PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16524504-6	2006	Compared to SHA group, bacterial count and TNF-alpha level were increased significantly in HES and RS groups, and they were higher at 1 hour and lower at 24 hours in HES group than those in RS group.	Hydroxyethyl Starch Derivatives	91-94	tumor necrosis factor	Rattus norvegicus	43-52	
16790644-5	2006	HES significantly reduced the increased intestinal levels of tumor necrosis factor-alpha, IL-6, cytokine-induced neutrophil chemoattractant-1, and the mRNAs in the endotoxemic rats.	Hydroxyethyl Starch Derivatives	0-3	tumor necrosis factor	Rattus norvegicus	61-88	
16524504-6	2006	Compared to SHA group, bacterial count and TNF-alpha level were increased significantly in HES and RS groups, and they were higher at 1 hour and lower at 24 hours in HES group than those in RS group.	Hydroxyethyl Starch Derivatives	166-169	tumor necrosis factor	Rattus norvegicus	43-52	
35178114-8	2022	Results: HES for fluid resuscitation augmented the survival of traumatic shock rats, upregulated the expressions of MEK and ERK1/2, and downregulated the expressions of IL-6 and TNF-alpha.	Hydroxyethyl Starch Derivatives	9-12	tumor necrosis factor	Rattus norvegicus	178-187	
16146468-3	2005	The present study was undertaken to test whether HES (200/0.5) has some effects on tissue NF-kappaB activity and systemic TNF-alpha expression induced by lipopolysaccharide in order to define a possible mechanism of the beneficial effects of HES.	Hydroxyethyl Starch Derivatives	49-52	tumor necrosis factor	Rattus norvegicus	122-131	
16146468-7	2005	RESULTS: 3.75 and 7.5 ml/kg HES suppressed LPS-induced NF-kappaB activation in the four tissues and decreased plasma TNF-alpha elevation.	Hydroxyethyl Starch Derivatives	28-31	tumor necrosis factor	Rattus norvegicus	117-126	
16146468-10	2005	CONCLUSION: Lower doses of HES may inhibit tissue NF-kappaB activation and systemic TNF-alpha elevation after LPS challenge, which might be helpful during sepsis.	Hydroxyethyl Starch Derivatives	27-30	tumor necrosis factor	Rattus norvegicus	84-93	
16104441-5	2005	HES significantly reduced the LPS-induced increase in intestinal levels of TNF-alpha, IL-1beta, IL-6, IL-8 and their corresponding mRNAs.	Hydroxyethyl Starch Derivatives	0-3	tumor necrosis factor	Rattus norvegicus	75-84	
14584760-6	2003	Treatment of rats with HES (3.75 and 7.5 ml/kg) prevented LPS-induced NF-kappaB activation, and inhibited, in a dose-related manner, LPS-induced TNF-alpha and CINC expression.	Hydroxyethyl Starch Derivatives	23-26	tumor necrosis factor	Rattus norvegicus	145-154	
15836676-7	2005	HES significantly reduced the increased hepatic levels of TNF-alpha, IL-1beta, IL-6, IL-8 and the mRNAs in the endotoxemic rats.	Hydroxyethyl Starch Derivatives	0-3	tumor necrosis factor	Rattus norvegicus	58-67	
29509042-5	2019	The expression level of TNF-alpha in the LR group was significantly lower than that in the HES group, especially during the first 12 hr post-fluid infusion.	Hydroxyethyl Starch Derivatives	91-94	tumor necrosis factor	Rattus norvegicus	24-33	
20451670-8	2010	Meanwhile, HES could significantly reduce TNF-alpha, IL-6, and ICAM-1 mRNA, inhibit NF-kappaB activation, and down-regulate TLR2 and TLR4 expression in the brain.	Hydroxyethyl Starch Derivatives	11-14	tumor necrosis factor	Rattus norvegicus	42-51	
17311869-5	2007	Infusion of HES 130/0.4 attenuated the pulmonary capillary leakage, reduced the elevations of MPO, TNF-alpha, IL-6, and NF-kappaB levels, and further increased the IL-10 level.	Hydroxyethyl Starch Derivatives	12-15	tumor necrosis factor	Rattus norvegicus	99-108