PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25050219-3 2014 We argue that upon contact with redox iron, fibrinogen is converted to a hydrophobic fibrin-like polymer that coats tumor cells and provides protection from immune-mediated destruction. Iron 38-42 fibrinogen beta chain Homo sapiens 44-54 24991945-3 2014 A primary mechanism posited to explain iron-mediated hypercoagulability is hydroxyl radical formation and modification of fibrinogen; however, iron has also been demonstrated to bind to fibrinogen. Iron 39-43 fibrinogen beta chain Homo sapiens 122-132 24991945-3 2014 A primary mechanism posited to explain iron-mediated hypercoagulability is hydroxyl radical formation and modification of fibrinogen; however, iron has also been demonstrated to bind to fibrinogen. Iron 39-43 fibrinogen beta chain Homo sapiens 186-196 24991945-3 2014 A primary mechanism posited to explain iron-mediated hypercoagulability is hydroxyl radical formation and modification of fibrinogen; however, iron has also been demonstrated to bind to fibrinogen. Iron 143-147 fibrinogen beta chain Homo sapiens 186-196 24991945-6 2014 Thus, reversible iron binding to fibrinogen mechanistically explains a significant portion of coagulation kinetic and ultrastructural hypercoagulability. Iron 17-21 fibrinogen beta chain Homo sapiens 33-43 24714688-3 2014 Here we summarize recent microscopy-based observations to the effect that iron can have major effects on erythrocyte morphology, on erythrocyte deformability and on both fibrinogen polymerization and the consequent structure of the fibrin clots formed, each of which contributes significantly and negatively to such diseases. Iron 74-78 fibrinogen beta chain Homo sapiens 170-180 26295816-0 2015 Chronic Migraineurs Form Carboxyhemefibrinogen and Iron-Bound Fibrinogen. Iron 51-55 fibrinogen beta chain Homo sapiens 62-72 26295816-3 2015 Further, CO and iron enhance plasmatic coagulation in part via a fibrinogen-dependent mechanism. Iron 16-20 fibrinogen beta chain Homo sapiens 65-75 26160488-8 2015 Functional iron deficiency was associated with significantly higher serum levels of fibrinogen, ferritin, transferrin saturation, total iron binding capacity, hepcidin and older age relative to patients with absolute iron deficiency. Iron 11-15 fibrinogen beta chain Homo sapiens 84-94 23721262-4 2013 We have shown that trivalent iron (FeIII) initiates a hydroxyl radical-catalyzed conversion of fibrinogen into a fibrin-like polymer (parafibrin) that is remarkably resistant to the proteolytic dissolution and thus promotes its intravascular deposition. Iron 29-33 fibrinogen beta chain Homo sapiens 95-105 23864430-0 2013 Functional binding analysis of human fibrinogen as an iron- and heme-binding protein. Iron 54-58 fibrinogen beta chain Homo sapiens 37-47 23864430-1 2013 Human fibrinogen is a metal ion-binding protein, but its mechanism of binding with iron and heme has not been elucidated in detail. Iron 83-87 fibrinogen beta chain Homo sapiens 6-16 23864430-3 2013 The fibrinogen beads bound hemin (iron-protoporphyrin IX: PPIX) as well as iron ion released from ferrous ammonium sulfate (FAS) more efficiently than Sepharose 4B beads alone. Iron 34-38 fibrinogen beta chain Homo sapiens 4-14 23864430-7 2013 These results suggest that human fibrinogen directly recognizes iron ion, the PPIX ring and metal ions complexed with the PPIX ring, and that the binding of hemin is augmented by iron ions. Iron 64-68 fibrinogen beta chain Homo sapiens 33-43 23864430-7 2013 These results suggest that human fibrinogen directly recognizes iron ion, the PPIX ring and metal ions complexed with the PPIX ring, and that the binding of hemin is augmented by iron ions. Iron 179-183 fibrinogen beta chain Homo sapiens 33-43 23721262-6 2013 We study the effects of certain amphiphilic substances on the iron- and thrombin-induced fibrinogen polymerization visualized using scanning electron microscopy. Iron 62-66 fibrinogen beta chain Homo sapiens 89-99 15614199-4 2005 MATERIAL/METHODS: In this study we investigated whether raloxifene is able to inhibit in vitro iron-mediated oxidation of fibrinogen. Iron 95-99 fibrinogen beta chain Homo sapiens 122-132 23170793-4 2013 We have recently shown that trivalent iron (ferric ions) generates hydroxyl radicals, which subsequently convert FBG into abnormal fibrin clots in the form of DMDs. Iron 38-42 fibrinogen beta chain Homo sapiens 113-116 22889519-6 2012 Iron-aggregated fibrinogen, by contrast to native molecule, could not be dissociated into polypeptide subunit chains as shown in a polyacrylamide gel electrophoresis. Iron 0-4 fibrinogen beta chain Homo sapiens 16-26 22889519-9 2012 In view of these findings, it is postulated that iron-induced alterations in fibrinogen structure is