PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7217669-0 1981 Interaction of C-reactive protein with artificial phosphatidylcholine bilayers and complement. Phosphatidylcholines 50-69 C-reactive protein Homo sapiens 15-33 7338519-2 1981 Liposomes composed of phosphatidylcholine and stearylamine were agglutinated with CRP. Phosphatidylcholines 22-41 C-reactive protein Homo sapiens 82-85 7338519-5 1981 Agglutination of liposomes caused by CRP was dependent on the fatty acid composition of phosphatidylcholine, cholesterol content and temperature. Phosphatidylcholines 88-107 C-reactive protein Homo sapiens 37-40 3919022-4 1985 Inhibition of platelet aggregation by CRP is accompanied by an inhibition of arachidonic acid release from both phosphatidylcholine and phosphatidylinositol. Phosphatidylcholines 112-131 C-reactive protein Homo sapiens 38-41 7217669-2 1981 Binding of CRP to multilamellar liposomes or unilamellar vesicles of egg-phosphatidylcholine required the presence of lysophosphatide in the bilayer. Phosphatidylcholines 73-92 C-reactive protein Homo sapiens 11-14 7217669-5 1981 In addition, incorporation of galactocyl cerebroside in phosphatidylcholine:lysophosphatidylcholine liposomes enhanced the binding of CRP. Phosphatidylcholines 56-75 C-reactive protein Homo sapiens 134-137 20364851-0 2010 C-reactive protein induced rearrangement of phosphatidylcholine on nanoparticle mimics of lipoprotein particles. Phosphatidylcholines 44-63 C-reactive protein Homo sapiens 0-18 7190145-0 1980 C-Reactive protein induced agglutination of lipid suspensions prepared in the presence and absence of phosphatidylcholine. Phosphatidylcholines 102-121 C-reactive protein Homo sapiens 0-18 7190145-1 1980 CRP-induced agglutination of lipid suspensions prepared in the presence and absence of phosphatidylcholine was studied by a newly devised quantitative method. Phosphatidylcholines 87-106 C-reactive protein Homo sapiens 0-3 7190145-2 1980 CRP caused as much agglutination of suspensions composed of egg yolk phosphatidylcholine, cholesterol, and Span 60 as of those composed of cholesterol and Span 60, suggesting that phosphocholine residues of phosphatidylcholine are not important as binding sites for CRP. Phosphatidylcholines 69-88 C-reactive protein Homo sapiens 0-3 7190145-2 1980 CRP caused as much agglutination of suspensions composed of egg yolk phosphatidylcholine, cholesterol, and Span 60 as of those composed of cholesterol and Span 60, suggesting that phosphocholine residues of phosphatidylcholine are not important as binding sites for CRP. Phosphatidylcholines 207-226 C-reactive protein Homo sapiens 0-3 7190145-4 1980 Although phosphatidylcholine is not an essential component for agglutination of suspensions, it may modify the mode of interaction of CRP with its binding site on lipid suspensions, since the sensitivity of the agglutination to phosphocholine and the Ca2+ requirement were influenced by the presence of phosphatidylcholine in the suspensions. Phosphatidylcholines 9-28 C-reactive protein Homo sapiens 134-137 7190145-4 1980 Although phosphatidylcholine is not an essential component for agglutination of suspensions, it may modify the mode of interaction of CRP with its binding site on lipid suspensions, since the sensitivity of the agglutination to phosphocholine and the Ca2+ requirement were influenced by the presence of phosphatidylcholine in the suspensions. Phosphatidylcholines 303-322 C-reactive protein Homo sapiens 134-137 28808571-3 2017 In addition, CRP may form a complex with oxidized low-density lipoprotein (oxLDL) via phosphatidylcholine, thus decreasing its pro-inflammatory effects within macrophages. Phosphatidylcholines 86-105 C-reactive protein Homo sapiens 13-16 28225631-1 2017 C-reactive protein (CRP) is a serum protein that binds to damaged membranes through a phosphatidylcholine binding site. Phosphatidylcholines 86-105 C-reactive protein Homo sapiens 0-18 28225631-1 2017 C-reactive protein (CRP) is a serum protein that binds to damaged membranes through a phosphatidylcholine binding site. Phosphatidylcholines 86-105 C-reactive protein Homo sapiens 20-23 24027600-1 2012 It has been reported that the oxidation of phosphatidylcholine (PC) is necessary for C-reactive protein (CRP) to bind to lipid membranes, but it remains elusive why CRP only binds oxidized membranes. Phosphatidylcholines 43-62 C-reactive protein Homo