PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1389024-2 1992 In a multicentre trial in which 380 depressed patients were treated for one year, tianeptine produced a significant reduction in the MADRS scores from day 14, with a sustained reduction maintained for up to 12 months; other measures of efficacy (HRSA, HSCL, and CGI) also reflected the improvement. tianeptine 82-92 selenocysteine lyase Homo sapiens 252-256 2700774-12 1989 The action of tianeptine on anxious-depressive symptomatology was confirmed by the concomitant improvement of global clinical rating and patients" self-rating (HSCL). tianeptine 14-24 selenocysteine lyase Homo sapiens 160-164