involved in pathogenesis of certain degenerative diseases associated with iron overload and persistent thrombosis. Iron 49-53 fibrinogen beta chain Homo sapiens 77-87 22889519-9 2012 In view of these findings, it is postulated that iron-induced alterations in fibrinogen structure is involved in pathogenesis of certain degenerative diseases associated with iron overload and persistent thrombosis. Iron 175-179 fibrinogen beta chain Homo sapiens 77-87 16675719-7 2006 CONCLUSIONS: Higher intake of iron, sugar, and caffeine, in addition to obesity, account largely for higher fibrinogen levels with Westernized lifestyle. Iron 30-34 fibrinogen beta chain Homo sapiens 108-118 23280783-10 2013 We conclude that SEM is a very effective tool for the visualization of circulatory consequences of the interaction of iron-induced hydroxyl radicals with human fibrinogen. Iron 118-122 fibrinogen beta chain Homo sapiens 160-170 23280783-11 2013 Furthermore, this novel fibrinogen model provides a convenient method to study the interactions of the intramolecular and intermolecular hydrophobic forces responsible for the maintenance of the tertiary structure of native fibrin(ogen) and the prevention of iron-induced DMDs formation by hydrophilic agents. Iron 259-263 fibrinogen beta chain Homo sapiens 24-34 34218987-8 2021 Similarly, FE induced a significant rise in TNFalpha, TF, fibrinogen, and PAI-1 (P-time<0.05); these parameters remained unchanged under LF and CE (P-time>0.05). Iron 11-13 fibrinogen beta chain Homo sapiens 58-68 10828478-11 2000 Multivariate analyses revealed that lower plasma fibrinogen was associated with low to normal body mass index in women, and with dietary intakes compatible with prudent dietary guidelines in men and women (low intakes of animal protein; trans fatty acids and higher intakes of plant protein; dietary fibre, vitamin E, and iron, and a high dietary P/S ratio). Iron 322-326 fibrinogen beta chain Homo sapiens 49-59 10828478-12 2000 Subjects in the higher quartiles of plasma fibrinogen had significantly lower iron, vitamin E, and vitamin B6 (women) status. Iron 78-82 fibrinogen beta chain Homo sapiens 43-53 10933414-9 1998 Univariate and multivariate analyses revealed significant (P<0.05) positive correlations of fibrinogen with smoking habit, age, body mass index (BMI), total and low-density lipoprotein (LDL) cholesterol, triglycerides, blood pressure and white blood cell count, and significant negative correlations with high-density lipoprotein (HDL) cholesterol, gamma glutamyl transferase (GGT), serum iron and ferritin. Iron 392-396 fibrinogen beta chain Homo sapiens 95-105 10933414-10 1998 The correlations with BMI, serum lipoproteins, iron, ferritin, and GGT suggest that nutritional status and therefore diet influences plasma fibrinogen. Iron 47-51 fibrinogen beta chain Homo sapiens 140-150 1568318-0 1992 Elimination of fibrinogen interference in a dye-binding method for iron. Iron 67-71 fibrinogen beta chain Homo sapiens 15-25 33589702-8 2021 Although dietary intakes of vitamin E, magnesium and iron were inversely associated with fibrinogen levels, clinical implications of these findings are uncertain since these results were of very small magnitude and mostly explained by intake levels of other nutrients. Iron 53-57 fibrinogen beta chain Homo sapiens 89-99 12686666-8 2003 RESULTS: HD patients on maintenance iron showed elevated carbonylated fibrinogen compared with healthy subjects. Iron 36-40 fibrinogen beta chain Homo sapiens 70-80 12686666-9 2003 During a HD session, carbonyls on fibrinogen further increased when 125 mg iron gluconate was administered, but no changes were detected with 62.5 mg iron gluconate or in the absence of iron. Iron 75-79 fibrinogen beta chain Homo sapiens 34-44 12686666-11 2003 CONCLUSIONS: The significant acute increase in carbonylated fibrinogen with 125 mg iron gluconate suggests that this iron dose should be used with caution. Iron 83-87 fibrinogen beta chain Homo sapiens 60-70 12686666-12 2003 As fibrinogen is highly susceptible to iron-induced oxidation in vivo, it may serve as a marker reflecting acute iron oxidative damage and as a tool in refinement of the existing clinical dose guidelines for intravenous iron therapy. Iron 39-43 fibrinogen beta chain Homo sapiens 3-13 12686666-12 2003 As fibrinogen is highly susceptible to iron-induced oxidation in vivo, it may serve as a marker reflecting acute iron oxidative damage and as a tool in refinement of the existing clinical dose guidelines for intravenous iron therapy. Iron 113-117 fibrinogen beta chain Homo sapiens 3-13 12686666-12 2003 As fibrinogen is highly susceptible to iron-induced oxidation in vivo, it may serve as a marker reflecting acute iron oxidative damage and as a tool in refinement of the