PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33765133-3 2021 Here, we show that the absence of PPARgamma affects neonatal development and VCAM-1 expression of splenic iron-recycling red pulp macrophages (RPMs) and bone marrow erythroblastic island macrophages (EIMs). Iron 106-110 vascular cell adhesion molecule 1 Homo sapiens 77-83 22093255-1 2012 BACKGROUND: We previously reported that iron chelators inhibit TNFalpha-mediated induction of VCAM-1 in human dermal microvascular endothelial cells. Iron 40-44 vascular cell adhesion molecule 1 Homo sapiens 94-100 24722448-3 2014 We found that expression levels of intracellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and adhesion of U937 cells increased in iron-treated human aortic endothelial cells through upregulated NADPH oxidase (NOx) and NF-kappaB signaling. Iron 170-174 vascular cell adhesion molecule 1 Homo sapiens 87-120 24722448-3 2014 We found that expression levels of intracellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and adhesion of U937 cells increased in iron-treated human aortic endothelial cells through upregulated NADPH oxidase (NOx) and NF-kappaB signaling. Iron 170-174 vascular cell adhesion molecule 1 Homo sapiens 122-128 22093255-5 2012 RESULTS: Hypoxia and the non-iron binding hypoxia mimetic dimethyl oxallyl glycine (DMOG) inhibited TNFalpha-mediated induction of VCAM-1. Iron 29-33 vascular cell adhesion molecule 1 Homo sapiens 131-137 22093255-8 2012 CONCLUSION: Iron chelators, non-metal binding hypoxia mimetics, and hypoxia all inhibit TNFalpha-mediated VCAM-1 expression. Iron 12-16 vascular cell adhesion molecule 1 Homo sapiens 106-112 22093255-2 2012 We hypothesized that iron chelators mediate inhibition of VCAM-1 via inhibition of iron-dependent enzymes such as those involved with oxygen sensing and that similar inhibition may be observed with agents which simulate hypoxia. Iron 21-25 vascular cell adhesion molecule 1 Homo sapiens 58-64 22093255-2 2012 We hypothesized that iron chelators mediate inhibition of VCAM-1 via inhibition of iron-dependent enzymes such as those involved with oxygen sensing and that similar inhibition may be observed with agents which simulate hypoxia. Iron 83-87 vascular cell adhesion molecule 1 Homo sapiens 58-64 20039148-1 2010 The present study was aimed to determine the effect of iron supplementation on levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in patients with iron deficiency anemia (IDA). Iron 55-59 vascular cell adhesion molecule 1 Homo sapiens 153-186 14708635-0 2003 Inhibition of vascular cell adhesion molecule-1 expression in human dermal microvascular endothelial cells by iron chelators. Iron 110-114 vascular cell adhesion molecule 1 Homo sapiens 14-47 17962718-0 2008 Expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in human endometrial stromal and epithelial cells is regulated by interferon-gamma but not iron. Iron 177-181 vascular cell adhesion molecule 1 Homo sapiens 52-85 17962718-3 2008 The purpose of this study was to investigate iron incorporation by human endometrial cells and to test whether iron may stimulate expression of intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1. Iron 111-115 vascular cell adhesion molecule 1 Homo sapiens 189-229 12713595-0 2003 Iron chelators inhibit VCAM-1 expression in human dermal microvascular endothelial cells. Iron 0-4 vascular cell adhesion molecule 1 Homo sapiens 23-29 12713595-3 2003 The iron chelators dipyridyl (DP) and desferoxamine (DFO) inhibited VCAM-1 protein and mRNA induction in a concentration- and time-dependent manner. Iron 4-8 vascular cell adhesion molecule 1 Homo sapiens 68-74 12713595-4 2003 The induction of VCAM-1 was not inhibited by nonmetal binding reactive oxygen species (ROS) scavengers, implying a direct effect of iron in the expression of these adhesion molecules. Iron 132-136 vascular cell adhesion molecule 1 Homo sapiens 17-23 12713595-5 2003 The effect of iron was mediated at the level of gene transcription since pretreatment with DP abrogated the TNF alpha-mediated up-regulation of VCAM-1 heterogeneous nuclear RNA. Iron 14-18 vascular cell adhesion molecule 1 Homo sapiens 144-150 12713595-10 2003 These data suggest that iron plays a critical role in TNF alpha mediated VCAM-1 induction in HDMEC, and the target for iron effects may be IRF-1, NF-kappa B, and potentially chromatin remodeling. Iron 24-28 vascular cell adhesion molecule 1 Homo sapiens 73-79