sapiens 85-103 24027600-1 2012 It has been reported that the oxidation of phosphatidylcholine (PC) is necessary for C-reactive protein (CRP) to bind to lipid membranes, but it remains elusive why CRP only binds oxidized membranes. Phosphatidylcholines 43-62 C-reactive protein Homo sapiens 105-108 24027600-1 2012 It has been reported that the oxidation of phosphatidylcholine (PC) is necessary for C-reactive protein (CRP) to bind to lipid membranes, but it remains elusive why CRP only binds oxidized membranes. Phosphatidylcholines 64-66 C-reactive protein Homo sapiens 85-103 24027600-1 2012 It has been reported that the oxidation of phosphatidylcholine (PC) is necessary for C-reactive protein (CRP) to bind to lipid membranes, but it remains elusive why CRP only binds oxidized membranes. Phosphatidylcholines 64-66 C-reactive protein Homo sapiens 105-108 21210202-0 2011 Phosphatidylcholine-rich nanoliposomes: potential tools for serum C-reactive protein reduction? Phosphatidylcholines 0-19 C-reactive protein Homo sapiens 66-84 20891039-3 2010 In parallel with CRP, the content of secretory phospholipase A, as a component of lipoproteins is on the rise; the enzyme hydrolyzes phosphatidylcholine in the surface monolayer of lipoproteins to form lysophosphatidylcholine that the CRP-pentamere displays a high affinity binding to. Phosphatidylcholines 133-152 C-reactive protein Homo sapiens 17-20 20891039-3 2010 In parallel with CRP, the content of secretory phospholipase A, as a component of lipoproteins is on the rise; the enzyme hydrolyzes phosphatidylcholine in the surface monolayer of lipoproteins to form lysophosphatidylcholine that the CRP-pentamere displays a high affinity binding to. Phosphatidylcholines 133-152 C-reactive protein Homo sapiens 235-238 20891039-6 2010 For this, lipoprotein-associated phospholipase A, hydrolyzes phosphatidylcholine to produce lysophosphatidylcholine that the CRP-pentamere binds to; it superimposes a physiological apoE/B-100-ligand, becomes itself a pathophysiological CRP/B-100-ligand, and directs a flow of the energy substrates towards the interstitial cells that exhibit pathophysiological CRB/B-100-receptors on the membrane. Phosphatidylcholines 61-80 C-reactive protein Homo sapiens 125-128 20891039-6 2010 For this, lipoprotein-associated phospholipase A, hydrolyzes phosphatidylcholine to produce lysophosphatidylcholine that the CRP-pentamere binds to; it superimposes a physiological apoE/B-100-ligand, becomes itself a pathophysiological CRP/B-100-ligand, and directs a flow of the energy substrates towards the interstitial cells that exhibit pathophysiological CRB/B-100-receptors on the membrane. Phosphatidylcholines 61-80 C-reactive protein Homo sapiens 236-239 471064-0 1979 Interaction of C-reactive protein with artificial phosphatidylcholine bilayers. Phosphatidylcholines 50-69 C-reactive protein Homo sapiens 15-33 471064-3 1979 CRP has a Ca2+-dependent binding specificity for phosphorylcholine, the polar head group of two widely distributed lipids, lecithin (phosphatidylcholine, PC) and sphingomyelin (SM). Phosphatidylcholines 133-152 C-reactive protein Homo sapiens 0-3 271994-9 1977 We conclude that (i) CRP can sensitize appropriate liposomes for complement-dependent damage via the primary complement pathway starting at the level of C1q; (ii) of those studied, liposomes that are most susceptible to membrane damage contain phosphatidylcholine, have a positive charge, and contain a ceramide glycolipid; and (iii) such liposomes also are sensitive, although to a much lesser degree, to complement-dependent lysis initiated in the absence of CRP and involving consumption of terminal in excess of early acting complement components. Phosphatidylcholines 244-263 C-reactive protein Homo sapiens 21-24 23449275-7 2012 C-reactive protein showed positive correlations with phosphatidylcholine, phosphatidylserine, phosphatidylinositol and total phospholipids in membranes from control subjects. Phosphatidylcholines 53-72 C-reactive protein Homo sapiens 0-18 15692104-2 2005 METHODS AND RESULTS: We found that CRP and annexin A5 at physiological concentrations bind Ca++ dependently to oxidized phosphatidylcholine present in oxidized LDL but not to native LDL. Phosphatidylcholines 120-139 C-reactive protein Homo sapiens 35-38 19454128-5 2009 Also an inverse correlation was observed between the C-reactive protein and membrane