PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35409380-1	2022	Branched chain amino acids (BCAAs), leucine, isoleucine and valine, are essential amino acids widely studied for their crucial role in the regulation of protein synthesis mainly through the activation of the mTOR signaling pathway and their emerging recognition as players in the regulation of various physiological and metabolic processes, such as glucose homeostasis.	Isoleucine	45-55	mechanistic target of rapamycin kinase	Homo sapiens	208-212	
28413737-2	2017	Recently, a number of studies have revealed that branched-chain amino acids (BCAAs) (leucine, isoleucine, and valine) play an important role in the regulation of protein synthesis by activating mammalian target of rapamycin (mTOR) in pancreatic beta cells.	Isoleucine	94-104	mechanistic target of rapamycin kinase	Homo sapiens	194-223	
28413737-2	2017	Recently, a number of studies have revealed that branched-chain amino acids (BCAAs) (leucine, isoleucine, and valine) play an important role in the regulation of protein synthesis by activating mammalian target of rapamycin (mTOR) in pancreatic beta cells.	Isoleucine	94-104	mechanistic target of rapamycin kinase	Homo sapiens	225-229	
27236753-8	2016	Whereas mTOR was not very sensitive to changes in insulin or acetate levels, it was highly sensitive to leucine and isoleucine, and this signal appeared to be effectively transduced to casein synthesis.	Isoleucine	116-126	mechanistic target of rapamycin kinase	Homo sapiens	8-12	
27490818-1	2016	BACKGROUND: The proteinogenic branched-chain amino acids (BCAAs) valine, leucine and isoleucine might play an unrecognised crucial role in the development of depression through their activation of the mammalian target of rapamycin (mTor) pathway.	Isoleucine	85-95	mechanistic target of rapamycin kinase	Homo sapiens	201-230	
27490818-1	2016	BACKGROUND: The proteinogenic branched-chain amino acids (BCAAs) valine, leucine and isoleucine might play an unrecognised crucial role in the development of depression through their activation of the mammalian target of rapamycin (mTor) pathway.	Isoleucine	85-95	mechanistic target of rapamycin kinase	Homo sapiens	232-236	
26500112-9	2015	The key residues involved in binding of PKI-179 were Ala-805 in PI3Kgamma and Ile-2163 in mTOR as they have lost maximum accessible surface area due to binding.	Isoleucine	78-81	mechanistic target of rapamycin kinase	Homo sapiens	90-94	
24359813-0	2014	Isoleucine, leucine, methionine, and threonine effects on mammalian target of rapamycin signaling in mammary tissue.	Isoleucine	0-10	mechanistic target of rapamycin kinase	Homo sapiens	58-87	
24359813-10	2014	Isoleucine and Thr positively affected mTOR phosphorylation.	Isoleucine	0-10	mechanistic target of rapamycin kinase	Homo sapiens	39-43	
22298573-3	2012	Omission of L-arginine, L-isoleucine, L-leucine, or all EAA reduced (P < 0.05) mammalian target of rapamycin (mTOR; Ser2448) and ribosomal protein S6 (rpS6; Ser235/236) phosphorylation in MAC-T cells.	Isoleucine	24-36	mechanistic target of rapamycin kinase	Homo sapiens	82-111	
22298573-3	2012	Omission of L-arginine, L-isoleucine, L-leucine, or all EAA reduced (P < 0.05) mammalian target of rapamycin (mTOR; Ser2448) and ribosomal protein S6 (rpS6; Ser235/236) phosphorylation in MAC-T cells.	Isoleucine	24-36	mechanistic target of rapamycin kinase	Homo sapiens	113-117