PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30289748-0 2019 Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer"s disease. Phosphatidylcholines 8-27 apolipoprotein E Homo sapiens 46-51 31717561-6 2019 In our hands, the plasma antioxidant capability (AOC), erythrocytes membrane fluidity, and the amount of phosphatidylcholine (PC) were demonstrated to be significantly decreased in the ApoE epsilon4 genotype and non-active subjects. Phosphatidylcholines 105-124 apolipoprotein E Homo sapiens 185-189 31717561-6 2019 In our hands, the plasma antioxidant capability (AOC), erythrocytes membrane fluidity, and the amount of phosphatidylcholine (PC) were demonstrated to be significantly decreased in the ApoE epsilon4 genotype and non-active subjects. Phosphatidylcholines 126-128 apolipoprotein E Homo sapiens 185-189 30289748-9 2019 Dietary sources of DHA in phospholipid form may provide a means to increase plasma levels of DHA-lysoPC, thereby decreasing the risk of AD.-Patrick, R. P. Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer"s disease. Phosphatidylcholines 163-182 apolipoprotein E Homo sapiens 201-206 10484608-8 1999 On the other hand, even in the presence of phosphatidylcholine liposomes, cholesterol efflux rates remained significantly higher from apoE-expressing macrophages than non-expressing cells. Phosphatidylcholines 43-62 apolipoprotein E Homo sapiens 134-138 22730894-5 2012 Comparison of increases in pyrene fluorescence upon binding of pyrene-labeled apoE4 to egg phosphatidylcholine small unilamellar vesicles suggests a two-step lipid-binding process; apoE4 initially binds to a lipid surface through the C-terminal helices followed by the slower conformational reorganization of the N-terminal helix bundle domain. Phosphatidylcholines 91-110 apolipoprotein E Homo sapiens 78-83 22730894-5 2012 Comparison of increases in pyrene fluorescence upon binding of pyrene-labeled apoE4 to egg phosphatidylcholine small unilamellar vesicles suggests a two-step lipid-binding process; apoE4 initially binds to a lipid surface through the C-terminal helices followed by the slower conformational reorganization of the N-terminal helix bundle domain. Phosphatidylcholines 91-110 apolipoprotein E Homo sapiens 181-186 10693931-4 2000 Our results showed that exogenously added apoE promoted the efflux of cholesterol and phosphatidylcholine from both astrocytes and neurons in culture, resulting in the generation of high-density lipoprotein-like particles. Phosphatidylcholines 86-105 apolipoprotein E Homo sapiens 42-46 10693931-7 2000 In contrast, the efflux of both cholesterol and phosphatidylcholine promoted by apoE was abolished following treatment with heparinase or lactoferrin, which block the interaction of apoE with heparan sulfate proteoglycans (HSPGs) or low-density lipoprotein receptor-related protein (LRP), respectively. Phosphatidylcholines 48-67 apolipoprotein E Homo sapiens 80-84 10693931-7 2000 In contrast, the efflux of both cholesterol and phosphatidylcholine promoted by apoE was abolished following treatment with heparinase or lactoferrin, which block the interaction of apoE with heparan sulfate proteoglycans (HSPGs) or low-density lipoprotein receptor-related protein (LRP), respectively. Phosphatidylcholines 48-67 apolipoprotein E Homo sapiens 182-186 25281910-5 2014 Upon binding of apoE3 and apoE4 variants to egg phosphatidylcholine small unilamellar vesicles, similar changes in Trp fluorescence or FRET efficiency were observed for the isoforms, indi- cating that the opening of the N-terminal helix bundle occurs similarly in apoE3 and apoE4. Phosphatidylcholines 48-67 apolipoprotein E Homo sapiens 16-21 25281910-5 2014 Upon binding of apoE3 and apoE4 variants to egg phosphatidylcholine small unilamellar vesicles, similar changes in Trp fluorescence or FRET efficiency were observed for the isoforms, indi- cating that the opening of the N-terminal helix bundle occurs similarly in apoE3 and apoE4. Phosphatidylcholines 48-67 apolipoprotein E Homo sapiens 26-31 17138935-2 2007 METHODS AND RESULTS: Cultured human aortic endothelial cells were stimulated with tumor necrosis factor (TNF)-alpha in the presence of human recombinant apoE3 solubilized in dimyristoyl phosphatidylcholine liposomes. Phosphatidylcholines 186-205 apolipoprotein E Homo sapiens 153-158 11533033-3 2001 To better understand apoE-lipid interactions on lipoprotein surfaces, we determined the thermodynamic parameters for binding of apoE4 and its 22- and 10-kDa fragments to triolein-egg phosphatidylcholine emulsions using a centrifugation assay and titration calorimetry. Phosphatidylcholines 183-202 apolipoprotein E Homo sapiens 128-133 9488694-8 1998 Incubation with phosphatidylcholine vesicles (PCV) displaced 30% of the apoE, suggesting that lipid content affects association of apoE with the ECM. Phosphatidylcholines 16-35 apolipoprotein E Homo sapiens 72-76 9488694-8 1998 Incubation with phosphatidylcholine vesicles (PCV) displaced 30% of the apoE, suggesting that lipid content affects association of apoE with the ECM. Phosphatidylcholines 16-35 apolipoprotein E Homo sapiens 131-135 1540589-8 1992 The hydrolysis of HDL-I phosphatidylcholine was approximately 3-fold higher than HDL-II, supporting the hypothesis that HL preferably hydrolyzes the phospholipids in apoE-rich HDL. Phosphatidylcholines 24-43 apolipoprotein E Homo sapiens 166-170 8940040-5 1996 Only the apoE-secreting cells and only in