PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9878788-9 1999 D609 which inhibits phosphatidylcholine-specific phospholipase-C (PLC), potently inhibited both CDP-DG accumulation and inositol phosphate formation. Phosphatidylcholines 20-39 cut-like homeobox 1 Rattus norvegicus 96-99 10082883-1 1999 Cytidine and choline, present in cytidine 5"-diphosphate choline (CDP-choline), are major precursors of the phosphatidylcholine found in cell membranes and important regulatory elements in phosphatide biosynthesis. Phosphatidylcholines 108-127 cut-like homeobox 1 Rattus norvegicus 66-69 10082883-2 1999 Administration of CDP-choline to rats increases blood and brain cytidine and choline levels; this enhances the production of endogenous CDP-choline which then combines with fatty acids (as diacylglycerol), to yield phosphatidylcholine. Phosphatidylcholines 215-234 cut-like homeobox 1 Rattus norvegicus 18-21 10082883-2 1999 Administration of CDP-choline to rats increases blood and brain cytidine and choline levels; this enhances the production of endogenous CDP-choline which then combines with fatty acids (as diacylglycerol), to yield phosphatidylcholine. Phosphatidylcholines 215-234 cut-like homeobox 1 Rattus norvegicus 136-139 8119913-4 1994 The CDP-choline pool increased 12-fold suggesting that the conversion of CDP-choline to PC, catalyzed by cholinesphosphotransferase, could not keep pace with the CT-catalyzed reaction. Phosphatidylcholines 88-90 cut-like homeobox 1 Rattus norvegicus 4-7 9370319-1 1997 CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the synthesis of CDP-choline and is regulatory for phosphatidylcholine biosynthesis. Phosphatidylcholines 107-126 cut-like homeobox 1 Rattus norvegicus 73-76 9370326-10 1997 There is reciprocal regulation of the Kennedy pathway for phosphatidylcholine biosynthesis (via CDP-choline) and phosphatidylethanolamine N-methyltransferase. Phosphatidylcholines 58-77 cut-like homeobox 1 Rattus norvegicus 96-99 8694509-4 1996 Mechanistic studies suggest that the slower growth of transfected hepatoma cells may be due to down regulation of CTP: phosphocholine cytidylyltransferase and the CDP-choline pathway for phosphatidylcholine biosynthesis. Phosphatidylcholines 187-206 cut-like homeobox 1 Rattus norvegicus 163-166 7616250-6 1995 When the oral CDP-choline treatment was prolonged for 42 and 90 days, brain phosphatidylcholine concentrations increased significantly (by 22-25%; p < 0.05) in rats consuming 500 mg/kg/day. Phosphatidylcholines 76-95 cut-like homeobox 1 Rattus norvegicus 14-17 8119913-4 1994 The CDP-choline pool increased 12-fold suggesting that the conversion of CDP-choline to PC, catalyzed by cholinesphosphotransferase, could not keep pace with the CT-catalyzed reaction. Phosphatidylcholines 88-90 cut-like homeobox 1 Rattus norvegicus 73-76 1333282-4 1992 The rate of incorporation of CMP into CDP-choline and CDP-ethanolamine was increased by increasing the concentration of phosphatidylcholine and phosphatidylethanolamine, respectively, in detergent-phospholipid micellar systems. Phosphatidylcholines 120-139 cut-like homeobox 1 Rattus norvegicus 38-41 8239304-2 1993 Both compounds enter the brain and can be used in phosphatidylcholine (PC) synthesis via the Kennedy (CDP-choline) cycle. Phosphatidylcholines 50-69 cut-like homeobox 1 Rattus norvegicus 102-105 8239304-2 1993 Both compounds enter the brain and can be used in phosphatidylcholine (PC) synthesis via the Kennedy (CDP-choline) cycle. Phosphatidylcholines 71-73 cut-like homeobox 1 Rattus norvegicus 102-105 8392813-3 1993 The developmental profile of the enzymes of the CDP-choline pathway suggests that CTP:choline-phosphate cytidylyltransferase catalyses a rate regulatory step in de novo phosphatidylcholine synthesis by fetal type II cells. Phosphatidylcholines 169-188 cut-like homeobox 1 Rattus norvegicus 48-51 8324883-4 1993 CDP-choline also did not antagonize