PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27129862-0	2016	Tianeptine induces mTORC1 activation in rat hippocampal neurons under toxic conditions.	tianeptine	0-10	CREB regulated transcription coactivator 1	Mus musculus	19-25	
27129862-3	2016	OBJECTIVE: The aim of the present study was to determine whether alterations in mTORC1 signaling are observable following treatment with tianeptine under toxic conditions induced by B27 deprivation.	tianeptine	137-147	CREB regulated transcription coactivator 1	Mus musculus	80-86	
27129862-7	2016	RESULTS: Tianeptine significantly increased the phosphorylation of mTORC1, 4E-BP-1, p70S6K, Akt, and ERK.	tianeptine	9-19	CREB regulated transcription coactivator 1	Mus musculus	67-73	
27129862-9	2016	Tianeptine increased BDNF, dendritic outgrowth, spine density, and synaptic proteins; all of these effects were blocked by the mTORC1 inhibitor.	tianeptine	0-10	CREB regulated transcription coactivator 1	Mus musculus	127-133	
27129862-10	2016	CONCLUSIONS: In this study, we demonstrated that tianeptine activates the mTORC1 signaling pathway and increases dendritic outgrowth, spine density, and synaptic proteins through mTORC1 signaling under toxic conditions in rat primary hippocampal neurons.	tianeptine	49-59	CREB regulated transcription coactivator 1	Mus musculus	74-80	
27129862-10	2016	CONCLUSIONS: In this study, we demonstrated that tianeptine activates the mTORC1 signaling pathway and increases dendritic outgrowth, spine density, and synaptic proteins through mTORC1 signaling under toxic conditions in rat primary hippocampal neurons.	tianeptine	49-59	CREB regulated transcription coactivator 1	Mus musculus	179-185