PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30159399-2 2018 The enzymes phospholipase C and D (PLC and PLD) both cleave the phosphorus-oxygen bonds of phosphate esters in phosphatidylcholine (PC) lipids. Phosphatidylcholines 111-130 heparan sulfate proteoglycan 2 Homo sapiens 35-38 30159399-2 2018 The enzymes phospholipase C and D (PLC and PLD) both cleave the phosphorus-oxygen bonds of phosphate esters in phosphatidylcholine (PC) lipids. Phosphatidylcholines 132-134 heparan sulfate proteoglycan 2 Homo sapiens 35-38 30159399-4 2018 While PLC converts PC to diacylglycerol (DAG), the interaction of PC with PLD produces phosphatidic acid (PA). Phosphatidylcholines 19-21 heparan sulfate proteoglycan 2 Homo sapiens 6-9 30159399-6 2018 We observed that PC liposomes completely disintegrate in the presence of PLC, as conversion of PC to DAG progresses. Phosphatidylcholines 17-19 heparan sulfate proteoglycan 2 Homo sapiens 73-76 20937607-2 2011 The signaling of these receptors change phosphatidylcholine-specific phospholipase C (PC-PLC) activity, but there have been no reported PC-PLC studies in migraine. Phosphatidylcholines 40-59 heparan sulfate proteoglycan 2 Homo sapiens 89-92 22101393-2 2012 D609 actions are widely attributed to inhibiting phosphatidylcholine (PC)-specific phospholipase C (PC-PLC). Phosphatidylcholines 49-68 heparan sulfate proteoglycan 2 Homo sapiens 103-106 22101393-2 2012 D609 actions are widely attributed to inhibiting phosphatidylcholine (PC)-specific phospholipase C (PC-PLC). Phosphatidylcholines 70-72 heparan sulfate proteoglycan 2 Homo sapiens 103-106 28315318-0 2017 Development of a liquid chromatography-mass spectrometry based enzyme activity assay for phosphatidylcholine-specific phospholipase C. Phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) hydrolyzes PC to generate the second messenger 1,2-diacylglycerol (DG) and phosphocholine. Phosphatidylcholines 89-108 heparan sulfate proteoglycan 2 Homo sapiens 189-192 28315318-0 2017 Development of a liquid chromatography-mass spectrometry based enzyme activity assay for phosphatidylcholine-specific phospholipase C. Phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) hydrolyzes PC to generate the second messenger 1,2-diacylglycerol (DG) and phosphocholine. Phosphatidylcholines 135-154 heparan sulfate proteoglycan 2 Homo sapiens 189-192 28315318-0 2017 Development of a liquid chromatography-mass spectrometry based enzyme activity assay for phosphatidylcholine-specific phospholipase C. Phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) hydrolyzes PC to generate the second messenger 1,2-diacylglycerol (DG) and phosphocholine. Phosphatidylcholines 156-158 heparan sulfate proteoglycan 2 Homo sapiens 189-192 28315318-0 2017 Development of a liquid chromatography-mass spectrometry based enzyme activity assay for phosphatidylcholine-specific phospholipase C. Phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) hydrolyzes PC to generate the second messenger 1,2-diacylglycerol (DG) and phosphocholine. Phosphatidylcholines 186-188 heparan sulfate proteoglycan 2 Homo sapiens 189-192 26402860-1 2015 PURPOSE: The role of phosphatidylcholine-specific phospholipase C (PC-PLC), the enzyme involved in cell differentiation and proliferation, has not yet been explored in tumor initiating cells (TICs). Phosphatidylcholines 21-40 heparan sulfate proteoglycan 2 Homo sapiens 70-73 22333571-0 2012 Distinction between phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) and phosphatidylinositol (PI)-specific phospolipase C (PI-PLC) needs clarification. Phosphatidylcholines 41-43 heparan sulfate proteoglycan 2 Homo sapiens 74-77 8039770-7 1994 In this paper, involvement of G proteins in the regulation