PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32718025-3 2020 Recently, several studies have identified intricate and complicated interplay between ferroptosis, ionizing radiation (IR), ATM (ataxia-telangiectasia mutated)/ATR (ATM and Rad3-related), and tumor suppressor p53, which signifies the participation of the DNA damage response (DDR) in iron-related cell death. Iron 284-288 tumor protein p53 Homo sapiens 209-212 33081324-0 2020 Deferasirox-Dependent Iron Chelation Enhances Mitochondrial Dysfunction and Restores p53 Signaling by Stabilization of p53 Family Members in Leukemic Cells. Iron 22-26 tumor protein p53 Homo sapiens 85-88 33081324-0 2020 Deferasirox-Dependent Iron Chelation Enhances Mitochondrial Dysfunction and Restores p53 Signaling by Stabilization of p53 Family Members in Leukemic Cells. Iron 22-26 tumor protein p53 Homo sapiens 119-122 34004477-8 2021 gamma-Fe2O3 and Fe3O4 NPs could also cause mitochondrial fusion and fission dysregulation, activate lipid peroxidation and iron metabolism-related genes in a P53-dependent manner. Iron 123-127 tumor protein p53 Homo sapiens 158-161 33785447-7 2021 In this review, we will summarize the roles of p53 in the regulation of glucose, lipid, amino acid, nucleotide, iron metabolism, and ROS production. Iron 112-116 tumor protein p53 Homo sapiens 47-50 33073884-2 2021 Alongside clinical platinum drugs, these bimetallic ruthenium-iron complexes have been screened for their cytotoxicity against MIA PaCa-2 (human pancreatic carcinoma), HCT116 p53+/+ (human colon carcinoma, p53-wild type) and ARPE-19 (human retinal pigment epithelial) cell lines. Iron 62-66 tumor protein p53 Homo sapiens 175-178 33520115-7 2021 In addition to this, iron chelators stimulate apoptotic and ER stress signalling pathways inducing cell death even in cells lacking a functional p53 gene. Iron 21-25 tumor protein p53 Homo sapiens 145-148 32942535-2 2020 In addition to loss of tumor suppressor functions, mutations in TP53 promote cancer progression by altering cellular iron acquisition and metabolism. Iron 117-121 tumor protein p53 Homo sapiens 64-68 32942535-3 2020 A newly identified role for TP53 in the coordination of iron homeostasis and cancer cell survival lies in the ability for TP53 to protect against ferroptosis, a form of iron-mediated cell death. Iron 56-60 tumor protein p53 Homo sapiens 28-32 32942535-3 2020 A newly identified role for TP53 in the coordination of iron homeostasis and cancer cell survival lies in the ability for TP53 to protect against ferroptosis, a form of iron-mediated cell death. Iron 56-60 tumor protein p53 Homo sapiens 122-126 32942535-3 2020 A newly identified role for TP53 in the coordination of iron homeostasis and cancer cell survival lies in the ability for TP53 to protect against ferroptosis, a form of iron-mediated cell death. Iron 169-173 tumor protein p53 Homo sapiens 28-32 32942535-3 2020 A newly identified role for TP53 in the coordination of iron homeostasis and cancer cell survival lies in the ability for TP53 to protect against ferroptosis, a form of iron-mediated cell death. Iron 169-173 tumor protein p53 Homo sapiens 122-126 32942535-7 2020 As iron-mediated lipid peroxidation is critical for ferroptosis induction, we hypothesized that iron acquisition pathways would be upregulated in mutant TP53-expressing cells. Iron 3-7 tumor protein p53 Homo sapiens 153-157 32942535-7 2020 As iron-mediated lipid peroxidation is critical for ferroptosis induction, we hypothesized that iron acquisition pathways would be upregulated in mutant TP53-expressing cells. Iron 96-100 tumor protein p53 Homo sapiens 153-157 32863216-7 2020 Importantly, mitochondrial p53 interacted with solute carrier family 25 member 28 (SLC25A28) to form complex and enhanced the activity of SLC25A28, which could lead to the abnormal accumulation of redox-active iron and hyperfunction of electron transfer chain (ETC). Iron 210-214 tumor protein p53 Homo sapiens 27-30 32193389-0 2020 Author Correction: African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin. Iron 