PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29467904-2 2018 Human sodium iodide symporter (hNIS) is a molecular target of certain tumors types. Iodides 13-19 solute carrier family 5 member 5 Homo sapiens 31-35 28974598-5 2017 Radiolabelling of iodide or a similar ion allows targeting of the NIS system with radiopharmaceuticals for imaging (123I-radioiodine and 99mTc-pertechnetate) and treatment (131I-radioiodine) by virtue of their gamma ray and beta-particle emissions, respectively.Scintigraphic imaging directly guides 131I-radioiodine treatment planning to maximise therapeutic benefit while minimising adverse reactions, in a personalised medicine approach. Iodides 18-24 solute carrier family 5 member 5 Homo sapiens 66-69 31966449-6 2017 An in vitro cellular assay using HepG2 hepatocellular carcinoma (HCC) cells exhibited iodide uptake after infection with Ad-Sur-NIS, and the uptake reached a maximum level at 30 min. Iodides 86-92 solute carrier family 5 member 5 Homo sapiens 128-131 28192058-1 2017 Active iodide (I-) transport in both the thyroid and some extrathyroidal tissues is mediated by the Na+/I- symporter (NIS). Iodides 7-13 solute carrier family 5 member 5 Homo sapiens 100-116 28117294-3 2017 The sodium dependent iodide transport activity of the thyroid gland is mainly attributed to the functional expression of the Na+/I- Symporter (NIS) localized at the basolateral membrane of thyrocytes. Iodides 21-27 solute carrier family 5 member 5 Homo sapiens 125-141 28117294-3 2017 The sodium dependent iodide transport activity of the thyroid gland is mainly attributed to the functional expression of the Na+/I- Symporter (NIS) localized at the basolateral membrane of thyrocytes. Iodides 21-27 solute carrier family 5 member 5 Homo sapiens 143-146 28192058-1 2017 Active iodide (I-) transport in both the thyroid and some extrathyroidal tissues is mediated by the Na+/I- symporter (NIS). Iodides 7-13 solute carrier family 5 member 5 Homo sapiens 118-121 26599396-1 2015 PURPOSE: Human sodium/iodide symporter (hNIS) protein is a membrane glycoprotein that transports iodide ions into thyroid cells. Iodides 22-28 solute carrier family 5 member 5 Homo sapiens 40-44 28036366-4 2016 hNIS is a glycoprotein that naturally transports iodide (I-) into thyroid cells and has the ability to symport the radiotracer 99mTc-pertechnetate (99mTcO4-). Iodides 49-55 solute carrier family 5 member 5 Homo sapiens 0-4 27614840-10 2016 Collectively, the present results from cell culture experiments with human mammary epithelial MCF-7 cells and from genetic studies show for the first time that the NIS gene and iodide uptake are regulated by SREBP in cultured human mammary epithelial cells. Iodides 177-183 solute carrier family 5 member 5 Homo sapiens 164-167 26282166-7 2015 Specifically, we found that miR-146b-3p binds to the 3"-untranslated region of PAX8 and sodium/iodide symporter (NIS), leading to impaired protein translation and a subsequent reduction in iodide uptake. Iodides 95-101 solute carrier family 5 member 5 Homo sapiens 113-116 26282166-9 2015 In conclusion, our study has uncovered the existence of a miR-146b-3p/PAX8/NIS regulatory circuit that may be exploited therapeutically to modulate thyroid cell differentiation and iodide uptake for improved treatment of advanced thyroid cancer. Iodides 181-187 solute carrier family 5 member 5 Homo sapiens 75-78 24708099-0 2014 NIS mediates iodide uptake in the female reproductive tract and is a poor prognostic factor in ovarian cancer. Iodides 13-19 solute carrier family 5 member 5 Homo sapiens 0-3 26204134-1 2015 CONTEXT: Iodide (I(-)), an essential constituent of the thyroid hormones, is actively accumulated in the thyroid by the Na(+)/I(-) symporter (NIS), a key plasma membrane protein encoded by the slc5a5 gene. Iodides 9-15 solute carrier family 5 member 5 Homo sapiens 120-140 26204134-1 2015 CONTEXT: Iodide (I(-)), an essential constituent of the thyroid hormones, is actively accumulated in the thyroid by the Na(+)/I(-) symporter (NIS), a key plasma membrane protein encoded by the slc5a5 gene. Iodides 9-15 solute carrier family 5 member 5 Homo sapiens 193-199 25615643-1 2015 PURPOSE: The aim of this study was to design a method of radionuclide for imaging and therapy of nasopharyngeal carcinoma (NPC) using the transferred human sodium/iodide symporter (hNIS) gene. Iodides 163-169 solute carrier family 5 member 5 Homo sapiens 181-185 25410753-12 2015 An effective therapy of (131)I was achieved activity in malignant glioma cells after induction of tumor-specific iodide uptake activity by GFAP promoter-directed hNIS gene expression in vitro and in vivo. Iodides 113-119 solute carrier family 5 member 5 Homo sapiens 162-166 25309780-1 2014 Iodide uptake across the membranes of thyroid follicular cells and cancer cells occurs through an active transport process mediated by the sodium-iodide symporter (NIS). Iodides 0-6 solute carrier family 5 member 5 Homo sapiens 164-167 24708099-1 2014 CONTEXT: The sodium iodide symporter (NIS) mediates active transport of iodide into the thyroid and the lactating mammary glands and is highly expressed in thyroid and breast carcinomas. Iodides 20-26 solute carrier family 5 member 5 Homo sapiens 38-41 24193032-1 2013 We recently demonstrated tumor-selective iodide uptake and therapeutic efficacy of combined radiovirotherapy after systemic delivery of the theranostic sodium iodide symporter (NIS) gene using a dendrimer-coated adenovirus. Iodides 41-47 solute carrier family 5 member 5 Homo sapiens 177-180 24884806-1 2014 BACKGROUND: Expression and function of sodium iodide symporter (NIS) is requisite for efficient iodide transport in thyrocytes, and its presence in cancer cells allows the use of radioiodine as a diagnostic and therapeutic tool in thyroid neoplasia. Iodides 46-52 solute carrier family 5 member 5 Homo sapiens 64-67 23988430-1 2014 The sodium/iodide symporter (NIS or SLC5A5) is an intrinsic membrane protein implicated in iodide uptake into thyroid follicular cells. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 36-42 23988430-1 2014 The sodium/iodide symporter (NIS or SLC5A5) is an intrinsic membrane protein implicated in iodide uptake into thyroid follicular cells. Iodides 91-97 solute carrier family 5 member 5 Homo sapiens 36-42 24888603-0 2014 Physiological sodium concentrations enhance the iodide affinity of the Na+/I- symporter. Iodides 48-54 solute carrier family 5 member 5 Homo sapiens 71-87 24369144-7 2014 Iodide accumulation was shown in different LNCaP cell lines after Ad.PSMApro-hNIS and Ad.CMV-hNIS infection, but not in different LNCaP cell lines after adenovirus.cytomegalovirus (Ad.CMV) infection. Iodides 0-6 solute carrier family 5 member 5 Homo sapiens 77-81 24369144-7 2014 Iodide accumulation was shown in different LNCaP cell lines after Ad.PSMApro-hNIS and Ad.CMV-hNIS infection, but not in different LNCaP cell lines after adenovirus.cytomegalovirus (Ad.CMV) infection. Iodides 0-6 solute carrier family 5 member 5 Homo sapiens 93-97 24369144-8 2014 At each time point, higher iodide uptake was shown in the C81 cells infected with Ad.PSMApro-hNIS than in the C33 cells (P < 0.05). Iodides 27-33 solute carrier family 5 member 5 Homo sapiens 93-97 23857380-2 2013 Na(+)/I(-) symporter (NIS) is a plasma membrane glycoprotein, which mediates active iodide uptake. Iodides 84-90 solute carrier family 5 member 5 Homo sapiens 0-20 24052075-1 2013 Thyroid iodide accumulation via the sodium/iodide symporter (NIS; SLC5A5) has been the basis for the longtime use of radio-iodide in the diagnosis and treatment of thyroid cancers. Iodides 8-14 solute carrier family 5 member 5 Homo sapiens 61-64 24052075-1 2013 Thyroid iodide accumulation via the sodium/iodide symporter (NIS; SLC5A5) has been the basis for the longtime use of radio-iodide in the diagnosis and treatment of thyroid cancers. Iodides 8-14 solute carrier family 5 member 5 Homo sapiens 66-72 23420532-8 2013 The clonogenic assay indicated that, following exposure to 500 muCi of (131)I-iodide for 12 h, >90% of cells transfected with the hNIS gene were killed. Iodides 77-84 solute carrier family 5 member 5 Homo sapiens 133-137 23471296-8 2013 Iodide also inhibits endogenous TRPM7-like currents as assessed in MCF-7 breast cancer cells, where upregulation of SLC5A5 sodium-iodide symporter enhances iodide uptake and inhibits cell proliferation. Iodides 0-6 solute carrier family 5 member 5 Homo sapiens 116-122 23471296-8 2013 Iodide also inhibits endogenous TRPM7-like currents as assessed in MCF-7 breast cancer cells, where upregulation of SLC5A5 sodium-iodide symporter enhances iodide uptake and inhibits cell proliferation. Iodides 130-136 solute carrier family 5 member 5 Homo sapiens 116-122 23441638-1 2013 BACKGROUND: Physiologic iodide-uptake, mediated by the sodium/iodide symporter (NIS), in the salivary gland confers its susceptibility to radioactive iodine-induced damage following (131)I treatment of thyroid cancer. Iodides 24-30 solute carrier family 5 member 5 Homo sapiens 80-83 23404856-1 2013 The Na(+)/I(-) symporter (NIS (SLC5A5)) is a transmembrane glycoprotein that mediates active iodide uptake into thyroid follicular cells. Iodides 93-99 solute carrier family 5 member 5 Homo sapiens 4-24 23404856-1 2013 The Na(+)/I(-) symporter (NIS (SLC5A5)) is a transmembrane glycoprotein that mediates active iodide uptake into thyroid follicular cells. Iodides 93-99 solute carrier family 5 member 5 Homo sapiens 31-37 23420532-11 2013 The experiments demonstrated that effective (131)I therapy was achieved in the malignant glioma cell lines following the induction of tumor-specific iodide uptake activity by GFAP promoter-directed hNIS gene expression in vitro and in vivo. Iodides 149-155 solute carrier family 5 member 5 Homo sapiens 198-202 22355179-1 2012 The selective increase of Na(+)/I(-) symporter (NIS)-mediated active iodide uptake in thyroid cells allows the use of radioiodine I(131) for diagnosis and targeted treatment of thyroid cancers. Iodides 69-75 solute carrier family 5 member 5 Homo sapiens 26-46 23117572-4 2013 Expression of Na(+)/I(-) symporter (NIS (SLC5A5)), the glycoprotein responsible for iodide transport, has been demonstrated in normal testicular tissue. Iodides 84-90 solute carrier family 5 member 5 Homo sapiens 14-34 23117572-4 2013 Expression of Na(+)/I(-) symporter (NIS (SLC5A5)), the glycoprotein responsible for iodide transport, has been demonstrated in normal testicular tissue. Iodides 84-90 solute carrier family 5 member 5 Homo sapiens 41-47 23181221-6 2012 The sodium-iodide symporter (NIS) is responsible for the ability of the thyroid gland to transport and concentrate iodide. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 22962269-3 2012 In this study, we investigated the functional role in tumor progression of the sodium/iodide symporter (NIS; aka SLC5A5), which is upregulated and mislocalized in many human carcinomas. Iodides 86-92 solute carrier family 5 member 5 Homo sapiens 113-119 23037808-0 2012 A steep radioiodine dose response scalable to humans in sodium-iodide symporter (NIS)-mediated radiovirotherapy for prostate cancer. Iodides 63-69 solute carrier family 5 member 5 Homo sapiens 81-84 23037808-1 2012 The sodium-iodide symporter (NIS) directs the uptake and concentration of iodide in thyroid cells. