PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35178114-8	2022	Results: HES for fluid resuscitation augmented the survival of traumatic shock rats, upregulated the expressions of MEK and ERK1/2, and downregulated the expressions of IL-6 and TNF-alpha.	Hydroxyethyl Starch Derivatives	9-12	interleukin 6	Rattus norvegicus	169-173	
17311869-5	2007	Infusion of HES 130/0.4 attenuated the pulmonary capillary leakage, reduced the elevations of MPO, TNF-alpha, IL-6, and NF-kappaB levels, and further increased the IL-10 level.	Hydroxyethyl Starch Derivatives	12-15	interleukin 6	Rattus norvegicus	110-114	
20451670-8	2010	Meanwhile, HES could significantly reduce TNF-alpha, IL-6, and ICAM-1 mRNA, inhibit NF-kappaB activation, and down-regulate TLR2 and TLR4 expression in the brain.	Hydroxyethyl Starch Derivatives	11-14	interleukin 6	Rattus norvegicus	53-57	
16104441-5	2005	HES significantly reduced the LPS-induced increase in intestinal levels of TNF-alpha, IL-1beta, IL-6, IL-8 and their corresponding mRNAs.	Hydroxyethyl Starch Derivatives	0-3	interleukin 6	Rattus norvegicus	96-100	
16616763-7	2006	Without obvious influence on systemic macro-hemodynamics, HES 15 ml/kg and 30 ml/kg significantly reduced CLP-induced elevation of pulmonary capillary permeability, wet/dry weight ratio, and production of IL-6.	Hydroxyethyl Starch Derivatives	58-61	interleukin 6	Rattus norvegicus	205-209	
16790644-5	2006	HES significantly reduced the increased intestinal levels of tumor necrosis factor-alpha, IL-6, cytokine-induced neutrophil chemoattractant-1, and the mRNAs in the endotoxemic rats.	Hydroxyethyl Starch Derivatives	0-3	interleukin 6	Rattus norvegicus	90-94	
15836676-7	2005	HES significantly reduced the increased hepatic levels of TNF-alpha, IL-1beta, IL-6, IL-8 and the mRNAs in the endotoxemic rats.	Hydroxyethyl Starch Derivatives	0-3	interleukin 6	Rattus norvegicus	79-83