PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18465874-8 2008 The presence in PfFKBD of Cys-106 and Ser-109 (substituting for His-87 and Ile-90, respectively, in human FKBP12), which are 4-5 A from the nearest atom of the FK506 compound, suggests possible routes for the rational design of analogues of FK506 with specific antiparasitic activity. Isoleucine 75-78 FKBP prolyl isomerase 1A pseudogene 4 Homo sapiens 106-112 7642551-6 1995 Mutations at FKBP12 residues Asp-37, Arg-42, His-87, and Ile-90 decrease calcineurin affinity of the mutant FKBP12.FK506 complex by as much as 2600-fold in the case of I90K. Isoleucine 57-60 FKBP prolyl isomerase 1A pseudogene 4 Homo sapiens 108-114