PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26005978-10 2015 -GSTP1 Ile/Ile 35.3% versus 60.9%; Ile/Val 45.9% versus 28.7%; Val/Val 18.8% versus 10.3%; p=0.0003. Isoleucine 7-10 glutathione S-transferase pi 1 Homo sapiens 1-6 34052967-3 2021 The aim of this study is to investigate whether individual or combined modifying effects of LOX G/A, GSTM1 active/null, GSTT1 active/null and GSTP1 Ile/Val polymorphisms are related to the risk of lung cancer in relation to smoking in the Egyptian population. Isoleucine 148-151 glutathione S-transferase pi 1 Homo sapiens 142-147 30617052-8 2019 For the meta-analysis of the GSTP1 Ile105Val polymorphism, compared with controls, an increased risk of NP cases was detected under the models of Val versus Ile (OR = 1.36; PA =0.027), Ile/Val versus Ile/Ile (OR = 1.70; PA =0.011) and Ile/Val+Val/Val versus Ile/Ile (OR = 1.65; PA =0.010). Isoleucine 35-38 glutathione S-transferase pi 1 Homo sapiens 29-34 26284209-4 2015 RESULTS: We observed a significant association of GSTP1-I/V (Isoleucine/Valine) allele and GSTP1-V/V (Valine / Valine) allele with MS (P = 0.047 and P = 0.044, respectively). Isoleucine 61-71 glutathione S-transferase pi 1 Homo sapiens 50-55 26284209-4 2015 RESULTS: We observed a significant association of GSTP1-I/V (Isoleucine/Valine) allele and GSTP1-V/V (Valine / Valine) allele with MS (P = 0.047 and P = 0.044, respectively). Isoleucine 61-71 glutathione S-transferase pi 1 Homo sapiens 91-96 26005978-10 2015 -GSTP1 Ile/Ile 35.3% versus 60.9%; Ile/Val 45.9% versus 28.7%; Val/Val 18.8% versus 10.3%; p=0.0003. Isoleucine 11-14 glutathione S-transferase pi 1 Homo sapiens 1-6 16235992-9 2005 The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele. Isoleucine 37-40 glutathione S-transferase pi 1 Homo sapiens 30-35 19808963-10 2009 One such difference is the presence of Ile(104) in GSTP1-1 close to the bound NBDHEX, whereas the corresponding position is occupied by an alanine in GSTM2-2. Isoleucine 39-42 glutathione S-transferase pi 1 Homo sapiens 51-58 18280004-3 2008 The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity. Isoleucine 105-115 glutathione S-transferase pi 1 Homo sapiens 4-9 18280004-3 2008 The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity. Isoleucine 105-115 glutathione S-transferase pi 1 Homo sapiens 186-191 18280004-3 2008 The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity. Isoleucine 117-120 glutathione S-transferase pi 1 Homo sapiens 4-9 18280004-3 2008 The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity. Isoleucine 117-120 glutathione S-transferase pi 1 Homo sapiens 186-191 21711092-2 2012 The substitution of isoleucine to valine residue at position 105 of the GSTP1 protein results in decreased enzyme activity and hence less capability of effective detoxification. Isoleucine 20-30 glutathione S-transferase pi 1 Homo sapiens 72-77 21729529-3 2011 The results indicated that the frequently of G allele and Ile/Val + Val/Val of GSTP1 gene (26.7%and 44% respectively) in AL group were higher than those in control group (10% and 16% respectively); the AL risk for persons with Ile/Val + Val/Val was 3.260-fold (95%CI = 1.527 - 5.236) of persons with Ile/Ile. Isoleucine 58-61 glutathione S-transferase pi 1 Homo sapiens 79-84 18521819-5 2008 The presence of valine alleles compared to isoleucine alleles in codon 105 in GSTP1 did not increase the risk of breast cancer development. Isoleucine 43-53 glutathione S-transferase pi 1 Homo sapiens 78-83 17676332-3 2008 RESULTS: Both the GSTP1 (105) isoleucine/isoleucine and GSTP1 (114) alanine/alanine genotypes showed higher levels of U-MDX than the other genotypes and the GSTP1 (114) genotype modified the P-MDX/U-MDX relationship. Isoleucine 30-40 glutathione S-transferase pi 1 Homo sapiens 18-23 17676332-3 2008 RESULTS: Both the GSTP1 (105) isoleucine/isoleucine and GSTP1 (114) alanine/alanine genotypes showed higher levels of U-MDX than the other genotypes and the GSTP1 (114) genotype modified the P-MDX/U-MDX relationship. Isoleucine 41-51 glutathione S-transferase pi 1 Homo sapiens 18-23 17676332-4 2008 GSTP1 (105) isoleucine/isoleucine was found to be associated with lower levels of S-IgG-MDI and fewer eye symptoms, but with an increased risk of symptoms in the airways, as well as with atopy. Isoleucine 12-22 glutathione S-transferase pi 1 Homo sapiens 0-5 18085999-6 2007 RESULTS: GSTP1 genotype distribution was Ile/Ile 58%, Ile/Val 35% and Val/Val 7%. Isoleucine 41-44 glutathione S-transferase pi 1 Homo sapiens 9-14 18085999-6 2007 RESULTS: GSTP1 genotype distribution was Ile/Ile 58%, Ile/Val 35% and Val/Val 7%. Isoleucine 45-48 glutathione S-transferase pi 1 Homo sapiens 9-14 18067039-9 2007 The genotypic distribution of GSTP1 was Ile(105)/Ile(105) in 47.3%, Ile(105)/Val(105) in 30.97% and Val(105)/Val(105) in 21.74% of ESRD patients. Isoleucine 40-43 glutathione S-transferase pi 1 Homo sapiens 30-35 18067039-9 2007 The