PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20338039-5 2010 Likewise, treatment with miltefosine produces an interference with the biosynthesis of phosphatidylcholine via both CDP-choline and phosphatidylethanolamine methylation. Phosphatidylcholines 87-106 cut like homeobox 1 Homo sapiens 116-119 20503434-2 2010 In most eukaryotic cells, PC and PE are synthesized by an aminoalcoholphosphotransferase reaction, which uses sn-1,2-diradylglycerol and either CDP-choline or CDP-ethanolamine, respectively. Phosphatidylcholines 26-28 cut like homeobox 1 Homo sapiens 144-147 20503434-2 2010 In most eukaryotic cells, PC and PE are synthesized by an aminoalcoholphosphotransferase reaction, which uses sn-1,2-diradylglycerol and either CDP-choline or CDP-ethanolamine, respectively. Phosphatidylcholines 26-28 cut like homeobox 1 Homo sapiens 159-162 17171187-1 2006 Cytidine 5"-diphosphocholine, CDP-choline, or citicoline is an essential intermediate in the biosynthetic pathway of structural phospholipids in cell membranes, particularly phosphatidylcholine. Phosphatidylcholines 174-193 cut like homeobox 1 Homo sapiens 30-33 19351232-1 2009 Citicoline (cytidine-5"-diphosphocholine or CDP-choline) is a precursor essential for the synthesis of phosphatidylcholine, one of the cell membrane components that is degraded during cerebral ischemia to free fatty acids and free radicals. Phosphatidylcholines 103-122 cut like homeobox 1 Homo sapiens 44-47 17179149-2 2007 In all nucleated mammalian cells, PC is synthesized from choline via the Kennedy (CDP-choline) pathway. Phosphatidylcholines 34-36 cut like homeobox 1 Homo sapiens 82-85 15756928-5 2005 CDP-choline might increase the PC levels by attenuating PLA(2) stimulation and loss of CCT activity. Phosphatidylcholines 31-33 cut like homeobox 1 Homo sapiens 0-3 16766520-3 2006 As previously described, an adaptive induction of phosphatidylcholine (PC) synthesis via CDP-choline was found upon FC loading. Phosphatidylcholines 50-69 cut like homeobox 1 Homo sapiens 89-92 16766520-3 2006 As previously described, an adaptive induction of phosphatidylcholine (PC) synthesis via CDP-choline was found upon FC loading. Phosphatidylcholines 71-73 cut like homeobox 1 Homo sapiens 89-92 16466701-2 2006 We reported in a previous study that HePC interferes with phosphatidylcholine (PC) synthesis in HepG2 cells via both CDP-choline and phosphatidylethanolamine (PE) methylation. Phosphatidylcholines 39-41 cut like homeobox 1 Homo sapiens 117-120 15846601-1 2005 BACKGROUND: CDP-choline (cytidine 5"-diphosphocholine) is a precursor essential for the synthesis of phosphatidylcholine, one of the cell membrane components that is degraded during cerebral ischaemia to free fatty acids and free radicals. Phosphatidylcholines 101-120 cut like homeobox 1 Homo sapiens 12-15 15079868-1 2004 Cytidine-5"-diphosphocholine (CDP-choline, also referred as citicoline), the key intermediate in phosphatidylcholine (PtdCho) synthesis, provided significant benefit in experimental central nervous system (CNS) injury including cerebral ischemia. Phosphatidylcholines 97-116 cut like homeobox 1 Homo sapiens 30-33 15079868-10 2004 These data indicate that PtdCho synthesis is impaired after brain ischemia, and CDP-choline may increase PtdCho levels by attenuating the loss of CCT activity and lyso-PtdCho formation. Phosphatidylcholines 105-111 cut like homeobox 1 Homo sapiens 80-83 15079868-1 2004 Cytidine-5"-diphosphocholine (CDP-choline, also referred as citicoline), the key intermediate in phosphatidylcholine (PtdCho) synthesis, provided significant benefit in experimental central nervous system (CNS) injury including cerebral ischemia. Phosphatidylcholines 118-124 cut like homeobox 1 Homo sapiens 30-33 15003397-1 