PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17236799-1	2007	Mitochondrial acetoacetyl-CoA thiolase (T2) deficiency is an inborn error of metabolism that affects isoleucine catabolism and ketone body metabolism.	Isoleucine	101-111	acetyl-CoA acetyltransferase 1	Homo sapiens	0-38	
28875337-0	2017	Clinical and molecular analysis of 6 Chinese patients with isoleucine metabolism defects: identification of 3 novel mutations in the HSD17B10 and ACAT1 gene.	Isoleucine	59-69	acetyl-CoA acetyltransferase 1	Homo sapiens	146-151	
28875337-1	2017	Hydroxysteroid (17beta) dehydrogenase 10 (HSD10) and mitochondrial acetoacetyl-CoA thiolase (beta-KT) are two adjacent enzymes for the degradation of isoleucine, thus HSD10 and beta-KT deficiencies are confusing at an early stage because of nearly the same elevation of typical metabolites in urine, such as 2-methyl-3-hydroxybutyric acid (2M3HBA) and tiglylglycine (TG).	Isoleucine	150-160	acetyl-CoA acetyltransferase 1	Homo sapiens	53-91	
20156697-1	2010	Mitochondrial acetoacetyl-CoA thiolase (T2) deficiency is an inborn error of metabolism affecting isoleucine catabolism and ketone body utilization.	Isoleucine	98-108	acetyl-CoA acetyltransferase 1	Homo sapiens	0-38	
15128923-1	2004	Mitochondrial acetoacetyl-CoA thiolase (T2) deficiency is an inborn error of metabolism that affects the catabolism of isoleucine and ketone bodies.	Isoleucine	119-129	acetyl-CoA acetyltransferase 1	Homo sapiens	0-38	
14518824-1	2003	Mitochondrial acetoacetyl-CoA thiolase (T2) deficiency is an inborn error of metabolism affecting isoleucine and ketone bodies in the catabolic process.	Isoleucine	98-108	acetyl-CoA acetyltransferase 1	Homo sapiens	0-38	
11914035-1	2002	Mitochondrial acetoacetyl-CoA thiolase (T2) deficiency is an inborn error of ketone body and isoleucine metabolism.	Isoleucine	93-103	acetyl-CoA acetyltransferase 1	Homo sapiens	0-38	
35273875-1	2022	Beta-ketothiolase (mitochondrial acetoacetyl-CoA thiolase, T2) deficiency is a rare inborn error of metabolism that is characterized by impaired metabolism of ketones and isoleucine.	Isoleucine	171-181	acetyl-CoA acetyltransferase 1	Homo sapiens	19-57	
11161836-1	2001	Mitochondrial acetoacetyl-CoA thiolase (T2 enzyme) deficiency (MIM 203750) is an autosomal recessive disorder of isoleucine and ketone-body metabolism.	Isoleucine	113-123	acetyl-CoA acetyltransferase 1	Homo sapiens	0-38	
9001814-1	1996	Mitochondrial acetoacetyl-CoA thiolase (T2) deficiency is an inherited metabolic disorder of isoleucine and ketone body catabolism.	Isoleucine	93-103	acetyl-CoA acetyltransferase 1	Homo sapiens	0-38	
34001203-1	2021	BACKGROUND: Beta-ketothiolase deficiency (BKTD) is an autosomal recessive disorder caused by biallelic mutation of ACAT1 that affects both isoleucine catabolism and ketolysis.	Isoleucine	139-149	acetyl-CoA acetyltransferase 1	Homo sapiens	115-120	
31228515-2	2019	In addition to this activity, ACAT1 is also involved in isoleucine degradation pathway.	Isoleucine	56-66	acetyl-CoA acetyltransferase 1	Homo sapiens	30-35