58-62 tumor protein p53 Homo sapiens 35-39 31191795-2 2019 It has shown that wild-type p53 can reverse EMT back to epithelial characteristics, and iron chelator acting as a p53 inducer has been demonstrated. Iron 88-92 tumor protein p53 Homo sapiens 114-117 31500291-0 2019 Distinct TP53 Mutation Subtypes Differentially Influence Cellular Iron Metabolism. Iron 66-70 tumor protein p53 Homo sapiens 9-13 31500291-1 2019 The most commonly mutated gene in all human cancers is the tumor suppressor gene TP53; however, in addition to the loss of tumor suppressor functions, mutations in TP53 can also promote cancer progression by altering cellular iron acquisition and metabolism. Iron 226-230 tumor protein p53 Homo sapiens 81-85 31500291-1 2019 The most commonly mutated gene in all human cancers is the tumor suppressor gene TP53; however, in addition to the loss of tumor suppressor functions, mutations in TP53 can also promote cancer progression by altering cellular iron acquisition and metabolism. Iron 226-230 tumor protein p53 Homo sapiens 164-168 31500291-2 2019 The primary objective of this work was to determine how TP53 mutation status influences the molecular control of iron homeostasis. Iron 113-117 tumor protein p53 Homo sapiens 56-60 31500291-4 2019 The introduction of distinct TP53 mutation types alone was sufficient to disrupt cellular iron metabolism. Iron 90-94 tumor protein p53 Homo sapiens 29-33 31500291-7 2019 In response to changes in iron availability, cells harboring either a wild-type TP53 or R273H TP53 mutation displayed canonical IRP-mediated responses, but neither IRP1 RNA binding activity nor IRP2 protein levels were affected by changes in iron status in cells harboring the R175H mutation type. Iron 26-30 tumor protein p53 Homo sapiens 80-84 31500291-7 2019 In response to changes in iron availability, cells harboring either a wild-type TP53 or R273H TP53 mutation displayed canonical IRP-mediated responses, but neither IRP1 RNA binding activity nor IRP2 protein levels were affected by changes in iron status in cells harboring the R175H mutation type. Iron 26-30 tumor protein p53 Homo sapiens 94-98 31500291-9 2019 These findings suggest a novel, IRP-independent mode of iron regulation in cells expressing distinct TP53 mutations. Iron 56-60 tumor protein p53 Homo sapiens 101-105 31980600-0 2020 African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin. Iron 39-43 tumor protein p53 Homo sapiens 16-20 30133149-5 2019 In this review, we will discuss the role of p53 tumor suppressor in iron homeostasis. Iron 68-72 tumor protein p53 Homo sapiens 44-47 30141807-10 2018 Our data indicate that lipin1 overexpression may cause reduction of intracellular iron content, which could activate the p53-p21-p27 signaling pathways, leading to cell cycle arrest at the G0/G1 phase in the hepatic carcinoma cells. Iron 82-86 tumor protein p53 Homo sapiens 121-124 29872820-6 2018 Furthermore, the reduction of the cellular iron content induced alterations of p53-p27-p21 signaling to arrest the cell cycle at S phase in SMMC7721 cells treated by chemerin. Iron 43-47 tumor protein p53 Homo sapiens 79-82 29777905-10 2018 Moreover, changes in ADI1 (biosynthetic) and SAT1 (catabolic) partially depended on the iron-regulated changes in c-Myc and/or p53. Iron 88-92 tumor protein p53 Homo sapiens 127-130 29544765-1 2018 PURPOSE: The heavy subunit of the iron storage protein ferritin (FHC) is essential for the intracellular iron metabolism and, at the same time, it represents a central hub of iron-independent pathways, such as cell proliferation, angiogenesis, p53 regulation, chemokine signalling, stem cell expansion, miRNAs expression. Iron 34-38 tumor protein p53 Homo sapiens 244-247 29292794-6 2017 Moreover, knockdown of p53 resulted in higher non-transferrin-bound iron uptake, which was mediated by increased ZIP14 levels. Iron 68-72 tumor protein p53 Homo sapiens 23-26 29695998-3 2018 However, p53 has a number of other functions that recent data strongly implicate in tumor suppression, particularly