2004 Choline kinase (CK) catalyzes the first phosphorylation reaction in the CDP-choline pathway for the biosynthesis of phosphatidylcholine (PC), yielding phosphocholine (P-Cho) from choline and ATP in the presence of Mg(2+). Phosphatidylcholines 116-135 cut like homeobox 1 Homo sapiens 72-75 15003397-1 2004 Choline kinase (CK) catalyzes the first phosphorylation reaction in the CDP-choline pathway for the biosynthesis of phosphatidylcholine (PC), yielding phosphocholine (P-Cho) from choline and ATP in the presence of Mg(2+). Phosphatidylcholines 137-139 cut like homeobox 1 Homo sapiens 72-75 14592540-0 2004 Hexadecylphosphocholine inhibits phosphatidylcholine synthesis via both the methylation of phosphatidylethanolamine and CDP-choline pathways in HepG2 cells. Phosphatidylcholines 33-52 cut like homeobox 1 Homo sapiens 120-123 14592540-1 2004 We reported in a recent publication that hexadecylphosphocholine (HePC), a lysophospholipid analogue, reduces cell proliferation in HepG2 cells and at the same time inhibits the biosynthesis of phosphatidylcholine (PC) via CDP-choline by acting upon CTP:phosphocholine cytidylyltransferase (CT). Phosphatidylcholines 194-213 cut like homeobox 1 Homo sapiens 223-226 14592540-1 2004 We reported in a recent publication that hexadecylphosphocholine (HePC), a lysophospholipid analogue, reduces cell proliferation in HepG2 cells and at the same time inhibits the biosynthesis of phosphatidylcholine (PC) via CDP-choline by acting upon CTP:phosphocholine cytidylyltransferase (CT). Phosphatidylcholines 68-70 cut like homeobox 1 Homo sapiens 223-226 14592540-7 2004 These results constitute the first experimental evidence that the inhibition of the synthesis of PC via CDP-choline by HePC is not counterbalanced by any increase in its formation via methylation. Phosphatidylcholines 97-99 cut like homeobox 1 Homo sapiens 104-107 12443983-1 2002 Citicoline, or CDP-choline, is an essential endogenous intermediate in the biosynthesis of phosphatidylcholine that may act as a neuroprotector in several models of neurodegeneration. Phosphatidylcholines 91-110 cut like homeobox 1 Homo sapiens 15-18 11796739-1 2002 Cytidine-5"-diphosphocholine (citicoline or CDP-choline), an intermediate in the biosynthesis of phosphatidylcholine (PtdCho), has shown beneficial effects in a number of CNS injury models and pathological conditions of the brain. Phosphatidylcholines 97-116 cut like homeobox 1 Homo sapiens 44-47 12021827-2 2002 Evidence from both animal and in vitro studies indicates that CDP-choline (citicoline) administration may increase phosphatidylcholine (PtdCho) synthesis and might reverse PtdCho loss. Phosphatidylcholines 115-134 cut like homeobox 1 Homo sapiens 62-65 12021827-2 2002 Evidence from both animal and in vitro studies indicates that CDP-choline (citicoline) administration may increase phosphatidylcholine (PtdCho) synthesis and might reverse PtdCho loss. Phosphatidylcholines 136-142 cut like homeobox 1 Homo sapiens 62-65 11796739-1 2002 Cytidine-5"-diphosphocholine (citicoline or CDP-choline), an intermediate in the biosynthesis of phosphatidylcholine (PtdCho), has shown beneficial effects in a number of CNS injury models and pathological conditions of the brain. Phosphatidylcholines 118-124 cut like homeobox 1 Homo sapiens 44-47 10893425-1 2000 A cholinephosphotransferase activity catalyzes the final step in the de novo synthesis of phosphatidylcholine via the transfer of a phosphocholine moiety from CDP choline to diacylglycerol. Phosphatidylcholines 90-109 cut like homeobox 1 Homo sapiens 159-162 11376003-1 2001 Previous studies suggest that the steps of the CDP- choline pathway of phosphatidylcholine synthesis are tightly linked in a so-called metabolon. Phosphatidylcholines 