PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35597409-20	2022	Isoquinoline alkaloids, including berberine, jateorhizine, coptisine, epiberberine, columbamine, and palmatine, were substrates of hOCT1 and hOCT2, but not the indole alkaloids evodiamine and rutaecarpine.	Berberine	34-43	solute carrier family 22 member 1	Homo sapiens	131-136	
35597409-19	2022	RESULTS: Berberine, jateorhizine, coptisine, epiberberine, columbamine, demethyleneberberine, and berberrubine could significantly inhibit hOCT1 and hOCT2 activity.	Berberine	9-18	solute carrier family 22 member 1	Homo sapiens	139-144	
18157518-5	2008	We identified the lipophilic organic cation berberine, a fluorescent plant alkaloid exhibiting a broad range of biological activities, as substrate of OCT1 and OCT2 with Michaelis-Menten constants of 14.8 microM and 4.4 microM, respectively.	Berberine	44-53	solute carrier family 22 member 1	Homo sapiens	151-155	
25359200-4	2015	To investigate whether this inhibitory effect of berberine on OCT1 and OCT2 could change the pharmacokinetics of metformin in vivo, we measured the effect of berberine co-administration on the pharmacokinetics of metformin at a single intravenous dose of 2 mg/kg metformin and 10 mg/kg berberine.	Berberine	49-58	solute carrier family 22 member 1	Homo sapiens	62-66	
25359200-5	2015	In HEK293 cells, berberine inhibited OCT1- and OCT2-mediated metformin uptake in a concentration dependent manner and IC50 values for OCT1 and OCT2 were 7.28 and 11.3 muM, respectively.	Berberine	17-26	solute carrier family 22 member 1	Homo sapiens	37-41	
25359200-5	2015	In HEK293 cells, berberine inhibited OCT1- and OCT2-mediated metformin uptake in a concentration dependent manner and IC50 values for OCT1 and OCT2 were 7.28 and 11.3 muM, respectively.	Berberine	17-26	solute carrier family 22 member 1	Homo sapiens	134-138	
18157518-0	2008	Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1).	Berberine	42-51	solute carrier family 22 member 1	Homo sapiens	101-129	
18157518-0	2008	Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1).	Berberine	42-51	solute carrier family 22 member 1	Homo sapiens	131-135	
18157518-0	2008	Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1).	Berberine	42-51	solute carrier family 22 member 1	Homo sapiens	137-144	
18157518-6	2008	Berberine also inhibited the uptake of the prototypic cations tetraethylammonium and 1-methyl-4-phenylpyridinium by MDCK-OCT1 and MDCK-OCT2 transfectants.	Berberine	0-9	solute carrier family 22 member 1	Homo sapiens	116-125	
18157518-7	2008	When transfected cells were grown polarized on permeable filter supports, berberine was transferred from the basolateral to the apical compartments many times faster by MDCK-OCT1/MDR1 P-gp double transfectants than by MDCK-OCT1 or MDCK-MDR1 P-gp single transfectants.	Berberine	74-83	solute carrier family 22 member 1	Homo sapiens	174-178	
18157518-7	2008	When transfected cells were grown polarized on permeable filter supports, berberine was transferred from the basolateral to the apical compartments many times faster by MDCK-OCT1/MDR1 P-gp double transfectants than by MDCK-OCT1 or MDCK-MDR1 P-gp single transfectants.	Berberine	74-83	solute carrier family 22 member 1	Homo sapiens	223-227