with regard to the control of metabolism and ferroptosis (iron- and lipid-peroxide-mediated cell death) by p53. Iron 174-178 tumor protein p53 Homo sapiens 9-12 29695998-3 2018 However, p53 has a number of other functions that recent data strongly implicate in tumor suppression, particularly with regard to the control of metabolism and ferroptosis (iron- and lipid-peroxide-mediated cell death) by p53. Iron 174-178 tumor protein p53 Homo sapiens 223-226 29292794-7 2017 Our study highlights a role for p53 in regulating nutrient metabolism and provides insight into how iron and possibly other metals such as zinc and manganese could be regulated in p53-inactivated tumor cells. Iron 100-104 tumor protein p53 Homo sapiens 32-35 29292794-7 2017 Our study highlights a role for p53 in regulating nutrient metabolism and provides insight into how iron and possibly other metals such as zinc and manganese could be regulated in p53-inactivated tumor cells. Iron 100-104 tumor protein p53 Homo sapiens 180-183 26517689-0 2016 Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy. Iron 53-57 tumor protein p53 Homo sapiens 6-9 28500782-11 2017 Further study uncovered that melatonin inhibited the upregulation of p53, ERK and p38 protein expressions in BMSCs with iron overload. Iron 120-124 tumor protein p53 Homo sapiens 69-72 28500782-12 2017 Collectively, melatonin plays a protective role in iron overload-induced osteogenic differentiation dysfunction and senescence through blocking ROS accumulation and p53/ERK/p38 activation. Iron 51-55 tumor protein p53 Homo sapiens 165-168 26517689-7 2016 Altogether, targeting BNIP3L in wild-type p53 colon cancer cells is a novel anticancer strategy activating iron depletion signaling and the mitophagy-related cell death pathway. Iron 107-111 tumor protein p53 Homo sapiens 42-45 25158131-0 2014 p53 directly regulates the transcription of the human frataxin gene and its lack of regulation in tumor cells decreases the utilization of mitochondrial iron. Iron 153-157 tumor protein p53 Homo sapiens 0-3 25594146-5 2015 RESULTS: In FSECs treated with catalytic iron for up to 6 days, we observed an increase in cell viability, NO production, and p53, pan-Ras, ERK/MAPK, PI3K/Akt, Ki67, and c-Myc activations (P < 0.05) in a dose-dependent and time-dependent manner. Iron 41-45 tumor protein p53 Homo sapiens 126-129 25217696-5 2014 Normal hematopoietic cells showed elevated ROS levels through increased intracellular iron levels when treated with lipocalin-2, which led to p53 pathway activation, increased apoptosis, and decreased cellular proliferation. Iron 86-90 tumor protein p53 Homo sapiens 142-145 27308524-0 2016 The heme-p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis. Iron 34-38 tumor protein p53 Homo sapiens 9-12 27308524-0 2016 The heme-p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis. Iron 34-38 tumor protein p53 Homo sapiens 53-56 23983135-9 2013 Heme iron intake was positively associated with the risk of P53 overexpressed tumors but not with tumors without P53 overexpression (Pheterogeneity = 0.12). Iron 5-9 tumor protein p53 Homo sapiens 60-63 24568186-8 2014 We speculated that iron, a by-product of HO-1-catalyzed reactions, could mediate 15d-PGJ2-induced p53 expression. Iron 19-23 tumor protein p53 Homo sapiens 98-101 24568186-9 2014 Upregulation of p53 expression by 15d-PGJ2 was abrogated by the iron chelator desferrioxamine in MCF-7 cells. Iron 64-68 tumor protein p53 Homo sapiens 16-19 24568186-13 2014 In conclusion, upregulation of p53 and p21 via HO-1 induction and subsequent release of iron with accumulation of H-ferritin may confer resistance to oxidative damage in cancer cells frequently challenged by redox-cycling anticancer drugs. Iron 88-92 tumor protein p53 Homo sapiens 31-34 24685134-0 2014 Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function. Iron 0-4 tumor protein p53 Homo sapiens 26-29 24685134-0 2014 Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function. Iron 0-4 tumor protein p53 Homo sapiens 60-63 24685134-0 2014 Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function. Iron 0-4 tumor protein p53 Homo sapiens 60-63 24685134-3 2014 Here, we report that the tumor suppressor protein p53 is downregulated during iron excess. Iron 78-82 tumor protein p53 Homo sapiens 50-53 24685134-5 2014 Moreover, in a tumorigenicity assay, iron deprivation suppressed wild-type p53-dependent tumor growth, suggesting that upregulation of wild-type p53 signaling underlies the selective efficacy of iron deprivation. Iron 37-41 tumor protein p53 Homo sapiens 75-78 24685134-5 2014 Moreover, in a tumorigenicity assay, iron deprivation suppressed wild-type p53-dependent tumor growth, suggesting that upregulation of wild-type p53 signaling underlies the selective efficacy of iron deprivation. Iron 37-41 tumor protein p53 Homo sapiens 145-148 24685134-5 2014 Moreover, in a tumorigenicity assay, iron deprivation suppressed wild-type p53-dependent tumor growth, suggesting that upregulation of wild-type p53 signaling underlies the selective efficacy of iron deprivation. Iron 195-199 tumor protein p53 Homo sapiens 75-78 24685134-5 2014 Moreover, in a tumorigenicity assay, iron deprivation suppressed wild-type p53-dependent tumor growth, suggesting that upregulation of wild-type p53 signaling underlies the selective efficacy of iron deprivation. Iron 195-199 tumor protein p53 Homo sapiens 145-148 24685134-6 2014 Our findings thus identify a direct link between iron/heme homeostasis and the regulation of p53 signaling, which not only provides mechanistic insights into iron-excess-associated tumorigenesis but may also help predict and improve outcomes in iron-deprivation-based chemotherapy. Iron 49-53 tumor protein p53 Homo sapiens 93-96 24685134-6 2014 Our findings thus identify a direct link between iron/heme homeostasis and the regulation of p53 signaling, which not only provides mechanistic insights into iron-excess-associated tumorigenesis but may also help predict and improve outcomes in iron-deprivation-based chemotherapy. Iron 158-162 tumor protein p53 Homo sapiens 93-96 24685134-6 2014 Our findings thus identify a direct link between iron/heme homeostasis and the regulation of p53 signaling, which not only provides mechanistic insights into iron-excess-associated tumorigenesis but may also help predict and improve outcomes in iron-deprivation-based chemotherapy. Iron 158-162 tumor protein p53 Homo sapiens 93-96 23983135-10 2013 Heme iron intake was associated with an increased risk of colorectal tumors harboring G>A transitions in KRAS and APC and overexpression of P53. Iron 5-9 tumor protein p53 Homo sapiens 143-146 23946774-7 2013 Even at low doses of radiation from iron ions, global genome profiling of the irradiated cells revealed the upregulation of genes associated with the activation of stress-related signaling pathways (ubiquitin-mediated proteolysis, p53 signaling, cell cycle and apoptosis), which occurred in a dose-dependent manner. Iron 36-40 tumor protein p53 Homo sapiens 231-234 23772810-12 2013 Excessive iron could also induce apoptosis, arrest cell cycle, and decrease function of BMMNC and UC-MSC, which was accompanied by increased ROS level and stimulated p38MAPK, p53 signaling pathway. Iron 10-14 tumor protein p53 Homo sapiens 175-178 23483119-4 2013 In the present study, we show that, in addition to these well-studied molecular mechanisms, the treatment of wild-type TP53 MCF-7 and mutant TP53 MDA-MB-231 human breast cancer cells with desferrioxamine (DFO), a model iron chelator, causes significant epigenetic alterations at the global and gene-specific levels. Iron 219-223 tumor protein p53 Homo sapiens 119-123 23483119-4 2013 In the present study, we show that, in addition to these well-studied molecular mechanisms, the treatment of wild-type TP53 MCF-7 and mutant TP53 MDA-MB-231 human breast cancer cells with desferrioxamine (DFO), a model iron chelator, causes significant epigenetic alterations at the global and gene-specific levels. Iron 219-223 tumor protein p53 Homo sapiens 141-145 23469783-8 2013 CONCLUSION: Iron overload