PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23457600-0	2013	Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells.	Berberine	0-9	Cbl proto-oncogene	Homo sapiens	107-110	
28846104-5	2017	Berberine binding promotes RXRalpha interaction with nuclear beta-catenin, leading to c-Cbl mediated degradation of beta-catenin, and consequently inhibits the proliferation of colon cancer cells.	Berberine	0-9	Cbl proto-oncogene	Homo sapiens	86-91	
23457600-7	2013	In this study, we also showed that berberine stimulated ubiquitin ligase Cbl activation and Cbl"s interaction with EGFR, and EGFR ubiquitinylation and down-regulation in these two cell lines in the presence or absence of EGF treatment.	Berberine	35-44	Cbl proto-oncogene	Homo sapiens	73-76	
23457600-7	2013	In this study, we also showed that berberine stimulated ubiquitin ligase Cbl activation and Cbl"s interaction with EGFR, and EGFR ubiquitinylation and down-regulation in these two cell lines in the presence or absence of EGF treatment.	Berberine	35-44	Cbl proto-oncogene	Homo sapiens	92-95	
23457600-8	2013	Knock-down Cbl expression blocked the effects of berberine on down-regulation of EGFR and inhibition of proliferation.	Berberine	49-58	Cbl proto-oncogene	Homo sapiens	11-14	
23457600-11	2013	Taken together, these data indicate that berberine enhances Cbl activity, resulting in down-regulation of EGFR expression and inhibition of proliferation in colon tumor cells.	Berberine	41-50	Cbl proto-oncogene	Homo sapiens	60-63