PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27840125-7	2016	We found that the pre-incubation with N-Acetyl-l-Cysteine (a quinone reductase inducer) or Deferoxamine (an iron chelator) prevents the generation of ROS, restores the autophagy degradation of mHtt and preserves the cell viability in SH-SY5Y cells expressing the polyQ Htt and exposed to DA.	Iron	108-112	huntingtin	Homo sapiens	194-197	
26545340-3	2016	Indeed, many proteins initially characterized in those diseases such as amyloid-beta protein, alpha-synuclein, and huntingtin have been linked to iron neurochemistry.	Iron	146-150	huntingtin	Homo sapiens	115-125	
11092755-4	2000	Moreover, upmodulation by deferoxamine mesylate implicates huntingtin as an iron-response protein.	Iron	76-80	huntingtin	Homo sapiens	59-69	
17116244-0	2006	Huntingtin inclusion bodies are iron-dependent centers of oxidative events.	Iron	32-36	huntingtin	Homo sapiens	0-10	
11092755-0	2000	Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles.	Iron	15-19	huntingtin	Homo sapiens	0-10	
11092755-3	2000	Although the majority did not differ, dramatic changes in six classes revealed that huntingtin"s function is essential for the normal nuclear (nucleoli, transcription factor-speckles) and perinuclear membrane (mitochondria, endoplasmic reticulum, Golgi and recycling endosomes) organelles and for proper regulation of the iron pathway.	Iron	322-326	huntingtin	Homo sapiens	84-94	
20547568-2	2010	Furthermore, the HTT gene has been functionally linked to iron (Fe) metabolism, and HD patients show alterations in brain and peripheral Fe homeostasis.	Iron	58-62	huntingtin	Homo sapiens	17-20	
11092755-6	2000	Thus, organelles that require huntingtin to function suggest roles for the protein in RNA biogenesis, trafficking and iron homeostasis to be explored in HD pathogenesis.	Iron	118-122	huntingtin	Homo sapiens	30-40	
34959389-13	2021	The mRNAs encoding HTT, APP and alphaSYN contain an atypical iron response element (IRE) in their 5"-untranslated regions (5"-UTRs) that bind iron regulatory protein 1 (IRP1), and Posiphen specifically bound this complex.	Iron	61-65	huntingtin	Homo sapiens	19-22