PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8157690-1	1994	Tyrosines 292 and 293 in the mammalian glucose transporter GLUT1 have been substituted by either isoleucine or phenylalanine.	Isoleucine	97-107	solute carrier family 2 member 1	Homo sapiens	59-64	
9374494-1	1997	A valine-to-isoleucine mutation at amino acid residue 197 of Glut2 or the equivalent residue 165 of Glut1 has been shown to impair glucose transport activity.	Isoleucine	12-22	solute carrier family 2 member 1	Homo sapiens	100-105	
8157690-7	1994	These data indicated that the Tyr-293-->Ile substitution produced no change in the affinity for D-glucose, a relatively small enhancement in the affinity for exofacial ligands, but a large approximately 300-fold reduction in affinity for cytochalasin B, suggesting that the mutated GLUT1 is locked in an outward facing conformation.	Isoleucine	43-46	solute carrier family 2 member 1	Homo sapiens	285-290	
27464458-0	2016	Effects of isoleucine on glucose uptake through the enhancement of muscular membrane concentrations of GLUT1 and GLUT4 and intestinal membrane concentrations of Na+/glucose co-transporter 1 (SGLT-1) and GLUT2.	Isoleucine	11-21	solute carrier family 2 member 1	Homo sapiens	103-108	
27464458-2	2016	Isoleucine has been reported to participate in regulation of glucose levels in many studies; therefore, this study was designed to examine the effect of isoleucine on intestinal and muscular GLUT expressions.	Isoleucine	0-10	solute carrier family 2 member 1	Homo sapiens	191-195	
27464458-4	2016	Supplementation of isoleucine in the diet significantly increased piglet average daily gain, enhanced GLUT1 expression in red muscle and GLUT4 expression in red muscle, white muscle and intermediate muscle (P<0 05).	Isoleucine	19-29	solute carrier family 2 member 1	Homo sapiens	102-107	
27464458-10	2016	The results of this study demonstrated that isoleucine supplementation enhanced the intestinal and muscular GLUT expressions, which have important implications that suggest that isoleucine could potentially increase muscle growth and intestinal development by enhancing local glucose uptake in animals and human beings.	Isoleucine	44-54	solute carrier family 2 member 1	Homo sapiens	108-112	
24804563-5	2014	The GalP/GLUT inhibitor forskolin was added to the ILV-labelled sample inducing a pronounced chemical shift change in one Ile residue and more subtle changes in other methyl groups.	Isoleucine	122-125	solute carrier family 2 member 1	Homo sapiens	9-13	
22492876-9	2012	A trinucleotide deletion in SLC2A1, coding for the deletion of isoleucine 435 or 436 in GLUT1, was identified in the proband.	Isoleucine	63-73	solute carrier family 2 member 1	Homo sapiens	28-34	
22492876-9	2012	A trinucleotide deletion in SLC2A1, coding for the deletion of isoleucine 435 or 436 in GLUT1, was identified in the proband.	Isoleucine	63-73	solute carrier family 2 member 1	Homo sapiens	88-93	
25922070-8	2015	Two structural models of the class II glucose transporters, hSLC2A9 and hSLC2A5, based on the crystal structure of hSLC2A1 (GLUT1), reveal that Ile-335 (or the homologous Ile-296 in hSLC2A5) is a key component for protein conformational changes when the protein translocates substrates.	Isoleucine	144-147	solute carrier family 2 member 1	Homo sapiens	115-122	
25922070-8	2015	Two structural models of the class II glucose transporters, hSLC2A9 and hSLC2A5, based on the crystal structure of hSLC2A1 (GLUT1), reveal that Ile-335 (or the homologous Ile-296 in hSLC2A5) is a key component for protein conformational changes when the protein translocates substrates.	Isoleucine	144-147	solute carrier family 2 member 1	Homo sapiens	124-129	
19366592-3	2009	The functional role of Ile(287) in human GLUT1, which corresponds to Asn(331) in Hxt2, was studied by its replacement with each of the other 19 amino acids.	Isoleucine	23-26	solute carrier family 2 member 1	Homo sapiens	41-46	
19366592-8	2009	These results suggest that Ile(287) is a key residue for maintaining high glucose affinity in GLUT1 as revealed in Hxt2 and is located at or near the exofacial glucose binding site.	Isoleucine	27-30	solute carrier family 2 member 1	Homo sapiens	94-99