PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9468621-5 1997 It has been reported in particular that expression of the human MDR3 and mouse mdr2 genes promote translocation of long chain phosphatidylcholine, while expression of the MDR1 gene stimulates the outward motion of phospholipids possessing at least one short chain. Phosphatidylcholines 126-145 ATP binding cassette subfamily B member 4 Homo sapiens 64-68 10448079-0 1999 Transport of phosphatidylcholine in MDR3-negative epithelial cell lines via drug-induced MDR1 P-glycoprotein. Phosphatidylcholines 13-32 ATP binding cassette subfamily B member 4 Homo sapiens 36-40 10448079-2 1999 We have examined a role for MDR1 P-gp in phosphatidylcholine transport in MDR3-negative epithelial cells that have been induced to express the MDR1 P-gp by exposure to cytotoxics. Phosphatidylcholines 41-60 ATP binding cassette subfamily B member 4 Homo sapiens 74-78 9551426-4 1998 MDR2 Pgp is exclusively a phosphatidylcholine translocase. Phosphatidylcholines 26-45 ATP binding cassette subfamily B member 4 Homo sapiens 0-4 9155155-4 1997 The other subclass, MDR3, which does not show the multidrug resistance, translocates phosphatidyl choline selectively into the outer leaflet of the liver canalicular membrane, and may protect the liver from the detergent effect of bile acids. Phosphatidylcholines 85-105 ATP binding cassette subfamily B member 4 Homo sapiens 20-24 34385322-0 2021 Structures of ABCB4 provide insight into phosphatidylcholine translocation. Phosphatidylcholines 41-60 ATP binding cassette subfamily B member 4 Homo sapiens 14-19 8898203-0 1996 MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Phosphatidylcholines 117-136 ATP binding cassette subfamily B member 4 Homo sapiens 71-75 8898203-2 1996 The homologous MDR3 Pgp is required for phosphatidylcholine secretion into bile. Phosphatidylcholines 40-59 ATP binding cassette subfamily B member 4 Homo sapiens 15-19 8898203-6 1996 MDR3 cells exclusively released a short-chain phosphatidylcholine. Phosphatidylcholines 46-65 ATP binding cassette subfamily B member 4 Homo sapiens 0-4 34107287-1 2021 ABCB4 is described as an ATP-binding cassette (ABC) transporter that primarily transports lipids of the phosphatidylcholine (PC) family but is also capable of translocating a subset of typical multidrug-resistance-associated drugs. Phosphatidylcholines 104-123 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 34107287-1 2021 ABCB4 is described as an ATP-binding cassette (ABC) transporter that primarily transports lipids of the phosphatidylcholine (PC) family but is also capable of translocating a subset of typical multidrug-resistance-associated drugs. Phosphatidylcholines 125-127 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 34385322-1 2021 ABCB4 is expressed in hepatocytes and translocates phosphatidylcholine into bile canaliculi. Phosphatidylcholines 51-70 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 34385322-6 2021 Its choline moiety is stabilized by cation-pi interactions with an essential tryptophan residue, rationalizing the specificity of ABCB4 for phosphatidylcholine. Phosphatidylcholines 140-159 ATP binding cassette subfamily B member 4 Homo sapiens 130-135 34385322-8 2021 Using a proteoliposome-based translocation assay with fluorescently labeled phosphatidylcholine analogs, we recapitulated the substrate specificity of ABCB4 in vitro and confirmed the role of the key tryptophan residue. Phosphatidylcholines 76-95 ATP binding cassette subfamily B member 4 Homo sapiens 151-156 34209301-1 2021 ABCB4 (ATP-binding cassette subfamily B member 4) is an ABC transporter expressed at the canalicular membrane of hepatocytes where it ensures phosphatidylcholine secretion into bile. Phosphatidylcholines 142-161 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 34209301-1 2021 ABCB4 (ATP-binding cassette subfamily B member 4) is an ABC transporter expressed at the canalicular membrane of hepatocytes where it ensures phosphatidylcholine secretion into bile. Phosphatidylcholines 142-161 ATP binding cassette subfamily B member 4 Homo sapiens 7-48 34209301-6 2021 Our results indicate that the overexpression of wild type RAB10 or its dominant-active mutant significantly increases the amount of ABCB4 at the plasma membrane expression and its phosphatidylcholine floppase function. Phosphatidylcholines 180-199 ATP binding cassette subfamily B member 4 Homo sapiens 132-137 34209301-8 2021 Taken together, our findings suggest that RAB10 regulates the plasma membrane targeting of ABCB4 and consequently its capacity to mediate phosphatidylcholine secretion. Phosphatidylcholines 138-157 ATP binding cassette subfamily B member 4 Homo sapiens 91-96 33672718-2 2021 Among these transporters, ABCB11 secretes bile acids, ABCB4 translocates phosphatidylcholine and ABCG5/G8 is responsible for cholesterol secretion, while ABCB1 and ABCC2 transport a variety of drugs and other compounds. Phosphatidylcholines 73-92 ATP binding cassette subfamily B member 4 Homo sapiens 54-59 35203270-1 2022 ABCB4, is an adenosine triphosphate-binding cassette (ABC) transporter localized at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine secretion into bile. Phosphatidylcholines 143-162 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 34022183-1 2021 ABCB4, also called multidrug resistant protein 3 (MDR3), is an ATP binding cassette transporter located in the canalicular membrane of hepatocytes that specifically translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 178-197 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 34022183-1 2021 ABCB4, also called multidrug resistant protein 3 (MDR3), is an ATP binding cassette transporter located in the canalicular membrane of hepatocytes that specifically translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 178-197 ATP binding cassette subfamily B member 4 Homo sapiens 19-48 34022183-1 2021 ABCB4, also called multidrug resistant protein 3 (MDR3), is an