PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12782031-5 2003 At the same time a chemical agent polyethylenimine that is also used for transient transfection of cells causes neither upregulation of p53 nor cellular response. Polyethyleneimine 34-50 tumor protein p53 Homo sapiens 136-139 26322477-0 2015 Induction of apoptosis in cancer cells through N-acetyl-l-leucine-modified polyethylenimine-mediated p53 gene delivery. Polyethyleneimine 75-91 tumor protein p53 Homo sapiens 101-104 26322477-1 2015 Herein, N-acetyl-L-leucine-modified polyethylenimine was successfully constructed through the EDC/NHS-mediated coupling reaction and employed as vectors to accomplish p53 gene delivery using HeLa (p53wt) and PC-3 cells (p53null) as models. Polyethyleneimine 36-52 tumor protein p53 Homo sapiens 167-170 27005182-0 2015 A polyethylenimine derivative-based nanocarrier for the highly efficient delivery of p53 gene to inhibit the proliferation of cancer cells. Polyethyleneimine 2-18 tumor protein p53 Homo sapiens 85-88 25829127-0 2015 N-Isopropylacrylamide-modified polyethylenimine-mediated p53 gene delivery to prevent the proliferation of cancer cells. Polyethyleneimine 31-47 tumor protein p53 Homo sapiens 57-60 25829127-1 2015 In this paper, N-isopropylacrylamide-modified polyethylenimine (PEN) was constructed through Michael addition and employed as a carrier to achieve the p53 gene delivery, using HeLa (p53wt) and PC-3 cells (p53null) as models. Polyethyleneimine 64-67 tumor protein p53 Homo sapiens 151-154 25829127-1 2015 In this paper, N-isopropylacrylamide-modified polyethylenimine (PEN) was constructed through Michael addition and employed as a carrier to achieve the p53 gene delivery, using HeLa (p53wt) and PC-3 cells (p53null) as models. Polyethyleneimine 64-67 tumor protein p53 Homo sapiens 182-185 25829127-2 2015 After PEN-mediated p53 transfection, expression level of p53 in HeLa and PC3 cells was up-regulated at both mRNA and protein levels. Polyethyleneimine 6-9 tumor protein p53 Homo sapiens 19-22 25829127-2 2015 After PEN-mediated p53 transfection, expression level of p53 in HeLa and PC3 cells was up-regulated at both mRNA and protein levels. Polyethyleneimine 6-9 tumor protein p53 Homo sapiens 57-60 25829127-4 2015 Using flow cytometric analysis, early apoptotic ratios of 54.95% and 27.06% after PEN-mediated p53 transfection were detected in PC-3 and HeLa cells, respectively, indicating that PC-3 cells were more sensitive to the exogenous p53 transfection than HeLa cells. Polyethyleneimine 82-85 tumor protein p53 Homo sapiens 95-98 25829127-4 2015 Using flow cytometric analysis, early apoptotic ratios of 54.95% and 27.06% after PEN-mediated p53 transfection were detected in PC-3 and HeLa cells, respectively, indicating that PC-3 cells were more sensitive to the exogenous p53 transfection than HeLa cells. Polyethyleneimine 82-85 tumor protein p53 Homo sapiens 228-231 25829127-6 2015 Through Western blotting, activity analysis of caspase-3, caspase-8 and caspase-9 and mitochondrial membrane potential measurement, the apoptosis induced by PEN-mediated p53 transfection was conducted in a mitochondria-dependent apoptosis pathway. Polyethyleneimine 157-160 tumor protein p53 Homo sapiens 170-173 25829127-7 2015 These results demonstrated that PEN could successfully mediate the p53 gene delivery and up-regulate the cellular p53 expression level, triggering a significant p53-dependent anti-proliferative effect on tumor cells. Polyethyleneimine 32-35 tumor protein p53 Homo sapiens 67-70 25829127-7 2015 These results demonstrated that PEN could successfully mediate the p53 gene delivery and up-regulate the cellular p53 expression level, triggering a significant p53-dependent anti-proliferative effect on tumor cells. Polyethyleneimine 32-35 tumor protein p53 Homo sapiens 114-117 25829127-7 2015 These results demonstrated that PEN could successfully mediate the p53 gene delivery and up-regulate the cellular p53 expression level, triggering a significant p53-dependent anti-proliferative effect on tumor cells. Polyethyleneimine 32-35 