can inhibit the proliferation of MSCs and induce their apoptosis through the generation of ROS, which is probably due to the stimulation of p38MAPK- p53 signaling pathway. Iron 12-16 tumor protein p53 Homo sapiens 175-178 18819919-0 2008 Post-transcriptional modulation of iron homeostasis during p53-dependent growth arrest. Iron 35-39 tumor protein p53 Homo sapiens 59-62 24112172-7 2013 The p53 expression was markedly increased in a concentration dependent manner in both iron treatment groups. Iron 86-90 tumor protein p53 Homo sapiens 4-7 24112172-8 2013 CONCLUSION: The soluble divalent iron and, to a greater degree trivalent iron, inhibited HASMC proliferation in a dosedependent manner, which may be attributed to reduction of PCNA expression and increase of p53 expression. Iron 33-37 tumor protein p53 Homo sapiens 208-211 24112172-8 2013 CONCLUSION: The soluble divalent iron and, to a greater degree trivalent iron, inhibited HASMC proliferation in a dosedependent manner, which may be attributed to reduction of PCNA expression and increase of p53 expression. Iron 73-77 tumor protein p53 Homo sapiens 208-211 20019189-0 2010 Iron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesis. Iron 0-4 tumor protein p53 Homo sapiens 45-48 20019189-4 2010 Iron dependent regulation of MDM2/p53 was confirmed ex-vivo in human monocytes, by manipulation of iron pool and in a genetic model of iron deficiency, leading to modulation of p53 target genes involved in the antioxidant response and apoptosis. Iron 0-4 tumor protein p53 Homo sapiens 34-37 20019189-4 2010 Iron dependent regulation of MDM2/p53 was confirmed ex-vivo in human monocytes, by manipulation of iron pool and in a genetic model of iron deficiency, leading to modulation of p53 target genes involved in the antioxidant response and apoptosis. Iron 0-4 tumor protein p53 Homo sapiens 177-180 20019189-4 2010 Iron dependent regulation of MDM2/p53 was confirmed ex-vivo in human monocytes, by manipulation of iron pool and in a genetic model of iron deficiency, leading to modulation of p53 target genes involved in the antioxidant response and apoptosis. Iron 99-103 tumor protein p53 Homo sapiens 34-37 20019189-5 2010 Iron status influenced p53 ubiquitination and degradation rate, and the MDM2 inhibitor nutlin increased p53 levels in iron-depleted cells. Iron 0-4 tumor protein p53 Homo sapiens 23-26 20019189-5 2010 Iron status influenced p53 ubiquitination and degradation rate, and the MDM2 inhibitor nutlin increased p53 levels in iron-depleted cells. Iron 118-122 tumor protein p53 Homo sapiens 104-107 20019189-7 2010 The MDM2 -309T > G promoter polymorphism, determining increased MDM2 and lower p53 activity, was associated with higher risk of hepatocarcinoma in cirrhotic patients with hemochromatosis, and with HFE mutations in patients with hepatocarcinoma without hemochromatosis, suggesting an interaction between MDM2 and iron in the pathogenesis of hepatocarcinoma. Iron 315-319 tumor protein p53 Homo sapiens 82-85 20019189-8 2010 In conclusion, iron status influences p53 activity and antioxidant response by modulating MDM2 expression. Iron 15-19 tumor protein p53 Homo sapiens 38-41 19716362-3 2009 The tumor suppressor p53 is induced upon iron depletion, and controls reactive oxygen species level. Iron 41-45 tumor protein p53 Homo sapiens 21-24 20023006-0 2010 Iron chelator-mediated alterations in gene expression: identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53. Iron 0-4 tumor protein p53 Homo sapiens 171-174 20023006-0 2010 Iron chelator-mediated alterations in gene expression: identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53. Iron 79-83 tumor protein p53 Homo sapiens 171-174 20023006-5 2010 Apart from iron-mediated regulation of expression via hypoxia inducible factor-1 alpha, it was noteworthy that the transcription factor p53 was also involved in iron-regulated gene expression. Iron 11-15 tumor protein p53 Homo sapiens 136-139 20185936-8 2010 CONCLUSIONS: Redox-active iron and copper in pleural fluid and saliva, upon encounter