ATP binding cassette transporter located in the canalicular membrane of hepatocytes that specifically translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 178-197 ATP binding cassette subfamily B member 4 Homo sapiens 50-54 34022183-1 2021 ABCB4, also called multidrug resistant protein 3 (MDR3), is an ATP binding cassette transporter located in the canalicular membrane of hepatocytes that specifically translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 199-201 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 34022183-1 2021 ABCB4, also called multidrug resistant protein 3 (MDR3), is an ATP binding cassette transporter located in the canalicular membrane of hepatocytes that specifically translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 199-201 ATP binding cassette subfamily B member 4 Homo sapiens 19-48 34022183-1 2021 ABCB4, also called multidrug resistant protein 3 (MDR3), is an ATP binding cassette transporter located in the canalicular membrane of hepatocytes that specifically translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 199-201 ATP binding cassette subfamily B member 4 Homo sapiens 50-54 33383947-2 2020 Six types have been reported, two of these are caused by deficiency of an ABC transporter; ABCB11 (bile salt export pump) in type 2; ABCB4 (phosphatidylcholine floppase) in type 3. Phosphatidylcholines 140-159 ATP binding cassette subfamily B member 4 Homo sapiens 133-138 33256620-2 2020 This gene encodes multidrug resistance protein-3 (MDR3) that acts as a hepatocanalicular floppase that transports phosphatidylcholine from the inner to the outer canalicular membrane. Phosphatidylcholines 114-133 ATP binding cassette subfamily B member 4 Homo sapiens 18-48 32917728-0 2020 Stimulation of the ATPase activity of MDR3/ABCB4 requires an intact phosphatidylcholine lipid. Phosphatidylcholines 68-87 ATP binding cassette subfamily B member 4 Homo sapiens 38-42 32917728-0 2020 Stimulation of the ATPase activity of MDR3/ABCB4 requires an intact phosphatidylcholine lipid. Phosphatidylcholines 68-87 ATP binding cassette subfamily B member 4 Homo sapiens 43-48 32917728-1 2020 ABCB4/MDR3 is located in the canalicular membrane of hepatocytes and translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 82-101 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 32917728-1 2020 ABCB4/MDR3 is located in the canalicular membrane of hepatocytes and translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 82-101 ATP binding cassette subfamily B member 4 Homo sapiens 6-10 32917728-1 2020 ABCB4/MDR3 is located in the canalicular membrane of hepatocytes and translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 103-105 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 32917728-1 2020 ABCB4/MDR3 is located in the canalicular membrane of hepatocytes and translocates phosphatidylcholine (PC) lipids from the cytoplasmic to the extracellular leaflet. Phosphatidylcholines 103-105 ATP binding cassette subfamily B member 4 Homo sapiens 6-10 33256620-2 2020 This gene encodes multidrug resistance protein-3 (MDR3) that acts as a hepatocanalicular floppase that transports phosphatidylcholine from the inner to the outer canalicular membrane. Phosphatidylcholines 114-133 ATP binding cassette subfamily B member 4 Homo sapiens 50-54 31873305-1 2020 ABCB4 is an ATP-binding cassette transporter that extrudes phosphatidylcholine into the bile canaliculi of the liver. Phosphatidylcholines 59-78 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 31886153-2 2019 ABCB11, the bile salt efflux pump of hepatocytes, coordinates cellular excretion of numerous conjugated bile salts into the bile canaliculi, whereas ABCB4 acts as an ATP-dependent floppase translocating phosphatidylcholine from the inner to the outer leaflet of the bile canalicular membrane. Phosphatidylcholines 203-222 ATP binding cassette subfamily B member 4 Homo sapiens 149-154 31176036-3 2019 In this study, we assessed the effects of taurine- or glycine-conjugated cholate, ursodeoxycholate and hyodeoxycholate on the ABCB4-mediated phosphatidylcholine (PC) efflux using Abcb4 knockout mice and HEK293 cells stably expressing ABCB4. Phosphatidylcholines 141-160 ATP binding cassette subfamily B member 4 Homo sapiens 234-239 31176036-7 2019 We also showed that the PC efflux from ABCB4-expressing HEK293 cells was stimulated by taurohyodeoxycholate much more strongly than the other tested bile salts. Phosphatidylcholines 24-26 ATP binding cassette subfamily B member 4 Homo sapiens 39-44 31176036-10 2019 Therefore, the enhancing effect of taurohyodeoxycholate on the ABCB4-mediated PC efflux may be due to the strong mixed micelle formation ability. Phosphatidylcholines 78-80 ATP binding cassette subfamily B member 4 Homo sapiens 63-68 31176036-3 2019 In this study, we assessed the effects of taurine- or glycine-conjugated cholate, ursodeoxycholate and hyodeoxycholate on the ABCB4-mediated phosphatidylcholine (PC) efflux using Abcb4 knockout mice and HEK293 cells stably expressing ABCB4. Phosphatidylcholines 162-164 ATP binding cassette subfamily B member 4 Homo sapiens 234-239 27112167-7 2016 The antifungal azoles, posaconazole, itraconazole, and ketoconazole, significantly inhibited MDR3-mediated phosphatidylcholine secretion. Phosphatidylcholines 107-126 ATP binding cassette subfamily B member 4 Homo sapiens 93-97 30730833-3 2019 Among these transporters, ABCB4 is essential for the translocation of phosphatidylcholine (PC) lipids from the inner to the outer leaflet of the canalicular membrane of hepatocytes. Phosphatidylcholines 70-89 ATP binding cassette subfamily B member 4 Homo sapiens 26-31 30730833-3 2019 Among these transporters, ABCB4 is essential for the translocation of phosphatidylcholine (PC) lipids from the inner to the outer leaflet of the canalicular membrane of hepatocytes. Phosphatidylcholines 91-93 ATP binding cassette subfamily B member 4 Homo sapiens 26-31 30730833-4 2019 ABCB4 deficiency can result in altered