PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32585319-1	2020	The bone morphogenetic protein (BMP)-SMAD signaling pathway plays a central role in regulating hepcidin, which is the master hormone governing systemic iron homeostasis.	Iron	152-156	SMAD family member 1	Homo sapiens	37-41	
19204324-6	2009	These effects are mediated through down-regulation of phosphorylation of Stat3 triggered by LPS and of Smad1/5/8 induced by iron.	Iron	124-128	SMAD family member 1	Homo sapiens	103-110	
34873429-9	2021	In CFA-saline rats, activities of the IL-6/STAT and BMP/SMAD pathways were enhanced in the liver compared with those in control rats and their levels were further increased in CFA-iron rats, whereas IL-6 expression remained unaffected after IV iron administration.	Iron	180-184	SMAD family member 1	Homo sapiens	56-60	
34873429-9	2021	In CFA-saline rats, activities of the IL-6/STAT and BMP/SMAD pathways were enhanced in the liver compared with those in control rats and their levels were further increased in CFA-iron rats, whereas IL-6 expression remained unaffected after IV iron administration.	Iron	244-248	SMAD family member 1	Homo sapiens	56-60	
34873429-10	2021	In HepG2 cells, iron caused phosphorylation of STAT-3 and SMAD1/5 and knockdown of STAT-3 and SMAD1/5 using siRNAs reduced iron-induced hepcidin upregulation to levels similar to those in corresponding control cells.	Iron	16-20	SMAD family member 1	Homo sapiens	58-65	
34873429-10	2021	In HepG2 cells, iron caused phosphorylation of STAT-3 and SMAD1/5 and knockdown of STAT-3 and SMAD1/5 using siRNAs reduced iron-induced hepcidin upregulation to levels similar to those in corresponding control cells.	Iron	16-20	SMAD family member 1	Homo sapiens	94-101	
34873429-10	2021	In HepG2 cells, iron caused phosphorylation of STAT-3 and SMAD1/5 and knockdown of STAT-3 and SMAD1/5 using siRNAs reduced iron-induced hepcidin upregulation to levels similar to those in corresponding control cells.	Iron	123-127	SMAD family member 1	Homo sapiens	94-101	
34786173-13	2021	CONCLUSION: Iron directly blocks hepatocellular hepcidin signaling through the BMP/SMAD pathway but independent of STAT3.	Iron	12-16	SMAD family member 1	Homo sapiens	83-87	
32585319-5	2020	Mutation or inactivation of BMP ligands, BMP receptors, HJV, SMADs or other proteins that modulate the BMP-SMAD pathway result in hepcidin dysregulation, leading to iron-related disorders, such as hemochromatosis and iron refractory iron deficiency anemia.	Iron	165-169	SMAD family member 1	Homo sapiens	61-65	
32585319-6	2020	Pharmacologic modulators of the BMP-SMAD pathway have shown efficacy in pre-clinical models to regulate hepcidin expression and treat iron-related disorders.	Iron	134-138	SMAD family member 1	Homo sapiens	36-40	
32585319-7	2020	This review will discuss recent insights into the role of the BMP-SMAD pathway in regulating hepcidin to control systemic iron homeostasis.	Iron	122-126	SMAD family member 1	Homo sapiens	66-70	
20658468-7	2010	Hepatic expression of BMP/Smad-related genes was examined in 20 HFE-HH males with significant iron overload, and compared to seven male HFE wild-type controls using quantitative real-time reverse transcription polymerase chain reaction.	Iron	94-98	SMAD family member 1	Homo sapiens	26-30	
34740612-1	2021	Liver sinusoidal endothelial cells (LSECs) derived bone morphogenetic protein 6 (BMP6) and the BMP6/SMAD signaling pathway are essential for expression of hepcidin, the secretion of which is considered the systemic master switch of iron homeostasis.	Iron	232-236	SMAD family member 1	Homo sapiens	100-104	
31324879-11	2019	The endogenous iron regulator erythroferrone reduced BMP2-SMAD1/5/8 signalling by ~30% specifically in subcutaneous abdominal preadipocytes (p < 0.01), suggesting it plays a role in restricting the expansion of the body"s largest AT depot during energy deficiency.	Iron	15-19	SMAD family member 1	Homo sapiens	58-65	
30510168-2	2019	Chronic hepatitis C virus (HCV) infection causes decreased expression of the iron hormone hepcidin, which is regulated by hepatic bone morphogenetic protein (BMP)/SMAD signalling.	Iron	77-81	SMAD family member 1	Homo sapiens	163-167