PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9393676-10 1997 We present strong evidence for a stimulation of hydrolysis of phosphatidyl-choline by human non-pancreatic sPLA2 in the presence of as little as 1 mol% phosphatidyl-methanol (<40 fold total rate enhancement). Phosphatidylcholines 62-82 phospholipase A2 group X Homo sapiens 107-112 29374817-1 2018 Secretory phospholipase A2 (sPLA2) group of enzymes have been shown to hydrolyze phospholipids, among which sPLA2 Group V (GV) and Group X (GX) exhibit high selectivity towards phosphatidylcholine-rich cellular plasma membranes. Phosphatidylcholines 177-196 phospholipase A2 group X Homo sapiens 0-26 9188469-9 1997 hGX sPLA2 prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine. Phosphatidylcholines 47-66 phospholipase A2 group X Homo sapiens 4-9 7542869-3 1995 We found that purified acute-phase SAA, but not the constitutive form, markedly enhances the lipolytic activity of sPLA2 in a dose-related manner with phosphatidylcholine/lysophosphatidylcholine or phosphatidylethanolamine/lysophosphatidylethanolamine liposomal substrates. Phosphatidylcholines 151-170 phospholipase A2 group X Homo sapiens 115-120 29374817-1 2018 Secretory phospholipase A2 (sPLA2) group of enzymes have been shown to hydrolyze phospholipids, among which sPLA2 Group V (GV) and Group X (GX) exhibit high selectivity towards phosphatidylcholine-rich cellular plasma membranes. Phosphatidylcholines 177-196 phospholipase A2 group X Homo sapiens 28-33 29374817-1 2018 Secretory phospholipase A2 (sPLA2) group of enzymes have been shown to hydrolyze phospholipids, among which sPLA2 Group V (GV) and Group X (GX) exhibit high selectivity towards phosphatidylcholine-rich cellular plasma membranes. Phosphatidylcholines 177-196 phospholipase A2 group X Homo sapiens 108-113 21855891-2 2011 The main conclusions from our experimental data indicate that phosphatidylcholine monolayers (PC), in contrast to phosphatidylethanolamine (PE) and phosphatidylglycerol (PG), were resistant to the hydrolysis by human intestinal sPLA2. Phosphatidylcholines 62-81 phospholipase A2 group X Homo sapiens 228-233 22706677-2 2012 We have previously shown that group X sPLA(2) (sPLA(2)-X) had a strong hydrolyzing activity toward phosphatidylcholine in low-density lipoprotein (LDL) linked to the formation of lipid droplets in the cytoplasm of macrophages. Phosphatidylcholines 99-118 phospholipase A2 group X Homo sapiens 38-45 22706677-2 2012 We have previously shown that group X sPLA(2) (sPLA(2)-X) had a strong hydrolyzing activity toward phosphatidylcholine in low-density lipoprotein (LDL) linked to the formation of lipid droplets in the cytoplasm of macrophages. Phosphatidylcholines 99-118 phospholipase A2 group X Homo sapiens 47-56 26056930-5 2015 The sensitivity of human sPLA2 to the liposome composition was checked using binary lipid mixtures of phosphatidylcholine (PC) and phosphatidylglycerol (PG) phospholipids with C14 and C16 acyl chains. Phosphatidylcholines 102-121 phospholipase A2 group X Homo sapiens 25-30 26056930-5 2015 The sensitivity of human sPLA2 to the liposome composition was checked using binary lipid mixtures of phosphatidylcholine (PC) and phosphatidylglycerol (PG) phospholipids with C14 and C16 acyl chains. Phosphatidylcholines 123-125 phospholipase A2 group X Homo sapiens 25-30 22743636-1 2012 Group V secretory phospholipase A2 (sPLA2-V) hydrolyzes phosphatidylcholine in low-density lipoprotein (LDL) to increase lysophosphatidylcholine (LPC) content. Phosphatidylcholines 56-75 phospholipase A2 group X Homo sapiens 36-41 20974857-4 2010 Exogenous sPLA(2)-X released lysophospholipid species that arise from phospholipids enriched in AA in eosinophils, including phosphatidylcholine, phosphatidylinositol, and phosphatidylethanolamine as well as plasmenyl phosphatidylcholine and phosphatidylethanolamine. Phosphatidylcholines 125-144 phospholipase A2 group X Homo sapiens 10-19 12732938-2 2003 We previously reported that the proinflammatory cytokine IL-6 increased the expression of sPLA(2) (a hydrolyzer of phosphatidylcholine) and decreased membrane integrity in an intestinal epithelial cell culture model. Phosphatidylcholines 115-134 phospholipase A2 group X Homo sapiens 90-97 24061892-1 2010 Secreted group X phospholipase A2 (sPLA2-X) is one of the most effective mammalian PLA2 enzymes at hydrolyzing plasma lipoproteins and phospholipids in the membranes of intact cells, due in particular to its relatively high binding affinity to zwitterionic phospholipid substrates, such as phosphatidylcholine. Phosphatidylcholines 290-309 phospholipase A2 group X Homo sapiens 35-42 17964533-1 2008 Secretory phospholipase A2 (sPLA2) hydrolyzes