PC to bile salt ratios, which led to intrahepatic cholestasis of pregnancy, low phospholipid associated cholelithiasis, drug induced liver injury or even progressive familial intrahepatic cholestasis type 3. Phosphatidylcholines 39-41 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 30222019-2 2019 MDR3 mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte into bile. Phosphatidylcholines 35-54 ATP binding cassette subfamily B member 4 Homo sapiens 0-4 31040306-1 2019 Adenosine triphosphate binding cassette transporter, subfamily B member 4 (ABCB4) is the transporter of phosphatidylcholine at the canalicular membrane of hepatocytes. Phosphatidylcholines 104-123 ATP binding cassette subfamily B member 4 Homo sapiens 75-80 28127842-2 2017 MDR3 mediates the translocation of phosphatidylcholine into bile. Phosphatidylcholines 35-54 ATP binding cassette subfamily B member 4 Homo sapiens 0-4 31538486-3 2019 ABCB4 encodes for a phospholipid translocator at the canalicular membrane of the hepatocyte, which "flops" phosphatidylcholine into bile. Phosphatidylcholines 107-126 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 30357767-1 2018 ATP-binding cassette subfamily B member 4 (ABCB4) is a phospholipid translocator at the canalicular membrane of the hepatocyte, which "flops" phosphatidylcholine into bile. Phosphatidylcholines 142-161 ATP binding cassette subfamily B member 4 Homo sapiens 0-41 30357767-1 2018 ATP-binding cassette subfamily B member 4 (ABCB4) is a phospholipid translocator at the canalicular membrane of the hepatocyte, which "flops" phosphatidylcholine into bile. Phosphatidylcholines 142-161 ATP binding cassette subfamily B member 4 Homo sapiens 43-48 29635711-6 2018 A smaller group of patients might develop gallstones primarily due low phosphatidylcholine concentrations in bile as a result of loss-of-function mutations of the ABCB4 transporter (low phospholipid-associated cholelithiasis syndrome). Phosphatidylcholines 71-90 ATP binding cassette subfamily B member 4 Homo sapiens 163-168 28220208-6 2017 ABCB4 flops phosphatidylcholine into the outer leaflet of the membrane to be extracted by bile salts in the canalicular space. Phosphatidylcholines 12-31 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 28012258-1 2017 ABCB4 (MDR3) is an adenosine triphosphate (ATP)-binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine (PC) secretion. Phosphatidylcholines 155-174 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 28012258-1 2017 ABCB4 (MDR3) is an adenosine triphosphate (ATP)-binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine (PC) secretion. Phosphatidylcholines 155-174 ATP binding cassette subfamily B member 4 Homo sapiens 7-11 28012258-1 2017 ABCB4 (MDR3) is an adenosine triphosphate (ATP)-binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine (PC) secretion. Phosphatidylcholines 176-178 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 28012258-1 2017 ABCB4 (MDR3) is an adenosine triphosphate (ATP)-binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine (PC) secretion. Phosphatidylcholines 176-178 ATP binding cassette subfamily B member 4 Homo sapiens 7-11 27256251-1 2016 Multidrug resistance 3 (MDR3), encoded by the ATP-binding cassette, subfamily B, member 4 gene (ABCB4), localizes to the canalicular membrane of hepatocytes and translocates phosphatidylcholine from the inner leaflet to the outer leaflet of the canalicular membrane. Phosphatidylcholines 174-193 ATP binding cassette subfamily B member 4 Homo sapiens 0-22 27256251-1 2016 Multidrug resistance 3 (MDR3), encoded by the ATP-binding cassette, subfamily B, member 4 gene (ABCB4), localizes to the canalicular membrane of hepatocytes and translocates phosphatidylcholine from the inner leaflet to the outer leaflet of the canalicular membrane. Phosphatidylcholines 174-193 ATP binding cassette subfamily B member 4 Homo sapiens 24-28 27256251-1 2016 Multidrug resistance 3 (MDR3), encoded by the ATP-binding cassette, subfamily B, member 4 gene (ABCB4), localizes to the canalicular membrane of hepatocytes and translocates phosphatidylcholine from the inner leaflet to the outer leaflet of the canalicular membrane. Phosphatidylcholines 174-193 ATP binding cassette subfamily B member 4 Homo sapiens 46-89 27256251-1 2016 Multidrug resistance 3 (MDR3), encoded by the ATP-binding cassette, subfamily B, member 4 gene (ABCB4), localizes to the canalicular membrane of hepatocytes and translocates phosphatidylcholine from the inner leaflet to the outer leaflet of the canalicular membrane. Phosphatidylcholines 174-193 ATP binding cassette subfamily B member 4 Homo sapiens 96-101 26153658-1 2016 BACKGROUND & AIMS: Monoallelic defects in ABCB4, which encodes the canalicular floppase for phosphatidylcholine MDR3, have been encountered in association with a variety of hepatobiliary disorders, particularly in adult subjects. Phosphatidylcholines 96-115 ATP binding cassette subfamily B member 4 Homo sapiens 46-51 26900700-1 2016 Multidrug resistance protein 3 (MDR3, ABCB4) is a hepatocellular membrane protein that mediates biliary secretion of phosphatidylcholine. Phosphatidylcholines 117-136 ATP binding cassette subfamily B member 4 Homo sapiens 0-30 26900700-1 2016 Multidrug resistance protein 3 (MDR3, ABCB4) is a hepatocellular membrane protein that mediates biliary secretion of phosphatidylcholine. Phosphatidylcholines 117-136 ATP binding cassette subfamily B member 4 Homo sapiens 32-36 26900700-1 2016 Multidrug resistance protein 3 (MDR3, ABCB4) is a hepatocellular membrane protein that mediates biliary secretion of phosphatidylcholine. Phosphatidylcholines 117-136 ATP binding cassette subfamily B member 4 Homo sapiens 38-43 26153658-1 2016 BACKGROUND & AIMS: Monoallelic defects in ABCB4, which encodes the canalicular floppase for phosphatidylcholine MDR3, have been encountered in association with a variety of hepatobiliary disorders, particularly in adult subjects. Phosphatidylcholines 96-115 ATP binding