PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2079689-6	1990	Studies on the enzymology of NDMA metabolism show that some Cytochrome P-450 isozymes exhibit significant NDMA-demethylase activity only at high NDMA concentrations.	Dimethylnitrosamine	29-33	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	60-76	
23186213-1	2012	Cytochrome P450 (P450) 2E1 is the major enzyme that oxidizes N-nitrosodimethylamine [N,N-dimethylnitrosamine (DMN)], a carcinogen and also a representative of some nitrosamines formed endogenously.	Dimethylnitrosamine	61-83	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-26	
23186213-1	2012	Cytochrome P450 (P450) 2E1 is the major enzyme that oxidizes N-nitrosodimethylamine [N,N-dimethylnitrosamine (DMN)], a carcinogen and also a representative of some nitrosamines formed endogenously.	Dimethylnitrosamine	85-108	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-26	
23186213-1	2012	Cytochrome P450 (P450) 2E1 is the major enzyme that oxidizes N-nitrosodimethylamine [N,N-dimethylnitrosamine (DMN)], a carcinogen and also a representative of some nitrosamines formed endogenously.	Dimethylnitrosamine	110-113	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-26	
20061389-1	2010	Cytochrome P450 (P450) 2A6 activates nitrosamines, including N,N-dimethylnitrosamine (DMN) and N,N-diethylnitrosamine (DEN), to alkyl diazohydroxides (which are DNA-alkylating agents) and also aldehydes (HCHO from DMN and CH(3)CHO from DEN).	Dimethylnitrosamine	61-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-26	
20061389-1	2010	Cytochrome P450 (P450) 2A6 activates nitrosamines, including N,N-dimethylnitrosamine (DMN) and N,N-diethylnitrosamine (DEN), to alkyl diazohydroxides (which are DNA-alkylating agents) and also aldehydes (HCHO from DMN and CH(3)CHO from DEN).	Dimethylnitrosamine	86-89	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-26	
20061389-1	2010	Cytochrome P450 (P450) 2A6 activates nitrosamines, including N,N-dimethylnitrosamine (DMN) and N,N-diethylnitrosamine (DEN), to alkyl diazohydroxides (which are DNA-alkylating agents) and also aldehydes (HCHO from DMN and CH(3)CHO from DEN).	Dimethylnitrosamine	214-217	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-26	
17763085-2	2007	NDMA is acutely toxic to humans at high doses, is genotoxic after cytochrome P-450 metabolism, and is carcinogenic in several animal species.	Dimethylnitrosamine	0-4	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	66-82	
2079689-6	1990	Studies on the enzymology of NDMA metabolism show that some Cytochrome P-450 isozymes exhibit significant NDMA-demethylase activity only at high NDMA concentrations.	Dimethylnitrosamine	106-110	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	60-76	
2651504-7	1989	We have demonstrated that dietary zinc deficiency increased the cytochrome P-450-dependent microsomal metabolism of methylbenzylnitrosamine and dimethylnitrosamine, two members of this class of dialkylnitrosamine carcinogens, while the addition of zinc in vitro noncompetitively inhibits the microsomal metabolism of these carcinogens.	Dimethylnitrosamine	144-163	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	64-80	
3181604-2	1988	In man and animals, there is an associated rise in microsomal cytochrome P-450, including a specific form (P-450IIEI) with high affinity for ethanol and for the activation of some drugs (i.e. acetaminophen), carcinogens (i.e. N-nitrosodimethylamine) and hepatotoxic agents (i.e. CCl4), thereby contributing to the susceptibility of alcoholics to xenobiotics, including industrial solvents.	Dimethylnitrosamine	226-248	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	62-78