71-90 cut like homeobox 1 Homo sapiens 47-50 11223016-2 2001 CDP-choline restored cardiolipin levels, arachidonic acid content of PtdCho, partially but significantly restored total PtdCho, and had no effect on PtdIns. Phosphatidylcholines 69-75 cut like homeobox 1 Homo sapiens 0-3 11223016-2 2001 CDP-choline restored cardiolipin levels, arachidonic acid content of PtdCho, partially but significantly restored total PtdCho, and had no effect on PtdIns. Phosphatidylcholines 120-126 cut like homeobox 1 Homo sapiens 0-3 11080206-10 2000 These data suggest multiple beneficial effects of CDP-choline: (1) stabilizing the cell membrane by restoring PtdCho and sphingomyelin (prominent components of outer cell membrane), (2) attenuating the release of ArAc and limiting its oxidative metabolism, and (3) restoring cardiolipin levels. Phosphatidylcholines 110-116 cut like homeobox 1 Homo sapiens 50-53 11055744-4 2000 The incubation of LA-N-1 nuclei with radioactive choline, phosphocholine or CDP-choline led to the production of labelled phosphatidylcholine. Phosphatidylcholines 122-141 cut like homeobox 1 Homo sapiens 76-79 10517269-1 1999 In cholinergic neurons choline is directed to three main pathways; (1) conversion to phosphorylcholine (PCh) and cytidine diphosphate choline (CDP-choline) for the synthesis of phosphatidylcholine, (2) acylation to the neurotransmitter acetylcholine and (3) oxidation to betaine for the formation of methionine. Phosphatidylcholines 177-196 cut like homeobox 1 Homo sapiens 143-146 10561698-1 1999 CDP-choline is a rate-limiting intermediate in the biosynthesis of phosphatidylcholine (PtdCho), an important component of the neural cell membrane. Phosphatidylcholines 67-86 cut like homeobox 1 Homo sapiens 0-3 10561698-1 1999 CDP-choline is a rate-limiting intermediate in the biosynthesis of phosphatidylcholine (PtdCho), an important component of the neural cell membrane. Phosphatidylcholines 88-94 cut like homeobox 1 Homo sapiens 0-3 10561698-3 1999 Exogenous treatment with CDP-choline stimulates PtdCho synthesis and prevents release of free fatty acids (FFA), especially arachidonic acid (AA), after ischemia/reperfusion. Phosphatidylcholines 48-54 cut like homeobox 1 Homo sapiens 25-28 10561698-10 1999 CDP-choline may act by increasing PtdCho synthesis via two pathways: (1) conversion of 1, 2-diacylglycerol to PtdCho, and (2) biosynthesis of S-adenosyl-L-methionine, thus stabilizing the membrane and reducing AA release and metabolism to leukotriene C(4). Phosphatidylcholines 34-40 cut like homeobox 1 Homo sapiens 0-3 10561698-10 1999 CDP-choline may act by increasing PtdCho synthesis via two pathways: (1) conversion of 1, 2-diacylglycerol to PtdCho, and (2) biosynthesis of S-adenosyl-L-methionine, thus stabilizing the membrane and reducing AA release and metabolism to leukotriene C(4). Phosphatidylcholines 110-116 cut like homeobox 1 Homo sapiens 0-3 10322420-4 1999 These processes involve the regulation of the CDP-choline and phosphatidylethanolamine-methylation pathways of phosphatidylcholine synthesis, CTP synthetase, phospholipase D and the phospholipid-transfer protein Sec14p. Phosphatidylcholines 111-130 cut like homeobox 1 Homo sapiens 46-49 10191259-1 1999 Cholinephosphotransferase catalyses the final step in the synthesis of phosphatidylcholine (PtdCho) via the Kennedy pathway by the transfer of phosphocholine from CDP-choline to diacylglycerol. Phosphatidylcholines 71-90 cut like homeobox 1 Homo sapiens 163-166 10191259-1 1999 Cholinephosphotransferase catalyses the final step in the synthesis of phosphatidylcholine (PtdCho) via the Kennedy pathway by the transfer of phosphocholine from CDP-choline to diacylglycerol. Phosphatidylcholines 92-98 cut like homeobox 1 Homo