cassette subfamily B member 4 Homo sapiens 116-120 26153658-10 2016 Phosphatidylcholine efflux activity was decreased to 56-18% of reference levels for MDR3 mutants T175A, A250T and S320F. Phosphatidylcholines 0-19 ATP binding cassette subfamily B member 4 Homo sapiens 84-88 26256905-1 2015 INTRODUCTION: Progressive familial intrahepatic cholestasis type 3 (PFIC-3) is a severe liver disorder associated with inherited dysfunction of multidrug resistance protein 3 (MDR3/ABCB4), which functions as a phospholipid floppase, translocating phosphatidylcholine from the inner to the outer hemileaflet of the canalicular membrane of hepatocytes. Phosphatidylcholines 247-266 ATP binding cassette subfamily B member 4 Homo sapiens 144-174 26789121-1 2016 ABCB4/MDR3, a member of the ABC superfamily, is an ATP-dependent phosphatidylcholine translocator expressed at the canalicular membrane of hepatocytes. Phosphatidylcholines 65-84 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 26789121-1 2016 ABCB4/MDR3, a member of the ABC superfamily, is an ATP-dependent phosphatidylcholine translocator expressed at the canalicular membrane of hepatocytes. Phosphatidylcholines 65-84 ATP binding cassette subfamily B member 4 Homo sapiens 6-10 26256905-1 2015 INTRODUCTION: Progressive familial intrahepatic cholestasis type 3 (PFIC-3) is a severe liver disorder associated with inherited dysfunction of multidrug resistance protein 3 (MDR3/ABCB4), which functions as a phospholipid floppase, translocating phosphatidylcholine from the inner to the outer hemileaflet of the canalicular membrane of hepatocytes. Phosphatidylcholines 247-266 ATP binding cassette subfamily B member 4 Homo sapiens 176-180 26256905-1 2015 INTRODUCTION: Progressive familial intrahepatic cholestasis type 3 (PFIC-3) is a severe liver disorder associated with inherited dysfunction of multidrug resistance protein 3 (MDR3/ABCB4), which functions as a phospholipid floppase, translocating phosphatidylcholine from the inner to the outer hemileaflet of the canalicular membrane of hepatocytes. Phosphatidylcholines 247-266 ATP binding cassette subfamily B member 4 Homo sapiens 181-186 24620780-8 2015 The levels of expression of genes associated with choline uptake (OCT1 and CTL1), phosphatidylcholine synthesis (PEMT and BHMT), and phosphatidylcholine transport (MDR3) were significantly upregulated in PBC compared with control livers. Phosphatidylcholines 82-101 ATP binding cassette subfamily B member 4 Homo sapiens 164-168 25601960-0 2015 ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner. Phosphatidylcholines 14-33 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 25601960-1 2015 ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile. Phosphatidylcholines 91-110 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 25601960-1 2015 ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile. Phosphatidylcholines 112-114 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 25601960-7 2015 ABCB4 must have evolved to exert its maximum activity in the SM-rich membrane environment of the canalicular membrane, where it transports PC as the physiological substrate. Phosphatidylcholines 139-141 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 24620780-8 2015 The levels of expression of genes associated with choline uptake (OCT1 and CTL1), phosphatidylcholine synthesis (PEMT and BHMT), and phosphatidylcholine transport (MDR3) were significantly upregulated in PBC compared with control livers. Phosphatidylcholines 133-152 ATP binding cassette subfamily B member 4 Homo sapiens 164-168 25533467-5 2015 The ATPase activity of wild type MDR3 was stimulated 2-fold by liver PC or 1,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine lipids. Phosphatidylcholines 69-71 ATP binding cassette subfamily B member 4 Homo sapiens 33-37 25173835-7 2015 An immunohistochemical examination revealed significantly worse disease-free and overall survival rates in patients with MDR3-negative HCC, in which the intratumoral accumulation of some phosphatidylcholine species was observed under imaging mass spectrometry. Phosphatidylcholines 187-206 ATP binding cassette subfamily B member 4 Homo sapiens 121-125 24806754-1 2014 UNLABELLED: ABCB4 flops phosphatidylcholine into the bile canaliculus to protect the biliary tree from the detergent activity of bile salts. Phosphatidylcholines 24-43 ATP binding cassette subfamily B member 4 Homo sapiens 12-17 24045840-1 2014 The ABCB4 gene encodes for MDR3, a protein that translocates phosphatidylcholine from the inner to the outer leaflet of the hepatocanalicular membrane; its deficiency favors the formation of "toxic bile". Phosphatidylcholines 61-80 ATP binding cassette subfamily B member 4 Homo sapiens 4-9 24045840-1 2014 The ABCB4 gene encodes for MDR3, a protein that translocates phosphatidylcholine from the inner to the outer leaflet of the hepatocanalicular membrane; its deficiency favors the formation of "toxic bile". Phosphatidylcholines 61-80 ATP binding cassette subfamily B member 4 Homo sapiens 27-31 24594635-1 2015 OBJECTIVE: Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a potentially lethal autosomal recessive liver disease associated with mutations in ABCB4, the gene encoding the canalicular translocator of phosphatidylcholine MDR3. Phosphatidylcholines 216-235 ATP binding cassette subfamily B member 4 Homo sapiens 159-164 24594635-5 2015 ABCB4 missense mutations were phenotyped in vitro by assessing their effects on MDR3 expression, subcellular localisation, and phosphatidylcholine-translocating activity. Phosphatidylcholines 127-146 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 24594635-9 2015 Phosphatidylcholine efflux assays indicated that T201M, P479L, S978P and E1118K mutations impaired MDR3 activity to variable degrees. Phosphatidylcholines 0-19 ATP binding cassette subfamily B member 4 Homo sapiens 99-103 25544413-1 2014 ABCB4 encodes MDR3 protein, involved in biliary phosphatidylcholine excretion.Higher