with CS, may be responsible for this carcinogenesis, mediated via alteration of p53 function. Iron 26-30 tumor protein p53 Homo sapiens 166-169 20041757-4 2010 For human cells irradiated with iron ions, cell survival was decreased, and in p53 mutant cells, the levels of mutagenesis were increased when HRR was impaired. Iron 32-36 tumor protein p53 Homo sapiens 79-82 18819919-2 2008 In this report we investigate changes in proteins of iron metabolism during p53-mediated replicative arrest. Iron 53-57 tumor protein p53 Homo sapiens 76-79 18819919-9 2008 Collectively, these results suggest that p53 may induce cell cycle arrest not only by well described mechanisms involving the induction of cyclin-dependent kinase inhibitors but also by the recruitment of pathways that reduce the availability of intracellular iron. Iron 260-264 tumor protein p53 Homo sapiens 41-44 17822515-6 2007 This article discusses three cellular regulators (p53, p21 and TRAIL) induced in synovial tissue that are important for iron metabolism. Iron 120-124 tumor protein p53 Homo sapiens 50-53 18314014-6 2008 Both DNA repair proteins, containing Fe-S clusters, and the transcription factor, p53, which is regulated through thiol-disulfide switches, can be oxidized from a distance through DNA-mediated CT. Iron 37-41 tumor protein p53 Homo sapiens 82-85 18042465-4 2008 In addition, the blockage of HO activity with the iron chelator DFO or with HO-1 siRNA inhibited the CoPP-induced expression of p53. Iron 50-54 tumor protein p53 Homo sapiens 128-131 18042465-7 2008 Based on these results, we conclude that HO activity is involved in the regulation of p53 expression in a ROS-independent mechanism, and also suggest that the expression of p53 in ARPE-19 cells is associated with heme metabolites such as biliverdin/bilirubin, carbon monoxide, and iron produced by the activity of HO. Iron 281-285 tumor protein p53 Homo sapiens 173-176 16957011-10 2006 Expression of p53 and p21WAF/CIP1 increased in cells incubated with Fe-S, but not with Fe-D. Bcl-2 expression was significantly down-regulated in cells incubated with Fe-S in comparison with Fe-D, while Bax expression was not modified by the iron compounds. Iron 68-72 tumor protein p53 Homo sapiens 14-17 17349663-11 2007 Fe-NTA enhanced the migration of TP53 signals into the comet tail of human leucocytes, indicating a high susceptibility of this tumour-relevant gene towards DNA damage induced by iron overload. Iron 179-183 tumor protein p53 Homo sapiens 33-37 17593032-0 2007 Hepcidin, a key regulator of iron metabolism, is transcriptionally activated by p53. Iron 29-33 tumor protein p53 Homo sapiens 80-83 17593032-11 2007 We hypothesise that hepcidin upregulation by p53 is part of a defence mechanism against cancer, through iron deprivation. Iron 104-108 tumor protein p53 Homo sapiens 45-48 17257079-2 2006 Growth modification caused by FSC iron involves a diminished expression of Bcl-2 and an overexpression of p53 proto-oncogene, accompanied by an increased incidence of apoptosis. Iron 34-38 tumor protein p53 Homo sapiens 106-109 16957011-10 2006 Expression of p53 and p21WAF/CIP1 increased in cells incubated with Fe-S, but not with Fe-D. Bcl-2 expression was significantly down-regulated in cells incubated with Fe-S in comparison with Fe-D, while Bax expression was not modified by the iron compounds. Iron 167-171 tumor protein p53 Homo sapiens 14-17 16957011-10 2006 Expression of p53 and p21WAF/CIP1 increased in cells incubated with Fe-S, but not with Fe-D. Bcl-2 expression was significantly down-regulated in cells incubated with Fe-S in comparison with Fe-D, while Bax expression was not modified by the iron compounds. Iron 242-246 tumor protein p53 Homo sapiens 14-17 16054986-4 2005 One cellular consequence of sustained oxidative stress and redox imbalance resulting from the combined actions of alcohol and iron is lipid peroxidation, resulting in the production of aldehydic products such as 4-hydroxy-2-nonenal, which has been linked to site-specific mutations of the p53 gene. Iron 126-130 