tumor protein p53 Homo sapiens 114-117 15293347-3 2004 METHODS: p53 nonviral-mediated gene transfer was achieved using glucosylated polyethylenimine (PEI) in conjunction with photochemical internalisation (PCI). Polyethyleneimine 77-93 tumor protein p53 Homo sapiens 9-12 15293347-3 2004 METHODS: p53 nonviral-mediated gene transfer was achieved using glucosylated polyethylenimine (PEI) in conjunction with photochemical internalisation (PCI). Polyethyleneimine 95-98 tumor protein p53 Homo sapiens 9-12 12874000-5 2003 Strikingly, administration of just 6 micro g of the polyethyleneimine/DNA-p53 vector every 3 days for 3 weeks indicated restoration of normal cell cycle regulation and apoptotic mechanisms as demonstrated by efficient p53 expression, increased apoptosis, and a 70% reduction in tumor size in an orthotopic bladder cancer model. Polyethyleneimine 52-69 tumor protein p53 Homo sapiens 74-77 12874000-5 2003 Strikingly, administration of just 6 micro g of the polyethyleneimine/DNA-p53 vector every 3 days for 3 weeks indicated restoration of normal cell cycle regulation and apoptotic mechanisms as demonstrated by efficient p53 expression, increased apoptosis, and a 70% reduction in tumor size in an orthotopic bladder cancer model. Polyethyleneimine 52-69 tumor protein p53 Homo sapiens 218-221 26816656-0 2016 Polyethyleneimine-modified calcium carbonate nanoparticles for p53 gene delivery. Polyethyleneimine 0-17 tumor protein p53 Homo sapiens 63-66 26816656-4 2016 After modified with polyethyleneimine (PEI), the ability of PEI-CaCO3 nanoparticles to carry GFP-marked p53 gene (pEGFP-C1-p53) into cancer cells to express P53 protein were studied. Polyethyleneimine 20-37 tumor protein p53 Homo sapiens 104-107 26816656-4 2016 After modified with polyethyleneimine (PEI), the ability of PEI-CaCO3 nanoparticles to carry GFP-marked p53 gene (pEGFP-C1-p53) into cancer cells to express P53 protein were studied. Polyethyleneimine 60-63 tumor protein p53 Homo sapiens 104-107 26816656-4 2016 After modified with polyethyleneimine (PEI), the ability of PEI-CaCO3 nanoparticles to carry GFP-marked p53 gene (pEGFP-C1-p53) into cancer cells to express P53 protein were studied. Polyethyleneimine 60-63 tumor protein p53 Homo sapiens 123-126 26816656-4 2016 After modified with polyethyleneimine (PEI), the ability of PEI-CaCO3 nanoparticles to carry GFP-marked p53 gene (pEGFP-C1-p53) into cancer cells to express P53 protein were studied. Polyethyleneimine 60-63 tumor protein p53 Homo sapiens 157-160 22764405-3 2012 Thermally crosslinked SPIONs (TCL-SPIONs) were conjugated with branched polyethylenimine (PEI 1800 Da) by EDC-NHS chemistry for p53 plasmid DNA delivery. Polyethyleneimine 72-88 tumor protein p53 Homo sapiens 128-131 12871058-10 2003 Therapeutic responses have been obtained in several animal lung tumor models when PEI-based formulations of p53 and other antitumor genes were delivered by aerosol. Polyethyleneimine 82-85 tumor protein p53 Homo sapiens 108-111 30524021-0 2019 Targeted polyethylenimine/(p53 plasmid) nanocomplexes for potential antitumor applications. Polyethyleneimine 9-25 tumor protein p53 Homo sapiens 27-30 11332991-0 2001 Improvement of nonviral p53 gene transfer in human carcinoma cells using glucosylated polyethylenimine derivatives. Polyethyleneimine 86-102 tumor protein p53 Homo sapiens 24-27 12659945-9 2003 We demonstrated an antisense ODN of p53 delivered by PEI/DOTAP-Chol combination effectively inhibited the biosynthesis of p53 protein in HepG2 (68% inhibiton) and 2.2.15 cells (43% inhibition). Polyethyleneimine 53-56 tumor protein p53 Homo sapiens 36-39 12659945-9 2003 We demonstrated an antisense ODN of p53 delivered by PEI/DOTAP-Chol combination effectively inhibited the biosynthesis of p53 protein in HepG2 (68% inhibiton) and 2.2.15 cells (43% inhibition). Polyethyleneimine 53-56 tumor protein p53 Homo sapiens 122-125 34452218-3 2021 This innovative approach explored the great capacity of both polyamidoamine (PAMAM)-paclitaxel (PTX) conjugate and polyethylenimine (PEI) polymers to complex a p53-encoding plasmid