the effect of hypoxia on phosphatidylcholine synthesis; rather it accentuated the hypoxia-induced reductions in cellular phosphocholine and phosphatidylcholine biosynthesis. Phosphatidylcholines 176-195 cut-like homeobox 1 Rattus norvegicus 0-3 8324883-5 1993 These results indicate that the exogenous administration of CDP-choline alters choline metabolism in the heart by reducing the formation of phosphocholine and phosphatidylcholine without altering choline uptake and suggest an effect of a CDP-choline metabolite on choline metabolism which is not effective in opposing the effect of hypoxia on phosphatidylcholine biosynthesis. Phosphatidylcholines 159-178 cut-like homeobox 1 Rattus norvegicus 60-63 8324883-5 1993 These results indicate that the exogenous administration of CDP-choline alters choline metabolism in the heart by reducing the formation of phosphocholine and phosphatidylcholine without altering choline uptake and suggest an effect of a CDP-choline metabolite on choline metabolism which is not effective in opposing the effect of hypoxia on phosphatidylcholine biosynthesis. Phosphatidylcholines 343-362 cut-like homeobox 1 Rattus norvegicus 60-63 8418887-4 1993 A phosphocholine cytidylyltransferase-mediated rise in cellular CDP choline content may explain the gemfibrozil-dependent rise in phosphatidylcholine biosynthesis since homogenates of monolayers incubated with CDP choline preferentially incorporate labeled diacylglycerol into phosphatidylcholine rather than triacylglycerol. Phosphatidylcholines 130-149 cut-like homeobox 1 Rattus norvegicus 64-67 8418887-4 1993 A phosphocholine cytidylyltransferase-mediated rise in cellular CDP choline content may explain the gemfibrozil-dependent rise in phosphatidylcholine biosynthesis since homogenates of monolayers incubated with CDP choline preferentially incorporate labeled diacylglycerol into phosphatidylcholine rather than triacylglycerol. Phosphatidylcholines 277-296 cut-like homeobox 1 Rattus norvegicus 64-67 8418887-6 1993 These results suggest that CDP choline may be a key regulator of the diacylglycerol branchpoint, since diacylglycerol is primarily incorporated into phosphatidylcholine or triacylglycerol depending on whether CDP choline is or is not available. Phosphatidylcholines 149-168 cut-like homeobox 1 Rattus norvegicus 27-30 8388315-1 1993 The phosphatidylcholine precursor, cytidine-diphosphocholine (CDP-choline), was injected intraperitoneally (IP) at the dose of 10 or 20 mg/kg/day for 20 days to 24-month-old male rats of the Sprague-Dawley strain that showed cognitive and motor deficits. Phosphatidylcholines 4-23 cut-like homeobox 1 Rattus norvegicus 62-65 8399325-5 1993 (4) The pool sizes of the intermediate metabolic products of the CDP-choline-pathway for the synthesis of phosphatidylcholine were also higher in the cells isolated from exposed animals. Phosphatidylcholines 106-125 cut-like homeobox 1 Rattus norvegicus 65-68 1333282-4 1992 The rate of incorporation of CMP into CDP-choline and CDP-ethanolamine was increased by increasing the concentration of phosphatidylcholine and phosphatidylethanolamine, respectively, in detergent-phospholipid micellar systems. Phosphatidylcholines 120-139 cut-like homeobox 1 Rattus norvegicus 54-57 1309795-14 1992 Instead, phosphatidylcholine biosynthesis appears to be inhibited due to a decreased level of diacylglycerol, a substrate for CDP-choline: 1,2-diacylglycerol cholinephosphotransferase. Phosphatidylcholines 9-28 cut-like homeobox 1 Rattus norvegicus 126-129 1590762-5 1992 The synthesis of phosphatidylcholine was dependent on addition of CDP-choline. Phosphatidylcholines 17-36 cut-like homeobox 1 Rattus norvegicus 66-69 1447319-10 1992 Analysis of the CDP-choline pathway of PC synthesis indicated that the regulatory enzyme, CTP:phosphorylcholine cytidylyltransferase, was stimulated about twofold by PDBu in cells having normal membrane, but not in