PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35597409-19 2022 RESULTS: Berberine, jateorhizine, coptisine, epiberberine, columbamine, demethyleneberberine, and berberrubine could significantly inhibit hOCT1 and hOCT2 activity. Berberine 9-18 solute carrier family 22 member 1 Homo sapiens 139-144 18157518-0 2008 Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). Berberine 42-51 solute carrier family 22 member 1 Homo sapiens 101-129 18157518-0 2008 Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). Berberine 42-51 solute carrier family 22 member 1 Homo sapiens 131-135 18157518-0 2008 Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). Berberine 42-51 solute carrier family 22 member 1 Homo sapiens 137-144 18157518-5 2008 We identified the lipophilic organic cation berberine, a fluorescent plant alkaloid exhibiting a broad range of biological activities, as substrate of OCT1 and OCT2 with Michaelis-Menten constants of 14.8 microM and 4.4 microM, respectively. Berberine 44-53 solute carrier family 22 member 1 Homo sapiens 151-155 18157518-6 2008 Berberine also inhibited the uptake of the prototypic cations tetraethylammonium and 1-methyl-4-phenylpyridinium by MDCK-OCT1 and MDCK-OCT2 transfectants. Berberine 0-9 solute carrier family 22 member 1 Homo sapiens 116-125 18157518-7 2008 When transfected cells were grown polarized on permeable filter supports, berberine was transferred from the basolateral to the apical compartments many times faster by MDCK-OCT1/MDR1 P-gp double transfectants than by MDCK-OCT1 or MDCK-MDR1 P-gp single transfectants. Berberine 74-83 solute carrier family 22 member 1 Homo sapiens 174-178 18157518-7 2008 When transfected cells were grown polarized on permeable filter supports, berberine was transferred from the basolateral to the apical compartments many times faster by MDCK-OCT1/MDR1 P-gp double transfectants than by MDCK-OCT1 or MDCK-MDR1 P-gp single transfectants. Berberine 74-83 solute carrier family 22 member 1 Homo sapiens 223-227 35597409-20 2022 Isoquinoline alkaloids, including berberine, jateorhizine, coptisine, epiberberine, columbamine, and palmatine, were substrates of hOCT1 and hOCT2, but not the indole alkaloids evodiamine and rutaecarpine. Berberine 34-43 solute carrier family 22 member 1 Homo sapiens 131-136 25359200-4 2015 To investigate whether this inhibitory effect of berberine on OCT1 and OCT2 could change the pharmacokinetics of metformin in vivo, we measured the effect of berberine co-administration on the pharmacokinetics of metformin at a single intravenous dose of 2 mg/kg metformin and 10 mg/kg berberine. Berberine 49-58 solute carrier family 22 member 1 Homo sapiens 62-66 25359200-5 2015 In HEK293 cells, berberine inhibited OCT1- and OCT2-mediated metformin uptake in a concentration dependent manner and IC50 values for OCT1 and OCT2 were 7.28 and 11.3 muM, respectively. Berberine 17-26 solute carrier family 22 member 1 Homo sapiens 37-41 25359200-5 2015 In HEK293 cells, berberine inhibited OCT1- and OCT2-mediated metformin uptake in a concentration dependent manner and IC50 values for OCT1 and OCT2 were 7.28 and 11.3 muM, respectively. Berberine 17-26 solute carrier family 22 member 1 Homo sapiens 134-138