the presence of 8-Br-cAMP released large amounts of labeled cholesterol or phosphatidylcholine into the medium. Phosphatidylcholines 117-136 apolipoprotein E Homo sapiens 9-13 8662812-3 1996 Treatment of macrophages with inhibitors of proteoglycan synthesis (4-methylumbelliferyl-beta-D-xyloside) or sulfation (sodium chlorate) enhanced the release of apoE from cells and significantly attenuated the increase in secretion produced by incubation with phosphatidylcholine vesicles (PV). Phosphatidylcholines 260-279 apolipoprotein E Homo sapiens 161-165 1730636-4 1992 This effect could be entirely reproduced by incubation with phosphatidylcholine vesicles which increased apoE accumulation in the medium by 2-6-fold. Phosphatidylcholines 60-79 apolipoprotein E Homo sapiens 105-109 2036455-0 1991 Activation of hepatic lipase catalyzed phosphatidylcholine hydrolysis by apolipoprotein E. Phosphatidylcholines 39-58 apolipoprotein E Homo sapiens 73-89 34225874-2 2021 Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management. Phosphatidylcholines 0-19 apolipoprotein E Homo sapiens 173-189 34225874-2 2021 Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management. Phosphatidylcholines 0-19 apolipoprotein E Homo sapiens 191-195 34225874-2 2021 Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management. Phosphatidylcholines 21-23 apolipoprotein E Homo sapiens 173-189 34225874-2 2021 Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management. Phosphatidylcholines 21-23 apolipoprotein E Homo sapiens 191-195 2760017-1 1989 When human apolipoprotein E (apoE), which forms a self-associated tetramer in an aqueous solution, bound to the surface of triolein/phosphatidylcholine microemulsion with a particle diameter of 26 nm, it became monomeric on the lipid particle surface without strong evidence for its accumulation on a particular particle that might be expected from its tetramer formation in the aqueous phase. Phosphatidylcholines 132-151 apolipoprotein E Homo sapiens 11-27 2760017-1 1989 When human apolipoprotein E (apoE), which forms a self-associated tetramer in an aqueous solution, bound to the surface of triolein/phosphatidylcholine microemulsion with a particle diameter of 26 nm, it became monomeric on the lipid particle surface without strong evidence for its accumulation on a particular particle that might be expected from its tetramer formation in the aqueous phase. Phosphatidylcholines 132-151 apolipoprotein E Homo sapiens 29-33 3591946-8 1987 Kinetic analysis of phosphatidylcholine-stabilized triglyceride emulsions revealed a significant decrease in immobilized enzyme Km and an increase in Vmax when the emulsion was supplemented with apoE. Phosphatidylcholines 20-39 apolipoprotein E Homo sapiens 195-199 4054131-6 1985 With egg yolk phosphatidylcholine as acyl donor, apo E was 15-19% as efficient as apolipoprotein A-I for activation of the acyltransferase. Phosphatidylcholines 14-33 apolipoprotein E Homo sapiens 49-54 4054131-7 1985 Apo-E-stimulated cholesteryl ester formation by the enzyme was enhanced when 1-oleoyl-2-palmitoyl-glycerophosphocholine was used as a substrate phospholipid (45% of apo A-I/phosphatidylcholine control) and most pronounced with dimyristoylglycerophosphocholine (75% of apo A-I/phosphatidylcholine control). Phosphatidylcholines 173-192 apolipoprotein E Homo sapiens 0-5 4054131-7 1985 Apo-E-stimulated cholesteryl ester formation by the enzyme was enhanced when 1-oleoyl-2-palmitoyl-glycerophosphocholine was used as a substrate phospholipid (45% of apo A-I/phosphatidylcholine control) and most pronounced with dimyristoylglycerophosphocholine (75% of apo A-I/phosphatidylcholine control). Phosphatidylcholines 276-295 apolipoprotein E Homo sapiens 0-5 32253242-5 2020 As a model for the lipidated state of ApoE in lipoprotein particles, we incorporated ApoE into phosphatidylcholine/phosphatidylethanolamine liposomes and found that the presence of ApoE on liposomes increased deposition of C1q and C4b from serum when analyzed using flow cytometry. Phosphatidylcholines 95-114 apolipoprotein E Homo sapiens 38-42 32253242-5 2020 As a model for the lipidated state of ApoE in lipoprotein particles, we incorporated ApoE into phosphatidylcholine/phosphatidylethanolamine liposomes and found that the presence of ApoE on liposomes increased deposition of C1q and C4b from serum when analyzed using flow cytometry. Phosphatidylcholines 95-114 apolipoprotein E Homo sapiens 85-89 32253242-5 2020 As a model for the lipidated state of ApoE in lipoprotein particles, we incorporated ApoE into phosphatidylcholine/phosphatidylethanolamine liposomes and found that the presence of ApoE on liposomes increased deposition of C1q and C4b from serum when analyzed using flow cytometry. Phosphatidylcholines 95-114 apolipoprotein E Homo sapiens 85-89 4041470-1 1985 Apolipoprotein A-IV, apolipoprotein E-2 and apolipoprotein E-3 were individually incorporated into defined phosphatidylcholine/cholesterol liposomes for study of lecithin:cholesterol acyltransferase activation. Phosphatidylcholines 107-126 apolipoprotein E Homo sapiens 44-62 3926761-1 1985 In a continued investigation of lecithin cholesterol acyltransferase reaction with micellar discoidal complexes of phosphatidylcholine, cholesterol, and various water soluble apolipoproteins, we prepared complexes containing human apo-E by the cholate dialysis method. Phosphatidylcholines 115-134 apolipoprotein E Homo sapiens 231-236