PE-deficient cells. Phosphatidylcholines 39-41 cut-like homeobox 1 Rattus norvegicus 16-19 2153111-2 1990 The effect of rat liver phosphatidylcholine transfer protein on the incorporation of CDP-choline and dioleoylglycerol into phosphatidylcholine catalyzed by rat liver microsomal CDP-choline: 1,2-diacyl-sn-glycerol cholinephosphotransferase was studied. Phosphatidylcholines 24-43 cut-like homeobox 1 Rattus norvegicus 85-88 2153111-2 1990 The effect of rat liver phosphatidylcholine transfer protein on the incorporation of CDP-choline and dioleoylglycerol into phosphatidylcholine catalyzed by rat liver microsomal CDP-choline: 1,2-diacyl-sn-glycerol cholinephosphotransferase was studied. Phosphatidylcholines 24-43 cut-like homeobox 1 Rattus norvegicus 177-180 2153111-2 1990 The effect of rat liver phosphatidylcholine transfer protein on the incorporation of CDP-choline and dioleoylglycerol into phosphatidylcholine catalyzed by rat liver microsomal CDP-choline: 1,2-diacyl-sn-glycerol cholinephosphotransferase was studied. Phosphatidylcholines 123-142 cut-like homeobox 1 Rattus norvegicus 85-88 2153111-2 1990 The effect of rat liver phosphatidylcholine transfer protein on the incorporation of CDP-choline and dioleoylglycerol into phosphatidylcholine catalyzed by rat liver microsomal CDP-choline: 1,2-diacyl-sn-glycerol cholinephosphotransferase was studied. Phosphatidylcholines 123-142 cut-like homeobox 1 Rattus norvegicus 177-180 2153111-3 1990 In the presence of phosphatidylcholine transfer protein, the incorporation of CDP-choline into phosphatidylcholine was markedly stimulated. Phosphatidylcholines 19-38 cut-like homeobox 1 Rattus norvegicus 78-81 2775183-8 1989 Thus phosphatidylcholine synthesis via reacylation of lysophosphatidylcholine, via the CDP-choline pathway or via methylation of phosphatidylethanolamine, will satisfy the requirements for secretion of very-low-density lipoprotein from hepatocytes. Phosphatidylcholines 5-24 cut-like homeobox 1 Rattus norvegicus 87-90 2925651-3 1989 Similarly, phosphatidylcholine synthesis in permeable cells incubated in the presence of exogenous CDP-choline was similar to that of intact hepatocytes and at the expense of microsomal neutral lipid synthesis. Phosphatidylcholines 11-30 cut-like homeobox 1 Rattus norvegicus 99-102 3117787-1 1987 Evidence for stimulation via protein kinase C. Phorbol esters have been shown to stimulate phosphatidylcholine synthesis via the CDP-choline pathway. Phosphatidylcholines 91-110 cut-like homeobox 1 Rattus norvegicus 129-132 2833521-19 1988 The results support the hypothesis that Golgi has the capacity to make certain phospholipids for lipoprotein secretion: phosphatidylcholine via the CDP-choline and methylation pathways, phosphatidylethanolamine by the CDP-ethanolamine pathway, and phosphatidylserine. Phosphatidylcholines 120-139 cut-like homeobox 1 Rattus norvegicus 148-151 3032160-2 1987 This enhanced synthesis of phosphatidylcholine was accompanied by an increased conversion of choline phosphate into CDP-choline. Phosphatidylcholines 27-46 cut-like homeobox 1 Rattus norvegicus 116-119 6372966-0 1984 Glucagon inhibits phosphatidylcholine biosynthesis via the CDP-choline and transmethylation pathways in cultured rat hepatocytes. Phosphatidylcholines 18-37 cut-like homeobox 1 Rattus norvegicus 59-62 3957904-2 1986 In liver, phosphatidylcholine is made both by the CDP-choline pathway and by the methylation of phosphatidylethanolamine, which in turn is derived from both serine (via phosphatidylserine) and ethanolamine (via CDP-ethanolamine). Phosphatidylcholines 10-29 cut-like homeobox 1 Rattus norvegicus 50-53 3957904-2 1986 In liver, phosphatidylcholine is made both by the CDP-choline pathway and by the methylation of phosphatidylethanolamine, which in turn is derived from both serine (via phosphatidylserine) and ethanolamine (via CDP-ethanolamine). Phosphatidylcholines 10-29 cut-like homeobox 