PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12021185-7 2002 In conclusion, our data demonstrate that 1) NIS is expressed in JAr cells; 2) iodide transport in JAr cells is regulated by hCG and by cAMP-dependent and -independent mechanisms; 3) the stimulation of iodide uptake is due to an increase in both NIS mRNA and protein levels; and 4) JAr cells may represent an excellent in vitro model suitable to analyze the molecular mechanisms involved in iodide transport from mother to fetus. Iodides 78-84 chorionic gonadotropin subunit beta 5 Homo sapiens 124-127 12444898-9 2002 CONCLUSION: Our data demonstrated that hCG stimulates iodide uptake in FRTL-5 cells by increasing NIS mRNA and protein levels. Iodides 54-60 chorionic gonadotropin subunit beta 5 Homo sapiens 39-42 12021185-4 2002 Functional analysis clearly showed that Jar cells are able to concentrate iodide in presence of hCG. Iodides 74-80 chorionic gonadotropin subunit beta 5 Homo sapiens 96-99 12444898-1 2002 BACKGROUND: Various clinical and experimental findings support the concept that human chorionic gonadotropin (hCG) can stimulate iodide uptake in thyroid cells. Iodides 129-135 chorionic gonadotropin subunit beta 5 Homo sapiens 110-113 12444898-2 2002 DESIGN: We investigated the molecular mechanisms underlying the effects of hCG on iodide uptake, and particularly its action on the expression of Na+/I- symporter (NIS) mRNA and protein. Iodides 82-88 chorionic gonadotropin subunit beta 5 Homo sapiens 75-78 12444898-5 2002 RESULTS: Iodide uptake was increased by hCG in a dose- and time-dependent manner: maximal effects were observed after 72 h of stimulation. Iodides 9-15 chorionic gonadotropin subunit beta 5 Homo sapiens 40-43 12021185-5 2002 Iodide accumulation increased after 2-h exposure to 5 IU/ml hCG, to 6-fold over the basal level after 8 h. This effect was reproduced using forskolin, the cAMP analog (Bu)(2)-cAMP, and phorbol acetate. Iodides 0-6 chorionic gonadotropin subunit beta 5 Homo sapiens 60-63 9349585-5 1997 Desialylated (ds)-hCG and deglycosylated (dg)-hCG dose-dependently stimulated T3 secretion, iodide uptake and organification, and in each case did so with about twice the intrinsic activity of native hCG. Iodides 92-98 chorionic gonadotropin subunit beta 5 Homo sapiens 18-21 10447009-2 1999 In FRTL-5 rat thyroid cells, hCG increases cyclic adenosine monophosphate (cAMP), iodide transport, and cell growth. Iodides 82-88 chorionic gonadotropin subunit beta 5 Homo sapiens 29-32 9349585-5 1997 Desialylated (ds)-hCG and deglycosylated (dg)-hCG dose-dependently stimulated T3 secretion, iodide uptake and organification, and in each case did so with about twice the intrinsic activity of native hCG. Iodides 92-98 chorionic gonadotropin subunit beta 5 Homo sapiens 46-49 9349585-5 1997 Desialylated (ds)-hCG and deglycosylated (dg)-hCG dose-dependently stimulated T3 secretion, iodide uptake and organification, and in each case did so with about twice the intrinsic activity of native hCG. Iodides 92-98 chorionic gonadotropin subunit beta 5 Homo sapiens 46-49 9349585-6 1997 Indeed, removal of the sialic acid or carbohydrate residues from native hCG transformed it into a thyroid stimulator that elicited a maximal response in terms of iodide uptake, organification and T3 secretion by human thyroid follicles as high as TSH and almost twice as high as native hCG. Iodides 162-168 chorionic gonadotropin subunit beta 5 Homo sapiens 72-75 2125573-9 1990 Partially purified hCG stimulated iodide uptake and growth of thyroid cells at concentrations of 50 X 10(3) U/l and above. Iodides 34-40 chorionic gonadotropin subunit beta 5 Homo sapiens 19-22 8045981-8 1994 The rise from basal to maximal levels achieved after hCG stimulation was 1.3 to 3.6 pmol/well for cAMP formation, 34 to 21,408 cpm/well for iodide uptake, 261 to 20,167 cpm/well for iodide organification, and 40 to 927 fmol/well for T3 secretion. Iodides 140-146 chorionic gonadotropin subunit beta 5 Homo sapiens 53-56 8045981-8 1994 The rise from basal to maximal levels achieved after hCG stimulation was 1.3 to 3.6 pmol/well for cAMP formation, 34 to 21,408 cpm/well for iodide uptake, 261 to 20,167 cpm/well for iodide organification, and 40 to 927 fmol/well for T3 secretion. Iodides 182-188 chorionic gonadotropin subunit beta 5 Homo sapiens 53-56 8045981-9 1994 Maximal levels elicited by hCG (200 mg/L) relative to maximal values achieved with bovine TSH were 49%, 56%, and 42% for iodide uptake, organification, and T3 secretion, respectively, and only 5% for cAMP. Iodides 121-127 chorionic gonadotropin subunit beta 5 Homo sapiens 27-30 8045981-10 1994 Iodide uptake proved to be the most sensitive indicator of the thyrotropic activity of hCG, with increases occurring at a concentration of 10 mg/L. Iodides 0-6 chorionic gonadotropin subunit beta 5 Homo sapiens 87-90 2225480-4 1990 Purified hCG stimulated iodide uptake into FRTL-5 cells with 25 x 10(3) IU/l being equivalent in potency to 1 mU/l of thyrotrophin (TSH). Iodides 24-30 chorionic gonadotropin subunit beta 5 Homo sapiens 9-12 2225480-8 1990 Six men with hCG-secreting testicular tumours were biochemically euthyroid although three of their sera stimulated iodide uptake into FRTL-5 cells. Iodides 115-121 chorionic gonadotropin subunit beta 5 Homo sapiens 13-16 1730805-10 1992 Purified hCG stimulated iodide uptake in a concentration-dependent manner. Iodides 24-30 chorionic gonadotropin subunit beta 5 Homo sapiens 9-12 1730805-11 1992 Stimulation of iodide uptake by TSH was inhibited by the simultaneous presence of low concentrations of hCG while activity was restored with high concentrations. Iodides 15-21 chorionic gonadotropin subunit beta 5 Homo sapiens 104-107