prevalence in women, biliary symptoms in young adults and ursodesoxycholic acid (UDCA) response are the main features. Phosphatidylcholines 48-67 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 25544413-1 2014 ABCB4 encodes MDR3 protein, involved in biliary phosphatidylcholine excretion.Higher prevalence in women, biliary symptoms in young adults and ursodesoxycholic acid (UDCA) response are the main features. Phosphatidylcholines 48-67 ATP binding cassette subfamily B member 4 Homo sapiens 14-18 24953525-1 2014 Adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4), also called multidrug resistance 3 (MDR3), is a member of the ATP-binding cassette transporter superfamily, which is localized at the canalicular membrane of hepatocytes, and mediates the translocation of phosphatidylcholine into bile. Phosphatidylcholines 284-303 ATP binding cassette subfamily B member 4 Homo sapiens 0-69 24953525-1 2014 Adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4), also called multidrug resistance 3 (MDR3), is a member of the ATP-binding cassette transporter superfamily, which is localized at the canalicular membrane of hepatocytes, and mediates the translocation of phosphatidylcholine into bile. Phosphatidylcholines 284-303 ATP binding cassette subfamily B member 4 Homo sapiens 71-76 24953525-1 2014 Adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4), also called multidrug resistance 3 (MDR3), is a member of the ATP-binding cassette transporter superfamily, which is localized at the canalicular membrane of hepatocytes, and mediates the translocation of phosphatidylcholine into bile. Phosphatidylcholines 284-303 ATP binding cassette subfamily B member 4 Homo sapiens 91-113 24953525-1 2014 Adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4), also called multidrug resistance 3 (MDR3), is a member of the ATP-binding cassette transporter superfamily, which is localized at the canalicular membrane of hepatocytes, and mediates the translocation of phosphatidylcholine into bile. Phosphatidylcholines 284-303 ATP binding cassette subfamily B member 4 Homo sapiens 115-119 24723470-1 2014 UNLABELLED: The ABCB4 transporter mediates phosphatidylcholine (PC) secretion at the canalicular membrane of hepatocytes and its genetic defects cause biliary diseases. Phosphatidylcholines 43-62 ATP binding cassette subfamily B member 4 Homo sapiens 16-21 24723470-1 2014 UNLABELLED: The ABCB4 transporter mediates phosphatidylcholine (PC) secretion at the canalicular membrane of hepatocytes and its genetic defects cause biliary diseases. Phosphatidylcholines 64-66 ATP binding cassette subfamily B member 4 Homo sapiens 16-21 24723470-10 2014 ABCB4-mediated PC secretion was also increased by pharmacological activation of protein kinases A or C and decreased by inhibition of these kinases. Phosphatidylcholines 15-17 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 24723470-12 2014 CONCLUSION: We identified disease-associated variants of ABCB4 involved in the phosphorylation of its N-terminal domain and leading to decreased PC secretion. Phosphatidylcholines 145-147 ATP binding cassette subfamily B member 4 Homo sapiens 57-62 24122873-1 2014 UNLABELLED: Multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 (MDR3/ABCB4) is a critical determinant of biliary phosphatidylcholine (PC) secretion. Phosphatidylcholines 139-158 ATP binding cassette subfamily B member 4 Homo sapiens 90-94 24122873-1 2014 UNLABELLED: Multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 (MDR3/ABCB4) is a critical determinant of biliary phosphatidylcholine (PC) secretion. Phosphatidylcholines 139-158 ATP binding cassette subfamily B member 4 Homo sapiens 95-100 24122873-1 2014 UNLABELLED: Multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 (MDR3/ABCB4) is a critical determinant of biliary phosphatidylcholine (PC) secretion. Phosphatidylcholines 160-162 ATP binding cassette subfamily B member 4 Homo sapiens 90-94 24122873-1 2014 UNLABELLED: Multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 (MDR3/ABCB4) is a critical determinant of biliary phosphatidylcholine (PC) secretion. Phosphatidylcholines 160-162 ATP binding cassette subfamily B member 4 Homo sapiens 95-100 25133187-6 2014 In the presence of bile salts, ABCB4 located in nonraft membranes mediates the efflux of phospholipids, preferentially phosphatidylcholine. Phosphatidylcholines 119-138 ATP binding cassette subfamily B member 4 Homo sapiens 31-36 23141892-2 2012 It is caused by a mutation of the gene ABCB4, which encodes the canalicular protein ABCB4/MDR3, a flippase that plays an essential role in the secretion of phosphatidylcholine into bile. Phosphatidylcholines 156-175 ATP binding cassette subfamily B member 4 Homo sapiens 39-44 23468132-5 2013 The expression of ABCB4, but not ABCB1, led to significant increases in the phosphatidylcholine (PC), phosphatidylethanolamine (PE), and sphingomyelin (SM) contents in nonraft membranes and further enrichment of SM and cholesterol in raft membranes. Phosphatidylcholines 76-95 ATP binding cassette subfamily B member 4 Homo sapiens 18-23 23468132-5 2013 The expression of ABCB4, but not ABCB1, led to significant increases in the phosphatidylcholine (PC), phosphatidylethanolamine (PE), and sphingomyelin (SM) contents in nonraft membranes and further enrichment of SM and cholesterol in raft membranes. Phosphatidylcholines 97-99 ATP binding cassette subfamily B member 4 Homo sapiens 18-23 23468132-6 2013 The ABCB4-mediated efflux of PC, PE, and SM was significantly stimulated by taurocholate, while the efflux of PE and SM was much less than that of PC. Phosphatidylcholines 29-31 ATP binding cassette subfamily B member 4 Homo sapiens 4-9 23468132-6 2013 The ABCB4-mediated efflux of PC, PE, and SM was significantly stimulated by taurocholate, while the efflux of PE and SM was much less than that of PC. Phosphatidylcholines 147-149 ATP binding cassette subfamily B member 4 Homo sapiens 4-9 23593265-1 2013 