1 Rattus norvegicus 211-214 3904950-5 1985 Phosphatidylcholine is made in liver by two alternate pathways, by the CDP-choline pathway and by the methylation of phosphatidylethanolamine. Phosphatidylcholines 0-19 cut-like homeobox 1 Rattus norvegicus 71-74 3904950-6 1985 Regulation of phosphatidylcholine biosynthesis by the CDP-choline pathway in rat liver is well established. Phosphatidylcholines 14-33 cut-like homeobox 1 Rattus norvegicus 54-57 20501174-9 1987 Since both of these compounds are used in the biosynthesis of phosphatidylcholine, both may be involved in the long-term effects of the CDP-choline. Phosphatidylcholines 62-81 cut-like homeobox 1 Rattus norvegicus 136-139 3947653-1 1986 When 600 X g supernatants of 10% (w/v) rat lung homogenates were incubated with CDP[Me-14C]choline both saturated and unsaturated species of phosphatidylcholine were formed from endogenous diacylglycerols. Phosphatidylcholines 141-160 cut-like homeobox 1 Rattus norvegicus 80-83 6372966-2 1984 Under conditions in which insulin (100 nM) stimulated [3H]acetate incorporation into fatty acid almost twofold, synthesis of phosphatidylcholine via CDP-choline and from phosphatidylethanolamine were unaffected. Phosphatidylcholines 125-144 cut-like homeobox 1 Rattus norvegicus 149-152 7070579-1 1982 The phospholipid composition and the in vitro incorporation of radioactive CDP-choline into phosphatidylcholine was studied in mitochondria and microsomal fraction obtained from liver and brain of 20 day old hyperthyroid or hypothyroid rats. Phosphatidylcholines 92-111 cut-like homeobox 1 Rattus norvegicus 75-78 6708133-9 1984 As a consequence, the (3H)/(14C) ratio in total lipid and in isolated phosphatidylcholine and choline plasmalogen increased after CDP-choline treatment. Phosphatidylcholines 70-89 cut-like homeobox 1 Rattus norvegicus 130-133 7142817-1 1982 Phosphatidylcholine synthesis from CDP-[methyl-14C]choline and membrane-bound diacyl-[U-14C]-sn-glycerol, formed through the glycerol phosphate pathway, has been examined in vitro in rat brain microsomes. Phosphatidylcholines 0-19 cut-like homeobox 1 Rattus norvegicus 35-38 6684464-3 1983 --This radioactivity is detected by the labelling of phosphatidyl-choline and endogenous sphingomyelin from CDP-choline. Phosphatidylcholines 53-73 cut-like homeobox 1 Rattus norvegicus 108-111 7146568-5 1982 There was also observed a marked increase in specific radioactivity of sphingomyelin, which could be due to a stimulation of CDP-choline: ceramide cholinephosphotransferase reaction with subsequent diminution of the rate of phosphatidylcholine synthesis via the CDP-amine pathway (involving cytidine diphosphocholine). Phosphatidylcholines 224-243 cut-like homeobox 1 Rattus norvegicus 125-128 6275886-11 1981 The rate of phosphatidylcholine synthesis measured from incorporation of di[1-14C]palmitoyl glycerol equalled that observed with labeled CDP choline. Phosphatidylcholines 12-31 cut-like homeobox 1 Rattus norvegicus 137-140 6244061-3 1980 Axonal transport of 1,2-diacyl-glycerol:CDP-choline choline phosphotransferase (EC 2.7.8.2), required for de novo phosphatidylcholine synthesis, was not apparent in these studies. Phosphatidylcholines 114-133 cut-like homeobox 1 Rattus norvegicus 40-43 6167576-1 1981 The effect of cAMP analogues on phosphatidylcholine formation via the CDP-choline pathway was investigated in cultured monolayers of rat hepatocytes. Phosphatidylcholines 32-51 cut-like homeobox 1 Rattus norvegicus 70-73 6272753-11 1981 These results provide good evidence that the rate-limiting step for phosphatidylcholine biosynthesis in these cultured hepatocytes is the conversion of phosphocholine into CDP-choline. Phosphatidylcholines 68-87 cut-like homeobox 1 Rattus norvegicus 172-175 6894548-1 1980 Incubation of rat lung microsomes with CDP[Me-14C]choline resulted in formation of radioactive lysophosphatidylcholine and