PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23148485-1 2012 Ca(2+)-independent lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a member of the phospholipase A(2) superfamily with a distinguishing characteristic of high specificity for oxidatively modified sn-2 fatty acid residues in phospholipids that has been especially well characterized for peroxidized species of phosphatidylcholines (PC). Phosphatidylcholines 318-338 phospholipase A2 group VII Homo sapiens 19-60 23148485-1 2012 Ca(2+)-independent lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a member of the phospholipase A(2) superfamily with a distinguishing characteristic of high specificity for oxidatively modified sn-2 fatty acid residues in phospholipids that has been especially well characterized for peroxidized species of phosphatidylcholines (PC). Phosphatidylcholines 318-338 phospholipase A2 group VII Homo sapiens 62-71 23148485-1 2012 Ca(2+)-independent lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a member of the phospholipase A(2) superfamily with a distinguishing characteristic of high specificity for oxidatively modified sn-2 fatty acid residues in phospholipids that has been especially well characterized for peroxidized species of phosphatidylcholines (PC). Phosphatidylcholines 340-342 phospholipase A2 group VII Homo sapiens 19-60 23148485-1 2012 Ca(2+)-independent lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a member of the phospholipase A(2) superfamily with a distinguishing characteristic of high specificity for oxidatively modified sn-2 fatty acid residues in phospholipids that has been especially well characterized for peroxidized species of phosphatidylcholines (PC). Phosphatidylcholines 340-342 phospholipase A2 group VII Homo sapiens 62-71 19895904-7 2010 To assess whether the reduced cellular association mediated by Lp-PLA2 was due to the hydrolysis of oxidized phosphatidylcholine (oxPC), we measured the concentration of lysophosphatidylcholine (lysoPC) in lipoprotein fractions after Lp-PLA2 treatment. Phosphatidylcholines 109-128 phospholipase A2 group VII Homo sapiens 63-70 21291330-1 2011 BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a lipoprotein-associated enzyme that cleaves oxidized phosphatidylcholines, generating pro-atherosclerotic lysophosphatidylcholine and oxidized free fatty acids. Phosphatidylcholines 119-139 phospholipase A2 group VII Homo sapiens 12-51 21291330-1 2011 BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a lipoprotein-associated enzyme that cleaves oxidized phosphatidylcholines, generating pro-atherosclerotic lysophosphatidylcholine and oxidized free fatty acids. Phosphatidylcholines 119-139 phospholipase A2 group VII Homo sapiens 53-60 16807087-1 2006 Plasma Platelet-activating-Factor (PAF)-acetylhydrolase (PAF-AH also named lipoprotein-PLA(2) or PLA(2)G7 gene) is secreted by macrophages, it degrades PAF and oxidation products of phosphatidylcholine produced upon LDL oxidation and/or oxidative stress, and thus is considered as a potentially anti-inflammatory enzyme. Phosphatidylcholines 182-201 phospholipase A2 group VII Homo sapiens 97-105 19667981-4 2009 RECENT FINDINGS: Lp-PLA2, also known as platelet-activating factor acetylhydrolase, rapidly cleaves oxidized phosphatidylcholine molecules produced during the oxidation of LDL and atherogenic lipoprotein Lp(a), generating the soluble proinflammatory and proapoptotic lipid mediators, lyso-phosphatidylcholine and oxidized nonesterified fatty acids. Phosphatidylcholines 109-128 phospholipase A2 group VII Homo sapiens 17-24 19667981-4 2009 RECENT FINDINGS: Lp-PLA2, also known as platelet-activating factor acetylhydrolase, rapidly cleaves oxidized phosphatidylcholine molecules produced during the oxidation of LDL and atherogenic lipoprotein Lp(a), generating the soluble proinflammatory and proapoptotic lipid mediators, lyso-phosphatidylcholine and oxidized nonesterified fatty acids. Phosphatidylcholines 109-128 phospholipase A2 group VII Homo sapiens 40-82 18165686-4 2008 Here we report a systematic analysis of the effects of in vitro oxidation in the absence and presence of an Lp-PLA(2) inhibitor on the phosphatidylcholine (PC) composition of human LDL. Phosphatidylcholines 135-154 phospholipase A2 group VII Homo sapiens 108-117 18165686-4 2008 Here we report a systematic analysis of the effects of in vitro oxidation in the absence and presence of an Lp-PLA(2) inhibitor on the phosphatidylcholine (PC) composition of human LDL. Phosphatidylcholines 156-158 phospholipase A2 group VII Homo sapiens 108-117 17827718-9 2007 In addition, PAF-AH selectively hydrolyzed oxidatively modified phosphatidylcholine. Phosphatidylcholines 64-83 phospholipase A2 group VII Homo sapiens 13-19 16807087-1 2006 Plasma Platelet-activating-Factor (PAF)-acetylhydrolase (PAF-AH also named lipoprotein-PLA(2) or PLA(2)G7 gene) is secreted by macrophages, it degrades PAF and oxidation products of phosphatidylcholine produced upon LDL oxidation and/or oxidative stress, and thus is considered as a potentially anti-inflammatory enzyme. Phosphatidylcholines 182-201 phospholipase A2 group VII Homo sapiens 7-55 16807087-1 2006 Plasma Platelet-activating-Factor (PAF)-acetylhydrolase (PAF-AH also named lipoprotein-PLA(2) or PLA(2)G7 gene) is secreted by macrophages, it degrades PAF and oxidation products of phosphatidylcholine produced upon LDL oxidation and/or oxidative stress, and thus is considered as a potentially anti-inflammatory enzyme. Phosphatidylcholines 182-201 phospholipase A2 group VII Homo sapiens 57-63 9494101-6 1998 Like LDL-PLA2, HSD-PLA2 was able to hydrolyse oxidatively modified phosphatidylcholines when supplemented to human LDL prior to copper-stimulated oxidation. Phosphatidylcholines 67-87 phospholipase A2 group VII Homo sapiens 5-13 15306175-0 2004 Effects of intravenous apolipoprotein A-I/phosphatidylcholine discs on paraoxonase and platelet-activating factor acetylhydrolase in human plasma and tissue fluid. Phosphatidylcholines 42-61 phospholipase A2 group VII Homo sapiens 87-129 11347966-2 2001 Substrates include oxidised phosphatidylcholine (PC), which is hydrolysed by Lp-PLA2 to lyso-PC and oxidised fatty acids. Phosphatidylcholines 28-47 phospholipase A2 group VII Homo sapiens 77-84 11347966-2 2001 Substrates include oxidised phosphatidylcholine (PC), which is hydrolysed by Lp-PLA2 to lyso-PC and oxidised fatty acids. Phosphatidylcholines 49-51 phospholipase A2 group VII Homo sapiens 77-84 10856534-3 2000 Such an investigation was important because Lp-PLA(2) participates in the oxidative modification of low density lipoprotein by cleaving oxidised phosphatidylcholines, generating lysophosphatidylcholine and oxidised free fatty acids. Phosphatidylcholines 145-165 phospholipase A2 group VII Homo sapiens 44-53 10591668-1 1999 We studied the expression of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), an enzyme capable of hydrolyzing platelet-activating factor (PAF), PAF-like phospholipids, and polar-modified phosphatidylcholines, in human and rabbit atherosclerotic lesions. Phosphatidylcholines 194-214 phospholipase A2 group VII Homo sapiens 29-70 10591668-1 1999 We studied the expression of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), an enzyme capable of hydrolyzing platelet-activating factor (PAF), PAF-like phospholipids, and polar-modified phosphatidylcholines, in human and rabbit atherosclerotic lesions. Phosphatidylcholines 194-214 phospholipase A2 group VII Homo sapiens 72-81 10591668-8 1999 It is concluded that (1) macrophages in both human and rabbit atherosclerotic lesions express Lp-PLA(2), which could cleave any oxidatively modified phosphatidylcholine present in the lesion area, and (2) modulation of Lp-PLA(2) activity could lead to antiatherogenic effects in the vessel wall. Phosphatidylcholines 149-168 phospholipase A2 group VII Homo sapiens 94-103 10395969-1 1999 To determine the relative importance of platelet-activating factor-acetylhydrolase (PAF-AH) and lecithin-cholesterol acyltransferase (LCAT) in the hydrolysis of oxidized phosphatidylcholines (OXPCs) to lyso-phosphatidylcholine (lyso-PC), we studied the formation and metabolism of OXPCs in the plasma of normal and PAF-AH-deficient subjects. Phosphatidylcholines 170-190 phospholipase A2 group VII Homo sapiens 40-82 10395969-1 1999 To determine the relative importance of platelet-activating factor-acetylhydrolase (PAF-AH) and lecithin-cholesterol acyltransferase (LCAT) in the hydrolysis of oxidized phosphatidylcholines (OXPCs) to lyso-phosphatidylcholine (lyso-PC), we studied the formation and metabolism of OXPCs in the plasma of normal and PAF-AH-deficient subjects. Phosphatidylcholines 170-190 phospholipase A2 group VII Homo sapiens 84-90 10381281-1 1999 Phosphatidylcholines (1-O-alcoxy-2-amino-2-desoxy-phosphocholines and 1-pyrene-labeled analogs) were synthesized and used to examine interactions with recombinant human