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 22750642-1 2012 Expression of the sodium iodide symporter (NIS) is required for efficient iodide uptake in thyroid and lactating breast. Iodides 25-31 solute carrier family 5 member 5 Homo sapiens 43-46 22750642-8 2012 Iodide uptake in mammalian cells is dependent on the level of NIS gene expression, but also successful translocation of NIS to the cell membrane and correct insertion. Iodides 0-6 solute carrier family 5 member 5 Homo sapiens 62-65 22750642-8 2012 Iodide uptake in mammalian cells is dependent on the level of NIS gene expression, but also successful translocation of NIS to the cell membrane and correct insertion. Iodides 0-6 solute carrier family 5 member 5 Homo sapiens 120-123 21801606-11 2011 These results demonstrated that radioiodine therapy was effective in treating malignant glioma cell lines following induction of tumor-specific iodide intake by the hTERT promoter-directed hNIS expression in vitro. Iodides 144-150 solute carrier family 5 member 5 Homo sapiens 189-193 21797672-8 2011 The in vitro clonogenic assay indicated that, after exposure to 100-1000 muCi of (131)I-iodide for 12 hours, 91%-94% of cells cotransfected with the hNIS and hTPO genes, 88%-93% of cells transfected with the hNIS gene, and only 62%-68% of control (nontransfected) cells were killed. Iodides 86-94 solute carrier family 5 member 5 Homo sapiens 149-153 21797672-8 2011 The in vitro clonogenic assay indicated that, after exposure to 100-1000 muCi of (131)I-iodide for 12 hours, 91%-94% of cells cotransfected with the hNIS and hTPO genes, 88%-93% of cells transfected with the hNIS gene, and only 62%-68% of control (nontransfected) cells were killed. Iodides 86-94 solute carrier family 5 member 5 Homo sapiens 208-212 21797672-9 2011 CONCLUSIONS: The experiments demonstrated that an effective therapy of (131)I was achieved in malignant glioma cell lines after induction of tumor-specific iodide uptake activity by the hTERT promoter-directed NIS expression in vitro. Iodides 156-162 solute carrier family 5 member 5 Homo sapiens 210-213 21989294-1 2011 BACKGROUND: Na+/I- symporter (NIS)-mediated iodide uptake allows radioiodine therapy for thyroid cancer. Iodides 44-50 solute carrier family 5 member 5 Homo sapiens 12-28 21989294-1 2011 BACKGROUND: Na+/I- symporter (NIS)-mediated iodide uptake allows radioiodine therapy for thyroid cancer. Iodides 44-50 solute carrier family 5 member 5 Homo sapiens 30-33 21702220-3 2011 The iodide is transported inside the thyroid epithelial cell via sodium iodide symporter (NIS) which is a trans-membrane protein. Iodides 4-10 solute carrier family 5 member 5 Homo sapiens 90-93 21565787-1 2011 CONTEXT: Iodide transport defect (ITD) is an autosomal recessive disorder caused by impaired Na(+)/I(-) symporter (NIS)-mediated active iodide accumulation into thyroid follicular cells. Iodides 136-142 solute carrier family 5 member 5 Homo sapiens 93-113 21565787-1 2011 CONTEXT: Iodide transport defect (ITD) is an autosomal recessive disorder caused by impaired Na(+)/I(-) symporter (NIS)-mediated active iodide accumulation into thyroid follicular cells. Iodides 136-142 solute carrier family 5 member 5 Homo sapiens 115-118 21565787-11 2011 Functional evaluation of the molecular mechanism responsible for impaired NIS-mediated iodide concentration in thyroid cells indicated that the identified mutation reduces NIS translation efficiency with a subsequent decrease in protein expression and function. Iodides 87-93 solute carrier family 5 member 5 Homo sapiens 74-77 21565787-11 2011 Functional evaluation of the molecular mechanism responsible for impaired NIS-mediated iodide concentration in thyroid cells indicated that the identified mutation reduces NIS translation efficiency with a subsequent decrease in protein expression and function. Iodides 87-93 solute carrier family 5 member 5 Homo sapiens 172-175 21499816-0 2011 Expression and localization of the sodium/iodide symporter (NIS) in testicular cells. Iodides 42-48 solute carrier family 5 member 5 Homo sapiens 60-63 21499816-2 2011 Few data are available on the sodium/iodide symporter (NIS) expression in human testis, a particular important prerequisite to predict radioiodine accumulation in the gonads of males with thyroid cancer exposed to such a treatment. Iodides 37-43 solute carrier family 5 member 5 Homo sapiens 55-58 20577737-1 2010 PURPOSE: The human sodium/iodide symporter (hNIS) is a well-established target in thyroid disease and reporter gene imaging using gamma emitters (123)I-iodide, (131)I-iodide and (99m)Tc-pertechnetate. Iodides 150-158 solute carrier family 5 member 5 Homo sapiens 44-48 21209020-1 2011 Na(+)/I(-) symporter (NIS)-mediated iodide uptake into thyroid follicular cells serves as the basis of radioiodine therapy for thyroid cancer. Iodides 36-42 solute carrier family 5 member 5 Homo sapiens 0-20 20479570-2 2011 The human sodium/iodide symporter (hNIS) is an integral plasma membrane glycoprotein mediating the active transport of iodide into thyroid follicular cells, a crucial step for thyroid hormone biosynthesis. Iodides 17-23 solute carrier family 5 member 5 Homo sapiens 35-39 20479570-4 2011 AIM: The aim of this study was to investigate if 10 substances usually used as drugs in clinical practice were able to inhibit NIS-mediated iodide uptake in vitro. Iodides 140-146 solute carrier family 5 member 5 Homo sapiens 127-130 20479570-9 2011 CONCLUSIONS: In conclusion, we carried out an in vitro assay to evaluate the potential inhibitory effect of common drugs on NISmediated iodide uptake by using CHO-hNIS cells. Iodides 136-142 solute carrier family 5 member 5 Homo sapiens 163-167 21085047-1 2011 PURPOSE: Accumulation of iodide and other substrates via the human sodium/iodide symporter (hNIS) is fundamental to imaging and therapy of thyroid disease, hNIS reporter gene imaging and hNIS-mediated gene therapy. Iodides 25-31 solute carrier family 5 member 5 Homo sapiens 92-96 21085047-1 2011 PURPOSE: Accumulation of iodide and other substrates via the human sodium/iodide symporter (hNIS) is fundamental to imaging and therapy of thyroid disease, hNIS reporter gene imaging and hNIS-mediated gene therapy. Iodides 25-31 solute carrier family 5 member 5 Homo sapiens 156-160 21085047-1 2011 PURPOSE: Accumulation of iodide and other substrates via the human sodium/iodide symporter (hNIS) is fundamental to imaging and therapy of thyroid disease, hNIS reporter gene imaging and hNIS-mediated gene therapy. Iodides 25-31 solute carrier family 5 member 5 Homo sapiens 156-160 20428214-1 2010 The sodium iodide symporter (NIS) directs the uptake and concentration of iodide in thyroid cells. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 22220168-4 2011 We have previously generated a stable human NIS-expressing ATC cell line, ARO, and the ability of iodide accumulation was restored. Iodides 98-104 solute carrier family 5 member 5 Homo sapiens 44-47 20577737-1 2010 PURPOSE: The human sodium/iodide symporter (hNIS) is a well-established target in thyroid disease and reporter gene imaging using gamma emitters (123)I-iodide, (131)I-iodide and (99m)Tc-pertechnetate. Iodides 165-173 solute carrier family 5 member 5 Homo sapiens 44-48 20123735-1 2010 Activity of the sodium/iodide symporter (NIS) in lactating breast is essential for iodide (I(-)) accumulation in milk. Iodides 23-29 solute carrier family 5 member 5 Homo sapiens 41-44 20681442-3 2010 The aim of this study is to transfer the human sodium/iodide symporter (hNIS) and the human thyroperoxidase (hTPO) genes into H460 lung cancer cell line, and to study the uptake ability of iodide after co-transfected hTPO and hNIS gene in cell lines. Iodides 54-60 solute carrier family 5 member 5 Homo sapiens 72-76 20681442-3 2010 The aim of this study is to transfer the human sodium/iodide symporter (hNIS) and the human thyroperoxidase (hTPO) genes into H460 lung cancer cell line, and to study the uptake ability of iodide after co-transfected hTPO and hNIS gene in cell lines. Iodides 189-195 solute carrier family 5 member 5 Homo sapiens 72-76 20681442-3 2010 The aim of this study is to transfer the human sodium/iodide symporter (hNIS) and the human thyroperoxidase (hTPO) genes into H460 lung cancer cell line, and to study the uptake ability of iodide after co-transfected hTPO and hNIS gene in cell lines. Iodides 189-195 solute carrier family 5 member 5 Homo sapiens 226-230 19618116-2 2010 The sodium iodide symporter, NIS, actively transports iodide across the plasma membrane and is exploited clinically to deliver radioactive iodide into cells. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 24899932-2 2010 Iodide uptake occurs across the membrane of the thyroid follicular cells and cancer cells through an active transporter process mediated by the sodium iodide symporter (NIS). Iodides 0-6 solute carrier family 5 member 5 Homo sapiens 169-172 20228127-0 2010 Human sodium-iodide symporter (hNIS) gene expression is inhibited by a trans-active transcriptional repressor, NIS-repressor, containing PARP-1 in thyroid cancer cells. Iodides 13-19 solute carrier family 5 member 5 Homo sapiens 31-35 20228127-0 2010 Human sodium-iodide symporter (hNIS) gene expression is inhibited by a trans-active transcriptional repressor, NIS-repressor, containing PARP-1 in thyroid cancer cells. Iodides 13-19 solute carrier family 5 member 5 Homo sapiens 32-35 19780099-1 2009 The Na(+)/I(-) symporter (NIS) mediates iodide uptake in the thyroid gland as well as in other NIS-expressing cells. Iodides 40-46 solute carrier family 5 member 5 Homo sapiens 4-24 20053774-1 2010 We examined whether human sodium/iodide symporter (hNIS) radioiodine gene therapy can modulate the phenotype of cancer cells and enhance the killing activities of CTLs in a mouse tumor model. Iodides 33-39 solute carrier family 5 member 5 Homo sapiens 51-55 19780099-1 2009 The Na(+)/I(-) symporter (NIS) mediates iodide uptake in the thyroid gland as well as in other NIS-expressing cells. Iodides 40-46 solute carrier family 5 member 5 Homo sapiens 26-29 19241193-1 2009 The sodium iodide symporter (NIS) present in the membranes of thyroid cells is responsible for the capacity of the thyroid to concentrate iodide. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 19196800-0 2009 Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid. Iodides 23-29 solute carrier family 5 member 5 Homo sapiens 40-43 19525464-3 2009 Furthermore, recent in vitro studies indicate that (131)I irradiation reduces iodide uptake by downregulating the expression of the sodium iodide symporter (NIS). Iodides 78-84 solute carrier family 5 member 5 Homo sapiens 157-160 18500672-1 2009 The Na(+)/I(-) symporter (NIS) is a transmembrane glycoprotein that mediates iodide uptake into thyroid follicular cells and serves as the molecular basis of radioiodine imaging and therapy for thyroid cancer patients. Iodides 77-83 solute carrier family 5 member 5 Homo sapiens 4-24 18500672-1 2009 The Na(+)/I(-) symporter (NIS) is a transmembrane glycoprotein that mediates iodide uptake into thyroid follicular cells and serves as the molecular basis of radioiodine imaging and therapy for thyroid cancer patients. Iodides 77-83 solute carrier family 5 member 5 Homo sapiens 26-29 19196800-3 2009 Uptake of iodide into the thyrocytes is mediated by an intrinsic membrane glycoprotein, the sodium-iodide symporter (NIS), which actively cotransports two sodium cations per each iodide anion. Iodides 10-16 solute carrier family 5 member 5 Homo sapiens 117-120 19196800-3 2009 Uptake of iodide into the thyrocytes is mediated by an intrinsic membrane glycoprotein, the sodium-iodide symporter (NIS), which actively cotransports two sodium cations per each iodide anion. Iodides 179-191 solute carrier family 5 member 5 Homo sapiens 117-120 19196800-4 2009 NIS-mediated transport of iodide is driven by the electrochemical sodium gradient generated by the Na(+)/K(+)-ATPase. Iodides 26-32 solute carrier family 5 member 5 Homo sapiens 0-3 19196800-6 2009 TSH and iodide regulate