phosphatidylcholine. Phosphatidylcholines 99-118 cut-like homeobox 1 Rattus norvegicus 39-42 208359-4 1978 Incubation of microsomes with labeled alkylacylglycerols and CDP-choline, in the initial absence of CDP-ethanolamine, produced labeled ethanolamine glycerophospholipids as well as labeled choline glycerophospholipids. Phosphatidylcholines 188-216 cut-like homeobox 1 Rattus norvegicus 61-64 7354136-3 1980 Lysine and aspartic acid appeared to modify the cholinephosphotransferase reaction in which cytidine 5"-diphosphocholine (CDP-choline) and 1,2-diacylglycerol react to form phosphatidylcholine, the major phospholipid of renal membranes. Phosphatidylcholines 172-191 cut-like homeobox 1 Rattus norvegicus 122-125 7370002-8 1980 Liver mitochondria isolated from normal animals incubated in vitro with CDP-choline, in the presence of different concentrations of L-thyroxine, showed also a marked decrease in the incorporation of label into phosphatidylcholine, whereas no significant changes were found in the total homogenate and in the microsomal fraction compared with control experiments. Phosphatidylcholines 210-229 cut-like homeobox 1 Rattus norvegicus 72-75 17116711-1 2006 Phosphatidylcholine is an essential phospholipid that is synthesized by 2 different pathways, the CDP-choline pathway and the methylation of phosphatidylethanolamine by phosphatidylethanolamine N-methyltransferase (PEMT). Phosphatidylcholines 0-19 cut-like homeobox 1 Rattus norvegicus 98-101 1123345-5 1975 The rate of phosphatidylcholine synthesis via the CDP-ester pathway responded in a way analogous to that of phosphatidylethanolamine synthesis upon the addition of choline and fatty acid, except that a 10- to 20-fold higher concentration of choline was required for maximal stimulation, probably due to the rapid oxidation of choline to betaine. Phosphatidylcholines 12-31 cut-like homeobox 1 Rattus norvegicus 50-53 29679463-1 2018 Cytidine-5"-diphosphocholine (CDP-choline) participates as an intermediary in the synthesis of phosphatidylcholine, an essential component of cellular membranes. Phosphatidylcholines 95-114 cut-like homeobox 1 Rattus norvegicus 30-33 27443959-2 2016 The most extensively studied cytidylyltransferase is CTP:phosphocholine cytidylyltransferase (CCT), which catalyzes conversion of phosphocholine and CTP to cytidine diphosphocholine (CDP-choline), a step critical for synthesis of the membrane phospholipid phosphatidylcholine (PC). Phosphatidylcholines 256-275 cut-like homeobox 1 Rattus norvegicus 183-186 27443959-2 2016 The most extensively studied cytidylyltransferase is CTP:phosphocholine cytidylyltransferase (CCT), which catalyzes conversion of phosphocholine and CTP to cytidine diphosphocholine (CDP-choline), a step critical for synthesis of the membrane phospholipid phosphatidylcholine (PC). Phosphatidylcholines 277-279 cut-like homeobox 1 Rattus norvegicus 183-186 24560778-1 2014 CDP-choline is an endogenous metabolite in phosphatidylcholine biosynthesis. Phosphatidylcholines 43-62 cut-like homeobox 1 Rattus norvegicus 0-3 21068006-1 2011 Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-choline) pathway in rat liver generates predominantly mono- and di-unsaturated molecular species, while polyunsaturated PC species are synthesized largely by the phosphatidylethanolamine-N-methyltransferase (PEMT) pathway. Phosphatidylcholines 0-19 cut-like homeobox 1 Rattus norvegicus 79-82 21068006-1 2011 Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-choline) pathway in rat liver generates predominantly mono- and di-unsaturated molecular species, while polyunsaturated PC species are synthesized largely by the phosphatidylethanolamine-N-methyltransferase (PEMT) pathway. Phosphatidylcholines 21-23 cut-like homeobox 1 Rattus norvegicus 79-82 1123345-11 1975 Under these conditions the rate of phosphatidylcholine synthesis via this pathway was 20 to 40 percent of that via diacylglycerols and