PAF-acetylhydrolase (PAF-AH), an enzyme purified from plasma, and with macrophage-like U937 cells. Phosphatidylcholines 0-20 phospholipase A2 group VII Homo sapiens 169-188 8514423-5 1993 In SP, PAF-AH-like activity was Ca(++)-independent, acid and heat labile, stable to freezing, not inhibited by phosphatidylcholine, but was inhibited by 10 mM disopropylfluorophosphate (DFP) and 13 mM phenylmethylsulfonylfluoride (PMSF). Phosphatidylcholines 111-130 phospholipase A2 group VII Homo sapiens 7-13 9437199-6 1997 As PAF:acetylhydrolase inactivates PAF and oxidized forms of phosphatidylcholine, we evaluated the relationship of lipoprotein-associated PAF:acetylhydrolase to PAF formation. Phosphatidylcholines 61-80 phospholipase A2 group VII Homo sapiens 3-22 9263748-2 1997 There is increasing evidence that oxidative modification of LDL is important for the pathogenesis of atherosclerosis, and the LDL-associated platelet-activating factor acetylhydrolase (PAF-AH) seems to play a key role in LDL oxidation by hydrolysing the oxidized phospholipids of phosphatidylcholine (PC) and producing lysophosphatidylcholine (lyso-PC). Phosphatidylcholines 280-299 phospholipase A2 group VII Homo sapiens 141-183 9263748-2 1997 There is increasing evidence that oxidative modification of LDL is important for the pathogenesis of atherosclerosis, and the LDL-associated platelet-activating factor acetylhydrolase (PAF-AH) seems to play a key role in LDL oxidation by hydrolysing the oxidized phospholipids of phosphatidylcholine (PC) and producing lysophosphatidylcholine (lyso-PC). Phosphatidylcholines 280-299 phospholipase A2 group VII Homo sapiens 185-191 9263748-2 1997 There is increasing evidence that oxidative modification of LDL is important for the pathogenesis of atherosclerosis, and the LDL-associated platelet-activating factor acetylhydrolase (PAF-AH) seems to play a key role in LDL oxidation by hydrolysing the oxidized phospholipids of phosphatidylcholine (PC) and producing lysophosphatidylcholine (lyso-PC). Phosphatidylcholines 301-303 phospholipase A2 group VII Homo sapiens 141-183 9263748-2 1997 There is increasing evidence that oxidative modification of LDL is important for the pathogenesis of atherosclerosis, and the LDL-associated platelet-activating factor acetylhydrolase (PAF-AH) seems to play a key role in LDL oxidation by hydrolysing the oxidized phospholipids of phosphatidylcholine (PC) and producing lysophosphatidylcholine (lyso-PC). Phosphatidylcholines 301-303 phospholipase A2 group VII Homo sapiens 185-191 8831934-15 1996 During Lp(a) oxidation, the PAF-AH activity decreases whereas an extensive hydrolysis of the endogenous PC to Lyso-PC is observed which is possibly due to the PAF-AH activity. Phosphatidylcholines 104-106 phospholipase A2 group VII Homo sapiens 159-165 1566749-3 1992 Since PAF-AH is also known to hydrolyze oxidized derivatives of phosphatidylcholine and since RBCs are not effector cells of PAF, the observed activity in RBC membranes may play a potential role in degrading oxidation products of membrane phospholipids. Phosphatidylcholines 64-83 phospholipase A2 group VII Homo sapiens 6-12 2494162-0 1989 An oxidized derivative of phosphatidylcholine is a substrate for the platelet-activating factor acetylhydrolase from human plasma. Phosphatidylcholines 26-45 phospholipase A2 group VII Homo sapiens 69-111 1908796-2 1991 This activity is mainly distributed in the microsomal fraction (76.5% of total) and has properties similar to the mammalian PAF-acetylhydrolase since it is Ca(2+)-independent, acid-labile, is inhibited by DFP and PMSF but it is not affected by egg yolk phosphatidylcholine. Phosphatidylcholines 253-272 phospholipase A2 group VII Homo sapiens 124-143 2494162-7 1989 We now have found that the purified PAF acetylhydrolase catalyzes the hydrolysis of the oxidized fragments of arachidonic acid from the sn-2 position of phosphatidylcholine. Phosphatidylcholines 153-172 phospholipase A2 group VII Homo sapiens 36-55 2723538-0 1989 Hydrolysis of phosphatidylcholine during LDL oxidation is mediated by platelet-activating factor acetylhydrolase. Phosphatidylcholines 14-33 phospholipase A2 group VII Homo sapiens 70-112 2723538-2 1989 In this study, we have shown that this phospholipid hydrolysis is brought about by an LDL-associated phospholipase A2 that can hydrolyze oxidized but not intact LDL phosphatidylcholine. Phosphatidylcholines 165-184 phospholipase A2 group VII Homo sapiens 86-117