PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16448747-5 2006 Our results showed that DAS administration leads to modulation of the DMBA-induced levels of p21/ras oncoprotein as early as 24h after the DMBA application, suggesting down-regulation of the p21/ras by DAS. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 70-74 Harvey rat sarcoma virus oncogene Mus musculus 93-100 16448747-0 2006 Regulation of p21/ras protein expression by diallyl sulfide in DMBA induced neoplastic changes in mouse skin. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 63-67 Harvey rat sarcoma virus oncogene Mus musculus 14-21 16448747-5 2006 Our results showed that DAS administration leads to modulation of the DMBA-induced levels of p21/ras oncoprotein as early as 24h after the DMBA application, suggesting down-regulation of the p21/ras by DAS. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 70-74 Harvey rat sarcoma virus oncogene Mus musculus 97-100 16448747-5 2006 Our results showed that DAS administration leads to modulation of the DMBA-induced levels of p21/ras oncoprotein as early as 24h after the DMBA application, suggesting down-regulation of the p21/ras by DAS. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 139-143 Harvey rat sarcoma virus oncogene Mus musculus 93-100 16448747-5 2006 Our results showed that DAS administration leads to modulation of the DMBA-induced levels of p21/ras oncoprotein as early as 24h after the DMBA application, suggesting down-regulation of the p21/ras by DAS. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 139-143 Harvey rat sarcoma virus oncogene Mus musculus 97-100 16448747-8 2006 DAS administration was also found to down regulate the DMBA-induced H-ras mRNA level in mouse skin tumors. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 55-59 Harvey rat sarcoma virus oncogene Mus musculus 68-73 16805855-2 2006 Previous studies showed that the mutation of c-Ha-ras induced by DMBA in the tumors of rasH2 were detected only in transgenes. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 65-69 Harvey rat sarcoma virus oncogene Mus musculus 45-53 16805855-3 2006 To examine if the difference between the codons of the c-Ha-ras gene in human and mouse contributed to the tissue-specific sensitivity to DMBA, we generated a line of transgenic mice, mras, carrying mouse c-Ha-ras genome with its own promoter. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 138-142 Harvey rat sarcoma virus oncogene Mus musculus 55-63 16805855-12 2006 These results indicate that the differences in the codon of the c-Ha-ras gene between mouse and human might contribute to the tissue-specific sensitivity of DMBA. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 157-161 Harvey rat sarcoma virus oncogene Mus musculus 64-72 11059761-8 2000 Collectively, these results indicate that the adenine adducts induced by both bay-region diol epoxides of DMBA lead to the mutation at codon 61 of H-ras and, consequently, initiate tumorigenesis in mouse skin. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 106-110 Harvey rat sarcoma virus oncogene Mus musculus 147-152 10928116-5 2000 The 48-hour experiment with female and male CBA/Ca inbred mice also determined the compound which effectively reduced the DMBA-induced c-myc and Ha-ras overexpressions in almost all tissues. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 122-126 Harvey rat sarcoma virus oncogene Mus musculus 145-151 10467416-3 1999 In this model, initiation, which involves mutation of H-ras induced by DMBA, can be distinguished from promotion induced by TPA, and progression to carcinoma. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 71-75 Harvey rat sarcoma virus oncogene Mus musculus 54-59 10469620-8 1999 These results show that melanocytes expressing an activated Ha-ras in the TPras transgenic mice are susceptible to induction of melanoma by DMBA. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 140-144 Harvey rat sarcoma virus oncogene Mus musculus 60-66 7627957-4 1995 Molecular analysis of these tumors revealed that the majority of papillomas (17/20) and carcinomas (9/10) showed DMBA-specific mutations (A to T transversion at the 61st codon) in the Ha-ras gene. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 113-117 Harvey rat sarcoma virus oncogene Mus musculus 184-190 18210756-6 2007 RESULTS: Coadministration of afobazole and DMBA resulted in a decrease of DMBA-induced overexpression of Ha-ras and p53. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 43-47 Harvey rat sarcoma virus oncogene Mus musculus 105-111 2118247-5 1990 Transforming H-ras genes were detected in two of 6 preneoplastic HOGs and 10 of 12 carcinomas from DMBA-treated mice. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 99-103 Harvey rat sarcoma virus oncogene Mus musculus 13-18 2118247-11 1990 The H-ras oncogene in one DMBA-treated HOG sample was activated by A to T while the second contained an A to G mutations, representative of both modes of mutational activation involved in this model of mammary tumorigenesis. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 26-30 Harvey rat sarcoma virus oncogene Mus musculus 4-9 2118247-12 1990 In summary, DMBA-induced point mutated H-ras oncogenes appear to potentiate the progression of hyperplastic outgrowths (HOG) to mammary carcinomas. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 12-16 Harvey rat sarcoma virus oncogene Mus musculus 39-44 25789788-6 2015 Importantly, Suv39h1 overexpression in mice confers resistance to a DMBA/TPA induced skin carcinogenesis protocol that is characterized by the accumulation of activating H-ras mutations. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 68-72 Harvey rat sarcoma virus oncogene Mus musculus 170-175 21827582-2 2011 DMBA mutates the Ha-ras gene, whereas TPA promotes the growth of transformed cells by activating cellular signaling molecules. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 0-4 Harvey rat sarcoma virus oncogene Mus musculus 17-23 25489104-3 2014 Here we report that mice lacking DUSP5 show a greatly increased sensitivity to mutant Harvey-Ras (HRas(Q61L))-driven papilloma formation in the 7,12-Dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate (DMBA/TPA) model of skin carcinogenesis. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 213-217 Harvey rat sarcoma virus oncogene Mus musculus 86-96 18210756-6 2007 RESULTS: Coadministration of afobazole and DMBA resulted in a decrease of DMBA-induced overexpression of Ha-ras and p53. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 74-78 Harvey rat sarcoma virus oncogene Mus musculus 105-111