PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18272324-5 2008 We also showed that iodide excess inhibits the expression of essential genes for thyroid differentiation: Tshr, Nis, Tg, and Tpo. Iodides 20-26 thyroid peroxidase Rattus norvegicus 125-128 18064720-7 2008 The significant increase in the concentration of iodide protein-bound fraction, which was observed simultaneously with TPO inhibition, could be due to thyroglobulin non-enzymic iodination under H(2)O(2)-generated oxidative stress. Iodides 49-55 thyroid peroxidase Rattus norvegicus 119-122 9849820-9 1998 In rats treated with iodide for 1 month, there was a modest decrease in Tg and TPO mRNA levels in follicular cells in contact with infiltrating mononuclear cells. Iodides 21-27 thyroid peroxidase Rattus norvegicus 79-82 15573527-9 2004 Extra iodide in the incubation media reduced TPO inhibition induced by BS but could not cancel it. Iodides 6-12 thyroid peroxidase Rattus norvegicus 45-48 10433193-10 1999 NIS mRNA was decreased at 6 and 24 h after acute iodide administration, whereas NIS protein was decreased only at 24 h. TPO mRNA was decreased at 6 days of chronic iodide ingestion and 24 h after acute iodide administration. Iodides 164-170 thyroid peroxidase Rattus norvegicus 120-123 10433193-10 1999 NIS mRNA was decreased at 6 and 24 h after acute iodide administration, whereas NIS protein was decreased only at 24 h. TPO mRNA was decreased at 6 days of chronic iodide ingestion and 24 h after acute iodide administration. Iodides 164-170 thyroid peroxidase Rattus norvegicus 120-123 9849820-10 1998 After 2 months of iodide treatment there was clearly a localized decrease in Tg and TPO mRNA levels in follicular cells in contact with infiltrating mononuclear cells. Iodides 18-24 thyroid peroxidase Rattus norvegicus 84-87 6861708-1 1983 We have previously shown that the thioureylene antithyroid drugs 6-propyl-2-thiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI) can inactivate thyroid peroxidase (TPO) in a model iodination system containing relatively high concentrations of iodide. Iodides 246-252 thyroid peroxidase Rattus norvegicus 147-165 9686152-1 1998 Previous studies have shown that in vitro thyroid peroxidase (TPO) iodide oxidation activity is decreased and thyroid T4-5"-deiodinase activity is increased 15 days after induction of experimental diabetes mellitus (DM). Iodides 67-73 thyroid peroxidase Rattus norvegicus 62-65 1752338-12 1991 In the present study, it has been demonstrated that BB/W rats appear to have a defect(s) in iodide metabolism possibly due to some abnormalities in TPO and Tg synthesis. Iodides 92-98 thyroid peroxidase Rattus norvegicus 148-151 744122-5 1978 Preincubation, as above, in the presence of iodide or thiocyanate prevented the irreversible inactivation of TPO. Iodides 44-50 thyroid peroxidase Rattus norvegicus 109-112 436767-5 1979 In the presence of iodide, the iodinating species [TPO.Ioxid], oxidizes thiourea to formamidine disulfide. Iodides 19-25 thyroid peroxidase Rattus norvegicus 51-54 27216871-2 2016 Administration of the goitrogen propylthiouracil (PTU) reduces TH production by inhibiting thyroperoxidase (TPO), an enzyme that oxidizes iodide for the synthesis of TH. Iodides 138-144 thyroid peroxidase Rattus norvegicus 91-106 27216871-2 2016 Administration of the goitrogen propylthiouracil (PTU) reduces TH production by inhibiting thyroperoxidase (TPO), an enzyme that oxidizes iodide for the synthesis of TH. Iodides 138-144 thyroid peroxidase Rattus norvegicus 108-111