genotypic distribution of GSTP1 was Ile(105)/Ile(105) in 47.3%, Ile(105)/Val(105) in 30.97% and Val(105)/Val(105) in 21.74% of ESRD patients. Isoleucine 49-52 glutathione S-transferase pi 1 Homo sapiens 30-35 18067039-9 2007 The genotypic distribution of GSTP1 was Ile(105)/Ile(105) in 47.3%, Ile(105)/Val(105) in 30.97% and Val(105)/Val(105) in 21.74% of ESRD patients. Isoleucine 49-52 glutathione S-transferase pi 1 Homo sapiens 30-35 16039055-10 2005 An isoleucine (Ile) to valine (Val) substitution at codon 105 (Ile105Val) in the GSTP1 gene was genotyped. Isoleucine 3-13 glutathione S-transferase pi 1 Homo sapiens 81-86 16039055-10 2005 An isoleucine (Ile) to valine (Val) substitution at codon 105 (Ile105Val) in the GSTP1 gene was genotyped. Isoleucine 15-18 glutathione S-transferase pi 1 Homo sapiens 81-86 16235992-9 2005 The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele. Isoleucine 51-54 glutathione S-transferase pi 1 Homo sapiens 30-35 16235992-9 2005 The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele. Isoleucine 51-54 glutathione S-transferase pi 1 Homo sapiens 30-35 16235992-9 2005 The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele. Isoleucine 51-54 glutathione S-transferase pi 1 Homo sapiens 30-35 15900216-5 2005 The GSTP1 gene displays a polymorphism at codon 105 resulting in an Ile to Val substitution, which alters the enzymatic activity of the protein, and this has been suggested as a putative high-risk genotype in various cancers. Isoleucine 68-71 glutathione S-transferase pi 1 Homo sapiens 4-9 15254763-1 2004 GSTP1, which encodes GSTPi, has a polymorphic site at codon 105 (exon 5), where an adenosine-to-guanine (A-G) transition causes an isoleucine-to-valine substitution (I105V). Isoleucine 131-141 glutathione S-transferase pi 1 Homo sapiens 0-5 15163523-3 2004 GSTP1 exon 5 gene presents a single-nucleotide polymorphism (a to g) that results into an amino-acid substitution (Ile to Val). Isoleucine 115-118 glutathione S-transferase pi 1 Homo sapiens 0-5 10344744-2 1999 The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (valine or alanine). Isoleucine 113-123 glutathione S-transferase pi 1 Homo sapiens 30-37 11113459-2 2000 The Pi class human glutathione (GSH) transferase (hGSTP1-1), which is polymorphic in humans with respect to amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), plays an important role in the detoxification of PAH-diol epoxides. Isoleucine 146-156 glutathione S-transferase pi 1 Homo sapiens 50-58 10799737-1 2000 The catalytic efficiencies of the allelic variants of human glutathione (GSH) S-transferase Pi (hGSTP1-1), which differ in their primary structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), in the GSH conjugation (detoxification) of acrolein and crotonaldehyde have been determined. Isoleucine 185-195 glutathione S-transferase pi 1 Homo sapiens 96-104 11434510-6 2001 The GSTP1 gene has a polymorphism at codon 105 resulting in an Ile to Val substitution which consequently alters the enzymatic activity of the protein and this has been suggested as a putative high-risk genotype in various cancers. Isoleucine 63-66 glutathione S-transferase pi 1 Homo sapiens 4-9 11307147-5 2001 Both polymorphic GSTP1 alleles have an A-to-G transition in exon 5, causing an isoleucine-to-valine change. Isoleucine 79-89 glutathione S-transferase pi 1 Homo sapiens 17-22 11071881-3 2000 Interestingly, the hGSTP1 locus is polymorphic in human populations and involves amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine). Isoleucine 119-129 glutathione S-transferase pi 1 Homo sapiens 19-25 10344744-2 1999 The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (valine or alanine). Isoleucine 113-123 glutathione S-transferase pi 1 Homo sapiens 39-47 9525277-1 1998 Previous studies have identified allelic variants of the human glutathione transferase (GST) Pi gene and showed that the two different encoded proteins with isoleucine (GSTP1-1/I-105) or valine (GSTP1-1/V-105) at position 105, respectively, differ significantly in their catalytic activities with model substrates. Isoleucine 157-167 glutathione S-transferase pi 1 Homo sapiens 169-176 10334644-1 1999 OBJECTIVES: The human GSTTP1 gene is polymorphic with an A-->G transition in exon 5 causing a replacement 105 Ile-->Val in the GSTP1 protein. Isoleucine 113-116 glutathione S-transferase pi 1 Homo sapiens 133-138 9576856-4 1998 Two human class Pi (P) enzymes (GST P1-1 with Ile or Val at position 105) displayed no activity towards the phospholipid hydroperoxide. Isoleucine 46-49 glutathione S-transferase pi 1 Homo sapiens 32-38 9299520-2 1997 The four possible isoforms of hGSTP1-1 with isoleucine or valine in position 104 and with alanine or valine in position 113 were produced by site-directed mutagenesis of the cDNA followed by bacterial expression and purification of the proteins. Isoleucine 44-54 glutathione S-transferase pi 1 Homo sapiens 30-38