PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27216871-2	2016	Administration of the goitrogen propylthiouracil (PTU) reduces TH production by inhibiting thyroperoxidase (TPO), an enzyme that oxidizes iodide for the synthesis of TH.	Iodides	138-144	thyroid peroxidase	Rattus norvegicus	91-106	
27216871-2	2016	Administration of the goitrogen propylthiouracil (PTU) reduces TH production by inhibiting thyroperoxidase (TPO), an enzyme that oxidizes iodide for the synthesis of TH.	Iodides	138-144	thyroid peroxidase	Rattus norvegicus	108-111	
18064720-7	2008	The significant increase in the concentration of iodide protein-bound fraction, which was observed simultaneously with TPO inhibition, could be due to thyroglobulin non-enzymic iodination under H(2)O(2)-generated oxidative stress.	Iodides	49-55	thyroid peroxidase	Rattus norvegicus	119-122	
18272324-5	2008	We also showed that iodide excess inhibits the expression of essential genes for thyroid differentiation: Tshr, Nis, Tg, and Tpo.	Iodides	20-26	thyroid peroxidase	Rattus norvegicus	125-128	
10433193-10	1999	NIS mRNA was decreased at 6 and 24 h after acute iodide administration, whereas NIS protein was decreased only at 24 h. TPO mRNA was decreased at 6 days of chronic iodide ingestion and 24 h after acute iodide administration.	Iodides	164-170	thyroid peroxidase	Rattus norvegicus	120-123	
15573527-9	2004	Extra iodide in the incubation media reduced TPO inhibition induced by BS but could not cancel it.	Iodides	6-12	thyroid peroxidase	Rattus norvegicus	45-48	
10433193-10	1999	NIS mRNA was decreased at 6 and 24 h after acute iodide administration, whereas NIS protein was decreased only at 24 h. TPO mRNA was decreased at 6 days of chronic iodide ingestion and 24 h after acute iodide administration.	Iodides	164-170	thyroid peroxidase	Rattus norvegicus	120-123	
744122-5	1978	Preincubation, as above, in the presence of iodide or thiocyanate prevented the irreversible inactivation of TPO.	Iodides	44-50	thyroid peroxidase	Rattus norvegicus	109-112	
9686152-1	1998	Previous studies have shown that in vitro thyroid peroxidase (TPO) iodide oxidation activity is decreased and thyroid T4-5"-deiodinase activity is increased 15 days after induction of experimental diabetes mellitus (DM).	Iodides	67-73	thyroid peroxidase	Rattus norvegicus	62-65	
1752338-12	1991	In the present study, it has been demonstrated that BB/W rats appear to have a defect(s) in iodide metabolism possibly due to some abnormalities in TPO and Tg synthesis.	Iodides	92-98	thyroid peroxidase	Rattus norvegicus	148-151	
6861708-1	1983	We have previously shown that the thioureylene antithyroid drugs 6-propyl-2-thiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI) can inactivate thyroid peroxidase (TPO) in a model iodination system containing relatively high concentrations of iodide.	Iodides	246-252	thyroid peroxidase	Rattus norvegicus	147-165	
436767-5	1979	In the presence of iodide, the iodinating species [TPO.Ioxid], oxidizes thiourea to formamidine disulfide.	Iodides	19-25	thyroid peroxidase	Rattus norvegicus	51-54	
9849820-9	1998	In rats treated with iodide for 1 month, there was a modest decrease in Tg and TPO mRNA levels in follicular cells in contact with infiltrating mononuclear cells.	Iodides	21-27	thyroid peroxidase	Rattus norvegicus	79-82	
9849820-10	1998	After 2 months of iodide treatment there was clearly a localized decrease in Tg and TPO mRNA levels in follicular cells in contact with infiltrating mononuclear cells.	Iodides	18-24	thyroid peroxidase	Rattus norvegicus	84-87