phosphatidylcholine and phosphatidylserine 20 : 4n-6. Phosphatidylcholines 85-104 C-reactive protein Homo sapiens 53-71 19425005-0 2009 Investigation of C-reactive protein binding to phosphatidyl choline by CZE and ESI-mass analysis. Phosphatidylcholines 47-67 C-reactive protein Homo sapiens 17-35 16962105-1 2006 C-reactive protein (CRP) is elevated in cardiovascular disease and binds to oxidized phosphatidylcholine (oxPtC) in the low-density lipoprotein (LDL) surface. Phosphatidylcholines 85-104 C-reactive protein Homo sapiens 0-18 16962105-1 2006 C-reactive protein (CRP) is elevated in cardiovascular disease and binds to oxidized phosphatidylcholine (oxPtC) in the low-density lipoprotein (LDL) surface. Phosphatidylcholines 85-104 C-reactive protein Homo sapiens 20-23 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Phosphatidylcholines 53-72 C-reactive protein Homo sapiens 143-161 12244213-9 2002 These data suggest that CRP binds OxLDL and apoptotic cells by recognition of a PC moiety that becomes accessible as a result of oxidation of PtC molecule. Phosphatidylcholines 142-145 C-reactive protein Homo sapiens 24-27 8144898-11 1994 CRP binding to complement-treated liposomes required phosphatidylcholine in addition to the MAC indicating that membrane phospholipids rather than the MAC proteins provide the binding sites for CRP. Phosphatidylcholines 53-72 C-reactive protein Homo sapiens 0-3 8336521-2 1993 Addition of 15 micrograms/ml CRP resulted in about 60% decrease in phospholipase D activity using phosphatidylcholine dispersed with Triton X-100 as substrate, and more using lipid suspension consisting of only phosphatidylcholine. Phosphatidylcholines 98-117 C-reactive protein Homo sapiens 29-32 8336521-2 1993 Addition of 15 micrograms/ml CRP resulted in about 60% decrease in phospholipase D activity using phosphatidylcholine dispersed with Triton X-100 as substrate, and more using lipid suspension consisting of only phosphatidylcholine. Phosphatidylcholines 211-230 C-reactive protein Homo sapiens 29-32 8336521-3 1993 In Lineweaver- Burk analysis with phosphatidylcholine dispersed with Triton X-100, the apparent Km value of phospholipase D for phosphatidylcholine increased from 2.27 mg/ml to 3.72 mg/ml by addition of 7.5 micrograms/ml CRP whereas the Vmax value was not altered. Phosphatidylcholines 34-53 C-reactive protein Homo sapiens 221-224 1900197-1 1991 C-reactive protein was highly purified from Japanese eel (Anguilla japonica) serum by precipitation with phosphatidyl-choline and Ca2+. Phosphatidylcholines 105-125 C-reactive protein Homo sapiens 0-18 1701623-3 1990 The proportion of 18:2 in serum phosphatidylcholine correlated inversely with such acute phase proteins as orosomucoid and C reactive protein. Phosphatidylcholines 32-51 C-reactive protein Homo sapiens 123-141 8336521-3 1993 In Lineweaver- Burk analysis with phosphatidylcholine dispersed with Triton X-100, the apparent Km value of phospholipase D for phosphatidylcholine increased from 2.27 mg/ml to 3.72 mg/ml by addition of 7.5 micrograms/ml CRP whereas the Vmax value was not altered. Phosphatidylcholines 128-147 C-reactive protein Homo sapiens 221-224 1657391-6 1991 On the other hand, CRP could aggregate liposome consisted of lyso-PC and phosphatidylcholine (PC), but not that consisted of PC alone. Phosphatidylcholines 73-92 C-reactive protein Homo sapiens 19-22 1657391-6 1991 On the other hand, CRP could aggregate liposome consisted of lyso-PC and phosphatidylcholine (PC), but not that consisted of PC alone. Phosphatidylcholines 66-68 C-reactive protein Homo sapiens 19-22 1657391-6 1991 On the other hand, CRP could aggregate liposome consisted of lyso-PC and phosphatidylcholine (PC), but not that consisted of PC alone. Phosphatidylcholines 94-96 C-reactive protein Homo sapiens 19-22 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Phosphatidylcholines 53-72 C-reactive protein Homo sapiens 163-166 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Phosphatidylcholines 74-76 C-reactive protein Homo sapiens 143-161 34608242-7 2021 Correlation analyses revealed sphingomyelin (SM) and phosphatidylcholine (PC) positively correlate to tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and interleukin-6 (IL-6), while phosphatidylglycerol (PG), and phosphatidylinositol (PI) negatively correlate with them. Phosphatidylcholines 74-76 C-reactive protein Homo sapiens 163-166