The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes. Phosphatidylcholines 188-207 ATP binding cassette subfamily B member 4 Homo sapiens 100-130 23593265-1 2013 The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes. Phosphatidylcholines 188-207 ATP binding cassette subfamily B member 4 Homo sapiens 132-136 23593265-1 2013 The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes. Phosphatidylcholines 188-207 ATP binding cassette subfamily B member 4 Homo sapiens 137-142 23305784-1 2013 Although human MDR1 and MDR3 share 86% similarity in their amino acid sequences and are predicted to share conserved domains for drug recognition, their physiological transport substrates are quite different: MDR1 transports xenobiotics and confers multidrug resistance, while MDR3 exports phosphatidylcholine into bile. Phosphatidylcholines 290-309 ATP binding cassette subfamily B member 4 Homo sapiens 24-28 23305784-1 2013 Although human MDR1 and MDR3 share 86% similarity in their amino acid sequences and are predicted to share conserved domains for drug recognition, their physiological transport substrates are quite different: MDR1 transports xenobiotics and confers multidrug resistance, while MDR3 exports phosphatidylcholine into bile. Phosphatidylcholines 290-309 ATP binding cassette subfamily B member 4 Homo sapiens 277-281 23141892-2 2012 It is caused by a mutation of the gene ABCB4, which encodes the canalicular protein ABCB4/MDR3, a flippase that plays an essential role in the secretion of phosphatidylcholine into bile. Phosphatidylcholines 156-175 ATP binding cassette subfamily B member 4 Homo sapiens 84-89 23141892-2 2012 It is caused by a mutation of the gene ABCB4, which encodes the canalicular protein ABCB4/MDR3, a flippase that plays an essential role in the secretion of phosphatidylcholine into bile. Phosphatidylcholines 156-175 ATP binding cassette subfamily B member 4 Homo sapiens 90-94 22859919-4 2012 There are two mechanisms to protect the canalicular membrane from solubilization by bile salts; ABCB4 secretes phosphatidylcholine into bile to form mixed micelles with bile salts, and ATP8B1 maintains the canalicular membrane in a liquid-ordered state. Phosphatidylcholines 111-130 ATP binding cassette subfamily B member 4 Homo sapiens 96-101 19674157-1 2009 AIM: Multidrug resistance protein 3 (MDR3/ABCB4), located on the bile canalicular membrane of hepatocytes, is responsible for the translocation of phosphatidylcholine across the plasma membrane, and its hereditary defect causes liver disorders, such as progressive familial intrahepatic cholestasis type 3. Phosphatidylcholines 147-166 ATP binding cassette subfamily B member 4 Homo sapiens 5-35 20153493-2 2010 In humans, ABCB4 appears to be exclusively expressed on the apical membrane of hepatocytes where it translocates phosphatidylcholine from the inner to the outer leaflet of the canalicular membrane. Phosphatidylcholines 113-132 ATP binding cassette subfamily B member 4 Homo sapiens 11-16 20422497-5 2010 In addition, genetic variants (as well as mutants) of the genes coding for the phosphatidylcholine translocator MDR3 and BSEP and for the farnesoid X receptor, which is critical in the transcriptional activation of MDR3 ( ABCB4) and BSEP ( ABCB11) have been associated with intrahepatic cholestasis of pregnancy. Phosphatidylcholines 79-98 ATP binding cassette subfamily B member 4 Homo sapiens 112-116 20422497-5 2010 In addition, genetic variants (as well as mutants) of the genes coding for the phosphatidylcholine translocator MDR3 and BSEP and for the farnesoid X receptor, which is critical in the transcriptional activation of MDR3 ( ABCB4) and BSEP ( ABCB11) have been associated with intrahepatic cholestasis of pregnancy. Phosphatidylcholines 79-98 ATP binding cassette subfamily B member 4 Homo sapiens 215-219 20422497-5 2010 In addition, genetic variants (as well as mutants) of the genes coding for the phosphatidylcholine translocator MDR3 and BSEP and for the farnesoid X receptor, which is critical in the transcriptional activation of MDR3 ( ABCB4) and BSEP ( ABCB11) have been associated with intrahepatic cholestasis of pregnancy. Phosphatidylcholines 79-98 ATP binding cassette subfamily B member 4 Homo sapiens 222-227 21801087-1 2011 INTRODUCTION: Multidrug resistance 3 (MDR3) P-glycoprotein is a lipid floppase that is encoded by the ATP-binding cassette sub-family B member 4 (ABCB4) gene and plays a crucial role in proper bile formation by transporting phosphatidylcholine across the canalicular plasma membrane of the hepatocyte into bile. Phosphatidylcholines 224-243 ATP binding cassette subfamily B member 4 Homo sapiens 14-36 21801087-1 2011 INTRODUCTION: Multidrug resistance 3 (MDR3) P-glycoprotein is a lipid floppase that is encoded by the ATP-binding cassette sub-family B member 4 (ABCB4) gene and plays a crucial role in proper bile formation by transporting phosphatidylcholine across the canalicular plasma membrane of the hepatocyte into bile. Phosphatidylcholines 224-243 ATP binding cassette subfamily B member 4 Homo sapiens 38-42 21801087-1 2011 INTRODUCTION: Multidrug resistance 3 (MDR3) P-glycoprotein is a lipid floppase that is encoded by the ATP-binding cassette sub-family B member 4 (ABCB4) gene and plays a crucial role in proper bile formation by transporting phosphatidylcholine across the canalicular plasma membrane of the hepatocyte into bile. Phosphatidylcholines 224-243 ATP binding cassette subfamily B member 4 Homo sapiens 102-144 21801087-1 2011 INTRODUCTION: Multidrug resistance 3 (MDR3) P-glycoprotein is a lipid floppase that is encoded by the ATP-binding cassette sub-family B member 4 (ABCB4) gene and plays a crucial role in proper bile formation by transporting phosphatidylcholine across the canalicular plasma membrane of the hepatocyte into bile. Phosphatidylcholines 224-243 ATP binding cassette subfamily B member 4 Homo sapiens 146-151 21638239-1 2011 The phospholipidfloppase MDR3 (gene symbol: ABCB4) is expressed in the canalicular