CDP-choline. Phosphatidylcholines 35-54 cut-like homeobox 1 Rattus norvegicus 135-138 168873-5 1975 This indicated that CDP-choline was formed at a similar rate from phosphorylcholine and phosphatidylcholines, the latter probably through the reverse reaction of cholinephosphotransferase (EC 2.7.8.2.). Phosphatidylcholines 88-108 cut-like homeobox 1 Rattus norvegicus 20-23 24578622-1 2014 BACKGROUND: CDP-choline is a key intermediate in the biosynthesis of phosphatidylcholine, which is an essential component of cellular membranes, and a cell signalling mediator. Phosphatidylcholines 69-88 cut-like homeobox 1 Rattus norvegicus 12-15 23228325-1 2013 BACKGROUND: Cytidine 5"-diphosphocholine (CDP-choline) is an endogenous intermediate in the biosynthesis of phosphatidylcholine, a contributor to the mucosal defense of the intestine. Phosphatidylcholines 108-127 cut-like homeobox 1 Rattus norvegicus 42-45 23228325-10 2013 In addition, NEC damage reduced intestinal tissue membrane phospholipids, whereas CDP-choline significantly enhanced total phospholipid and phosphatidylcholine levels. Phosphatidylcholines 140-159 cut-like homeobox 1 Rattus norvegicus 82-85 21068006-1 2011 Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-choline) pathway in rat liver generates predominantly mono- and di-unsaturated molecular species, while polyunsaturated PC species are synthesized largely by the phosphatidylethanolamine-N-methyltransferase (PEMT) pathway. Phosphatidylcholines 203-205 cut-like homeobox 1 Rattus norvegicus 79-82 18423905-3 2008 Brain phosphatidylcholine (PC) synthesis utilizes both the uridine formed from the metabolism of exogenous CDP-choline and UMP, and the choline formed from that of CDP-choline. Phosphatidylcholines 6-25 cut-like homeobox 1 Rattus norvegicus 107-110 18423905-3 2008 Brain phosphatidylcholine (PC) synthesis utilizes both the uridine formed from the metabolism of exogenous CDP-choline and UMP, and the choline formed from that of CDP-choline. Phosphatidylcholines 6-25 cut-like homeobox 1 Rattus norvegicus 164-167 18423905-3 2008 Brain phosphatidylcholine (PC) synthesis utilizes both the uridine formed from the metabolism of exogenous CDP-choline and UMP, and the choline formed from that of CDP-choline. Phosphatidylcholines 27-29 cut-like homeobox 1 Rattus norvegicus 107-110 18423905-3 2008 Brain phosphatidylcholine (PC) synthesis utilizes both the uridine formed from the metabolism of exogenous CDP-choline and UMP, and the choline formed from that of CDP-choline. Phosphatidylcholines 27-29 cut-like homeobox 1 Rattus norvegicus 164-167 17917852-1 2007 CDP-choline is an endogenous metabolite in phosphatidylcholine biosynthesis. Phosphatidylcholines 43-62 cut-like homeobox 1 Rattus norvegicus 0-3 17184749-1 2007 The biosynthesis of brain membrane phosphatides, e.g., phosphatidylcholine (PtdCho), may utilize three circulating compounds: choline, uridine (a precursor for UTP, CTP, and CDP-choline), and a PUFA (e.g., docosahexaenoic acid); moreover, oral administration of the uridine source uridine-5"-monophosphate (UMP) can significantly increase levels of the phosphatides throughout the rodent brain. Phosphatidylcholines 55-74 cut-like homeobox 1 Rattus norvegicus 174-177 17184749-1 2007 The biosynthesis of brain membrane phosphatides, e.g., phosphatidylcholine (PtdCho), may utilize three circulating compounds: choline, uridine (a precursor for UTP, CTP, and CDP-choline), and a PUFA (e.g., docosahexaenoic acid); moreover, oral administration of the uridine source uridine-5"-monophosphate (UMP) can significantly increase levels of the phosphatides throughout the rodent brain. Phosphatidylcholines 76-82 cut-like homeobox 1 Rattus norvegicus 174-177 16153613-5 2005 CDP-choline liposomes deliver the agent intact to the brain, circumventing the rate-limiting, cytidine triphosphate:phosphocholine cytidylyltransferase in phosphatidylcholine synthesis. Phosphatidylcholines 