PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12004058-8	2002	Remarkably, the double replacements of Lys(366) and Val(384) in murine FXR (corresponding to Asn(354) and Ile(372) in human FXR) with Asn(366) and Ile(384) explained the difference in both potency and maximum activation; compared with the wild-type murine FXR-LBD, the double mutant gained 8-fold affinity and more than 250% maximum response to CDCA in vitro.	Isoleucine	106-109	nuclear receptor subfamily 1, group H, member 4	Mus musculus	71-74	
12004058-8	2002	Remarkably, the double replacements of Lys(366) and Val(384) in murine FXR (corresponding to Asn(354) and Ile(372) in human FXR) with Asn(366) and Ile(384) explained the difference in both potency and maximum activation; compared with the wild-type murine FXR-LBD, the double mutant gained 8-fold affinity and more than 250% maximum response to CDCA in vitro.	Isoleucine	106-109	nuclear receptor subfamily 1, group H, member 4	Mus musculus	124-127	
12004058-8	2002	Remarkably, the double replacements of Lys(366) and Val(384) in murine FXR (corresponding to Asn(354) and Ile(372) in human FXR) with Asn(366) and Ile(384) explained the difference in both potency and maximum activation; compared with the wild-type murine FXR-LBD, the double mutant gained 8-fold affinity and more than 250% maximum response to CDCA in vitro.	Isoleucine	147-150	nuclear receptor subfamily 1, group H, member 4	Mus musculus	71-74	
12004058-8	2002	Remarkably, the double replacements of Lys(366) and Val(384) in murine FXR (corresponding to Asn(354) and Ile(372) in human FXR) with Asn(366) and Ile(384) explained the difference in both potency and maximum activation; compared with the wild-type murine FXR-LBD, the double mutant gained 8-fold affinity and more than 250% maximum response to CDCA in vitro.	Isoleucine	147-150	nuclear receptor subfamily 1, group H, member 4	Mus musculus	124-127	
12004058-10	2002	These results demonstrate that Asn(354) and Ile(372) are critically important for FXR function and that murine FXR can be "humanized" by substituting with the two corresponding residues of human FXR.	Isoleucine	44-47	nuclear receptor subfamily 1, group H, member 4	Mus musculus	82-85	
12004058-10	2002	These results demonstrate that Asn(354) and Ile(372) are critically important for FXR function and that murine FXR can be "humanized" by substituting with the two corresponding residues of human FXR.	Isoleucine	44-47	nuclear receptor subfamily 1, group H, member 4	Mus musculus	111-114