PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10515458-1	1999	We showed in a transient coexpression study that a single proline substitution for any of the five conserved leucine or isoleucine residues located in the envelope (Env) transmembrane protein gp41 zipper motif of the human immunodeficiency virus type 1 dominantly interferes with wild-type Env-mediated viral infectivity.	Isoleucine	120-130	endogenous retrovirus group K member 20	Homo sapiens	165-168	
21851958-3	2011	By constructing chimeric Envs and fine mapping between sensitive and resistant Env clones, we found that substitution of highly conserved isoleucine (I) with methionine (M) (ATA to ATG) at position 424 in the C4 domain conferred enhanced neutralization sensitivity of Env-pseudotyped viruses to autologous and heterologous plasma antibodies.	Isoleucine	138-148	endogenous retrovirus group K member 20	Homo sapiens	25-28	
21851958-3	2011	By constructing chimeric Envs and fine mapping between sensitive and resistant Env clones, we found that substitution of highly conserved isoleucine (I) with methionine (M) (ATA to ATG) at position 424 in the C4 domain conferred enhanced neutralization sensitivity of Env-pseudotyped viruses to autologous and heterologous plasma antibodies.	Isoleucine	138-148	endogenous retrovirus group K member 20	Homo sapiens	79-82	
15992850-9	2005	In addition, we found a correlation between side-chain beta-branching at amino acid position 166 and binding of Mab F7-299 to oligomeric Env and cell-to-cell fusion, suggesting local secondary structure constraints in the region around isoleucine-166 as one determinant of gp135 RBS exposure and antibody binding.	Isoleucine	236-246	endogenous retrovirus group K member 20	Homo sapiens	137-140	
11859090-4	2002	Analyses of additional mutants with deletions at Ile-830, Ala-836, and Ile-840 demonstrated that the Delta 830 mutant exhibited the most significant inhibitory effect on Env steady-state expression.	Isoleucine	49-52	endogenous retrovirus group K member 20	Homo sapiens	170-173	
11859090-4	2002	Analyses of additional mutants with deletions at Ile-830, Ala-836, and Ile-840 demonstrated that the Delta 830 mutant exhibited the most significant inhibitory effect on Env steady-state expression.	Isoleucine	71-74	endogenous retrovirus group K member 20	Homo sapiens	170-173	
8497069-2	1993	This highly conserved zipper motif, which consists of a heptad repeat of leucine or isoleucine residues, has been suggested to play a role in HIV-1 env glycoprotein oligomerization.	Isoleucine	84-94	endogenous retrovirus group K member 20	Homo sapiens	148-151	
30021898-3	2018	Changes in "restraining" amino acid residues, such as leucine 193 and isoleucine 423, destabilize State 1 Env, which then assumes entry-competent, downstream conformations.	Isoleucine	70-80	endogenous retrovirus group K member 20	Homo sapiens	106-109