membrane of hepatocytes and mediates the biliary excretion of phosphatidylcholine, which is required for the formation of mixed micelles in bile. Phosphatidylcholines 145-164 ATP binding cassette subfamily B member 4 Homo sapiens 25-29 21638239-1 2011 The phospholipidfloppase MDR3 (gene symbol: ABCB4) is expressed in the canalicular membrane of hepatocytes and mediates the biliary excretion of phosphatidylcholine, which is required for the formation of mixed micelles in bile. Phosphatidylcholines 145-164 ATP binding cassette subfamily B member 4 Homo sapiens 44-49 19674157-1 2009 AIM: Multidrug resistance protein 3 (MDR3/ABCB4), located on the bile canalicular membrane of hepatocytes, is responsible for the translocation of phosphatidylcholine across the plasma membrane, and its hereditary defect causes liver disorders, such as progressive familial intrahepatic cholestasis type 3. Phosphatidylcholines 147-166 ATP binding cassette subfamily B member 4 Homo sapiens 37-41 19674157-1 2009 AIM: Multidrug resistance protein 3 (MDR3/ABCB4), located on the bile canalicular membrane of hepatocytes, is responsible for the translocation of phosphatidylcholine across the plasma membrane, and its hereditary defect causes liver disorders, such as progressive familial intrahepatic cholestasis type 3. Phosphatidylcholines 147-166 ATP binding cassette subfamily B member 4 Homo sapiens 42-47 19674157-8 2009 Consequently, ABCB4-mediated phosphatidylcholine translocation activity was significantly reduced when endogenous RACK1 expression was suppressed in HeLa cells. Phosphatidylcholines 29-48 ATP binding cassette subfamily B member 4 Homo sapiens 14-19 19018976-1 2009 BACKGROUND AND AIMS: Mutations in the gene encoding the ABCB4 [adenosine triphosphate (ATP)-binding cassette, sub-family B (MDR/TAP), member 4] transporter lower phosphatidylcholine output into bile and contribute to cholesterol gallstone formation by decreasing the solubility of cholesterol in bile. Phosphatidylcholines 162-181 ATP binding cassette subfamily B member 4 Homo sapiens 56-61 19185004-3 2009 The disease is caused by mutations of the adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4) [multidrug resistance 3 (MDR3)] gene encoding a specific hepatocellular canalicular transporter involved in biliary phosphatidylcholine secretion. Phosphatidylcholines 236-255 ATP binding cassette subfamily B member 4 Homo sapiens 121-143 19185004-3 2009 The disease is caused by mutations of the adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4) [multidrug resistance 3 (MDR3)] gene encoding a specific hepatocellular canalicular transporter involved in biliary phosphatidylcholine secretion. Phosphatidylcholines 236-255 ATP binding cassette subfamily B member 4 Homo sapiens 113-118 19185004-3 2009 The disease is caused by mutations of the adenosine triphosphate (ATP)-binding cassette, sub-family B, member 4 (ABCB4) [multidrug resistance 3 (MDR3)] gene encoding a specific hepatocellular canalicular transporter involved in biliary phosphatidylcholine secretion. Phosphatidylcholines 236-255 ATP binding cassette subfamily B member 4 Homo sapiens 145-149 19273348-1 2009 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future. Phosphatidylcholines 157-176 ATP binding cassette subfamily B member 4 Homo sapiens 202-206 19273348-1 2009 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future. Phosphatidylcholines 157-176 ATP binding cassette subfamily B member 4 Homo sapiens 208-213 19273348-1 2009 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future. Phosphatidylcholines 157-176 ATP binding cassette subfamily B member 4 Homo sapiens 339-344 19273348-1 2009 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future. Phosphatidylcholines 157-176 ATP binding cassette subfamily B member 4 Homo sapiens 202-206 19273348-1 2009 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future. Phosphatidylcholines 157-176 ATP binding cassette subfamily B member 4 Homo sapiens 479-484 19273348-1 2009 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future. Phosphatidylcholines 157-176 ATP binding cassette subfamily B member 4 Homo sapiens 202-206 19273348-1 2009 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future. Phosphatidylcholines 157-176 ATP binding cassette subfamily B member 4 Homo sapiens 202-206 19273348-1 2009 Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require liver transplantation.Several MDR3 mutations have been identified in children with PFIC3 and are associated to low level of phospholipids in bile leading to high biliary cholesterol saturation index.MDR3 mutations are associated to loss of canalicular MDR3 protein and /or to loss of protein function.There is evidence that biallelic or monoallelic MDR3 defect causes or predisposes to 6 human liver diseases (PFIC3, adult biliary cirrhosis, low phospholipid associated cholelithiasis syndrome, transient neonatal cholestasis, intrahepatic cholestasis of pregnancy, drug induced cholestasis).Some patients with MDR3 deficiency may benefit from ursodeoxycholic acid therapy and could be good candidates to a targeted pharmacological approach and/or to cell therapy in the future. Phosphatidylcholines 157-176 ATP binding cassette subfamily B member 4 Homo sapiens 479-484 18221610-1 2007 ABCB4 (MDR3), a lipid translocator, moves phosphatidylcholine from the inner to the outer leaflet of the canalicular membrane. Phosphatidylcholines 42-61 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 18781607-10 2008 Bile from a mutation homozygote showed a reduced phosphatidylcholine/bile acid ratio, consistent with reduced ABCB4 phosphatidylcholine transport activity. Phosphatidylcholines 116-135 ATP binding cassette subfamily B member 4 Homo sapiens 110-115 18221610-1 2007 ABCB4 (MDR3), a lipid translocator, moves phosphatidylcholine from the inner to the outer leaflet of the canalicular membrane. Phosphatidylcholines 42-61 ATP binding cassette subfamily B member 4 Homo sapiens 7-11 17608770-4 