sapiens 163-166 10728571-9 1999 PC biosynthesis seemed to be carried out through the CDP-choline pathway, which was stimulated in the oncogenic cells, whereas PE was more likely, a product of phosphatidylserine decarboxylation rather than the CDP-ethanolamine pathway. Phosphatidylcholines 0-2 cut like homeobox 1 Homo sapiens 53-56 8888372-8 1996 These results suggest that the cytidine moiety of CDP-choline stimulates phosphatidylcholine synthesis in human brain cell membranes in older subjects. Phosphatidylcholines 73-92 cut like homeobox 1 Homo sapiens 50-53 9748300-8 1998 Moreover, geranylgeraniol and farnesol induced a rapid inhibition of phosphatidylcholine biosynthesis at the last step of the CDP-choline pathway controlled by choline phosphotransferase and not at the level of CTP:phosphocholine cytidylyltransferase, the key enzyme of the pathway. Phosphatidylcholines 69-88 cut like homeobox 1 Homo sapiens 126-129 9727944-3 1998 The most significant changes were increases in the concentration of the glycolytic intermediate, fructose-1,6-bisphosphate and in the concentration of CDP-choline, which is an intermediate in phosphatidylcholine biosynthesis. Phosphatidylcholines 192-211 cut like homeobox 1 Homo sapiens 151-154 8043301-4 1994 In contrast, the rate of incorporation of labeled choline into PC, presumably via CDP-choline, was virtually identical in cells that had been preincubated in the presence or absence of 1 mM choline. Phosphatidylcholines 63-65 cut like homeobox 1 Homo sapiens 82-85 7477743-3 1995 Exogenous administration of CDP-choline provides both choline and cytidine which access the brain and serve as substrates for the synthesis of phosphatidylcholine, a primary neuronal membrane component; the choline also enhances brain acetylcholine synthesis. Phosphatidylcholines 143-162 cut like homeobox 1 Homo sapiens 28-31 7760585-1 1994 CDP-choline participates in brain phospholipid metabolism and acts as an endogenous intermediate in a biosynthetic pathway incorporating free choline into phosphatidylcholine and choline plasmalogens in several tissues, including the central nervous system (CNS). Phosphatidylcholines 155-174 cut like homeobox 1 Homo sapiens 0-3 7869846-2 1995 As the product of the rate-limiting step in the synthesis of phosphatidylcholine from choline, CDP-choline and its hydrolysis products (cytidine and choline) play important roles in generation of phospholipids involved in membrane formation and repair. Phosphatidylcholines 61-80 cut like homeobox 1 Homo sapiens 95-98 8051988-5 1994 CDP-choline (cytidine-5-diphosphate-choline) participates in the phospholipid metabolism pathway incorporating free choline into phosphatidyl-choline and choline plasmalogens in several tissues, including the central nervous system. Phosphatidylcholines 129-149 cut like homeobox 1 Homo sapiens 0-3 1854804-1 1991 The major route of phosphatidylcholine (PtdCho) biosynthesis in mammalian cells is the sequence: choline (Cho)----phosphocholine (PCho)----cytidinediphosphate choline (CDP-Cho)----PtdCho. Phosphatidylcholines 19-38 cut like homeobox 1 Homo sapiens 168-171 8383672-4 1993 The stimulation of phosphatidylcholine synthesis was correlated with a decrease in phosphocholine and an increase in CDP-choline, indicating that cytidylyltransferase is regulatory under these conditions. Phosphatidylcholines 19-38 cut like homeobox 1 Homo sapiens 117-120 2061317-0 1991 Channeling of intermediates in the CDP-choline pathway of phosphatidylcholine biosynthesis in cultured glioma cells is dependent on intracellular Ca2+. Phosphatidylcholines 58-77 cut like homeobox 1 Homo sapiens 35-38 2061317-1 1991 The major route of phosphatidylcholine (Ptd-choline) biosynthesis in mammalian cells is the CDP-choline pathway