of phospholipase A2 and phosphatidylcholine-specific PLC and PLD is also discussed. Phosphatidylcholines 83-102 heparan sulfate proteoglycan 2 Homo sapiens 112-115 19002082-1 2008 Phosphatidylcholine-specific phospholipase C (PC-PLC) catalyzes the hydrolysis of the ester linkage between glycerol and phosphate in phosphocholine (PC) and other phosphatides, such as sphingomylin (SM) and phosphatidylethanolamine (PE). Phosphatidylcholines 0-19 heparan sulfate proteoglycan 2 Homo sapiens 49-52 11101661-7 2000 Unexpectedly, PC-PLC inhibited HBL lysis of sheep erythrocytes (<2% PC) and enhanced the discontinuous haemolysis pattern that is characteristic of HBL in sheep blood agar. Phosphatidylcholines 14-16 heparan sulfate proteoglycan 2 Homo sapiens 17-20 9218127-7 1997 The sustained phase is mediated by a Ca(2+)-independent isoform of PKC, PKC-epsilon DAG for this process is generated by PLC- and PLD-mediated hydrolysis of PC. Phosphatidylcholines 157-159 heparan sulfate proteoglycan 2 Homo sapiens 121-124 9034754-2 1996 Exclusively phosphatidylcholine (PC) specific phospholipase C (PC-PLC) was found to be inhibited in a dose-dependent manner. Phosphatidylcholines 12-31 heparan sulfate proteoglycan 2 Homo sapiens 66-69 9034754-2 1996 Exclusively phosphatidylcholine (PC) specific phospholipase C (PC-PLC) was found to be inhibited in a dose-dependent manner. Phosphatidylcholines 33-35 heparan sulfate proteoglycan 2 Homo sapiens 66-69 10072552-1 1999 This study uses human alveolar macrophages to determine whether activation of a phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) is linked to activation of the p42/44 (ERK) kinases by LPS. Phosphatidylcholines 80-99 heparan sulfate proteoglycan 2 Homo sapiens 134-137 10072552-1 1999 This study uses human alveolar macrophages to determine whether activation of a phosphatidylcholine (PC)-specific phospholipase C (PC-PLC) is linked to activation of the p42/44 (ERK) kinases by LPS. Phosphatidylcholines 101-103 heparan sulfate proteoglycan 2 Homo sapiens 134-137 8389049-1 1993 In human non-small cell lung cancer cells (PC-14) exposed to DHA-VC for 24 hr, a dose-dependent increase in phosphatidylcholine-specific phospholipase C (PC-PLC) activity was seen. Phosphatidylcholines 108-127 heparan sulfate proteoglycan 2 Homo sapiens 157-160 7900958-4 1993 Generation of diacylglycerol (DAG) by a variety of enzymes such as phosphoinositide and phosphatidylcholine specific PLC, by a combination of phospholipase D and phosphatidic hydrolase, and by triglyceride lipase is examined. Phosphatidylcholines 88-107 heparan sulfate proteoglycan 2 Homo sapiens 117-120 1497353-3 1992 Phosphatidylethanolamine (PE), phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylinositol (PI) also inhibit PLC delta in the presence of spermine but are much less effective than SM. Phosphatidylcholines 31-50 heparan sulfate proteoglycan 2 Homo sapiens 125-128 1497353-3 1992 Phosphatidylethanolamine (PE), phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylinositol (PI) also inhibit PLC delta in the presence of spermine but are much less effective than SM. Phosphatidylcholines 52-54 heparan sulfate proteoglycan 2 Homo sapiens 125-128 1623116-7 1992 The data clearly indicate that LPS stimulates phosphatidylcholine breakdown, implying that the liberation of phosphatidic acid or diacylglycerol via PLC/PLD reaction may be relevant to the initiation of LPS-induced monocytic activation. Phosphatidylcholines 46-65 heparan sulfate proteoglycan 2 Homo sapiens 149-152 1770112-1 1991 A simple procedure is described for the purification of phosphatidylcholine-hydrolyzing phospholipase C(PLC). Phosphatidylcholines 56-75 heparan sulfate proteoglycan 2 Homo sapiens 104-107