PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21781835-3	1997	Using dimethylbenz(a)anthracene (DMBA) as a prototype, studies from this laboratory have found that genetic polymorphisms, at the Ah receptor locus, the major histocompatibility complex and the Lps locus, control the magnitude of the cell-mediated immune response to these carcinogenic compounds.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	33-37	aryl-hydrocarbon receptor	Mus musculus	130-141	
19393233-5	2009	Feeding of this synthetic coumarin induced positive modulations in expression of all biomarkers in DMBA administered mice, giving clues on its possible signaling pathway(s) - primarily through down-regulation of Aryl hydrocarbon receptor and PCNA and up-regulation of apoptotic proteins like Bax, Bad, Cytochrome c, Apaf, Caspase-3 and Caspase-9, resulting in an appreciable reduction in growth of papilloma in mice.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	99-103	aryl-hydrocarbon receptor	Mus musculus	212-237	
10570060-1	1999	We previously demonstrated that murine bone marrow stromal cells express high levels of cytochrome P4501B1 (CYP1B1) that metabolizes 7,12-dimethylbenza[a]anthracene (DMBA), and that DMBA activates the Ah receptor (AhR) in these cells in vitro.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	166-170	aryl-hydrocarbon receptor	Mus musculus	201-212	
10570060-1	1999	We previously demonstrated that murine bone marrow stromal cells express high levels of cytochrome P4501B1 (CYP1B1) that metabolizes 7,12-dimethylbenza[a]anthracene (DMBA), and that DMBA activates the Ah receptor (AhR) in these cells in vitro.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	166-170	aryl-hydrocarbon receptor	Mus musculus	214-217	
10570060-1	1999	We previously demonstrated that murine bone marrow stromal cells express high levels of cytochrome P4501B1 (CYP1B1) that metabolizes 7,12-dimethylbenza[a]anthracene (DMBA), and that DMBA activates the Ah receptor (AhR) in these cells in vitro.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	182-186	aryl-hydrocarbon receptor	Mus musculus	201-212	
10570060-1	1999	We previously demonstrated that murine bone marrow stromal cells express high levels of cytochrome P4501B1 (CYP1B1) that metabolizes 7,12-dimethylbenza[a]anthracene (DMBA), and that DMBA activates the Ah receptor (AhR) in these cells in vitro.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	182-186	aryl-hydrocarbon receptor	Mus musculus	214-217	
10570060-7	1999	DMBA caused apoptosis when cocultured with primary bone marrow stromal cells isolated from AhR-null mice but not CYP1B1-null mice.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	0-4	aryl-hydrocarbon receptor	Mus musculus	91-94	
10570060-8	1999	When cocultured with AhR-null primary bone marrow stromal cells, DMBA induced approximately 50% of the pre-B-cell apoptosis seen with stromal cells from AhR-heterozygous mice.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	65-69	aryl-hydrocarbon receptor	Mus musculus	21-24	
14613719-3	2003	Wild-type (AhR(b)) mice treated with DMBA for 48 h exhibit a large loss in BM cellularity and disruption of marrow structure that is not seen for BP treatment.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	37-41	aryl-hydrocarbon receptor	Mus musculus	11-14	
14613719-4	2003	In congenic mice with a low affinity AhR (AhR(d)), DMBA and BP are equally toxic to the BM whereas AhR(d) x CYP1B1-null mice are fully protected.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	51-55	aryl-hydrocarbon receptor	Mus musculus	37-40	
14613719-4	2003	In congenic mice with a low affinity AhR (AhR(d)), DMBA and BP are equally toxic to the BM whereas AhR(d) x CYP1B1-null mice are fully protected.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	51-55	aryl-hydrocarbon receptor	Mus musculus	42-48	
10570060-8	1999	When cocultured with AhR-null primary bone marrow stromal cells, DMBA induced approximately 50% of the pre-B-cell apoptosis seen with stromal cells from AhR-heterozygous mice.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	65-69	aryl-hydrocarbon receptor	Mus musculus	153-156	
12369593-2	1994	We also determined the intrinsic features of DMBA as an aryl hydrocarbon hydroxylase (AHH) inducer through either its binding ability to Ah receptor or its inducing effects on benzo(a)pyrene (BP) hydroxylase or DMBA hydroxylase.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	45-49	aryl-hydrocarbon receptor	Mus musculus	137-148	
12369593-3	1994	DMBA is a poor ligand of the Ah receptor (26-fold and 4.3-fold weaker than 3-methylcholanthrene and BP respectively) and a very weak AHH inducer (ten million-fold weaker than TCDD).	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	0-4	aryl-hydrocarbon receptor	Mus musculus	29-40	
20619141-9	2010	CONCLUSION: Since AhR is known to be ligand-activated by DMBA to release signals for several downstream proteins initiating reactive oxygen species generation, the down-regulation of AhR by scopoletin appeared to play a significant role in subsequent down-regulation of some key signal proteins.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	57-61	aryl-hydrocarbon receptor	Mus musculus	18-21