which involves stepwise conversion of choline to phosphocholine (P-choline), cytidine diphosphate choline (CDP-choline), and Ptd-choline. Phosphatidylcholines 19-38 cut like homeobox 1 Homo sapiens 92-95 2061317-1 1991 The major route of phosphatidylcholine (Ptd-choline) biosynthesis in mammalian cells is the CDP-choline pathway which involves stepwise conversion of choline to phosphocholine (P-choline), cytidine diphosphate choline (CDP-choline), and Ptd-choline. Phosphatidylcholines 19-38 cut like homeobox 1 Homo sapiens 219-222 2061317-1 1991 The major route of phosphatidylcholine (Ptd-choline) biosynthesis in mammalian cells is the CDP-choline pathway which involves stepwise conversion of choline to phosphocholine (P-choline), cytidine diphosphate choline (CDP-choline), and Ptd-choline. Phosphatidylcholines 40-51 cut like homeobox 1 Homo sapiens 92-95 2061317-1 1991 The major route of phosphatidylcholine (Ptd-choline) biosynthesis in mammalian cells is the CDP-choline pathway which involves stepwise conversion of choline to phosphocholine (P-choline), cytidine diphosphate choline (CDP-choline), and Ptd-choline. Phosphatidylcholines 40-51 cut like homeobox 1 Homo sapiens 219-222 2061317-1 1991 The major route of phosphatidylcholine (Ptd-choline) biosynthesis in mammalian cells is the CDP-choline pathway which involves stepwise conversion of choline to phosphocholine (P-choline), cytidine diphosphate choline (CDP-choline), and Ptd-choline. Phosphatidylcholines 237-248 cut like homeobox 1 Homo sapiens 92-95 2061317-11 1991 These results suggest that channeling of intermediates in the CDP-choline pathway of Ptd-choline biosynthesis in glioma cells is mediated by intracellular Ca2+ levels that may coordinately regulate the steps involved in conversion of choline to Ptd-choline. Phosphatidylcholines 85-96 cut like homeobox 1 Homo sapiens 62-65 1854804-1 1991 The major route of phosphatidylcholine (PtdCho) biosynthesis in mammalian cells is the sequence: choline (Cho)----phosphocholine (PCho)----cytidinediphosphate choline (CDP-Cho)----PtdCho. Phosphatidylcholines 40-46 cut like homeobox 1 Homo sapiens 168-171 1776744-2 1991 Experimental studies have shown that the administration of CDP-choline increases the total amount of phosphatidylcholine and other related phospholipids in the brain and in some cases may enhance neurotransmission. Phosphatidylcholines 101-120 cut like homeobox 1 Homo sapiens 59-62 6863389-4 1983 Since this was observed with glycerol, choline, and orthophosphate labelings, and not with methyl labeling, it appears that the CDP-choline plus diacylglycerol pathway rather than the phosphatidylethanolamine to PC pathway was augmented. Phosphatidylcholines 212-214 cut like homeobox 1 Homo sapiens 128-131 2846391-2 1988 The CDP-choline pathway is the major route of phosphatidylcholine (PC) biosynthesis in mammalian cells. Phosphatidylcholines 46-65 cut like homeobox 1 Homo sapiens 4-7 2846391-2 1988 The CDP-choline pathway is the major route of phosphatidylcholine (PC) biosynthesis in mammalian cells. Phosphatidylcholines 67-69 cut like homeobox 1 Homo sapiens 4-7 3756002-0 1986 The supply of both CDP-choline and diacylglycerol can regulate the rate of phosphatidylcholine synthesis in HeLa cells. Phosphatidylcholines 75-94 cut like homeobox 1 Homo sapiens 19-22 3756002-1 1986 The incorporation of [methyl-14C]CDP-choline into phosphatidylcholine was measured in HeLa cells permeabilized with 0.125 mg digitonin/mL. Phosphatidylcholines 50-69 cut like homeobox 1 Homo sapiens 33-36 3756002-2 1986 The rate of phosphatidylcholine formation was influenced by the concentration of CDP-choline in the medium. Phosphatidylcholines 12-31 cut like homeobox 1 Homo sapiens 81-84 3756002-6 1986 The incorporation