phosphatidylcholines (PC) within lipid bilayers to produce lyso-PC and a fatty acid, which can act as signaling molecule in biological membranes. Phosphatidylcholines 46-66 phospholipase A2 group X Homo sapiens 0-26 17964533-1 2008 Secretory phospholipase A2 (sPLA2) hydrolyzes phosphatidylcholines (PC) within lipid bilayers to produce lyso-PC and a fatty acid, which can act as signaling molecule in biological membranes. Phosphatidylcholines 46-66 phospholipase A2 group X Homo sapiens 28-33 17964533-1 2008 Secretory phospholipase A2 (sPLA2) hydrolyzes phosphatidylcholines (PC) within lipid bilayers to produce lyso-PC and a fatty acid, which can act as signaling molecule in biological membranes. Phosphatidylcholines 68-70 phospholipase A2 group X Homo sapiens 0-26 17964533-1 2008 Secretory phospholipase A2 (sPLA2) hydrolyzes phosphatidylcholines (PC) within lipid bilayers to produce lyso-PC and a fatty acid, which can act as signaling molecule in biological membranes. Phosphatidylcholines 68-70 phospholipase A2 group X Homo sapiens 28-33 17148553-4 2007 In liposomes containing synthetic phosphatidylcholines (PCs), sPLA(2)X showed no clear selectivity among the various sn-2 unsaturated fatty acids. Phosphatidylcholines 56-59 phospholipase A2 group X Homo sapiens 62-70 16962371-5 2006 Among different sPLA(2)s, hGX sPLA(2) has the highest affinity towards phosphatidylcholine (PC), the major phospholipid of cellular membranes and plasma lipoproteins. Phosphatidylcholines 71-90 phospholipase A2 group X Homo sapiens 16-23 16962371-5 2006 Among different sPLA(2)s, hGX sPLA(2) has the highest affinity towards phosphatidylcholine (PC), the major phospholipid of cellular membranes and plasma lipoproteins. Phosphatidylcholines 92-94 phospholipase A2 group X Homo sapiens 16-23 18587072-1 2008 We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown. Phosphatidylcholines 105-124 phospholipase A2 group X Homo sapiens 137-171 18587072-1 2008 We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown. Phosphatidylcholines 105-124 phospholipase A2 group X Homo sapiens 173-178 18587072-1 2008 We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown. Phosphatidylcholines 126-132 phospholipase A2 group X Homo sapiens 137-171 18587072-1 2008 We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown. Phosphatidylcholines 126-132 phospholipase A2 group X Homo sapiens 173-178 18587072-1 2008 We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown. Phosphatidylcholines 126-132 phospholipase A2 group X Homo sapiens 280-285 18587072-4 2008 Group V sPLA2 showed preferential release of linoleate from LDL and HDL at SM/PtdCho ratio 1.5 and 0.6, respectively. Phosphatidylcholines 78-84 phospholipase A2 group X Homo sapiens 8-13 12604528-2 2003 More specifically, hydrolysis of phosphatidylcholine (PC) liposomes by bee venom sPLA(2) at 10 micro M Ca(2+) was attenuated by these peptides while augmented product formation was observed in the presence of 5 mM Ca(2+). Phosphatidylcholines 33-52 phospholipase A2 group X Homo sapiens 81-88 10486736-4 1999 Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was also utilized to confirm the phosphatidylcholine, a substrate of sPLA2. Phosphatidylcholines 110-129 phospholipase A2 group X Homo sapiens 146-151 11294854-2 2001 Analysis of erythrocyte phospholipid metabolism by thin-layer chromatography revealed significant hydrolysis of both phosphatidylcholine and phosphatidylethanolamine during incubation with ionomycin and sPLA(2). Phosphatidylcholines 117-136 phospholipase A2 group X Homo sapiens 203-210 12043230-3 2002 sPLA2 was measured with enzyme immunoassay, catalytic activity--using aqueous emulsion of 14C-labelled phosphatidylcholine. Phosphatidylcholines 103-122 phospholipase A2 group X Homo sapiens 0-5 10567392-6 1999 The mature sPLA(2)-X induced the release of arachidonic acid from phosphatidylcholine more efficiently than other human sPLA(2) groups (IB, IIA, IID, and V) and elicited a prompt and marked release of arachidonic acid from human monocytic THP-1 cells compared with sPLA(2)-IB and -IIA with concomitant production of prostaglandin E(2). Phosphatidylcholines 66-85 phospholipase A2 group X Homo sapiens 11-20 9755106-5 1998 Our results demonstrate that mammalian group I sPLA2 hydrolyzes phosphatidylcholine (PC), producing free fatty acids and lysophosphatidylcholine, and increases gammamin. Phosphatidylcholines 64-83 phospholipase A2 group X Homo sapiens 47-52 9755106-5 1998 Our results demonstrate that mammalian group I sPLA2 hydrolyzes phosphatidylcholine (PC), producing free fatty acids and lysophosphatidylcholine, and increases gammamin. Phosphatidylcholines 85-87 phospholipase A2 group X Homo sapiens 47-52