PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17116244-0 2006 Huntingtin inclusion bodies are iron-dependent centers of oxidative events. Iron 32-36 huntingtin Homo sapiens 0-10 11092755-4 2000 Moreover, upmodulation by deferoxamine mesylate implicates huntingtin as an iron-response protein. Iron 76-80 huntingtin Homo sapiens 59-69 11092755-6 2000 Thus, organelles that require huntingtin to function suggest roles for the protein in RNA biogenesis, trafficking and iron homeostasis to be explored in HD pathogenesis. Iron 118-122 huntingtin Homo sapiens 30-40 27840125-7 2016 We found that the pre-incubation with N-Acetyl-l-Cysteine (a quinone reductase inducer) or Deferoxamine (an iron chelator) prevents the generation of ROS, restores the autophagy degradation of mHtt and preserves the cell viability in SH-SY5Y cells expressing the polyQ Htt and exposed to DA. Iron 108-112 huntingtin Homo sapiens 194-197 20547568-2 2010 Furthermore, the HTT gene has been functionally linked to iron (Fe) metabolism, and HD patients show alterations in brain and peripheral Fe homeostasis. Iron 58-62 huntingtin Homo sapiens 17-20 11092755-0 2000 Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles. Iron 15-19 huntingtin Homo sapiens 0-10 11092755-3 2000 Although the majority did not differ, dramatic changes in six classes revealed that huntingtin"s function is essential for the normal nuclear (nucleoli, transcription factor-speckles) and perinuclear membrane (mitochondria, endoplasmic reticulum, Golgi and recycling endosomes) organelles and for proper regulation of the iron pathway. Iron 322-326 huntingtin Homo sapiens 84-94 34959389-13 2021 The mRNAs encoding HTT, APP and alphaSYN contain an atypical iron response element (IRE) in their 5"-untranslated regions (5"-UTRs) that bind iron regulatory protein 1 (IRP1), and Posiphen specifically bound this complex. Iron 61-65 huntingtin Homo sapiens 19-22 26545340-3 2016 Indeed, many proteins initially characterized in those diseases such as amyloid-beta protein, alpha-synuclein, and huntingtin have been linked to iron neurochemistry. Iron 146-150 huntingtin Homo sapiens 115-125