of [methyl-14C]CDP-choline into phosphatidylcholine was stimulated by the supply of diacylglycerol in both HeLa cells and isolated microsomes. Phosphatidylcholines 50-69 cut like homeobox 1 Homo sapiens 33-36 3756002-11 1986 Furthermore, incubation of microsomes with [3H]diacylglycerol and [14C]CDP-choline showed that both of the substrates were incorporated into phosphatidylcholine at the same rate. Phosphatidylcholines 141-160 cut like homeobox 1 Homo sapiens 71-74 3756002-13 1986 These results suggest that both in the permeabilized cells and in isolated membranes, the biosynthesis of phosphatidylcholine can be limited by both CDP-choline and diacylglycerol. Phosphatidylcholines 106-125 cut like homeobox 1 Homo sapiens 149-152 3839593-3 1985 Cytidine diphosphocholine (CDP-choline) is an essential intermediary in the biosynthesis of PC. Phosphatidylcholines 92-94 cut like homeobox 1 Homo sapiens 27-30 2917151-0 1989 Co-ordinate control of CDP-choline and phosphatidylethanolamine methyltransferase pathways for phosphatidylcholine biosynthesis occurs in response to change in diet fat. Phosphatidylcholines 95-114 cut like homeobox 1 Homo sapiens 23-26 2647398-1 1989 Based on the cholinergic-deficiency hypothesis of tardive dyskinesia (TD), we administered cytidine diphosphoryl choline (CDP-Choline) (a naturally occurring biochemical intermediary in the synthesis of phosphatidylcholine), 500 mg twice a day orally, to four women and one man with TD for 2 to 8 weeks in a double-blind, placebo-controlled crossover trial. Phosphatidylcholines 203-222 cut like homeobox 1 Homo sapiens 122-125 2893798-4 1988 The limiting step in phosphatidylcholine biosynthesis was the formation of CDP-choline catalyzed by CTP:choline-phosphate cytidylyltransferase (EC 2.7.7.15) as monitored by the decrease in phosphocholine labeling following phospholipase C treatment of cells prelabeled with [3H]choline. Phosphatidylcholines 21-40 cut like homeobox 1 Homo sapiens 75-78 3163212-3 1988 In addition, the increased synthesis of ara-CDP-choline associated with these high doses may serve as an alternate substrate for phosphatidyl choline synthesis, which may contribute to membrane fragility and cell lysis. Phosphatidylcholines 129-149 cut like homeobox 1 Homo sapiens 44-47 3032677-0 1987 De novo CDP-choline-dependent glycerophosphorylcholine synthesis and its involvement as an intermediate in phosphatidylcholine synthesis. Phosphatidylcholines 107-126 cut like homeobox 1 Homo sapiens 8-11 3032677-1 1987 The activity of CDP-choline-dependent glycerophosphorylcholine synthetase (CDP-choline:sn-3-glycerophosphate cholinetransferase), a newly discovered enzyme involved in the recently proposed pathways of acyl-specific phosphatidylcholine synthesis, is reported in rat liver. Phosphatidylcholines 216-235 cut like homeobox 1 Homo sapiens 16-19 3032677-1 1987 The activity of CDP-choline-dependent glycerophosphorylcholine synthetase (CDP-choline:sn-3-glycerophosphate cholinetransferase), a newly discovered enzyme involved in the recently proposed pathways of acyl-specific phosphatidylcholine synthesis, is reported in rat liver. Phosphatidylcholines 216-235 cut like homeobox 1 Homo sapiens 75-78 3998733-4 1985 The incubation of microsomes with CDP-[14C]choline or [14C]choline showed that most of the newly synthesized phosphatidylcholine molecules were localized in the external leaflet. Phosphatidylcholines 109-128 cut like homeobox 1 Homo sapiens 34-37 6304446-2 1983 The labeling of choline glycerophospholipid (CGP) from radioactive cytidine-5"-diphosphate choline (CDP-choline) in vitro shows a maximum at pH 8.0 (using Hepes [4-(2-hydroxyethyl)-piperazine-1-ethane-2-sulfonic acid] as a buffer) and is stimulated by Mn2+, Mg2+ and