iodide accumulation by modulating NIS activity via transcriptional and posttranscriptional mechanisms. Iodides 8-14 solute carrier family 5 member 5 Homo sapiens 58-61 19196800-6 2009 TSH and iodide regulate iodide accumulation by modulating NIS activity via transcriptional and posttranscriptional mechanisms. Iodides 24-30 solute carrier family 5 member 5 Homo sapiens 58-61 19196800-7 2009 Biallelic mutations in the NIS gene lead to a congenital iodide transport defect, an autosomal recessive condition characterized by hypothyroidism, goiter, low thyroid iodide uptake, and a low saliva/plasma iodide ratio. Iodides 57-63 solute carrier family 5 member 5 Homo sapiens 27-30 19029227-1 2009 OBJECTIVE: The active transport of iodide into thyroid cells is mediated by the Na(+)/I(-) symporter (NIS) located in the basolateral membrane. Iodides 35-41 solute carrier family 5 member 5 Homo sapiens 80-100 19029227-1 2009 OBJECTIVE: The active transport of iodide into thyroid cells is mediated by the Na(+)/I(-) symporter (NIS) located in the basolateral membrane. Iodides 35-41 solute carrier family 5 member 5 Homo sapiens 102-105 19098211-12 2009 RESULTS: Infection of human pancreatic cancer cell lines with MV-NIS in vitro resulted in syncytia formation, marked iodide uptake, and ultimately cell death. Iodides 117-123 solute carrier family 5 member 5 Homo sapiens 65-68 18708479-8 2008 These findings suggested that the decreased levels of iodide uptake activity of SLC5A5 mutants resulted from lower catalytic rates. Iodides 54-60 solute carrier family 5 member 5 Homo sapiens 80-86 19331152-9 2009 CONCLUSION: Transduction of the hNIS gene controlled by the novel EIIAPA chimeric promoter successfully induces iodide transport in hepatoma. Iodides 112-118 solute carrier family 5 member 5 Homo sapiens 32-36 18708479-1 2008 The sodium/iodide symporter (SLC5A5; also known as NIS), a transmembrane glycoprotein principally in the thyroid gland, is responsible for the accumulation of iodide necessary for thyroid hormones. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-35 18708479-1 2008 The sodium/iodide symporter (SLC5A5; also known as NIS), a transmembrane glycoprotein principally in the thyroid gland, is responsible for the accumulation of iodide necessary for thyroid hormones. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 51-54 18708479-1 2008 The sodium/iodide symporter (SLC5A5; also known as NIS), a transmembrane glycoprotein principally in the thyroid gland, is responsible for the accumulation of iodide necessary for thyroid hormones. Iodides 159-165 solute carrier family 5 member 5 Homo sapiens 29-35 18708479-1 2008 The sodium/iodide symporter (SLC5A5; also known as NIS), a transmembrane glycoprotein principally in the thyroid gland, is responsible for the accumulation of iodide necessary for thyroid hormones. Iodides 159-165 solute carrier family 5 member 5 Homo sapiens 51-54 18708479-2 2008 Our previous study indicated that a novel exon 6 deletion (residues 233-280) in SLC5A5 loses the iodide uptake activity. Iodides 97-103 solute carrier family 5 member 5 Homo sapiens 80-86 18708479-3 2008 Herein we characterized the role of His-226 in iodide transport of SLC5A5. Iodides 47-53 solute carrier family 5 member 5 Homo sapiens 67-73 18708479-9 2008 In conclusion, our data first identified the involvement of extracellular charged amino acid residue in the iodide uptake ability of SLC5A5. Iodides 108-114 solute carrier family 5 member 5 Homo sapiens 133-139 18470848-0 2008 Enhanced iodide sequestration by 3-biphenyl-5,6-dihydroimidazo[2,1-b]thiazole in sodium/iodide symporter (NIS)-expressing cells. Iodides 9-15 solute carrier family 5 member 5 Homo sapiens 106-109 18470848-0 2008 Enhanced iodide sequestration by 3-biphenyl-5,6-dihydroimidazo[2,1-b]thiazole in sodium/iodide symporter (NIS)-expressing cells. Iodides 88-94 solute carrier family 5 member 5 Homo sapiens 106-109 18470848-1 2008 The ability of the sodium/iodide symporter (NIS) to take up iodide has long provided the basis for cytoreductive gene therapy and cancer treatment with radioiodide. Iodides 26-32 solute carrier family 5 member 5 Homo sapiens 44-47 18470848-3 2008 We identified and characterized a small organic molecule capable of increasing iodide retention in HEK293 cells permanently transfected with human NIS cDNA (hNIS-HEK293) and in the rat thyroid-derived cell line FRTL-5. Iodides 79-85 solute carrier family 5 member 5 Homo sapiens 147-150 18470848-6 2008 This new compound is not only an attractive chemical tool to investigate the mechanisms of iodide flux at the cellular level, but also opens promising perspectives in the treatment of cancer after NIS gene transfer. Iodides 91-97 solute carrier family 5 member 5 Homo sapiens 197-200 18404268-1 2008 PURPOSE: We reported recently the induction of selective iodide uptake in prostate cancer cells (LNCaP) by prostate-specific antigen (PSA) promoter-directed sodium iodide symporter (NIS) expression that allowed a significant therapeutic effect of (131)I. Iodides 57-63 solute carrier family 5 member 5 Homo sapiens 182-185 18202121-1 2008 The lack of Na(+)/I(-) symporter (NIS) gene expression in some thyroid cancer patients has been a major hurdle that limits the efficacy of standard radioactive iodide therapy. Iodides 160-166 solute carrier family 5 member 5 Homo sapiens 34-37 18202121-1 2008 The lack of Na(+)/I(-) symporter (NIS) gene expression in some thyroid cancer patients has been a major hurdle that limits the efficacy of standard radioactive iodide therapy. Iodides 160-166 solute carrier family 5 member 5 Homo sapiens 12-32 18307189-1 2008 The Na(+)/I(-) symporter (NIS) mediates iodide uptake into thyroid follicular cells. Iodides 40-46 solute carrier family 5 member 5 Homo sapiens 4-24 18283639-1 2008 The expression of the Na/I Symporter (NIS) in the basolateral cell membrane of the thyroid follicular cells is responsible for the active accumulation of iodide within the thyroid gland and for the subsequent biosynthesis of thyroid hormones. Iodides 154-160 solute carrier family 5 member 5 Homo sapiens 22-36 18283639-1 2008 The expression of the Na/I Symporter (NIS) in the basolateral cell membrane of the thyroid follicular cells is responsible for the active accumulation of iodide within the thyroid gland and for the subsequent biosynthesis of thyroid hormones. Iodides 154-160 solute carrier family 5 member 5 Homo sapiens 38-41 18307189-1 2008 The Na(+)/I(-) symporter (NIS) mediates iodide uptake into thyroid follicular cells. Iodides 40-46 solute carrier family 5 member 5 Homo sapiens 26-29 18372236-1 2008 The active transport of iodide from the bloodstream into thyroid follicular cells is mediated by the Na+/I- symporter (NIS). Iodides 24-30 solute carrier family 5 member 5 Homo sapiens 101-117 17913707-1 2007 The Na+/I- symporter (NIS)-mediated iodide uptake activity is the basis for targeted radioiodide ablation of thyroid cancers. Iodides 36-42 solute carrier family 5 member 5 Homo sapiens 4-20 17913707-4 2007 Kinetic analysis of NIS mutants of the corresponding phosphorylated amino acid residue indicated that the velocity of iodide transport of NIS is modulated by the phosphorylation status of Ser-43 and Ser-581. Iodides 118-124 solute carrier family 5 member 5 Homo sapiens 20-23 17913707-4 2007 Kinetic analysis of NIS mutants of the corresponding phosphorylated amino acid residue indicated that the velocity of iodide transport of NIS is modulated by the phosphorylation status of Ser-43 and Ser-581. Iodides 118-124 solute carrier family 5 member 5 Homo sapiens 138-141 17913707-1 2007 The Na+/I- symporter (NIS)-mediated iodide uptake activity is the basis for targeted radioiodide ablation of thyroid cancers. Iodides 36-42 solute carrier family 5 member 5 Homo sapiens 22-25 17695547-2 2007 This study aims to restore the iodide uptake by transferring and expressing human sodium iodide symporter (hNIS) in these cancer cells for 131I gene therapy. Iodides 31-37 solute carrier family 5 member 5 Homo sapiens 107-111 17698909-1 2007 CONTEXT: We reported recently the induction of iodide accumulation in prostate cancer cells (LNCaP) by prostate-specific antigen promoter-directed sodium iodide symporter (NIS) expression that allowed a significant therapeutic effect of (131)iodine ((131)I). Iodides 47-53 solute carrier family 5 member 5 Homo sapiens 172-175 17698909-2 2007 These data demonstrated the potential of the NIS gene as a novel therapeutic gene, although in some extrathyroidal tumors, therapeutic efficacy may be limited by rapid iodide efflux due to a lack of iodide organification. Iodides 168-174 solute carrier family 5 member 5 Homo sapiens 45-48 17698909-2 2007 These data demonstrated the potential of the NIS gene as a novel therapeutic gene, although in some extrathyroidal tumors, therapeutic efficacy may be limited by rapid iodide efflux due to a lack of iodide organification. Iodides 199-205 solute carrier family 5 member 5 Homo sapiens 45-48 18167272-1 2007 OBJECTIVE: To clone human mucin 1 (MUC1) gene promoter and apply to drive human sodium/iodide symporter (hNIS) gene targeting expression in pancreatic carcinoma cells. Iodides 87-93 solute carrier family 5 member 5 Homo sapiens 105-109 17931047-7 2007 We conclude that a therapeutic effect of (131)I was demonstrated in vivo in MTC cell xenografts after adenovirus-mediated induction of tumor-specific iodide accumulation by CEA promoter-directed hNIS expression. Iodides 150-156 solute carrier family 5 member 5 Homo sapiens 195-199 17891230-3 2007 However, the studies related to the mechanisms of iodide transport were only possible after the cloning of the gene that encodes the sodium/iodide symporter (NIS). Iodides 50-56 solute carrier family 5 member 5 Homo sapiens 158-161 17912014-7 2007 RESULTS: A 23- and 15.5-fold increase in iodide uptake was observed in Ad/MUC1/NIS-infected MUC1-positive Capan-2 and SW1990 cells with no significant increase observed in MUC1-negative Hela cells or in cells infected with the control virus. Iodides 41-47 solute carrier family 5 member 5 Homo sapiens 79-82 17639055-1 2007 The Na(+)/I(-) symporter (NIS)-mediated iodide uptake is the basis for targeted radioiodine ablation of thyroid cancers. Iodides 40-46 solute carrier family 5 member 5 Homo sapiens 4-24 17639055-1 2007 The Na(+)/I(-) symporter (NIS)-mediated iodide uptake is the basis for targeted radioiodine ablation of thyroid cancers. Iodides 40-46 solute carrier family 5 member 5 Homo sapiens 26-29 17266027-1 2007 Human sodium iodide symporter (hNIS) is a transmembrane protein that actively transports iodide ions into thyroid cells. Iodides 13-19 solute carrier family 5 member 5 Homo sapiens 31-35 17214887-1 2007 BACKGROUND: The sodium/iodide symporter (NIS) is a plasma membrane glycoprotein that mediates iodide (I-) transport in the thyroid, lactating breast, salivary glands, and stomach. Iodides 23-29 solute carrier family 5 member 5 Homo sapiens 41-44 17611400-4 2007 In vitro iodide uptake and efflux were measured in CT26-hNIS cells at various time points. Iodides 9-15 solute carrier family 5 member 5 Homo sapiens 56-60 17611400-8 2007 The iodide uptakes of CT26-hNIS tumors were 10-fold greater than those of CT26 tumors. Iodides 4-10 solute carrier family 5 member 5 Homo sapiens 27-31 17696829-1 2007 OBJECTIVE: Nonfunctioning thyroid nodules (NFTNs) display a diminished iodide-concentrating ability, owing to defective expression and cell membrane targeting of the sodium-iodide symporter (NIS). Iodides 71-77 solute carrier family 5 member 5 Homo sapiens 191-194 17158760-1 2006 This study analyzes the uptake and antiproliferative effect of two different chemical forms of iodine, iodide (I-) and molecular iodine (I2), in MCF-7 cells, which are inducible for the Na+/I- symporter (NIS) and positive for pendrin (PDS). Iodides 103-109 solute carrier family 5 member 5 Homo sapiens 186-202 16984250-3 2006 The Na(+)/I(-) symporter (NIS) localized in placental cells appears to be involved in iodide exchange. Iodides 86-92 solute carrier family 5 member 5 Homo sapiens 4-24 16984250-3 2006 The Na(+)/I(-) symporter (NIS) localized in placental cells appears to be involved in iodide exchange. Iodides 86-92 solute carrier family 5 member 5 Homo sapiens 26-29 16644756-4 2006 Functional hNIS expression in hepatoma cells was confirmed by an iodide uptake assay. Iodides 65-71 solute carrier family 5 member 5 Homo sapiens 11-15 17045167-1 2006 The plasma membrane glycoprotein sodium/iodide symporter (NIS) is crucial for thyroid hormone biosynthesis and mediates the iodide uptake of thyrocytes. Iodides 40-46 solute carrier family 5 member 5 Homo sapiens 58-61 16954431-1 2006 The sodium/iodide symporter (NIS) mediates iodide uptake in the thyroid gland and lactating breast. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 16954431-1 2006 The sodium/iodide symporter (NIS) mediates iodide uptake in the thyroid gland and lactating breast. Iodides 43-49 solute carrier family 5 member 5 Homo sapiens 29-32 16644756-14 2006 CONCLUSION: A therapeutic effect of (131)I on hepatoma cells in vitro and in vivo has been demonstrated after tumor-specific iodide uptake induced by mAlb-directed hNIS gene expression. Iodides 125-131 solute carrier family 5 member 5 Homo sapiens 164-168 16631088-5 2006 hNIS function was determined by iodide uptake assay and MnSOD, and p53 protein levels were assessed by Western blots. Iodides 32-38 solute carrier family 5 member 5 Homo sapiens 0-4 16253762-1 2005 The sodium/iodide symporter (NIS) actively transports iodide into thyrocytes. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 16253762-7 2005 By transient transfection and I-125 uptake assay, we found that the wild type NIS-expressing HepG2 cells accumulated six times more iodide than mutant and mock HepG2 cells. Iodides 132-138 solute carrier family 5 member 5 Homo sapiens 78-81 16105966-0 2005 Cell surface targeting accounts for the difference in iodide uptake activity between human Na+/I- symporter and rat Na+/I- symporter. Iodides 54-60 solute carrier family 5 member 5 Homo sapiens 91-107 16257484-3 2005 Since earlier morphological studies showed that some phthalates induced thyroid hyperactivity, we thought it important to investigate possible effects of six major phthalates on the transcriptional activity of sodium/iodide symporter (NIS). Iodides 217-223 solute carrier family 5 member 5 Homo sapiens 235-238 15781380-1 2005 The existence of the natriuric/iodide symporter (NIS) represents a new view to understand the thyroid metabolism of iodide. Iodides 31-37 solute carrier family 5 member 5 Homo sapiens 49-52 16029487-1 2005 BACKGROUND: Recovery of iodide uptake in thyroid cancer cells by means of obtaining the functional expression of the sodium/iodide symporter (NIS) represents an innovative strategy for the treatment of poorly differentiated thyroid cancer. Iodides 24-30 solute carrier family 5 member 5 Homo sapiens 142-145 16029487-1 2005 BACKGROUND: Recovery of iodide uptake in thyroid cancer cells by means of obtaining the functional expression of the sodium/iodide symporter (NIS) represents an innovative strategy for the treatment of poorly differentiated thyroid cancer. Iodides 124-130 solute carrier family 5 member 5 Homo sapiens 142-145 15941870-4 2005 Functional hNIS expression was confirmed by iodide accumulation assays, Northern and Western blot analysis, immunostaining, and in vitro clonogenic assay. Iodides 44-50 solute carrier family 5 member 5 Homo sapiens 11-15 15941870-5 2005 RESULTS: hNIS-transfected TT cells showed perchlorate-sensitive iodide uptake, accumulating 125-I about 12-fold in vitro with organification of 4% of accumulated iodide resulting in a significant decrease in iodide efflux. Iodides 64-70 solute carrier family 5 member 5 Homo sapiens 9-13 15941870-5 2005 RESULTS: hNIS-transfected TT cells showed perchlorate-sensitive iodide uptake, accumulating 125-I about 12-fold in vitro with organification of 4% of accumulated iodide resulting in a significant decrease in iodide efflux. Iodides 162-168 solute carrier family 5 member 5 Homo sapiens 9-13 15941870-9 2005 CONCLUSIONS: A therapeutic effect of 131-I has been demonstrated in MTC cells after induction of tissue-specific iodide uptake activity by calcitonin promoter-directed hNIS expression. Iodides 113-119 solute carrier family 5 member 5 Homo sapiens 168-172 15781380-3 2005 Clinical perspectives of NIS activity modulation would ameliorate the diagnosis and the treatment of thyroid diseases by using radioisotopes transported by the NIS (131 iodide, 99m technetium, 188 rhenium). Iodides 169-175 solute carrier family 5 member 5 Homo sapiens 25-28 15781380-3 2005 Clinical perspectives of NIS activity modulation would ameliorate the diagnosis and the treatment of thyroid diseases by using radioisotopes transported by the NIS (131 iodide, 99m technetium, 188 rhenium). Iodides 169-175 solute carrier family 5 member 5 Homo sapiens 160-163 15648551-2 2004 Na+/I- symporter (NIS) is highly expressed in BC cells, and previous studies demonstrated that iodine content in BC is lower than in remote normal breast tissue, suggesting a disorder of iodide uptake in BC. Iodides 187-193 solute carrier family 5 member 5 Homo sapiens 0-16 15746050-1 2005 PURPOSE: Expression of the sodium iodide symporter (NIS) in the thyroid gland provides for effective imaging and treatment of thyroid cancer using radiolabeled iodide. Iodides 34-40 solute carrier family 5 member 5 Homo sapiens 52-55 15695791-5 2005 The iodide uptake of F3-NIS III cells was initially higher by up to 12.9-fold than that of nontransfected HB1.F3 cells. Iodides 4-10 solute carrier family 5 member 5 Homo sapiens 24-27 15695791-8 2005 RESULTS: As hNIS transgene was gradually silenced in F3-NIS III cells, after the eighth passage its iodide uptake was 1.9-fold higher than that of nontransfected HB1.F3 cells. Iodides 100-106 solute carrier family 5 member 5 Homo sapiens 12-16 15695791-8 2005 RESULTS: As hNIS transgene was gradually silenced in F3-NIS III cells, after the eighth passage its iodide uptake was 1.9-fold higher than that of nontransfected HB1.F3 cells. Iodides 100-106 solute carrier family 5 member 5 Homo sapiens 13-16 15695791-9 2005 5-azacytidine treatment (up to 40 micromol/L) for 24 h in F3-NIS III cells increased iodide uptake and hNIS messenger RNA (mRNA) 1.8- and 1.9-fold versus nontreated F3-NIS cells, respectively. Iodides 85-91 solute carrier family 5 member 5 Homo sapiens 61-64 15695791-10 2005 Moreover, after TSA treatment (up to 62.5 nmol/L) for 24 h, iodide uptake and hNIS mRNA in F3-NIS III cells increased 36- and 1.9-fold versus nontreated F3-NIS III cells, respectively. Iodides 60-66 solute carrier family 5 member 5 Homo sapiens 94-97 15221289-1 2004 PURPOSE: We evaluated the feasibility of non-invasive imaging of recombinant adenovirus-mediated human sodium-iodide symporter (hNIS) gene expression by (99m)TcO(4)(-) scintigraphy in skeletal muscle of rats. Iodides 110-116 solute carrier family 5 member 5 Homo sapiens 128-132 15001644-1 2004 Iodide transport by thyrocytes involves two transporters, namely the Na(+)/I (-) symporter located at the basolateral pole and possibly pendrin in the apical membranes of the cell. Iodides 0-6 solute carrier family 5 member 5 Homo sapiens 69-90 15136633-2 2004 This study evaluates the iodide kinetics and dosimetry of iodide in hNIS-expressing thyroid carcinoma cells under optimized conditions. Iodides 25-31 solute carrier family 5 member 5 Homo sapiens 68-72 15136633-2 2004 This study evaluates the iodide kinetics and dosimetry of iodide in hNIS-expressing thyroid carcinoma cells under optimized conditions. Iodides 58-64 solute carrier family 5 member 5 Homo sapiens 68-72 15136633-6 2004 RESULTS: hNIS-expressing cell lines accumulated up to 49 times more iodide than did noninfected cells, with a maximal iodide uptake after 30 min of incubation. Iodides 68-74 solute carrier family 5 member 5 Homo sapiens 9-13 15136633-6 2004 RESULTS: hNIS-expressing cell lines accumulated up to 49 times more iodide than did noninfected cells, with a maximal iodide uptake after 30 min of incubation. Iodides 118-124 solute carrier family 5 member 5 Homo sapiens 9-13 15215159-1 2004 The uptake of iodide by epithelial thyroid cells requires the expression of a specific transporter, the Na(+)/I(-) symporter, NIS. Iodides 14-20 solute carrier family 5 member 5 Homo sapiens 104-124 15215159-1 2004 The uptake of iodide by epithelial thyroid cells requires the expression of a specific transporter, the Na(+)/I(-) symporter, NIS. Iodides 14-20 solute carrier family 5 member 5 Homo sapiens 126-129 15240514-0 2004 The Na+/I- symporter mediates iodide uptake in breast cancer metastases and can be selectively down-regulated in the thyroid. Iodides 30-36 solute carrier family 5 member 5 Homo sapiens 4-20 15240514-1 2004 PURPOSE: The Na(+)/I(-) symporter (NIS) is a key plasma membrane protein that mediates active iodide (I(-)) transport in the thyroid, lactating breast, and other tissues. Iodides 94-100 solute carrier family 5 member 5 Homo sapiens 13-33 15136633-8 2004 In mice, the hNIS-expressing tumors accumulated up to 23 and 19.5 times more iodide than did the wild-type tumors in lithium-treated and control animals, respectively. Iodides 77-83 solute carrier family 5 member 5 Homo sapiens 13-17 15136633-11 2004 CONCLUSION: Transduction of the hNIS gene in rat thyroid carcinoma cells induces iodide transport, which is associated with rapid efflux. Iodides 81-87 solute carrier family 5 member 5 Homo sapiens 32-36 14734652-0 2004 The Q267E mutation in the sodium/iodide symporter (NIS) causes congenital iodide transport defect (ITD) by decreasing the NIS turnover number. Iodides 33-39 solute carrier family 5 member 5 Homo sapiens 51-54 14734652-0 2004 The Q267E mutation in the sodium/iodide symporter (NIS) causes congenital iodide transport defect (ITD) by decreasing the NIS turnover number. Iodides 33-39 solute carrier family 5 member 5 Homo sapiens 122-125 14734652-1 2004 The Na(+)/I(-) symporter (NIS) is a key plasma membrane glycoprotein that mediates active iodide (I(-)) transport in the thyroid and other tissues. Iodides 90-96 solute carrier family 5 member 5 Homo sapiens 4-24 14734652-1 2004 The Na(+)/I(-) symporter (NIS) is a key plasma membrane glycoprotein that mediates active iodide (I(-)) transport in the thyroid and other tissues. Iodides 90-96 solute carrier family 5 member 5 Homo sapiens 26-29 14633711-4 2003 The ability of Ad-ARR(2)PB/hNIS to cause NIS expression in tumor cells was characterized by iodide uptake assay and compared with Ad-CMV/hNIS in which the h-NIS expression is driven by the cytomegalovirus (CMV) promoter. Iodides 92-98 solute carrier family 5 member 5 Homo sapiens 28-31 15068624-2 2004 The sodium iodide symporter (NIS) is the first step in thyroid hormone synthesis and mediates the active iodide transport in the thyroid cells suggesting that decreased iodide uptake could be a result of changes in NIS expression or molecular defects in the NIS gene. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 15068624-2 2004 The sodium iodide symporter (NIS) is the first step in thyroid hormone synthesis and mediates the active iodide transport in the thyroid cells suggesting that decreased iodide uptake could be a result of changes in NIS expression or molecular defects in the NIS gene. