PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12908908-9	2003	At the transcriptional level, DMBA induced the CYP1 enzyme expressions by stimulating the xenobiotic response element (XRE)-dependent transactivation pathway.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	30-34	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	47-51	
28103884-11	2017	Mechanistically, Induction of AhR/CYP1A1 by TCDD and DMBA was associated with significant increase in beta-Catenin mRNA and protein expression, nuclear translocation and its downstream target Cyclin D1, whereas AhR or CYP1A1 knockdown using shRNA dramatically inhibited beta-Catenin cellular content and nuclear translocation.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	53-57	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	34-40	
28103884-11	2017	Mechanistically, Induction of AhR/CYP1A1 by TCDD and DMBA was associated with significant increase in beta-Catenin mRNA and protein expression, nuclear translocation and its downstream target Cyclin D1, whereas AhR or CYP1A1 knockdown using shRNA dramatically inhibited beta-Catenin cellular content and nuclear translocation.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	53-57	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	218-224	
16307765-6	2006	CYP1A1 and 1B1 are enzymes that catalyze the biotransformation of dimethylbenz[a]anthracene (DMBA).	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	66-91	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-14	
16307765-6	2006	CYP1A1 and 1B1 are enzymes that catalyze the biotransformation of dimethylbenz[a]anthracene (DMBA).	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	93-97	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-14	
28103884-9	2017	Activation of AhR/CYP1A1 in MCF-7 cells by TCDD and DMBA, strong AhR activators, significantly increased CSC-specific markers, mammosphere formation, aldehyde dehydrogenase (ALDH) activity, and percentage of side population (SP) cells, whereas inactivation of AhR/CYP1A1 using chemical inhibitor, alpha-naphthoflavone (alpha-NF), or by genetic shRNA knockdown, significantly inhibited the upregulation of ALDH activity and SP cells.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	52-56	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	18-24	
28103884-9	2017	Activation of AhR/CYP1A1 in MCF-7 cells by TCDD and DMBA, strong AhR activators, significantly increased CSC-specific markers, mammosphere formation, aldehyde dehydrogenase (ALDH) activity, and percentage of side population (SP) cells, whereas inactivation of AhR/CYP1A1 using chemical inhibitor, alpha-naphthoflavone (alpha-NF), or by genetic shRNA knockdown, significantly inhibited the upregulation of ALDH activity and SP cells.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	52-56	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	264-270	
12908908-4	2003	DMBA is metabolized into a DNA-attacking moiety by two phase I cytochrome P450 (CYP) enzymes CYP1A1 and CYP1B1.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	0-4	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	93-99	
12908908-10	2003	When genistein (25 micromol/l) was co-administered with DMBA, the XRE-Luc activity the CYP1 mRNA abundances were significantly suppressed.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	56-60	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	87-91	
11076701-10	2000	This suggests that the metabolic activation and covalent binding of (3)H-Trp-P-1 and (3)H-DMBA in HUVEC are most likely mediated by CYP1A1.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	90-94	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	132-138	
12844379-2	2003	The soyabean isoflavone genistein was demonstrated earlier in our laboratory to be an effective inhibitor of dimethylbenz[a]anthracene (DMBA)-induced DNA damage in MCF-7 cells by curbing cytochrome P450 (CYP) 1 enzymes.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	136-140	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	187-210	
12118336-6	2002	When exposed to DMBA or 2,3,7,8-tetrachlorodibenzo-p-dioxin, the resistant cell lines have a diminished capacity to carry out ethoxyresorufin-O-deethylation, indicating that the induction of cytochrome P450 1A1 (CYP1A1) enzyme is impaired.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	16-20	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	191-210	
12118336-6	2002	When exposed to DMBA or 2,3,7,8-tetrachlorodibenzo-p-dioxin, the resistant cell lines have a diminished capacity to carry out ethoxyresorufin-O-deethylation, indicating that the induction of cytochrome P450 1A1 (CYP1A1) enzyme is impaired.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	16-20	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	212-218	
7756127-3	1995	This study has shown that the expression of CYP1A1 and UGT is concomitantly induced by 3-methylcholanthrene, dimethylbenz[a]anthracene, and RA, and that of NADPH reductase is only enhanced by phenobarbital and RA.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	109-134	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	44-50	
10357772-8	1999	Based on activities of recombinant enzyme and expression levels, differences in 7,2-dimethylbenz [a]anthracene (DMBA) metabolism between the cell lines were consistent with differences in CYP1A1 and CYP1B1 expression.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	112-116	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	188-194	
7756127-5	1995	Using the reverse transcriptase-polymerase chain reaction, we have demonstrated that the effects of 3-methylcholanthrene, dimethylbenz[a]anthracene and RA on CYP1A1 expression correlate with an increase of CYP1A1 mRNA level.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	122-147	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	158-164	
7756127-5	1995	Using the reverse transcriptase-polymerase chain reaction, we have demonstrated that the effects of 3-methylcholanthrene, dimethylbenz[a]anthracene and RA on CYP1A1 expression correlate with an increase of CYP1A1 mRNA level.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	122-147	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	206-212