2007 MDR2, the amino acid sequence of which has 86% similarity to that of MDR1, excretes phosphatidylcholine and cholesterol in the presence of bile salts. Phosphatidylcholines 84-103 ATP binding cassette subfamily B member 4 Homo sapiens 0-4 17726488-2 2007 ABCB4 is the liver-specific membrane transporter of phosphatidylcholine, a major and exclusive component of mammalian bile. Phosphatidylcholines 52-71 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 17523162-11 2007 Mass spectrometry revealed that, in the presence of taurocholate, HEK/ABCB4 cells preferentially secreted PC compared to sphingomyelin. Phosphatidylcholines 106-108 ATP binding cassette subfamily B member 4 Homo sapiens 70-75 17523162-2 2007 ABCB4 has been shown to be required for phosphatidylcholine (PC) secretion into the bile and to translocate PC across the plasma membrane. Phosphatidylcholines 40-59 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 17523162-2 2007 ABCB4 has been shown to be required for phosphatidylcholine (PC) secretion into the bile and to translocate PC across the plasma membrane. Phosphatidylcholines 61-63 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 17523162-2 2007 ABCB4 has been shown to be required for phosphatidylcholine (PC) secretion into the bile and to translocate PC across the plasma membrane. Phosphatidylcholines 108-110 ATP binding cassette subfamily B member 4 Homo sapiens 0-5 17273143-1 2007 The ABCB4 gene codes for a protein involved in the transport of phosphatidylcholine across the canalicular membrane of the hepatocyte. Phosphatidylcholines 64-83 ATP binding cassette subfamily B member 4 Homo sapiens 4-9 16854530-1 2006 The MDR3 protein is a transporter of phosphatidylcholine on the canalicular membrane of human hepatocytes. Phosphatidylcholines 37-56 ATP binding cassette subfamily B member 4 Homo sapiens 4-8 10856718-1 2000 Since it was found that the P-glycoproteins encoded by the MDR3 (MDR2) gene in humans and the Mdr2 gene in mice are primarily phosphatidylcholine translocators, there has been increasing interest in the possibility that other ATP binding cassette (ABC) transporters are involved in lipid transport. Phosphatidylcholines 126-145 ATP binding cassette subfamily B member 4 Homo sapiens 59-63 15258199-0 2004 Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARalpha-mediated redistribution of ABCB4. Phosphatidylcholines 63-65 ATP binding cassette subfamily B member 4 Homo sapiens 121-126 15696852-7 2004 The second ABC transporter, ABCB4 (MDR3) regulates the secretion in bile of phosphatidylcholine (PC), while ABCG5/G8 is active in the excretion of cholesterol and sterols into bile. Phosphatidylcholines 76-95 ATP binding cassette subfamily B member 4 Homo sapiens 28-33 15696852-7 2004 The second ABC transporter, ABCB4 (MDR3) regulates the secretion in bile of phosphatidylcholine (PC), while ABCG5/G8 is active in the excretion of cholesterol and sterols into bile. Phosphatidylcholines 76-95 ATP binding cassette subfamily B member 4 Homo sapiens 35-39 15696852-7 2004 The second ABC transporter, ABCB4 (MDR3) regulates the secretion in bile of phosphatidylcholine (PC), while ABCG5/G8 is active in the excretion of cholesterol and sterols into bile. Phosphatidylcholines 97-99 ATP binding cassette subfamily B member 4 Homo sapiens 28-33 15696852-7 2004 The second ABC transporter, ABCB4 (MDR3) regulates the secretion in bile of phosphatidylcholine (PC), while ABCG5/G8 is active in the excretion of cholesterol and sterols into bile. Phosphatidylcholines 97-99 ATP binding cassette subfamily B member 4 Homo sapiens 35-39 11313316-2 2001 MDR3 is the phosphatidylcholine translocator across the hepatocyte canalicular membrane. Phosphatidylcholines 12-31 ATP binding cassette subfamily B member 4 Homo sapiens 0-4 11147995-1 2000 Aim of the present study was to establish a cell system to study the physiological function of human MDR3 P-glycoprotein in cellular phosphatidylcholine (PC) secretion. Phosphatidylcholines 133-152 ATP binding cassette subfamily B member 4 Homo sapiens 101-105 11147995-1 2000 Aim of the present study was to establish a cell system to study the physiological function of human MDR3 P-glycoprotein in cellular phosphatidylcholine (PC) secretion. Phosphatidylcholines 154-156 ATP binding cassette subfamily B member 4 Homo sapiens 101-105 10918072-2 2000 The MDR3 P-glycoprotein is a transmembrane protein that translocates phosphatidylcholine. Phosphatidylcholines 69-88 ATP binding cassette subfamily B member 4 Homo sapiens 4-8 10918072-8 2000 MDR3 P-glycoprotein-dependent transport of a short-chain phosphatidylcholine analog and drugs was inhibited by several MDR reversal agents and other drugs, indicating an interaction between these compounds and MDR3 P-gp. Phosphatidylcholines 57-76 ATP binding cassette subfamily B member 4 Homo sapiens 0-4 10918072-8 2000 MDR3 P-glycoprotein-dependent transport of a short-chain phosphatidylcholine analog and drugs was inhibited by several MDR reversal agents and other drugs, indicating an interaction between these compounds and MDR3 P-gp. Phosphatidylcholines 57-76 ATP binding cassette subfamily B member 4 Homo sapiens 210-214 10856718-1 2000 Since it was found that the P-glycoproteins encoded by the MDR3 (MDR2) gene in humans and the Mdr2 gene in mice are primarily phosphatidylcholine translocators, there has been increasing interest in the possibility that other ATP binding cassette (ABC) transporters are involved in lipid transport. Phosphatidylcholines 126-145 ATP binding cassette subfamily B member 4 Homo sapiens 65-69 10856718-1 2000 Since it was found that the P-glycoproteins encoded by the MDR3 (MDR2) gene in humans and the Mdr2 gene in mice are primarily phosphatidylcholine translocators, there has been increasing interest in the possibility that other ATP binding cassette (ABC) transporters are involved in lipid transport. Phosphatidylcholines 126-145 ATP binding cassette subfamily B member 4 Homo sapiens 94-98