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 215-218 15068624-2 2004 The sodium iodide symporter (NIS) is the first step in thyroid hormone synthesis and mediates the active iodide transport in the thyroid cells suggesting that decreased iodide uptake could be a result of changes in NIS expression or molecular defects in the NIS gene. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 215-218 15068624-2 2004 The sodium iodide symporter (NIS) is the first step in thyroid hormone synthesis and mediates the active iodide transport in the thyroid cells suggesting that decreased iodide uptake could be a result of changes in NIS expression or molecular defects in the NIS gene. Iodides 105-111 solute carrier family 5 member 5 Homo sapiens 29-32 14712300-1 2004 The sodium iodide symporter (NIS) mediates iodide uptake into thyrocytes and is the molecular basis of thyroid radioiodine therapy. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 14870777-1 2003 The sodium iodide symporter (NIS) is a plasma basolateral membrane protein that actively transports iodide to the thyroid follicular cells as the first step of thyroid hormone biosynthesis. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 14870777-2 2003 NIS also mediates active iodide transport in other human tissues including the salivary glands, lactating mammary gland and gastric mucosa. Iodides 25-31 solute carrier family 5 member 5 Homo sapiens 0-3 12381453-1 2002 The cellular expression of the sodium iodide symporter (NIS) has been shown to confer iodide-concentrating capacity in non-thyroid cell types. Iodides 38-44 solute carrier family 5 member 5 Homo sapiens 56-59 12649158-8 2003 Tumor xenografts in severe combined immunodeficiency mice expressing hNIS could be imaged using iodine-123 (123I) and shown to retain iodide for up to 48 hours. Iodides 134-140 solute carrier family 5 member 5 Homo sapiens 69-73 12914397-2 2003 The sodium iodide symporter NIS) is an intrinsic plasma membrane protein that mediates the active transport of iodide in the thyroid gland and a number of extrathyrioidal tissues, in particular lactating mammary gland. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 28-31 12914397-3 2003 Because of its crucial role in the ability of thyroid follicular cells to trap iodide of NIS opened an exciting and extensivenew field of thyroid-related research. Iodides 79-85 solute carrier family 5 member 5 Homo sapiens 89-92 12914397-5 2003 In addition, NIS-mediated iodide accumulation allows diagnostic thyroid scintigraphy as well as effective therapeutic application of radio-iodide in benign and malignant thyroid disease. Iodides 26-32 solute carrier family 5 member 5 Homo sapiens 13-16 12690461-8 2003 We conclude that these animals have established a specialised adaptive mechanism, most probably at the level of the Na(+)/I(-) symporter, that acts to enhance the uptake of dietary iodide into the gut and again from the serum into the follicular cells of the thyroid gland. Iodides 181-187 solute carrier family 5 member 5 Homo sapiens 116-136 12705478-1 2003 The function of the sodium iodide symporter (Na(+)/I(-), (NIS), a membrane protein that mediates iodide transport into cells, is the best described in the thyroid cells. Iodides 27-33 solute carrier family 5 member 5 Homo sapiens 58-61 12390328-1 2002 The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of iodide in the thyroid gland and a number of extrathyroidal tissues, in particular lactating mammary gland. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 12390328-2 2002 Because of its crucial role in the ability of thyroid follicular cells to trap iodide, cloning of NIS opened an exciting and extensive new field of thyroid-related research. Iodides 79-85 solute carrier family 5 member 5 Homo sapiens 98-101 12390328-4 2002 In addition to its key function in thyroid physiology, NIS-mediated iodide accumulation allows diagnostic thyroid scintigraphy as well as effective therapeutic application of radioiodine in benign and malignant thyroid disease. Iodides 68-74 solute carrier family 5 member 5 Homo sapiens 55-58 12792733-5 2003 These hNIS-transduced cells actively transported iodide into the cytoplasm at the level of 11635.3, 61571.6, and 19367.5 pmoles/10(6) cells in ARO, FRO, and NPA, respectively. Iodides 49-55 solute carrier family 5 member 5 Homo sapiens 6-10 12792733-8 2003 The present study indicates that functional hNIS can be efficiently expressed and is responsible for active transport of iodide in hNIS-negative human thyroid cancer cells by a recombinant adenovirus. Iodides 121-127 solute carrier family 5 member 5 Homo sapiens 44-48 12792733-8 2003 The present study indicates that functional hNIS can be efficiently expressed and is responsible for active transport of iodide in hNIS-negative human thyroid cancer cells by a recombinant adenovirus. Iodides 121-127 solute carrier family 5 member 5 Homo sapiens 131-135 12792733-10 2003 Therefore, these kinetic characteristics of iodide uptake and efflux may limit the therapeutic potential of hNIS/radioiodide-based treatment following exogenous hNIS expression in human thyroid cancer. Iodides 44-50 solute carrier family 5 member 5 Homo sapiens 108-112 12792733-10 2003 Therefore, these kinetic characteristics of iodide uptake and efflux may limit the therapeutic potential of hNIS/radioiodide-based treatment following exogenous hNIS expression in human thyroid cancer. Iodides 44-50 solute carrier family 5 member 5 Homo sapiens 161-165 12704416-3 2003 hNIS-expressing cell lines accumulated up to 200 times more iodide when compared to wild-type cells. Iodides 60-66 solute carrier family 5 member 5 Homo sapiens 0-4 12704416-5 2003 In rats, the hNIS-expressing tumors accumulated up to 20 times more iodide when compared to contralateral transplanted wild-type tumors. Iodides 68-74 solute carrier family 5 member 5 Homo sapiens 13-17 12704416-8 2003 Although transduction of the hNIS gene induces iodide transport in rat prostate adenocarcinoma a rapid efflux occurs, which leads to a low absorbed dose in genetically modified tumors. Iodides 47-53 solute carrier family 5 member 5 Homo sapiens 29-33 12586784-1 2003 The sodium/iodide symporter (NIS) is a membrane protein mediating the active transport of iodide into the thyroid gland. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 12489024-2 2003 The NIS mediates the normal physiological transport of iodide across the thyroid cell membrane. Iodides 55-61 solute carrier family 5 member 5 Homo sapiens 4-7 12475396-1 2002 BACKGROUND: Sodium/iodide symporter (NIS) is a key protein in iodide transport by thyroid cells and this activity is a prerequisite for effective radioiodide treatment of thyroid cancer. Iodides 19-25 solute carrier family 5 member 5 Homo sapiens 37-40 12475396-2 2002 In the majority of thyroid cancers, however, iodide uptake is reduced, probably as a result of decreased NIS protein expression. Iodides 45-51 solute carrier family 5 member 5 Homo sapiens 105-108 12396625-3 2002 The Na/I symporter (NIS) gene is expressed mainly in the thyroid and is responsible for iodide accumulation in this organ. Iodides 88-94 solute carrier family 5 member 5 Homo sapiens 4-18 12396625-3 2002 The Na/I symporter (NIS) gene is expressed mainly in the thyroid and is responsible for iodide accumulation in this organ. Iodides 88-94 solute carrier family 5 member 5 Homo sapiens 20-23 11228531-2 2000 We observed perchlorate-inhibitable iodide uptake up to 41-fold over control in all NIS-transfected cells. Iodides 36-42 solute carrier family 5 member 5 Homo sapiens 84-87 12161518-2 2002 These were the only cases reported to date who received long-term iodide treatment over 10 yr. We examined the sodium/iodide symporter (NIS) gene of these patients. Iodides 66-72 solute carrier family 5 member 5 Homo sapiens 136-139 11889195-2 2002 However, loss of iodide uptake is frequently observed in metastasized thyroid cancer, which may be explained by diminished expression of the human sodium-iodide symporter (hNIS). Iodides 17-23 solute carrier family 5 member 5 Homo sapiens 172-176 11889195-3 2002 We studied whether transfection of hNIS into the hNIS-deficient follicular thyroid carcinoma cell line FTC133 restores the in vivo iodide accumulation in xenografted tumors and their susceptibility to radioiodide therapy. Iodides 131-137 solute carrier family 5 member 5 Homo sapiens 35-39 11889195-12 2002 We conclude that hNIS transfection into a hNIS-defective thyroid carcinoma cell line restores the in vivo iodide accumulation. Iodides 106-112 solute carrier family 5 member 5 Homo sapiens 17-21 11889195-12 2002 We conclude that hNIS transfection into a hNIS-defective thyroid carcinoma cell line restores the in vivo iodide accumulation. Iodides 106-112 solute carrier family 5 member 5 Homo sapiens 42-46 11788674-4 2002 A defect in the expression or structure of the sodium iodide symporter (NIS) gene has been hypothesized as a possible cause of the impaired iodide trapping in nonfunctioning thyroid nodules. Iodides 54-60 solute carrier family 5 member 5 Homo sapiens 72-75 11458618-1 2001 BACKGROUND: Thyroid Na+/I- symporter (NIS) is thought to play an important role in iodide uptake in thyrocytes. Iodides 83-89 solute carrier family 5 member 5 Homo sapiens 20-36 11458618-1 2001 BACKGROUND: Thyroid Na+/I- symporter (NIS) is thought to play an important role in iodide uptake in thyrocytes. Iodides 83-89 solute carrier family 5 member 5 Homo sapiens 38-41 11216532-3 2001 We therefore investigated whether the accumulation of iodide may be induced by the retroviral transfer of the hNIS gene in nonthyroid tumor cells. Iodides 54-60 solute carrier family 5 member 5 Homo sapiens 110-114 11216532-12 2001 In rats, the hNIS-expressing tumors accumulated six times more iodide than did the contralateral wild-type tumor as monitored by scintigraphy. Iodides 63-69 solute carrier family 5 member 5 Homo sapiens 13-17 11720877-0 2001 Sodium/iodide symporter (NIS) and pendrin are expressed differently in hot and cold nodules of thyroid toxic multinodular goiter. Iodides 7-13 solute carrier family 5 member 5 Homo sapiens 25-28 11231356-1 2001 BACKGROUND: The human sodium iodide symporter (hNIS) is a transmembrane protein that mediates the active transport of iodide in the thyroid gland. Iodides 29-35 solute carrier family 5 member 5 Homo sapiens 47-51 11231356-2 2001 Following cloning of NIS, NIS expression has been detected in a broad range of nonthyroidal tissues, suggesting that iodide transport in these tissues is conferred by the expression of functional NIS protein. Iodides 117-123 solute carrier family 5 member 5 Homo sapiens 21-24 11231356-2 2001 Following cloning of NIS, NIS expression has been detected in a broad range of nonthyroidal tissues, suggesting that iodide transport in these tissues is conferred by the expression of functional NIS protein. Iodides 117-123 solute carrier family 5 member 5 Homo sapiens 26-29 11231356-2 2001 Following cloning of NIS, NIS expression has been detected in a broad range of nonthyroidal tissues, suggesting that iodide transport in these tissues is conferred by the expression of functional NIS protein. Iodides 117-123 solute carrier family 5 member 5 Homo sapiens 26-29 11231356-3 2001 METHODS: The aim of this study was to examine functional hNIS expression in kidney by reverse transcription-polymerase chain reaction (RT-PCR), ribonuclease protection assay (RPA), immunohistochemistry, and Western blot analysis accompanied by iodide accumulation studies in kidney cells. Iodides 244-250 solute carrier family 5 member 5 Homo sapiens 57-61 11231356-10 2001 CONCLUSIONS: Functional hNIS expression