155-174 cut-like homeobox 1 Rattus norvegicus 0-3 14698037-7 2004 The evaluation of PC biosynthetic enzymes revealed that microsomal, as well as nuclear, CTP:phosphocholine cytidylyltransferase (CCT), and nuclear-CDP-choline:1,2-diacylglycerol cholinephosphotransferase (CTP) activities were affected by COX-2 inhibition. Phosphatidylcholines 18-20 cut-like homeobox 1 Rattus norvegicus 147-150 15686962-1 2005 BACKGROUND AND PURPOSE: Cytidine-5"-diphosphocholine (citicoline or CDP-choline), an intermediate in the biosynthesis of phosphatidylcholine, has shown beneficial effects in a number of CNS injury models including cerebral ischemia. Phosphatidylcholines 121-140 cut-like homeobox 1 Rattus norvegicus 68-71 16055952-2 2005 PC synthesis is controlled by cellular levels of its precursor, cytidine-5"-diphosphate choline (CDP-choline), which is produced from cytidine triphosphate (CTP) and phosphocholine. Phosphatidylcholines 0-2 cut-like homeobox 1 Rattus norvegicus 97-100 12706232-1 2003 Oral administration of CDP-choline to rats raises plasma and brain cytidine levels and increases brain levels of phosphatidylcholine (PC). Phosphatidylcholines 113-132 cut-like homeobox 1 Rattus norvegicus 23-26 12706232-1 2003 Oral administration of CDP-choline to rats raises plasma and brain cytidine levels and increases brain levels of phosphatidylcholine (PC). Phosphatidylcholines 134-136 cut-like homeobox 1 Rattus norvegicus 23-26 12718547-1 2003 CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) contains a central region that functions as a catalytic domain, converting phosphocholine and cytidine 5"-triphosphate (CTP) to CDP-choline for the subsequent synthesis of phosphatidylcholine. Phosphatidylcholines 229-248 cut-like homeobox 1 Rattus norvegicus 185-188 12691414-1 2003 OBJECT: In previous studies at their laboratory the authors showed that cytidinediphosphocholine (CDP-choline), an intermediate of phosphatidylcholine synthesis, decreases edema formation and blood-brain barrier disruption following traumatic brain injury (TBI). Phosphatidylcholines 131-150 cut-like homeobox 1 Rattus norvegicus 98-101 11880242-1 2002 Choline and ethanolamine are substrates for de novo synthesis of phosphatidylcholine (PtdC) and phosphatidylethanolamine (PtdE) through the CDP-choline and CDP-ethanolamine pathways. Phosphatidylcholines 65-84 cut-like homeobox 1 Rattus norvegicus 140-143 11880242-1 2002 Choline and ethanolamine are substrates for de novo synthesis of phosphatidylcholine (PtdC) and phosphatidylethanolamine (PtdE) through the CDP-choline and CDP-ethanolamine pathways. Phosphatidylcholines 65-84 cut-like homeobox 1 Rattus norvegicus 156-159 11880242-1 2002 Choline and ethanolamine are substrates for de novo synthesis of phosphatidylcholine (PtdC) and phosphatidylethanolamine (PtdE) through the CDP-choline and CDP-ethanolamine pathways. Phosphatidylcholines 86-90 cut-like homeobox 1 Rattus norvegicus 140-143 11880242-1 2002 Choline and ethanolamine are substrates for de novo synthesis of phosphatidylcholine (PtdC) and phosphatidylethanolamine (PtdE) through the CDP-choline and CDP-ethanolamine pathways. Phosphatidylcholines 86-90 cut-like homeobox 1 Rattus norvegicus 156-159 11269664-0 2001 Modulation of biosynthesis of phosphatidylcholine via CDP-choline in rat liver: influence of ethanol on the microsomal cholinephosphotransferase activity. Phosphatidylcholines 30-49 cut-like homeobox 1 Rattus norvegicus 54-57 11269664-1 2001 We have studied in vitro the effects of ethanol on the different enzymes involved in the biosynthesis of phosphatidylcholine (PC) via CDP-choline. Phosphatidylcholines 105-124 cut-like homeobox 1 Rattus norvegicus 134-137 11269664-1 2001 We have studied in vitro the effects of ethanol on the different enzymes involved in the biosynthesis of phosphatidylcholine (PC) via CDP-choline. Phosphatidylcholines 126-128 cut-like homeobox 1 Rattus norvegicus 134-137