PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20658468-7 2010 Hepatic expression of BMP/Smad-related genes was examined in 20 HFE-HH males with significant iron overload, and compared to seven male HFE wild-type controls using quantitative real-time reverse transcription polymerase chain reaction. Iron 94-98 SMAD family member 1 Homo sapiens 26-30 19204324-6 2009 These effects are mediated through down-regulation of phosphorylation of Stat3 triggered by LPS and of Smad1/5/8 induced by iron. Iron 124-128 SMAD family member 1 Homo sapiens 103-110 32585319-1 2020 The bone morphogenetic protein (BMP)-SMAD signaling pathway plays a central role in regulating hepcidin, which is the master hormone governing systemic iron homeostasis. Iron 152-156 SMAD family member 1 Homo sapiens 37-41 31324879-11 2019 The endogenous iron regulator erythroferrone reduced BMP2-SMAD1/5/8 signalling by ~30% specifically in subcutaneous abdominal preadipocytes (p < 0.01), suggesting it plays a role in restricting the expansion of the body"s largest AT depot during energy deficiency. Iron 15-19 SMAD family member 1 Homo sapiens 58-65 30510168-2 2019 Chronic hepatitis C virus (HCV) infection causes decreased expression of the iron hormone hepcidin, which is regulated by hepatic bone morphogenetic protein (BMP)/SMAD signalling. Iron 77-81 SMAD family member 1 Homo sapiens 163-167 34740612-1 2021 Liver sinusoidal endothelial cells (LSECs) derived bone morphogenetic protein 6 (BMP6) and the BMP6/SMAD signaling pathway are essential for expression of hepcidin, the secretion of which is considered the systemic master switch of iron homeostasis. Iron 232-236 SMAD family member 1 Homo sapiens 100-104 34873429-9 2021 In CFA-saline rats, activities of the IL-6/STAT and BMP/SMAD pathways were enhanced in the liver compared with those in control rats and their levels were further increased in CFA-iron rats, whereas IL-6 expression remained unaffected after IV iron administration. Iron 180-184 SMAD family member 1 Homo sapiens 56-60 34873429-9 2021 In CFA-saline rats, activities of the IL-6/STAT and BMP/SMAD pathways were enhanced in the liver compared with those in control rats and their levels were further increased in CFA-iron rats, whereas IL-6 expression remained unaffected after IV iron administration. Iron 244-248 SMAD family member 1 Homo sapiens 56-60 34873429-10 2021 In HepG2 cells, iron caused phosphorylation of STAT-3 and SMAD1/5 and knockdown of STAT-3 and SMAD1/5 using siRNAs reduced iron-induced hepcidin upregulation to levels similar to those in corresponding control cells. Iron 16-20 SMAD family member 1 Homo sapiens 58-65 34873429-10 2021 In HepG2 cells, iron caused phosphorylation of STAT-3 and SMAD1/5 and knockdown of STAT-3 and SMAD1/5 using siRNAs reduced iron-induced hepcidin upregulation to levels similar to those in corresponding control cells. Iron 16-20 SMAD family member 1 Homo sapiens 94-101 34873429-10 2021 In HepG2 cells, iron caused phosphorylation of STAT-3 and SMAD1/5 and knockdown of STAT-3 and SMAD1/5 using siRNAs reduced iron-induced hepcidin upregulation to levels similar to those in corresponding control cells. Iron 123-127 SMAD family member 1 Homo sapiens 94-101 34786173-13 2021 CONCLUSION: Iron directly blocks hepatocellular hepcidin signaling through the BMP/SMAD pathway but independent of STAT3. Iron 12-16 SMAD family member 1 Homo sapiens 83-87 32585319-5 2020 Mutation or inactivation of BMP ligands, BMP receptors, HJV, SMADs or other proteins that modulate the BMP-SMAD pathway result in hepcidin dysregulation, leading to iron-related disorders, such as hemochromatosis and iron refractory iron deficiency anemia. Iron 165-169 SMAD family member 1 Homo sapiens 61-65 32585319-6 2020 Pharmacologic modulators of the BMP-SMAD pathway have shown efficacy in pre-clinical models to regulate hepcidin expression and treat iron-related disorders. Iron 134-138 SMAD family member 1 Homo sapiens 36-40 32585319-7 2020 This review will discuss recent insights into the role of the BMP-SMAD pathway in regulating hepcidin to control systemic iron homeostasis. Iron 122-126 SMAD family member 1 Homo sapiens 66-70