PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34853814-2 2021 Due to its iodide trapping activity, NIS is a powerful theranostic tool for diagnostic imaging and the application of therapeutic radionuclides. Iodides 11-17 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 37-40 12941836-3 2003 Expression of NIS and TPO facilitated concentration of iodide in tumors. Iodides 55-61 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 14-17 12941836-4 2003 As a consequence of the marked increase in intracellular levels of iodide, apoptosis was seen in >95% of NIS/TPO-modified lung cancer cells. Iodides 67-73 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 108-111 12941836-9 2003 This is the first report demonstrating that a therapeutic dose of nonradioactive iodide has potent efficacy and high selectivity against lung cancer when used in combination with genetic modification of cancer cells to express the NIS/TPO genes. Iodides 81-87 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 231-234 11431151-2 2001 With the purpose of using the mouse as an animal model to analyse the role of the sodium iodide symporter (NIS) in iodide transport and its regulation in the mammary gland, mouse NIS (mNIS) cDNA was isolated from lactating mice. Iodides 89-95 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 107-110 11431151-4 2001 Expression of mNIS in cultured mammalian cells induced cellular iodide accumulation. Iodides 64-70 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 14-18 32826330-6 2020 To elucidate the mechanism underlying this phenomenon, we used a drug-free mouse model of hypothyroidism: mice lacking the sodium/iodide symporter (NIS), the plasma membrane protein that mediates active iodide uptake in the thyroid. Iodides 130-136 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 148-151 30121623-6 2019 Radioiodide uptake assays revealed a 4.9-fold increase in NIS-mediated perchlorate-sensitive iodide uptake in SMAD-NIS-MSCs after TGFB1 stimulation compared to unstimulated cells demonstrating the successful establishment of MSCs, which induce NIS expression in response to activation of TGFB1 signaling using a SMAD-responsive promoter. Iodides 5-11 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 58-61 32026684-1 2020 Iodide homeostasis and thyroid hormone metabolism in the brain are potentially related to changes in activity of the sodium iodide symporter (NIS). Iodides 0-6 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 117-140 30121623-6 2019 Radioiodide uptake assays revealed a 4.9-fold increase in NIS-mediated perchlorate-sensitive iodide uptake in SMAD-NIS-MSCs after TGFB1 stimulation compared to unstimulated cells demonstrating the successful establishment of MSCs, which induce NIS expression in response to activation of TGFB1 signaling using a SMAD-responsive promoter. Iodides 5-11 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 115-118 30121623-6 2019 Radioiodide uptake assays revealed a 4.9-fold increase in NIS-mediated perchlorate-sensitive iodide uptake in SMAD-NIS-MSCs after TGFB1 stimulation compared to unstimulated cells demonstrating the successful establishment of MSCs, which induce NIS expression in response to activation of TGFB1 signaling using a SMAD-responsive promoter. Iodides 5-11 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 115-118 27599561-14 2016 In contrast, the iodide symporter gene Slc5a5 was markedly downregulated resulting in impaired iodide uptake and reduced thyroid hormone levels in transgenic thyroid tissue. Iodides 17-23 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 39-45 28706256-0 2017 An extremely high dietary iodide supply forestalls severe hypothyroidism in Na+/I- symporter (NIS) knockout mice. Iodides 26-32 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 76-92 28706256-0 2017 An extremely high dietary iodide supply forestalls severe hypothyroidism in Na+/I- symporter (NIS) knockout mice. Iodides 26-32 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 94-97 28706256-1 2017 The sodium/iodide symporter (NIS) mediates active iodide (I-) accumulation in the thyroid, the first step in thyroid hormone (TH) biosynthesis. Iodides 11-17 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 29-32 30116045-2 2018 Here, we developed a positron emission tomography (PET) technique based on the sodium-iodide symporter (NIS) gene fused with the carboxyl-terminal of ornithine decarboxylase (cODC) that noninvasively images cancer cells with inhibited proteasome activity. Iodides 86-92 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 104-107 27599561-14 2016 In contrast, the iodide symporter gene Slc5a5 was markedly downregulated resulting in impaired iodide uptake and reduced thyroid hormone levels in transgenic thyroid tissue. Iodides 95-101 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 39-45 20529371-0 2010 Effect of thyroid statuses on sodium/iodide symporter (NIS) gene expression in the extrathyroidal tissues in mice. Iodides 37-43 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 55-58 26660892-3 2016 Iodide plays an important role in thyroid function at multiple steps of thyroid colloid synthesis and transport among which sodium/iodide symporter (NIS) and pendrin are essential. Iodides 0-6 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 124-147 26660892-3 2016 Iodide plays an important role in thyroid function at multiple steps of thyroid colloid synthesis and transport among which sodium/iodide symporter (NIS) and pendrin are essential. Iodides 0-6 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 149-152 26660892-9 2016 Based on these findings, we concluded that the occurrence of thyroid colloid retention exacerbated by excess iodide was associated with the suppression of NIS and pendrin expression, providing an additional insight of the potential mechanism of action of excess iodide on thyroid gland. Iodides 109-115 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 155-158 26660892-9 2016 Based on these findings, we concluded that the occurrence of thyroid colloid retention exacerbated by excess iodide was associated with the suppression of NIS and pendrin expression, providing an additional insight of the potential mechanism of action of excess iodide on thyroid gland. Iodides 262-268 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 155-158 21993965-1 2012 The sodium/iodide symporter (SLC5A5, also known as NIS) is a transmembrane glycoprotein. Iodides 11-17 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 29-35 21993965-1 2012 The sodium/iodide symporter (SLC5A5, also known as NIS) is a transmembrane glycoprotein. Iodides 11-17 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 51-54 20529371-1 2010 BACKGROUND: Iodide that is essential for thyroid hormone synthesis is actively transported into the thyroid follicular cells via sodium/iodide symporter (NIS) protein in vertebrates. Iodides 12-18 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 154-157 17515401-4 2007 Iodide uptake assays showed accumulation of radioactive iodide in VSV(Delta51)-NIS-infected myeloma cells that was specific to the function of the NIS transgene. Iodides 0-6 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 79-82 16121204-3 2006 Radioiodide is routinely and effectively used for the treatment of benign and malignant thyroid disease as a result of native thyroidal expression of NIS, which mediates iodide uptake. Iodides 5-11 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 150-153 16121204-4 2006 In vitro gene transfer studies in ovarian cancer cells revealed a 12- and five-fold increase in iodide uptake when transduced with Ad/CMV/NIS or Ad/MUC1/NIS, respectively. Iodides 96-102 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 138-141 16121204-4 2006 In vitro gene transfer studies in ovarian cancer cells revealed a 12- and five-fold increase in iodide uptake when transduced with Ad/CMV/NIS or Ad/MUC1/NIS, respectively. Iodides 96-102 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 153-156 14729653-1 2004 Lactating breast tissue and some breast cancers express the sodium/iodide symporter (NIS) and concentrate iodide. Iodides 67-73 solute carrier family 5 (sodium iodide symporter), member 5 Mus musculus 85-88