diacylglycerol. Phosphatidylcholines 45-48 cut like homeobox 1 Homo sapiens 100-103 6856033-4 1983 At short times after the isotope administration a rapid labeling of phosphatidylcholine was detected, when cells were incubated with CDP-choline. Phosphatidylcholines 68-87 cut like homeobox 1 Homo sapiens 133-136 7076675-0 1982 Inhibition of phosphatidylethanolamine N-methylation by 3-deazaadenosine stimulates the synthesis of phosphatidylcholine via the CDP-choline pathway. Phosphatidylcholines 101-120 cut like homeobox 1 Homo sapiens 129-132 7093220-3 1982 The addition of [3H]methionine to cells that were grown in 1 mM dimethylethanolamine efficiently radiolabeled phosphatidylcholine (by methylation of phosphatidyldimethylethanolamine) and sphingomyelin but not phosphocholine or CDP-choline. Phosphatidylcholines 110-129 cut like homeobox 1 Homo sapiens 227-230 33574922-1 2021 Choline kinase (ChK) catalyzes the first step in the CDP-choline pathway for the synthesis of phosphatidylcholine. Phosphatidylcholines 94-113 cut like homeobox 1 Homo sapiens 53-56 33789160-1 2021 The membrane phospholipids phosphatidylcholine and phosphatidylethanolamine (PE) are synthesized de novo by the CDP-choline and CDP-ethanolamine (Kennedy) pathway, in which the extracellular substrates choline and ethanolamine are transported into the cell, phosphorylated, and coupled with diacylglycerol to form the final phospholipid product. Phosphatidylcholines 27-46 cut like homeobox 1 Homo sapiens 112-115 33789160-1 2021 The membrane phospholipids phosphatidylcholine and phosphatidylethanolamine (PE) are synthesized de novo by the CDP-choline and CDP-ethanolamine (Kennedy) pathway, in which the extracellular substrates choline and ethanolamine are transported into the cell, phosphorylated, and coupled with diacylglycerol to form the final phospholipid product. Phosphatidylcholines 27-46 cut like homeobox 1 Homo sapiens 128-131 33454021-1 2020 The two branches of the Kennedy pathways (CDP-choline and CDP-ethanolamine) are the predominant pathways responsible for the synthesis of the most abundant phospholipids, phosphatidylcholine and phosphatidylethanolamine, respectively, in mammalian membranes. Phosphatidylcholines 171-190 cut like homeobox 1 Homo sapiens 42-45 33606602-10 2021 Daily co-administration of CDP-diacylglycerol significantly enhanced the beneficial effects of CDP-choline and also modified the ATII cell lipidome, reversing the infection-induced decrease in phosphatidylcholine and increasing levels of most other lipid classes in ATII cells. Phosphatidylcholines 193-212 cut like homeobox 1 Homo sapiens 27-30 33454021-1 2020 The two branches of the Kennedy pathways (CDP-choline and CDP-ethanolamine) are the predominant pathways responsible for the synthesis of the most abundant phospholipids, phosphatidylcholine and phosphatidylethanolamine, respectively, in mammalian membranes. Phosphatidylcholines 171-190 cut like homeobox 1 Homo sapiens 58-61 26961241-5 2016 The POPC conjugate of the NS5B inhibitors was assumed to result from two sequential reactions: hydroxylation of the bicyclic methine to a tertiary alcohol and addition of POPC by CDP-choline: 1,2-diacylglycerol cholinephosphotransferase, an enzyme responsible for the final step in the biosynthesis of phosphatidylcholine. Phosphatidylcholines 302-321 cut like homeobox 1 Homo sapiens 179-182 32778895-7 2020 Direct incorporation of methyl-D9-choline demonstrated that this transition was driven by an active CDP-choline pathway that synthesized PC enriched in species containing oleic and linoleic acids. Phosphatidylcholines 137-139 cut like homeobox 1 Homo sapiens 100-103 27769579-2 2017 Choline kinases possess enzyme activity that catalyses the conversion of choline to phosphocholine, which