PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17213652-0	2007	Human MDR1 and MRP1 recognize berberine as their transport substrate.	Berberine	30-39	ATP binding cassette subfamily C member 1	Homo sapiens	15-19	
33362566-7	2020	Furthermore, berberine treatment concentration-dependently down-regulated the multidrug resistance-associated protein 1 and multi-drug resistance-1 protein levels in the BGC-823/DDP and SGC7901/DDP cells.	Berberine	13-22	ATP binding cassette subfamily C member 1	Homo sapiens	78-119	
33362566-12	2020	Further mechanistic findings suggested that berberine-mediated DDP-sensitivity may be associated with reduced expression of drug transporters (multi-drug resistance-1 and multidrug resistance-associated protein 1), enhanced apoptosis and repressed PI3K/AKT/mTOR signaling.	Berberine	44-53	ATP binding cassette subfamily C member 1	Homo sapiens	124-212	
17213652-2	2007	Cells expressing MDR1 or MRP1 accumulated less berberine.	Berberine	47-56	ATP binding cassette subfamily C member 1	Homo sapiens	25-29	
17213652-3	2007	Berberine accumulation depended on the cellular ATP level, and was reversed by typical inhibitors of MDR1, suggesting that human MDR1 and MRP1 directly efflux berberine as their substrate.	Berberine	0-9	ATP binding cassette subfamily C member 1	Homo sapiens	138-142	
17213652-3	2007	Berberine accumulation depended on the cellular ATP level, and was reversed by typical inhibitors of MDR1, suggesting that human MDR1 and MRP1 directly efflux berberine as their substrate.	Berberine	159-168	ATP binding cassette subfamily C member 1	Homo sapiens	138-142