tumor protein p53 Homo sapiens 289-292 15135642-0 2004 Mutational biases associated with potential iron-binding DNA motifs in rodent lacI and human p53 mutational databases. Iron 44-48 tumor protein p53 Homo sapiens 93-96 12416732-14 2002 Hepatic DNA of iron-loaded patients shows evidence of damage, including mutations of the tumor suppressor gene p53. Iron 15-19 tumor protein p53 Homo sapiens 111-114 12869419-0 2003 The effect of potent iron chelators on the regulation of p53: examination of the expression, localization and DNA-binding activity of p53 and the transactivation of WAF1. Iron 21-25 tumor protein p53 Homo sapiens 57-60 12869419-0 2003 The effect of potent iron chelators on the regulation of p53: examination of the expression, localization and DNA-binding activity of p53 and the transactivation of WAF1. Iron 21-25 tumor protein p53 Homo sapiens 134-137 12869419-10 2003 Our experiments demonstrated: (i) that the elevated WAF1 mRNA expression after Fe chelation was due to increased transcription and also to a post-transcriptional mechanism that was sensitive to cycloheximide; and (ii) that Fe-chelation increased WAF1 expression through a p53-independent pathway. Iron 79-81 tumor protein p53 Homo sapiens 272-275 11642302-3 2001 Adaptive response by 5~20 cGy of such C- or Fe-ion irradiation to both lethal and mutagenic effects of the challenging X-ray exposure (1~3 Gy) was difficult to be seen in this TK6 cells, but surprisingly, a relatively high level of p53 and its related proteins induction was observed after low-dose irradiations of heavy-ions. Iron 44-46 tumor protein p53 Homo sapiens 232-235 11698570-0 2001 Oxidative stress and p53 mutations in the carcinogenesis of iron overload-associated hepatocellular carcinoma. Iron 60-64 tumor protein p53 Homo sapiens 21-24 11576999-0 2001 p53-independent apoptosis mediated by tachpyridine, an anti-cancer iron chelator. Iron 67-71 tumor protein p53 Homo sapiens 0-3 12387362-0 2002 Abeta[25-35] peptide and iron promote apoptosis in lymphocytes by an oxidative stress mechanism: involvement of H2O2, caspase-3, NF-kappaB, p53 and c-Jun. Iron 25-29 tumor protein p53 Homo sapiens 140-143 11448240-6 2001 WTK1 cells (mutant TP53) were more resistant to the cytotoxic effects of both gamma rays and (56)Fe particles, but showed greater cytogenetic and mutagenic damage than TK6 cells (TP53(+)). Iron 97-99 tumor protein p53 Homo sapiens 19-23 9865721-4 1998 The iron chelator deferoxamine induced both HIF-1alpha and p53, but p53 up-regulation could still be detected in HIF-1alpha-deficient cells, suggesting that mechanisms other than HIF-1alpha activation contribute to oxygen-regulated p53 induction. Iron 4-8 tumor protein p53 Homo sapiens 59-62 11208917-3 2001 We have also shown that reactive iron (Fe3+) and cGMP staining spatially resemble that of HO-1; which, in turn, colocalizes in motor neurons with transcription factors: Fas-associated protein containing death domain (FADD), tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and p53. Iron 33-37 tumor protein p53 Homo sapiens 298-301 10930054-6 2000 Analysis of patient urine following administration of OL(1)p53 reveals a 7.5-fold increase in iron excretion at low doses (0.05 mg/kg/h). Iron 94-98 tumor protein p53 Homo sapiens 59-62 11050162-7 2000 These results are consistent with the hypothesis that the generation of oxygen/nitrogen species and unsaturated aldehydes from iron and copper overload in hemochromatosis and WD causes mutations in the p53 tumor suppressor gene. Iron 127-131 tumor protein p53 Homo sapiens 202-205 9576849-10 1998 The induction of p53 by H2O2 was abolished by the iron chelator deferoxamine and the protein synthesis inhibitor cycloheximide. Iron 50-54 tumor protein p53 Homo sapiens 17-20 26560363-0 2015 Regulation of iron homeostasis by the p53-ISCU pathway. Iron 14-18 tumor protein p53 Homo sapiens 38-41 33821487-8 2021 It summarises the excess-iron-induced alterations in MSC components, processes and discusses signalling pathways involving ROS, PI3K/AKT, MAPK, p53, AMPK/MFF/DRP1 