is further converted to cytidine diphosphate-coline (CDP-choline) in the biosynthesis of phosphatidylcholine (PC). Phosphatidylcholines 195-214 cut like homeobox 1 Homo sapiens 159-162 27769579-2 2017 Choline kinases possess enzyme activity that catalyses the conversion of choline to phosphocholine, which is further converted to cytidine diphosphate-coline (CDP-choline) in the biosynthesis of phosphatidylcholine (PC). Phosphatidylcholines 216-218 cut like homeobox 1 Homo sapiens 159-162 29178478-3 2018 The main pathway for the synthesis of PC is the Kennedy (CDP-choline) pathway. Phosphatidylcholines 38-40 cut like homeobox 1 Homo sapiens 57-60 29178478-4 2018 In this pathway, choline is converted to phosphocholine by choline kinase, phosphocholine is metabolized to CDP-choline by the rate-determining enzyme for this pathway, CTP:phosphocholine cytidylyltransferase, and cholinephosphotransferase condenses CDP-choline with diacylglycerol to produce PC. Phosphatidylcholines 293-295 cut like homeobox 1 Homo sapiens 108-111 29450391-1 2017 Citicoline is the generic name of cytidine-5"-diphosphocholine (CDP-choline), an endogenous compound that is able to increase the levels of neurotransmitters in the central nervous system by interacting with the synthesis of cellular membranes phospholipids, especially phosphatidylcholine. Phosphatidylcholines 270-289 cut like homeobox 1 Homo sapiens 64-67 26108622-1 2015 The reversible association of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) with membranes regulates the synthesis of phosphatidylcholine (PC) by the CDP-choline (Kennedy) pathway. Phosphatidylcholines 129-148 cut like homeobox 1 Homo sapiens 161-164 26108622-1 2015 The reversible association of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) with membranes regulates the synthesis of phosphatidylcholine (PC) by the CDP-choline (Kennedy) pathway. Phosphatidylcholines 150-152 cut like homeobox 1 Homo sapiens 161-164 24080101-2 2013 Choline kinase (ChoK) is the first enzyme in the CDP-choline pathway that synthesizes phosphatidylcholine (PC), the major phospholipid in eukaryotic cell membranes. Phosphatidylcholines 86-105 cut like homeobox 1 Homo sapiens 49-52 24583375-3 2014 Our results show that the CDP-choline pathway is the only de novo route for PC biosynthesis in both HOB and MG-63 cells. Phosphatidylcholines 76-78 cut like homeobox 1 Homo sapiens 26-29 24080101-2 2013 Choline kinase (ChoK) is the first enzyme in the CDP-choline pathway that synthesizes phosphatidylcholine (PC), the major phospholipid in eukaryotic cell membranes. Phosphatidylcholines 107-109 cut like homeobox 1 Homo sapiens 49-52 23505262-0 2013 Retraction: CDP-choline significantly restores phosphatidylcholine levels by differentially affecting phospholipase A2 and CTP: phosphocholine cytidylyltransferase after stroke. Phosphatidylcholines 47-66 cut like homeobox 1 Homo sapiens 12-15 22278967-1 2012 Choline kinase (ChoK) is the first enzyme in the CDP-choline pathway that synthesizes phosphatidylcholine, the major phospholipid in eukaryotic cell membranes. Phosphatidylcholines 86-105 cut like homeobox 1 Homo sapiens 49-52 23010477-1 2013 The CDP-choline pathway of phosphatidylcholine (PtdCho) biosynthesis was first described more than 50 years ago. Phosphatidylcholines 27-46 cut like homeobox 1 Homo sapiens 4-7 23010477-1 2013 The CDP-choline pathway of phosphatidylcholine (PtdCho) biosynthesis was first described more than 50 years ago. Phosphatidylcholines 48-54 cut like homeobox 1 Homo sapiens 4-7 23010477-6 2013 Regulated PtdCho turnover mediated by phospholipases or neuropathy target esterase participates in the mammalian CDP-choline cycle. Phosphatidylcholines 10-16 cut like homeobox 1 Homo sapiens 113-116