DNA (pDNA), highlighting the utility of considering two compacting agents. Polyethyleneimine 115-131 tumor protein p53 Homo sapiens 160-163 34452218-3 2021 This innovative approach explored the great capacity of both polyamidoamine (PAMAM)-paclitaxel (PTX) conjugate and polyethylenimine (PEI) polymers to complex a p53-encoding plasmid DNA (pDNA), highlighting the utility of considering two compacting agents. Polyethyleneimine 133-136 tumor protein p53 Homo sapiens 160-163 35215593-2 2022 In this work, polyethylenimine (PEI) has been used to complex p53 encoded plasmid DNA (pDNA), and the anticancer drug methotrexate (MTX) has also been loaded into the vectors. Polyethyleneimine 14-30 tumor protein p53 Homo sapiens 62-65 35215593-2 2022 In this work, polyethylenimine (PEI) has been used to complex p53 encoded plasmid DNA (pDNA), and the anticancer drug methotrexate (MTX) has also been loaded into the vectors. Polyethyleneimine 32-35 tumor protein p53 Homo sapiens 62-65 27122200-0 2016 Investigation of the Sequential Actions of Doxorubicin and p53 on Tumor Cell Growth Via Branched Polyethylenimine-beta-cyclodextrin Conjugates. Polyethyleneimine 97-113 tumor protein p53 Homo sapiens 59-62 27122200-3 2016 Briefly, branched polyethylenimine (BPEI) was conjugated with beta-cyclodextrin hydrate (beta-CD) to form BPEI-beta-CD backbone, and p53 plasmid was condensed by positively charged BPEI via electrostatic interaction, while Dox was first conjugated with adamantine (AD) and then assembled with BPEI-beta-CD backbone via the host-guest interaction. Polyethyleneimine 18-34 tumor protein p53 Homo sapiens 133-136 29680675-4 2018 Thioketal-crosslinked polyethylenimine (TK-PEI) was synthesized to condense p53 gene to form nanocomplexes (NCs), and hyaluronic acid (HA) modified with pheophytin a (Pha) was coated onto NCs to enhance their colloidal stability and enable cancer cell targeting. Polyethyleneimine 22-38 tumor protein p53 Homo sapiens 76-79 29061817-0 2017 Synergistic Inhibition of Human Carcinoma Cell Growth via Co-Delivery of p53 Plasmid DNA and bcl-2 Antisense Oligodeoxyribonucleotide by Cholic Acid-modified Polyethylenimine. Polyethyleneimine 158-174 tumor protein p53 Homo sapiens 73-76 32263321-4 2016 In this system, Doxorubicin-loaded aptamer duplex and plasmid DNA (p53) can be bound by PEI by electronic interactions to form stable complexes which effectively protect the aptamer and p53 from DNase degradation. Polyethyleneimine 88-91 tumor protein p53 Homo sapiens 67-70 32263321-4 2016 In this system, Doxorubicin-loaded aptamer duplex and plasmid DNA (p53) can be bound by PEI by electronic interactions to form stable complexes which effectively protect the aptamer and p53 from DNase degradation. Polyethyleneimine 88-91 tumor protein p53 Homo sapiens 186-189 32263321-8 2016 RT-PCR and Western blot analysis confirmed that p53 could be effectively delivered and expressed in HeLa cells by PEI/ARAD/p53 complexes. Polyethyleneimine 114-117 tumor protein p53 Homo sapiens 48-51 32263321-9 2016 Moreover, the apoptosis percentage of HeLa cells treated with PEI/ARAD/Dox/p53 complex increased to 40.8%, compared to 24.7% for PEI/ARAD/Dox complex and 11.5% for PEI/ARAD/p53, respectively. Polyethyleneimine 62-65 tumor protein p53 Homo sapiens 75-78 32263321-9 2016 Moreover, the apoptosis percentage of HeLa cells treated with PEI/ARAD/Dox/p53 complex increased to 40.8%, compared to 24.7% for PEI/ARAD/Dox complex and 11.5% for PEI/ARAD/p53, respectively. Polyethyleneimine 62-65 tumor protein p53 Homo sapiens 173-176 32263321-9 2016 Moreover, the apoptosis percentage of HeLa cells treated with PEI/ARAD/Dox/p53 complex increased to 40.8%, compared to 24.7% for PEI/ARAD/Dox complex and 11.5% for PEI/ARAD/p53, respectively. Polyethyleneimine 129-132 tumor protein p53 Homo sapiens 75-78 32263321-9 2016 Moreover, the apoptosis percentage of HeLa cells treated with PEI/ARAD/Dox/p53 complex increased to 40.8%, compared to 24.7% for PEI/ARAD/Dox complex and 11.5% for PEI/ARAD/p53, respectively. Polyethyleneimine 129-132 tumor protein p53 Homo sapiens 75-78