and Wnt. Iron 25-29 tumor protein p53 Homo sapiens 144-147 8590632-0 1995 Iron deprivation results in an increase in p53 expression. Iron 0-4 tumor protein p53 Homo sapiens 43-46 8590632-1 1995 Deferoxamine (DFO)-induced iron deprivation caused an increase in p53 expression in ML-1 and Raji cells. Iron 27-31 tumor protein p53 Homo sapiens 66-69 26560363-2 2015 Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis. Iron 35-39 tumor protein p53 Homo sapiens 21-24 26560363-2 2015 Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis. Iron 99-103 tumor protein p53 Homo sapiens 21-24 26560363-2 2015 Here, we report that p53 regulates iron metabolism through the transcriptional regulation of ISCU (iron-sulfur cluster assembly enzyme), which encodes a scaffold protein that plays a critical role in Fe-S cluster biogenesis. Iron 200-202 tumor protein p53 Homo sapiens 21-24 26560363-5 2015 In addition, in response to DNA damage, p53 induced FTH1 and suppressed transferrin receptor, which regulates iron entry into cells. Iron 110-114 tumor protein p53 Homo sapiens 40-43 26560363-6 2015 HCT116 p53(+/+) cells were resistant to iron accumulation, but HCT116 p53(-/-) cells accumulated intracellular iron after DNA damage. Iron 111-115 tumor protein p53 Homo sapiens 70-73 26560363-9 2015 Our finding revealed a novel role of the p53-ISCU pathway in the maintenance of iron homeostasis in hepatocellular carcinogenesis. Iron 80-84 tumor protein p53 Homo sapiens 41-44 34502536-4 2021 Long-term exposure to TiO2 nanoparticles co-doped with 1% of iron and nitrogen led to the alteration of p53 protein activity and the gene expression controlled by this suppressor (NF-kB and mdm2), DNA damage, cell cycle disruptions at the G2/M and S phases, and lysosomal membrane permeabilization and the subsequent release of cathepsin B, triggering the intrinsic pathway of apoptosis in a Bax- and p53-independent manner. Iron 61-65 tumor protein p53 Homo sapiens 104-107 34888245-0 2021 High-LET Carbon and Iron Ions Elicit a Prolonged and Amplified p53 Signaling and Inflammatory Response Compared to low-LET X-Rays in Human Peripheral Blood Mononuclear Cells. Iron 20-24 tumor protein p53 Homo sapiens 63-66 34831070-8 2021 Suppressing iron metabolism by MSM also regulated p38/p53/ERK signaling and microRNA expressions, such as upregulating miR-130a and downregulating miR-221 and miR-222, which resulted in TRAIL induction and thereby extrinsic pathway of apoptosis. Iron 12-16 tumor protein p53 Homo sapiens 54-57 34502536-4 2021 Long-term exposure to TiO2 nanoparticles co-doped with 1% of iron and nitrogen led to the alteration of p53 protein activity and the gene expression controlled by this suppressor (NF-kB and mdm2), DNA damage, cell cycle disruptions at the G2/M and S phases, and lysosomal membrane permeabilization and the subsequent release of cathepsin B, triggering the intrinsic pathway of apoptosis in a Bax- and p53-independent manner. Iron 61-65 tumor protein p53 Homo sapiens 401-404 34395447-0 2021 The p53 Family: A Role in Lipid and Iron Metabolism. Iron 36-40 tumor protein p53 Homo sapiens 4-7 34298093-7 2021 Heme-iron induced lipid peroxidation and DNA oxidation by interacting with Nox4-independent mechanisms, promoting p53/p21 activity and cellular senescence. Iron 5-9 tumor protein p53 Homo sapiens 114-117 34395447-3 2021 In this review, we strive to cover the relevant studies that demonstrate the roles of p53, p63, and p73 in lipid and iron metabolism. Iron 117-121 tumor protein p53 Homo sapiens 86-89 35505371-1 2022 BACKGROUND: Ferroptosis is an iron dependent cell death closely associated with p53 signaling pathway and is aberrantly regulated in glioblastoma (GBM), yet the underlying mechanism needs more exploration. Iron 30-34 tumor protein p53 Homo sapiens 80-83 35447365-3 2022 The ferroptosis is mainly regulated by the metabolism of iron, lipids and amino acids through System Xc-, voltage-dependent anion channels, p53, p62-Keap1-Nrf2, mevalonate and other pathways. Iron 57-61 tumor protein p53 Homo sapiens 140-143