thyroglobulin Homo sapiens 71-84 17532758-1 2007 CONTEXT: Thyroid dyshormonogenesis is associated with mutations in the thyroglobulin (TG) gene and characterized by normal organification of iodide and low serum TG. Iodides 141-147 thyroglobulin Homo sapiens 86-88 23444413-0 2013 Thyroglobulin in smoking mothers and their newborns at delivery suggests autoregulation of placental iodide transport overcoming thiocyanate inhibition. Iodides 101-107 thyroglobulin Homo sapiens 0-13 22498723-1 2012 Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8. Iodides 125-131 thyroglobulin Homo sapiens 203-216 22498723-1 2012 Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8. Iodides 125-131 thyroglobulin Homo sapiens 218-220 14976143-2 2004 Upon iodide uptake, thyroperoxidase catalyzes iodination of tyrosine residues in thyroglobulin, retaining iodide within thyroid follicles. Iodides 5-11 thyroglobulin Homo sapiens 81-94 14976143-2 2004 Upon iodide uptake, thyroperoxidase catalyzes iodination of tyrosine residues in thyroglobulin, retaining iodide within thyroid follicles. Iodides 106-112 thyroglobulin Homo sapiens 81-94 1446262-9 1992 In the culture chamber system, thyroglobulin was weakly iodinated (6 atoms of iodide per mole of thyroglobulin; in vivo up to 40 atoms per mole) but hormonogenesis efficiency was close to this one observed in vivo (40%). Iodides 78-84 thyroglobulin Homo sapiens 31-44 8943171-8 1997 The thyroglobulin levels fell significantly over the 52-week follow-up period in the iodide group. Iodides 85-91 thyroglobulin Homo sapiens 4-17 1446629-2 1992 The long-term iodination of thyroglobulin secreted into the apical medium of thyroid cells cultured as monolayers on porous bottom chambers reached 5.87 +/- 1.66 atoms of iodine/mol thyroglobulin after 11 days incubation in the presence of TSH (0.1 mU/ml) and iodide (0.5 microM) in the basal medium. Iodides 260-266 thyroglobulin Homo sapiens 28-41 11396699-1 2001 The thyroid concentrates iodide from the serum and oxidizes it at the apical membrane, attaching it to tyrosyl residues within thyroglobulin (Tg) to make diiodotyrosine and monoiodotyrosine. Iodides 25-31 thyroglobulin Homo sapiens 127-140 11396699-1 2001 The thyroid concentrates iodide from the serum and oxidizes it at the apical membrane, attaching it to tyrosyl residues within thyroglobulin (Tg) to make diiodotyrosine and monoiodotyrosine. Iodides 25-31 thyroglobulin Homo sapiens 142-144 11137035-0 2001 Effects of thyroglobulin and pendrin on iodide flux through the thyrocyte. Iodides 40-46 thyroglobulin Homo sapiens 11-24 10875253-1 2000 Here, we studied the fragmentation of the prothyroid hormone, thyroglobulin (Tg), which occurs during thyroid hormone synthesis, a process which involves iodide, thyroperoxidase, and the H2O2-generating system, consisting of glucose and glucose oxidase. Iodides 154-160 thyroglobulin Homo sapiens 62-75 10537174-0 1999 Follicular thyroglobulin suppresses iodide uptake by suppressing expression of the sodium/iodide symporter gene. Iodides 36-42 thyroglobulin Homo sapiens 11-24 10537174-0 1999 Follicular thyroglobulin suppresses iodide uptake by suppressing expression of the sodium/iodide symporter gene. Iodides 90-96 thyroglobulin Homo sapiens 11-24 1446629-9 1992 Our culture system makes it possible to demonstrate that this high iodide concentration in the basal medium did not increase apical iodide concentration above 10 microM but decreased apical thyroglobulin concentration. Iodides 67-73 thyroglobulin Homo sapiens 190-203 1446262-10 1992 Iodide concentrations higher than 0.5 microM daily added to the basal medium inhibited iodination of thyroglobulin and hormonosynthesis. Iodides 0-6 thyroglobulin Homo sapiens 101-114 3698909-0 1986 Evidence, by in vitro enzymatic iodination of thyroglobulin, that the efficiency of coupling is determined by the initial iodide concentration. Iodides 122-128 thyroglobulin Homo sapiens 46-59 1954313-8 1991 Excess of iodide (0.2 M KJ) or equimolar concentration of diiodotyrosine protects the Tg molecule from iodine induced inactivation. Iodides 10-16 thyroglobulin Homo sapiens 86-88 1999676-6 1991 TSH increased the amount of thyroglobulin secreted into the apical medium by five- to sixfold, whereas high basal iodide concentrations (greater than 5 mumol/l) inhibited thyroglobulin secretion by TSH-stimulated cells. Iodides 114-120 thyroglobulin Homo sapiens 171-184 3698909-9 1986 Provided that initially nonlimiting noninhibiting H2O2 and iodide concentrations are used and that iodination and coupling are allowed to proceed to completion, the extent of coupling is a function of the degree of iodination of Tgb achieved, and its efficiency is determined not just by the native structure of Tgb, but also by the initial iodide concentration used. Iodides 59-65 thyroglobulin Homo sapiens 229-232 3698909-9 1986 Provided that initially nonlimiting noninhibiting H2O2 and iodide concentrations are used and that iodination and coupling are allowed to proceed to completion, the extent of coupling is a function of the degree of iodination of Tgb achieved, and its efficiency is determined not just by the native structure of Tgb, but also by the initial iodide concentration used. Iodides 341-347 thyroglobulin Homo sapiens 229-232 6267713-1 1981 Thyroid peroxidase in involved in several steps of the biosynthesis of thyroid hormone utilizing H2O2: peroxidation of iodide to iodine, iodination of thyroglobulin (Tg) and coupling reaction leading to T4 and T3 formation. Iodides 119-125 thyroglobulin Homo sapiens 151-164 1212981-1 1975 The effect of excess iodide on hog thyroid gland has been examined with regard to the change in the chemical composition of thyroglobulin and in the accumulation of 27-S iodoprotein by the in vivo treatment of hogs with iodide for various lengths of time. Iodides 21-27 thyroglobulin Homo sapiens 124-137 1212981-2 1975 The iodine content of thyroglobulin was either unchanged by short term administration of excess iodide, or somewhat lowered. Iodides 96-102 thyroglobulin Homo sapiens 22-35 1212981-3 1975 However, the iodine content as well as the total amount of thyroglobulin increased in the glands enlarged by prolonged treatment with iodide. Iodides 134-140 thyroglobulin Homo sapiens 59-72 1212981-6 1975 Monoiodotyrosine and diiodotyrosine increased in parallel with the increase in the iodine content (0.15 to 1.17%) caused by the iodide treatment, while thyroxine increased but reached a plateau at the level of three residues per mole of thyroglobulin, and no change was observed even in the proteins with the higher iodine content than 0.75%. Iodides 128-134 thyroglobulin Homo sapiens 237-250 1190729-3 1975 With high iodide concentrations a highly iodinated thyroglobulin (40-50 iodine atoms) containing no thyroxine was obtained after 3 minutes of incubation. Iodides 10-16 thyroglobulin Homo sapiens 51-64