PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16773207-5	2006	YC-1 blocked the HIF-1alpha induction by hypoxia, iron chelation, and proteasomal inhibition and also degraded ectopically expressed HIF-1alpha.	Iron	50-54	RNA binding motif single stranded interacting protein 1	Homo sapiens	0-4	
9646941-0	1998	Synergistic activation of soluble guanylate cyclase by YC-1 and carbon monoxide: implications for the role of cleavage of the iron-histidine bond during activation by nitric oxide.	Iron	126-130	RNA binding motif single stranded interacting protein 1	Homo sapiens	55-59	
20353168-9	2010	YC-1 binding also strains the Fe-histidine bond, leading to a population of the five-coordinate sGC-CO complex in addition to a conformationally distinct population of the six-coordinate sGC-CO complex.	Iron	30-32	RNA binding motif single stranded interacting protein 1	Homo sapiens	0-4	
12540839-6	2003	These results revealed that YC-1 facilitated cleavage of the proximal His-iron bond and caused geometrical distortion of the five-coordinate NO-heme.	Iron	74-78	RNA binding motif single stranded interacting protein 1	Homo sapiens	28-32	
12540839-7	2003	Resonance Raman studies demonstrated the presence of two iron-CO stretch modes at 488 and 521 cm(-1) specific to the YC-1-bound CO complex of the native enzyme.	Iron	57-61	RNA binding motif single stranded interacting protein 1	Homo sapiens	117-121	
12540839-9	2003	These results indicate that YC-1 stimulates enzyme activity by weakening or cleaving the proximal His-iron bond in the CO complex as well as the NO complex.	Iron	102-106	RNA binding motif single stranded interacting protein 1	Homo sapiens	28-32	
9920755-6	1999	It is, therefore, a reasonable inference that ligand binding at the heme iron atom is intimately connected with enzyme activation, a hypothesis that would have been difficult to maintain if the earlier report, that YC-1 has no effect on CO binding, were correct.	Iron	73-77	RNA binding motif single stranded interacting protein 1	Homo sapiens	215-219