existing clinical dose guidelines for intravenous iron therapy. Iron 113-117 fibrinogen beta chain Homo sapiens 3-13 34447779-0 2021 Certain Associations Between Iron Biomarkers and Total and gamma" Fibrinogen and Plasma Clot Properties Are Mediated by Fibrinogen Genotypes. Iron 29-33 fibrinogen beta chain Homo sapiens 120-130 25986992-2 2015 Of interest, SCD patients can become iron overloaded after transfusion, and iron can enhance fibrinogen as a substrate for thrombin, resulting in thrombi that commence coagulation quickly and form rapidly. Iron 76-80 fibrinogen beta chain Homo sapiens 93-103 6421970-5 1984 Studies of the mechanism by which iron prevents a normal plasma coagulation revealed that the proenzymes of the coagulation cascade and fibrinogen were not damaged by iron. Iron 34-38 fibrinogen beta chain Homo sapiens 136-146 6421970-7 1984 Instead, thrombin was markedly inhibited by iron in its clotting effect on fibrinogen and, specifically, in its fibrinopeptide A-generating capacity, the inhibitory effect being reversible upon iron removal by EDTA chelation and gel filtration. Iron 44-48 fibrinogen beta chain Homo sapiens 75-85 26782808-0 2016 Iron modulates the alpha chain of fibrinogen. Iron 0-4 fibrinogen beta chain Homo sapiens 34-44 26782808-1 2016 Iron-bound fibrinogen has been noted to accelerate plasmatic coagulation in patients with divergent conditions involving upregulation of heme oxygenase activity, including hemodialysis, Alzheimer"s disease, sickle cell anemia, and chronic migraine. Iron 0-4 fibrinogen beta chain Homo sapiens 11-21 26782808-2 2016 Our goal was to determine if a site of iron-fibrinogen interaction was on the alpha chain. Iron 39-43 fibrinogen beta chain Homo sapiens 44-54 26782808-5 2016 Iron enhances plasmatic coagulation kinetics by modulating the alpha chain of fibrinogen. Iron 0-4 fibrinogen beta chain Homo sapiens 78-88 25860295-6 2015 Bovine fibrinogen immobilized on CNBr-activated Sepharose 4B beads showed affinity for hemin, Sn-PPIX, Zn-PPIX, and iron-free PPIX in the order Sn-PPIX < iron-free PPIX < hemin < Zn-PPIX. Iron 116-120 fibrinogen beta chain Homo sapiens 7-17 25860295-6 2015 Bovine fibrinogen immobilized on CNBr-activated Sepharose 4B beads showed affinity for hemin, Sn-PPIX, Zn-PPIX, and iron-free PPIX in the order Sn-PPIX < iron-free PPIX < hemin < Zn-PPIX. Iron 157-161 fibrinogen beta chain Homo sapiens 7-17 34447779-16 2021 Conclusion: This is the first large-scale epidemiological study to relate fibrinogen concentration and functionality to markers of iron status and to take genetic factors into consideration. Iron 131-135 fibrinogen beta chain Homo sapiens 74-84 34447779-17 2021 We have detected a relationship between iron biomarkers and fibrinogen as well as clot characteristics that are influenced by the genetic make-up of an individual. Iron 40-44 fibrinogen beta chain Homo sapiens 60-70 33440293-4 2021 Hypochlorite-modified fibrinogen is stable at 37 C as assessed by precipitation assays, and has reduced susceptibility to iron-induced (hydroxyl-mediated) precipitation compared to native fibrinogen. Iron 123-127 fibrinogen beta chain Homo sapiens 22-32 28726133-1 2017 While the administration of antivenom to treat hemotoxic snake bite injury remains the gold standard of therapy, we have demonstrated that modifying human fibrinogen with iron and carbon monoxide renders it resistant to fibrinogenolytic snake venom enzymes. Iron 171-175 fibrinogen beta chain Homo sapiens 155-165 27281365-11 2017 Another contributing factor to carcinogenesis is the excessive consumption of red meat containing redox-active iron (Fe+3) that initiates parafibrin formation from blood fibrinogen. Iron 111-115 fibrinogen beta chain Homo sapiens 170-180 27281365-11 2017 Another contributing factor to carcinogenesis is the excessive consumption of red meat containing redox-active iron (Fe+3) that initiates parafibrin formation from blood fibrinogen. Iron 117-119 fibrinogen beta chain Homo sapiens 170-180 27229173-5 2016 We confirmed that fibrinogen can coordinate with the haem iron to form a protein-haem complex which shows pseudo-peroxidase activity, and in the presence of hydrogen peroxide, the complex can induce the dityrosine formation between fibrinogen molecules, leading to the fibrin network necessary for the blood coagulation. Iron 58-62 fibrinogen beta chain Homo sapiens 18-28 27229173-5 2016 We confirmed that fibrinogen can coordinate with the haem iron to form a protein-haem complex which shows pseudo-peroxidase activity, and in the presence of hydrogen peroxide, the complex can induce the dityrosine formation between fibrinogen molecules, leading to the fibrin network necessary for the blood coagulation. Iron 58-62 fibrinogen beta chain Homo sapiens 232-242