PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12149252-6	2002	Additional studies revealed that the internal salt bridge (Ile(16)-Asp(194)) of factor Xa(Y225P) is partially destabilized, a process that is reversible upon occupation of the S1 site.	Isoleucine	59-62	coagulation factor X	Homo sapiens	80-89	
1778986-1	1991	Three DNA constructs, pETB-40, 41, and 42, encoding human big endothelin-1 (ET-1) preceded by the specific recognition sequence (Ile-Glu-Gly-Arg) for the activated blood coagulation factor Xa (FXa), fused in frame to the N-terminal portion of beta Gal, were expressed in Escherichia coli.	Isoleucine	129-132	coagulation factor X	Homo sapiens	182-191	
12362232-3	2002	It converts prothrombin to thrombin by cleaving both the peptide bonds Arg(274)-Thr(275) and Arg(323)-Ile(324), similar to mammalian factor Xa.	Isoleucine	102-105	coagulation factor X	Homo sapiens	133-142	
11925440-1	2002	Factor Xa (FXa) hydrolyzes two peptide bonds in prothrombin having (Glu/Asp)-Gly-Arg-(Thr/Ile) for P(3)-P(2)-P(1)-P(1)" residues, but the exact preferences of its catalytic groove remain largely unknown.	Isoleucine	90-93	coagulation factor X	Homo sapiens	0-9	
11925440-1	2002	Factor Xa (FXa) hydrolyzes two peptide bonds in prothrombin having (Glu/Asp)-Gly-Arg-(Thr/Ile) for P(3)-P(2)-P(1)-P(1)" residues, but the exact preferences of its catalytic groove remain largely unknown.	Isoleucine	90-93	coagulation factor X	Homo sapiens	11-14	
8621077-1	1996	The Arg-encoding triplet (AGG) in the recognition sequence Ile-Glu-Gly-Arg for factor Xa can be used to generate a StuI restriction site (AGGCCT) which greatly facilitates the construction of DNA fragments encoding fusion proteins.	Isoleucine	59-62	coagulation factor X	Homo sapiens	79-88	
8573072-8	1996	When the target sequence of the restriction protease factor Xa (Ile-Glu-Gly-Arg) was used as the linker between maltose-binding protein and human phenylalanine hydroxylase, cleavage of the fusion protein gave a mixture of full-length hydroxylase and a truncated form of the enzyme lacking the 13 N-terminal residues.	Isoleucine	64-68	coagulation factor X	Homo sapiens	53-62	
8473344-4	1993	In fact, point mutation of the P1" site from Ser (present in AT-III) to Ile (present in prothrombin) is sufficient to dissociate heparin-dependent thrombin and Factor Xa inhibitory activities.	Isoleucine	72-75	coagulation factor X	Homo sapiens	160-169	
3536894-4	1986	The complete prorenin sequence was then excised from the renatured hybrid protein using blood coagulation factor Xa, a proteinase which is highly specific for the tetrapeptide insert Ile-Glu-Gly-Arg introduced between the 9 amino-terminal residues of the trp E gene product and the first amino acid (Thr 1) of prorenin.	Isoleucine	183-186	coagulation factor X	Homo sapiens	106-115