PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35134390-1	2022	Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG).	Phosphatidylcholines	84-103	phospholipase D2	Homo sapiens	51-55	
18523140-1	2008	The phosphatidylcholine-using phospholipase D (PLD) isoform PLD2 is widely expressed in mammalian cells and is activated in response to a variety of promitogenic agonists.	Phosphatidylcholines	4-23	phospholipase D2	Homo sapiens	60-64	
9538008-1	1998	Two widely expressed mammalian phosphatidylcholine (PC)-specific phospholipases D (PLD), PLD1 and PLD2, have been identified.	Phosphatidylcholines	31-50	phospholipase D2	Homo sapiens	98-102	
11000525-2	2000	To date, two types of mammalian phosphatidylcholine-specific PLD cDNAs, designated as PLD-1 and PLD-2, have been cloned.	Phosphatidylcholines	32-51	phospholipase D2	Homo sapiens	96-101	
10852916-11	2000	PLD2 regulates the breakdown of phosphatidylcholine and has been implicated in vesicular trafficking.	Phosphatidylcholines	32-51	phospholipase D2	Homo sapiens	0-4	
9867870-1	1999	The mammalian phosphatidylcholine-specific phospholipase D (PLD) enzymes PLD1 and PLD2 have been proposed to play roles in signal transduction and membrane vesicular trafficking in distinct subcellular compartments.	Phosphatidylcholines	14-33	phospholipase D2	Homo sapiens	82-86	
35134390-1	2022	Classical phospholipase D (PLD) isoforms, PLD1 and PLD2, catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) which can be further dephosphorylated to diacylglycerol (DAG).	Phosphatidylcholines	105-107	phospholipase D2	Homo sapiens	51-55	
19855431-5	2010	Phosphatidic acid is generated from the cleavage of phosphatidylcholine by phospholipase D2 and is a key activator of the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/AKT survival signaling pathways.	Phosphatidylcholines	52-71	phospholipase D2	Homo sapiens	75-91	
32086667-4	2020	PLD1 and PLD2 are highly selective for phosphatidylcholine (PC), whereas autotaxin has broader substrate specificity for lysophospholipids but by virtue of the high abundance of lysophosphatidylcholine (LPC) in extracellular fluids predominantly hydrolyses this substrate.	Phosphatidylcholines	39-58	phospholipase D2	Homo sapiens	9-13	
32086667-4	2020	PLD1 and PLD2 are highly selective for phosphatidylcholine (PC), whereas autotaxin has broader substrate specificity for lysophospholipids but by virtue of the high abundance of lysophosphatidylcholine (LPC) in extracellular fluids predominantly hydrolyses this substrate.	Phosphatidylcholines	60-62	phospholipase D2	Homo sapiens	9-13	
26695710-1	2016	Phospholipase D2 (PLD2) is a lipid-signaling enzyme that produces the signaling molecule phosphatidic acid (PA) by catalyzing the hydrolysis of phosphatidylcholine (PC).	Phosphatidylcholines	144-163	phospholipase D2	Homo sapiens	0-16	
26695710-1	2016	Phospholipase D2 (PLD2) is a lipid-signaling enzyme that produces the signaling molecule phosphatidic acid (PA) by catalyzing the hydrolysis of phosphatidylcholine (PC).	Phosphatidylcholines	144-163	phospholipase D2	Homo sapiens	18-22	
26695710-1	2016	Phospholipase D2 (PLD2) is a lipid-signaling enzyme that produces the signaling molecule phosphatidic acid (PA) by catalyzing the hydrolysis of phosphatidylcholine (PC).	Phosphatidylcholines	165-167	phospholipase D2	Homo sapiens	0-16	
26695710-1	2016	Phospholipase D2 (PLD2) is a lipid-signaling enzyme that produces the signaling molecule phosphatidic acid (PA) by catalyzing the hydrolysis of phosphatidylcholine (PC).	Phosphatidylcholines	165-167	phospholipase D2	Homo sapiens	18-22