was demonstrated in the renal tubular system, suggesting that renal iodide transport may be, at least in part, an active process driven by NIS. Iodides 108-114 solute carrier family 5 member 5 Homo sapiens 24-28 11231356-10 2001 CONCLUSIONS: Functional hNIS expression was demonstrated in the renal tubular system, suggesting that renal iodide transport may be, at least in part, an active process driven by NIS. Iodides 108-114 solute carrier family 5 member 5 Homo sapiens 25-28 11216532-0 2001 Transfer of the human NaI symporter gene enhances iodide uptake in hepatoma cells. Iodides 50-56 solute carrier family 5 member 5 Homo sapiens 22-35 11216532-2 2001 The transport of iodide across the cell membrane is mediated by the human NaI symporter (hNIS). Iodides 17-23 solute carrier family 5 member 5 Homo sapiens 74-87 11216532-2 2001 The transport of iodide across the cell membrane is mediated by the human NaI symporter (hNIS). Iodides 17-23 solute carrier family 5 member 5 Homo sapiens 89-93 11170832-5 2001 We conclude that NIS is expressed in placenta and may mediate placental iodide transport. Iodides 72-78 solute carrier family 5 member 5 Homo sapiens 17-20 11573141-1 2001 The uptake of iodide in thyroid epithelial cells is mediated by the sodium/iodide symporter (NIS). Iodides 14-20 solute carrier family 5 member 5 Homo sapiens 93-96 11573141-3 2001 Loss of iodide uptake due to diminished expression of the human NIS (hNIS) is frequently observed in metastasized thyroid cancer. Iodides 8-14 solute carrier family 5 member 5 Homo sapiens 64-67 11573141-3 2001 Loss of iodide uptake due to diminished expression of the human NIS (hNIS) is frequently observed in metastasized thyroid cancer. Iodides 8-14 solute carrier family 5 member 5 Homo sapiens 69-73 11573141-9 2001 Iodide uptake in the hNIS transfected tumor was much higher than in non-transfected tumor, but a rapid release of radioactivity from the hNIS transfected tumor was observed. Iodides 0-6 solute carrier family 5 member 5 Homo sapiens 21-25 11573143-2 2001 The transport of iodide across the cell membrane is mediated by the sodium iodide symporter (hNIS). Iodides 17-23 solute carrier family 5 member 5 Homo sapiens 93-97 11573143-7 2001 In rats, the hNIS-expressing tumors accumulated six times more iodide as compared to the contralateral wild type tumor as monitored by scintigraphy. Iodides 63-69 solute carrier family 5 member 5 Homo sapiens 13-17 11573143-11 2001 For a therapeutic application of the hNIS gene, however, additional conditions need to be defined which inhibit the iodide efflux. Iodides 116-122 solute carrier family 5 member 5 Homo sapiens 37-41 11128720-0 2000 Reestablishment of in vitro and in vivo iodide uptake by transfection of the human sodium iodide symporter (hNIS) in a hNIS defective human thyroid carcinoma cell line. Iodides 40-46 solute carrier family 5 member 5 Homo sapiens 108-112 11078986-6 2000 Five of these metastatic lymph nodes were positive at the post-treatment total-body iodine-131 scan; in the other three, the total-body scan showed no uptake in the metastatic tissues, indicating an alteration downstream to the NIS mRNA synthesis causing the loss of iodide uptake. Iodides 267-273 solute carrier family 5 member 5 Homo sapiens 228-231 11128720-0 2000 Reestablishment of in vitro and in vivo iodide uptake by transfection of the human sodium iodide symporter (hNIS) in a hNIS defective human thyroid carcinoma cell line. Iodides 40-46 solute carrier family 5 member 5 Homo sapiens 119-123 11128720-2 2000 However, loss of iodide uptake is frequently observed in metastasized thyroid cancer, which may be explained by diminished expression of the human sodium iodide symporter (hNIS). Iodides 17-23 solute carrier family 5 member 5 Homo sapiens 172-176 11128720-6 2000 hNIS mRNA expression corresponded with iodide uptake in semiquantitative polymerase chain reaction. Iodides 39-45 solute carrier family 5 member 5 Homo sapiens 0-4 11128720-9 2000 Iodide uptake in the hNIS transfected tumor was much higher than in the nontransfected tumor, which corresponded with hNIS mRNA expression in tumors. Iodides 0-6 solute carrier family 5 member 5 Homo sapiens 21-25 11128720-9 2000 Iodide uptake in the hNIS transfected tumor was much higher than in the nontransfected tumor, which corresponded with hNIS mRNA expression in tumors. Iodides 0-6 solute carrier family 5 member 5 Homo sapiens 118-122 10902780-1 2000 Molecular cloning of the sodium/iodide symporter (NIS) allowed identification of NIS gene mutations in patients with iodide trapping defect. Iodides 32-38 solute carrier family 5 member 5 Homo sapiens 50-53 10890895-1 2000 The sodium/iodide symporter (NIS) stimulates iodide uptake in normal lactating breast, but is not known to be active in nonlactating breast or breast cancer. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 10910060-1 2000 The Na+/I- symporter (NIS) present in the membranes of thyroid cells is responsible for the capacity of the thyroid to concentrate iodide. Iodides 131-137 solute carrier family 5 member 5 Homo sapiens 4-20 10910060-1 2000 The Na+/I- symporter (NIS) present in the membranes of thyroid cells is responsible for the capacity of the thyroid to concentrate iodide. Iodides 131-137 solute carrier family 5 member 5 Homo sapiens 22-25 11061560-0 2000 Rarity of anti- Na+/I- symporter (NIS) antibody with iodide uptake inhibiting activity in autoimmune thyroid diseases (AITD). Iodides 53-59 solute carrier family 5 member 5 Homo sapiens 16-32 11061560-0 2000 Rarity of anti- Na+/I- symporter (NIS) antibody with iodide uptake inhibiting activity in autoimmune thyroid diseases (AITD). Iodides 53-59 solute carrier family 5 member 5 Homo sapiens 34-37 11061560-2 2000 Prior to cloning of NIS, Raspe et al found iodide uptake inhibiting sera were rare in autoimmune thyroid diseases (AITD) while post-cloning, others reported the presence of antibody in 12-15% of Hashimoto"s thyroiditis (HT) and 30-84% of Graves" disease (GD). Iodides 43-49 solute carrier family 5 member 5 Homo sapiens 20-23 10902780-1 2000 Molecular cloning of the sodium/iodide symporter (NIS) allowed identification of NIS gene mutations in patients with iodide trapping defect. Iodides 32-38 solute carrier family 5 member 5 Homo sapiens 81-84 9745437-1 1998 The Na+/I- symporter (NIS) is the plasma membrane protein that mediates active iodide uptake into thyroid follicular cells. Iodides 79-85 solute carrier family 5 member 5 Homo sapiens 4-20 10893432-1 2000 The Na(+)/I(-) symporter (NIS) is an intrinsic membrane protein that mediates the active transport of iodide into the thyroid and other tissues, such as salivary glands, gastric mucosa, and lactating mammary gland. Iodides 102-108 solute carrier family 5 member 5 Homo sapiens 4-24 10893432-1 2000 The Na(+)/I(-) symporter (NIS) is an intrinsic membrane protein that mediates the active transport of iodide into the thyroid and other tissues, such as salivary glands, gastric mucosa, and lactating mammary gland. Iodides 102-108 solute carrier family 5 member 5 Homo sapiens 26-29 10893432-2 2000 NIS plays key roles in thyroid pathophysiology as the route by which iodide reaches the gland for thyroid hormone biosynthesis and as a means for diagnostic scintigraphic imaging and for radioiodide therapy in hyperthyroidism and thyroid cancer. Iodides 69-75 solute carrier family 5 member 5 Homo sapiens 0-3 10907960-1 2000 Active iodide uptake across the basal membrane mediated by human sodium iodide symporter (hNIS) has been shown to be a process coupled with the flow of sodium. Iodides 7-13 solute carrier family 5 member 5 Homo sapiens 90-94 10907960-5 2000 Thyroid and metastatic tissues were then obtained for this study, which is aimed at comparing the iodide trapping ability in vivo and in vitro of hNIS, and then comparing their expression in both thyroid tissue and metastatic tissues. Iodides 98-104 solute carrier family 5 member 5 Homo sapiens 146-150 10843191-12 2000 Eight of the 11 (73%) GD and 3 of the 7 (43%) AH sera, which were positive for hNIS antibodies in the immunoprecipitation assay, were also found to inhibit iodide uptake in hNIS-transfected CHO-K1 cells, suggesting the existence of antibodies in some serum samples that bind to the symporter without modulating its function. Iodides 156-162 solute carrier family 5 member 5 Homo sapiens 79-83 10843191-12 2000 Eight of the 11 (73%) GD and 3 of the 7 (43%) AH sera, which were positive for hNIS antibodies in the immunoprecipitation assay, were also found to inhibit iodide uptake in hNIS-transfected CHO-K1 cells, suggesting the existence of antibodies in some serum samples that bind to the symporter without modulating its function. Iodides 156-162 solute carrier family 5 member 5 Homo sapiens 173-177 10843191-13 2000 Overall, a significant correlation was found between the iodide uptake inhibition and the binding assays for hNIS antibody detection (r = 0.49, P < 0.0001). Iodides 57-63 solute carrier family 5 member 5 Homo sapiens 109-113 10588823-1 1999 The recent cloning of the thyroidal protein that is responsible for iodide transport, the sodium iodide symporter (hNIS), has made possible studies designed to characterize its structure, function and expression in thyroidal tissues. Iodides 68-74 solute carrier family 5 member 5 Homo sapiens 115-119 10443704-1 1999 The thyroid sodium-iodide symporter (NIS) is responsible for iodide concentrating ability within thyroid follicular cells. Iodides 19-25 solute carrier family 5 member 5 Homo sapiens 37-40 10483259-9 1999 In conclusion, it is suggested that the incidence of the antibodies against NaIS is higher in Graves" disease than Hashimoto"s thyroiditis, and these antibodies inhibit iodide uptake. Iodides 169-175 solute carrier family 5 member 5 Homo sapiens 76-80 10232600-2 1999 Causing prostate cancer cells to express functionally active sodium iodide symporter (NIS) would enable those cells to concentrate iodide from plasma and might offer the ability to treat prostate cancer with radioiodine. Iodides 68-74 solute carrier family 5 member 5 Homo sapiens 86-89 10232600-9 1999 Prostate cells transfected with NIS/PSA-pEGFP-1 showed perchlorate-sensitive, androgen-dependent iodide uptake in a range comparable to that observed in control cell lines transfected with hNIS cDNA. Iodides 97-103 solute carrier family 5 member 5 Homo sapiens 32-35 10232600-13 1999 In conclusion, tissue-specific androgen-dependent iodide uptake activity has been induced in prostate cancer cells by PSA promoter-directed NIS expression. Iodides 50-56 solute carrier family 5 member 5 Homo sapiens 140-143 10365677-2 1999 Given the critical role of the Na+/I- symporter (NIS) in controlling iodide access to the thyroid gland, altered expression of NIS may be responsible, at least in part, for an enhanced or diminished capacity to concentrate iodide. Iodides 69-75 solute carrier family 5 member 5 Homo sapiens 31-47 10365677-2 1999 Given the critical role of the Na+/I- symporter (NIS) in controlling iodide access to the thyroid gland, altered expression of NIS may be responsible, at least in part, for an enhanced or diminished capacity to concentrate iodide. Iodides 69-75 solute carrier family 5 member 5 Homo sapiens 49-52 10365677-2 1999 Given the critical role of the Na+/I- symporter (NIS) in controlling iodide access to the thyroid gland, altered expression of NIS may be responsible, at least in part, for an enhanced or diminished capacity to concentrate iodide. Iodides 223-229 solute carrier family 5 member 5 Homo sapiens 127-130 10319949-1 1999 The sodium iodide symporter (NIS) is the plasma membrane protein that mediates active iodide uptake into thyroid follicular cells. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 9814499-1 1998 Antipeptide antibodies raised against the carboxyl-terminal region of the human sodium/iodide (Na+/I-) symporter (hNIS) were used to investigate by immunohistochemistry the presence and distribution of the hNIS protein in normal thyroid tissues, in some pathological nonneoplastic thyroid tissues, and in different histotypes of thyroid neoplasms. Iodides 87-93 solute carrier family 5 member 5 Homo sapiens 95-112 9814499-1 1998 Antipeptide antibodies raised against the carboxyl-terminal region of the human sodium/iodide (Na+/I-) symporter (hNIS) were used to investigate by immunohistochemistry the presence and distribution of the hNIS protein in normal thyroid tissues, in some pathological nonneoplastic thyroid tissues, and in different histotypes of thyroid neoplasms. Iodides 87-93 solute carrier family 5 member 5 Homo sapiens 114-118 9876351-1 1998 OBJECTIVE: Iodide uptake by the thyroid gland is mediated by the sodium iodide symporter (NIS). Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 90-93 9876351-9 1998 In these experiments, there was a good correlation between NIS mRNA expression and iodide uptake. Iodides 83-89 solute carrier family 5 member 5 Homo sapiens 59-62 10720070-1 2000 In the thyroid, active transport of iodide is under control of the TSH-dependent Na+/I- symporter (NIS), whereas in the breast such control is less well understood. Iodides 36-42 solute carrier family 5 member 5 Homo sapiens 81-97 10779135-1 2000 The sodium iodide symporter (NIS) is a plasma membrane protein that is responsible for iodide transport into thyroid cells. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 10576759-1 1999 The recent cloning of the gene encoding the sodium/iodide symporter (NIS) has enabled better characterization of the molecular mechanisms underlying iodide transport, thus opening the way to clarifying its role in thyroid diseases. Iodides 51-57 solute carrier family 5 member 5 Homo sapiens 69-72 10576759-2 1999 Several studies, at both the mRNA and the protein expression levels, have demonstrated that TSH, the primary regulator of iodide uptake, upregulates NIS gene expression and NIS protein abundance, both in vitro and in vivo. Iodides 122-128 solute carrier family 5 member 5 Homo sapiens 149-152 10576759-3 1999 However, other factors, including iodide, retinoic acid, transforming growth factor-beta, interleukin-1alpha and tumour necrosis factor alpha, may participate in the regulation of NIS expression. Iodides 34-40 solute carrier family 5 member 5 Homo sapiens 180-183 10566669-1 1999 The human sodium iodide symporter (hNIS) is an intrinsic transmembrane protein that mediates the active transport of iodide across the basolateral membrane of thyroid follicular cells. Iodides 17-23 solute carrier family 5 member 5 Homo sapiens 35-39 10566669-8 1999 In conclusion, our study demonstrates the expression of hNIS protein by several human exocrine glands, suggesting that iodide transport in these glands is a specific property conferred by the expression of hNIS protein, which may serve important functions by concentrating iodine in glandular secretions. Iodides 119-125 solute carrier family 5 member 5 Homo sapiens 56-60 10566669-8 1999 In conclusion, our study demonstrates the expression of hNIS protein by several human exocrine glands, suggesting that iodide transport in these glands is a specific property conferred by the expression of hNIS protein, which may serve important functions by concentrating iodine in glandular secretions. Iodides 119-125 solute carrier family 5 member 5 Homo sapiens 206-210 10404820-0 1999 Restoration of iodide uptake in dedifferentiated thyroid carcinoma: relationship to human Na+/I-symporter gene methylation status. Iodides 15-21 solute carrier family 5 member 5 Homo sapiens 90-105 10403177-3 1999 A defect in the NIS (iodide trapping defect) can result in hypothyroidism, the severity of which is variable and influenced, in part, by the amount of iodine supply. Iodides 21-27 solute carrier family 5 member 5 Homo sapiens 16-19 10403177-4 1999 The molecular cloning of NIS and characterization of its genomic organization allowed the identification of NIS gene mutations in patients expressing the phenotype of iodide trapping defect. Iodides 167-173 solute carrier family 5 member 5 Homo sapiens 25-28 10403177-4 1999 The molecular cloning of NIS and characterization of its genomic organization allowed the identification of NIS gene mutations in patients expressing the phenotype of iodide trapping defect. Iodides 167-173 solute carrier family 5 member 5 Homo sapiens 108-111 10355044-1 1999 Cloning, functional characterisation, and diagnostic proof of the expression of sodium-iodide-symporter (NIS) in the thyroid are essential steps for a better understanding of function and regulation of thyroid hormone synthesis, which is limited by the availability of the trace element iodide. Iodides 87-93 solute carrier family 5 member 5 Homo sapiens 105-108 10355044-4 1999 Experimental protocols aiming at the functional expression of NIS in thyroid tumors or their metastases which lost capability for iodide uptake are currently developed. Iodides 130-136 solute carrier family 5 member 5 Homo sapiens 62-65 10355044-5 1999 Furthermore, techniques are under investigation to express functional NIS by gene transfer in those benign or malignant tissues, tumors, metastases, which normally do not accumulate iodide. Iodides 182-188 solute carrier family 5 member 5 Homo sapiens 70-73 9751526-1 1998 The human Na+/I- symporter (hNIS) is the plasma membrane protein that mediates active iodide uptake into several tissues, such as the thyroid and salivary glands. Iodides 86-92 solute carrier family 5 member 5 Homo sapiens 10-26 9751526-1 1998 The human Na+/I- symporter (hNIS) is the plasma membrane protein that mediates active iodide uptake into several tissues, such as the thyroid and salivary glands. Iodides 86-92 solute carrier family 5 member 5 Homo sapiens 28-32 9745458-5 1998 The NIS mutants carrying these mutations had minimal iodide uptake activity when expressed in COS-7 cells, confirming that the identified mutations are the direct cause of the iodide transport defect in these patients. Iodides 53-59 solute carrier family 5 member 5 Homo sapiens 4-7 9745458-6 1998 Genotyping of unaffected family members and functional assays of co-transfected COS-7 cells indicate that expression of one normal NIS allele in the heterozygote (T354P, G93R, or G543E) is sufficient to maintain active iodide uptake activity. Iodides 219-225 solute carrier family 5 member 5 Homo sapiens 131-134 9745437-1 1998 The Na+/I- symporter (NIS) is the plasma membrane protein that mediates active iodide uptake into thyroid follicular cells. Iodides 79-85 solute carrier family 5 member 5 Homo sapiens 22-25 9672241-1 1998 The Na+/I- symporter (NIS) catalyzes the accumulation of iodide into thyroid cells, an essential step in the biosynthesis of thyroid hormones. Iodides 57-63 solute carrier family 5 member 5 Homo sapiens 4-20 9525971-2 1998 The Na+/I- symporter (NIS) is primarily responsible for the uptake of iodide into thyroid cells. Iodides 70-76 solute carrier family 5 member 5 Homo sapiens 4-20 9525971-2 1998 The Na+/I- symporter (NIS) is primarily responsible for the uptake of iodide into thyroid cells. Iodides 70-76 solute carrier family 5 member 5 Homo sapiens 22-25 9806481-6 1998 Sodium dependent iodide symporter (NIS) actively transports iodide into the thyroid cells to produce thyroid hormones. Iodides 17-23 solute carrier family 5 member 5 Homo sapiens 35-38 9543144-1 1998 The transport of iodide into the thyroid, catalyzed by the Na+/I- symporter (NIS), is the initial and rate-limiting step in the formation of thyroid hormones. Iodides 17-23 solute carrier family 5 member 5 Homo sapiens 59-75 9543144-1 1998 The transport of iodide into the thyroid, catalyzed by the Na+/I- symporter (NIS), is the initial and rate-limiting step in the formation of thyroid hormones. Iodides 17-23 solute carrier family 5 member 5 Homo sapiens 77-80 9543144-10 1998 In summary, we have established a CHO cell line stably expressing the hNIS and shown that antibodies in GD sera can inhibit iodide uptake in these cells. Iodides 124-130 solute carrier family 5 member 5 Homo sapiens 70-74 9672241-1 1998 The Na+/I- symporter (NIS) catalyzes the accumulation of iodide into thyroid cells, an essential step in the biosynthesis of thyroid hormones. Iodides 57-63 solute carrier family 5 member 5 Homo sapiens 22-25 9549759-1 1998 Perchlorate competitively blocks iodide from entering the thyroid by an effect on the Na+/I- symporter thus preventing the further synthesis of thyroid hormone but has no effect on the iodination process itself. Iodides 33-39 solute carrier family 5 member 5 Homo sapiens 86-102 9865544-1 1998 The recently cloned sodium-iodide symporter (NIS) represents a key molecule for thyroid function by efficiently accumulating iodide from the circulation into the thyrocyte against an electrochemical gradient. Iodides 27-33 solute carrier family 5 member 5 Homo sapiens 45-48 34922208-1 2022 BACKGROUND: Sodium/iodide symporter (NIS) acts as a vital role in regulation of iodide uptake in thyroid cancer. Iodides 19-25 solute carrier family 5 member 5 Homo sapiens 37-40 9492156-1 1998 Elucidation of the regulation of human sodium-iodide symporter (hNIS) gene expression is critical to understanding its effects on iodide concentration abilities of thyroid and thyroid carcinomas. Iodides 46-52 solute carrier family 5 member 5 Homo sapiens 64-68 7980604-2 1994 These follicles exhibit on their basolateral membrane domain the Na+/I- symporter which allows iodide to accumulate in the thyrocytes. Iodides 95-101 solute carrier family 5 member 5 Homo sapiens 65-81 7980604-3 1994 The initial rate of iodide influx through the Na+/I- symporter is inhibited up to 98% by the chloride channel blockers. Iodides 20-26 solute carrier family 5 member 5 Homo sapiens 46-62 9231811-1 1997 The active iodide uptake of the thyroid gland in humans is mediated by the human sodium iodide symporter (hNIS). Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 106-110 8806637-2 1996 We report here the nucleotide and amino acid sequence of the human sodium iodide symporter (hNIS), which mediates the iodide uptake activity in the thyroid gland. Iodides 74-80 solute carrier family 5 member 5 Homo sapiens 92-96 8806637-4 1996 Transient expression of the hNIS cDNA conferred perchlorate-sensitive iodide uptake to a nonthyroid cell line, COS-7. Iodides 70-76 solute carrier family 5 member 5 Homo sapiens 28-32 8806637-5 1996 The expression of hNIS was detected at variable levels in papillary thyroid carcinoma tissues but not in any of the thyroid carcinoma cell lines that have lost the iodide uptake activity. Iodides 164-170 solute carrier family 5 member 5 Homo sapiens 18-22 33779310-0 2021 The iodide transport defect-causing Y348D mutation in the Na+/I- symporter (NIS) renders the protein intrinsically inactive and impairs its targeting to the plasma membrane. Iodides 4-10 solute carrier family 5 member 5 Homo sapiens 58-74 34922208-1 2022 BACKGROUND: Sodium/iodide symporter (NIS) acts as a vital role in regulation of iodide uptake in thyroid cancer. Iodides 80-86 solute carrier family 5 member 5 Homo sapiens 37-40 34922208-2 2022 However, the efficient approach to increase NIS expression and the mechanism of NIS-mediated iodide uptake in thyroid cancer remain unclear. Iodides 93-99 solute carrier family 5 member 5 Homo sapiens 80-83 34922208-9 2022 saRNA-mediated NIS expression inhibited cell proliferation, induced apoptosis and autophagy, and promoted iodide uptake in SW579 cells. Iodides 106-112 solute carrier family 5 member 5 Homo sapiens 15-18 34922208-11 2022 For mechanism analysis, we found that NIS upregulation exerted the effects on cell proliferation, apoptosis, autophagy, and iodide uptake via regulating AMPK/mTOR pathway. Iodides 124-130 solute carrier family 5 member 5 Homo sapiens 38-41 34922208-12 2022 We also demonstrated that saRNA-mediated NIS expression promoted iodide uptake in vivo. Iodides 65-71 solute carrier family 5 member 5 Homo sapiens 41-44 34922208-13 2022 CONCLUSION: saRNA-mediated NIS expression acted as a critical role in increasing iodide uptake via AMPK/mTOR pathway in thyroid cancer. Iodides 81-87 solute carrier family 5 member 5 Homo sapiens 27-30 34387194-1 2021 The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active iodide transport into the thyroid gland and into several extrathyroidal tissues. Iodides 95-101 solute carrier family 5 member 5 Homo sapiens 29-32 34514854-1 2021 BACKGROUND: Iodide transport defect (ITD) is an uncommon cause of dyshormonogenic congenital hypothyroidism due to homozygous or compound heterozygous pathogenic variants in the SLC5A5 gene, which encodes the sodium/iodide symporter (NIS), causing deficient iodide accumulation in thyroid follicular cells, thus impairing thyroid hormonogenesis. Iodides 12-18 solute carrier family 5 member 5 Homo sapiens 178-184 34514854-1 2021 BACKGROUND: Iodide transport defect (ITD) is an uncommon cause of dyshormonogenic congenital hypothyroidism due to homozygous or compound heterozygous pathogenic variants in the SLC5A5 gene, which encodes the sodium/iodide symporter (NIS), causing deficient iodide accumulation in thyroid follicular cells, thus impairing thyroid hormonogenesis. Iodides 216-222 solute carrier family 5 member 5 Homo sapiens 178-184 34806438-1 2022 The sodium-iodide symporter (NIS, SLC5A5) is expressed at the basolateral membrane of the thyroid follicular cell, and facilitates the thyroidal iodide uptake required for thyroid hormone biosynthesis. Iodides 145-151 solute carrier family 5 member 5 Homo sapiens 29-32 34806438-1 2022 The sodium-iodide symporter (NIS, SLC5A5) is expressed at the basolateral membrane of the thyroid follicular cell, and facilitates the thyroidal iodide uptake required for thyroid hormone biosynthesis. Iodides 145-151 solute carrier family 5 member 5 Homo sapiens 34-40 34771624-8 2021 Through a systematic validation of the detected interactions by co-immunoprecipitation and Western blot, followed by the biochemical and functional characterization of the contribution of each interactor to NIS PM residency and iodide uptake, we were able to identify a pathway by which the PM localization and function of NIS depends on its binding to SRC kinase, which leads to the recruitment and activation of the small GTPase RAC1. Iodides 228-234 solute carrier family 5 member 5 Homo sapiens 323-326 34520744-1 2022 The sodium iodide symporter (NIS) functions to transport iodide and is critical for successful radioiodide ablation of cancer cells. Iodides 57-63 solute carrier family 5 member 5 Homo sapiens 29-32 34387194-2 2021 NIS-mediated iodide uptake plays a pivotal role in the biosynthesis of thyroid hormones, of which iodide is an essential constituent. Iodides 13-19 solute carrier family 5 member 5 Homo sapiens 0-3 34387194-2 2021 NIS-mediated iodide uptake plays a pivotal role in the biosynthesis of thyroid hormones, of which iodide is an essential constituent. Iodides 98-104 solute carrier family 5 member 5 Homo sapiens 0-3 34387194-6 2021 A review on the hormones, cytokines, and iodide itself that regulate NIS is provided. Iodides 41-47 solute carrier family 5 member 5 Homo sapiens 69-72 35600585-2 2022 ITD is an autosomal recessive disorder caused by loss-of-function variants in the sodium/iodide symporter (NIS)-coding SLC5A5 gene. Iodides 89-95 solute carrier family 5 member 5 Homo sapiens 119-125 34196428-0 2021 The PDZ protein SCRIB regulates sodium/iodide symporter (NIS) expression at the basolateral plasma membrane. Iodides 39-45 solute carrier family 5 member 5 Homo sapiens 57-60 34196428-1 2021 The sodium/iodide symporter (NIS) expresses at the basolateral plasma membrane of the thyroid follicular cell and mediates iodide accumulation required for normal thyroid hormonogenesis. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 34196428-1 2021 The sodium/iodide symporter (NIS) expresses at the basolateral plasma membrane of the thyroid follicular cell and mediates iodide accumulation required for normal thyroid hormonogenesis. Iodides 123-129 solute carrier family 5 member 5 Homo sapiens 29-32 34196428-5 2021 As a result, R636* NIS is barely targeted to the plasma membrane and therefore iodide transport is reduced. Iodides 79-85 solute carrier family 5 member 5 Homo sapiens 19-22 33055303-1 2020 Objective: Iodide transport across thyrocytes constitutes a critical step for thyroid hormone biosynthesis, mediated mainly by the basolateral sodium-iodide-symporter (NIS (SLC5A5)) and the apical anion exchanger pendrin (PDS (SLC26A4)). Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 173-179 35438852-1 2022 OBJECTIVES: Iodide transport defect (ITD) is one of the principal causes of congenital hypothyroidism (CH) and its primary molecular mechanism is a mutation of the sodium/iodide symporter (NIS) gene. Iodides 12-18 solute carrier family 5 member 5 Homo sapiens 189-192 35438852-1 2022 OBJECTIVES: Iodide transport defect (ITD) is one of the principal causes of congenital hypothyroidism (CH) and its primary molecular mechanism is a mutation of the sodium/iodide symporter (NIS) gene. Iodides 171-177 solute carrier family 5 member 5 Homo sapiens 189-192 33974556-2 2021 However, the Na+/I- symporter (NIS), which mediates active iodide uptake into thyroid follicular cells, is also expressed in several non-thyroidal tissues. Iodides 59-65 solute carrier family 5 member 5 Homo sapiens 13-29 33974556-2 2021 However, the Na+/I- symporter (NIS), which mediates active iodide uptake into thyroid follicular cells, is also expressed in several non-thyroidal tissues. Iodides 59-65 solute carrier family 5 member 5 Homo sapiens 31-34 33002449-2 2021 The sodium iodide symporter (NIS) transports iodide across mammalian intestinal and thyroid epithelia to deliver iodide for thyroid hormone production. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 33002449-2 2021 The sodium iodide symporter (NIS) transports iodide across mammalian intestinal and thyroid epithelia to deliver iodide for thyroid hormone production. Iodides 45-51 solute carrier family 5 member 5 Homo sapiens 29-32 33912899-1 2021 CONTEXT: Iodide transport defect (ITD) (Online Mendelian Inheritance in Man #274400) is an uncommon cause of dyshormonogenic congenital hypothyroidism due to loss-of-function variants in the SLC5A5 gene, which encodes the sodium/iodide symporter (NIS), causing deficient iodide accumulation in thyroid follicular cells. Iodides 9-15 solute carrier family 5 member 5 Homo sapiens 191-197 33912899-1 2021 CONTEXT: Iodide transport defect (ITD) (Online Mendelian Inheritance in Man #274400) is an uncommon cause of dyshormonogenic congenital hypothyroidism due to loss-of-function variants in the SLC5A5 gene, which encodes the sodium/iodide symporter (NIS), causing deficient iodide accumulation in thyroid follicular cells. Iodides 229-235 solute carrier family 5 member 5 Homo sapiens 191-197 33291224-8 2020 These species D Ad vectors also successfully expressed the hNIS gene during infection leading to increased iodide uptake in multiple cancer cell lines. Iodides 107-113 solute carrier family 5 member 5 Homo sapiens 59-63 32084174-1 2020 The sodium iodide symporter (NIS) transports iodide, which is necessary for thyroid hormone production. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 32049985-1 2020 The sodium-iodide symporter (NIS) mediates transport of iodide across the basolateral membrane of thyroid cells. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 32049985-11 2020 Additionally, TNF-alpha and PMA were shown to have a negative impact on TSH-induced iodide uptake, consistent with the observed transcriptional downregulation of NIS. Iodides 84-90 solute carrier family 5 member 5 Homo sapiens 162-165 32049985-13 2020 A better understanding of the mechanisms underlying NIS expression in the context of normal thyroid physiology may guide the development of pharmacological strategies to increase the efficiency of iodide uptake. Iodides 197-203 solute carrier family 5 member 5 Homo sapiens 52-55 32049985-4 2020 Defective NIS expression is the main reason for impaired iodide uptake in TC and NIS downregulation has been associated with several pathways linked to malignant transformation. Iodides 57-63 solute carrier family 5 member 5 Homo sapiens 10-13 30217930-1 2018 The sodium iodide symporter (NIS) is a classical iodide pump typically localized within the cell plasma membrane in thyroid cells, where NIS expression is believed to ensure success of mainstay radioiodide therapy in thyroid cancers. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 29-32 31533238-7 2019 The sodium iodide symporter (NIS) is a plasma membrane glycoprotein, a member of solute carrier family 5A (SLC5A5), located on the basolateral surfaces of the thyroid follicular epithelial cells, which mediates active iodide transport into thyroid follicular cells. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 107-113 31115276-2 2019 ITD is an uncommon cause of dyshormonogenetic congenital hypothyroidism that results from inactivating mutations in the sodium/iodide symporter (NIS)-coding SLC5A5 gene. Iodides 127-133 solute carrier family 5 member 5 Homo sapiens 157-163 30191346-1 2019 BACKGROUND: Recent studies have described important roles for the sodium iodide symporter (NIS) in tumor behavior. Iodides 73-79 solute carrier family 5 member 5 Homo sapiens 91-94 30595693-4 2018 Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80-90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells. Iodides 206-212 solute carrier family 5 member 5 Homo sapiens 41-44 30595693-4 2018 Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80-90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells. Iodides 206-212 solute carrier family 5 member 5 Homo sapiens 45-51 30595693-4 2018 Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80-90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells. Iodides 206-212 solute carrier family 5 member 5 Homo sapiens 53-85 30217930-1 2018 The sodium iodide symporter (NIS) is a classical iodide pump typically localized within the cell plasma membrane in thyroid cells, where NIS expression is believed to ensure success of mainstay radioiodide therapy in thyroid cancers. Iodides 11-17 solute carrier family 5 member 5 Homo sapiens 137-140 29631680-5 2018 Sodium Iodide Symporter (NIS) gene is a plasma membrane glycoprotein that mediates iodide uptake in thyroid glands, stomach, salivary glands, lactating mammary glands and intestine. Iodides 83-89 solute carrier family 5 member 5 Homo sapiens 25-28 29242405-11 2018 Mechanistically, reactivation of functional hNIS expression could be attributed to activation of the transcription factors activating transcription factor 3 and protooncogene c-fosConclusion: DLCs could represent a promising adjunctive therapy for restoring iodide avidity within the full spectrum from RAI-refractory dedifferentiated to ATC. Iodides 258-264 solute carrier family 5 member 5 Homo sapiens 44-48 29631680-6 2018 NIS gene transports iodide from the blood to the gastric epithelial cells. Iodides 20-26 solute carrier family 5 member 5 Homo sapiens 0-3